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Magnesium metal and its corrosion products:Promising materials for tumor interventional therapy

Journal of Magnesium and Alloys 2023年第3期11卷 763-775页

作者： Binghui Xu Yuna Song Kairan Yang Yichen Li Bendong Chen Xia Liao qingan jia Xi'an Key Laboratory of Stem Cell and Regenerative Medicine Institute of Medical ResearchNorthwestern Polytechnical UniversityXi’an 710038China Shaanxi Provincial Key Laboratory of Infection and Immune Disease Shaanxi Provincial People's HospitalXi’an 710038China School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710038China Department of Hepatobiliary Surgery General HospitalNingxia Medical UniversityYinchuan 750001China Department of Nutrition First Affiliated Hospital of Xi'an Jiaotong UniversityXi’an 710038China Institute of Medical Research Northwestern Polytechnical University127 West Youyi RoadXi’an 710072China

Magnesium is generally known to degrade in aqueous environments by an electrochemical reaction.The corrosion products of magnesium include hydrogen gas,Mg^(2+),and Mg(OH)_(2).Here,we summarize the published literature describing the corrosion characteristics of magnesium,and the antitumor properties of magnesium-associated corrosion products,aiming to induce the therapeutic properties of magnesium and magnesium alloys in solid tumors.The therapeutic potential of corrosion products of magnesium is enormous.Hydrogen gas exhibits antioxidant and anti-inflammatory properties,which amount to potential anti-tumor characteristics.Mg(OH)_(2),which creates a localized alkaline microenvironment,represents a second approach for anti-tumor therapy with magnesium metal.Upregulated concentrations of Mg^(2+)ions in the local tumor microenvironment remodelling are considered a third approach for anti-tumor therapy.Therefore,we speculate about the different physical forms of magnesium that could create an anti-tumor microenvironment upon tumor interventional therapy,a technique that precisely places anti-tumor implants like particles and stents.Finally,we present our viewpoints on the potential use of magnesium in diverse solid tumor therapies to inhibit tumor progression.

关键词： Magnesium Hydrogen gas Mg(OH)_(2) Mg^(2+) Cancer Interventional therapy

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Traditional Chinese medicine as supportive care for the management of liver cancer: Past, present, and future

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Genes & Diseases 2020年第3期7卷 370-379页

作者： Xia Liao Yang Bu qingan jia Department of Nutrition First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China Department of Hepatobiliary Surgery General HospitalNingxia Medical UniversityYinchuan750001China Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China

Liver cancer is the sixth most commonly diagnosed cancer and the fourth leading cause of cancer death worldwide.Western medicine and therapies are the primary treatment strategies of hepatocellular carcinoma(HCC),but the general prognosis for HCC patients is still dismal.Under these circumstances,HCC prevention is particularly important.Traditional Chinese medicine(TCM)encompasses a wealth of documented therapeutic resources,and“preventative treatment”is the principle of TCM.In China,TCM has been used for HCC prevention for thousands of years,and has also been demonstrated to be effective for the treatment of HCC in modern China.However,the TCM theory for prevention and treatment of HCC is more widely accepted in China than abroad.In this review,we first summarize the herbs and ancient formulas with therapeutic effects on HCC.We also review the research status of TCM in modern medicine as well as the current obstacles in its development.Finally,we discuss the future of TCM in the context of precision and integrated medicine.After reviewing the literature,we believe that TCM,through ancient development,is an advanced method of cancer treatment with positive curative effects,despite its surrounding controversy.Furthermore,precise analyses and systematic research methods provides novel approaches to modernize TCM for the future.

关键词： Chinese herbal medicine Hepatocellular carcinoma Molecular mechanism Network pharmacology Traditional Chinese medicine

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Anion-Regulated Weakly Solvating Electrolytes for High-Voltage Lithium Metal Batteries

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Energy & Environmental Materials 2023年第6期6卷 259-265页

作者： Zhipeng jiang Jisheng Mo Chen Li Haiwen Li qingan Zhang Ziqi Zeng jia Xie Yongtao Li School of Materials Science and Engineering&Low-Carbon New Materials Research Center Anhui University of TechnologyMaanshan 243002China Key Laboratory of Green Fabrication and Surface Technology of Advanced Metal Materials of Ministry of Education Anhui University of TechnologyMaanshan 243002China State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China Hefei General Machinery Research Institute Hefei 230031China

Development of advanced high-voltage electrolytes is key to achieving high-energy-density lithium metal batteries(LMBs).Weakly solvating electrolytes(WSE)can produce unique anion-driven interphasial chemistry via altering the solvating power of the solvent,but it is difficult to dissolve the majority of Li salts and fail to cycle at a cut-off voltage above 4.5 V.Herein,we present a new-type WSE that is regulated by the anion rather than the solvent,and the first realize stable cycling of dimethoxyethane(DME)at 4.6 V without the use of the“solvent-in-salt”strategy.The relationships between the degree of dissociation of salts,the solvation structure of electrolytes,and the electrochemical performance of LMBs were systematically investigated.We found that LiBF_(4),which has the lowest degree of dissociation,can construct an anion-rich inner solvation shell,resulting in anion-derived anode/cathode interphases.Thanks to such unusual solvation structure and interphasial chemistry,the Li-LiCoO_(2)full cell with LiBF_(4)-based WSE could deliver excellent rate performance(115 mAh g^(-1)at 10 C)and outstanding cycling stability even under practical conditions,including high loading(10.7 mg cm^(-2)),thin Li(50μm),and limited electrolyte(1.2μL mg^(-1)).

关键词： high-voltage LiCoO_(2) lithium metal batteries solvation structure weakly solvating electrolyte

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Synergetic effect of multiple phases on hydrogen desorption kinetics and cycle durability in ball milled MgH2–PrF3–Al–Ni composite

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Progress in Natural Science:Materials International 2021年第1期31卷 152-158页

作者： Zhonghui Sun jia Zhou qingan Zhang School of Materials Science and Engineering Anhui University of Technology

A new Mg MgH–PrF–Al–Ni composite was prepared by ball milling under hydrogen atmosphere. After initial dehydrogenation and rehydrogenation, PrAl, MgF, PrHand MgNiHnanoparticles formed accompanying the main phase MgH. The hydrogen absorption-desorption properties were measured by using a Sieverts-type apparatus. The results showed that the Mg MgH–PrF–Al–Ni composite improved cycle stability and enhanced hydrogen desorption kinetics. The improvement of hydrogen absorption-desorption properties is ascribed to the synergetic effect of the in situ formed PrAl, MgF, PrHand MgNiHnanoparticles. This work provides an important inspiration for the improvement of hydrogen storage properties in Mg-based materials.

关键词： Magnesium hydride Hydrogen desorption kinetics Cycle durability Synergetic effect

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Review on Research about Wake Effects of Offshore Wind Turbines

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Energy Engineering 2022年第4期119卷 1341-1360页

作者： Yehong Dong Guangyin Tang Yan jia Zekun Wang Xiaomin Rong Chang Cai qingan Li Yingjian Yang Southern Marine Science and Engineering Guangdong Laboratory(Zhanjiang) Zhanjiang524013China CSIS(Chongqing)HaizhuangWind Power Equipment Co. Ltd.Chongqing401122China Offshore Technology Center of CCS Tianjin300457China School of Energy and Power Engineering Inner Mongolia University of TechnologyHohhot010051China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing100190China

In recent years,the construction of offshore wind farms is developing rapidly.As the wake effect of the upstream wind turbines seriously affect the performance of the downstream wind turbines,the wake effect of offshore wind turbines has become one of the research hotspots.First,this article reviews the research methods of wake effects,including CFD numerical simulation method,wind turbine wake model based on roughness and engineering wake models.However,there is no general model that can be used directly.Then it puts forward some factors that affect the wake of offshore wind turbines.The turbulence intensity in offshore wind fields is lower than that in onshore wind fields.This makes the wake recovery length of offshore wind turbines longer than that of onshore wind turbines.Floating offshore wind turbines are simultaneously disturbed by wind loads and wave loads.Unsteady movement of the platform caused by wave loads.It affects the development and changes of the wake of wind turbines.In this regard,the focus of research on the wake effects of offshore wind farms will be the proposal of accurate prediction models for the wake effects of sea wind farms.

关键词： Wind energy offshore wind turbines wake effects offshore wind farms

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耐高温环氧胶粘剂在航空发动机组件粘接中的应用

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粘接 2024年第6期51卷 30-33页

作者：任俊辉贾向辉魏彤赵柯庆安集团有限公司陕西西安710077

J-27H耐高温环氧胶粘剂具有耐高温性好、剪切强度高的特点,可用于航空发动机高温部件石墨制品、陶瓷制品等与金属材料的粘接。为了提高J-27H耐高温环氧胶粘剂应用效果,在某航空发动机产品使用J-27H进行零件粘接,工艺流程复杂,在实际施... 详细信息

J-27H耐高温环氧胶粘剂具有耐高温性好、剪切强度高的特点,可用于航空发动机高温部件石墨制品、陶瓷制品等与金属材料的粘接。为了提高J-27H耐高温环氧胶粘剂应用效果,在某航空发动机产品使用J-27H进行零件粘接,工艺流程复杂,在实际施工过程中如果操作不当,会导致粘接组件脱落现象。为了更好地应用J-27H耐高温环氧胶粘剂,保证零件粘接质量,通过对粘接前清洗、胶粘剂配制、胶粘剂固化、粘接后机加工序进行全流程优化设计,确认了最佳工艺方案,保证了产品的粘接质量。

关键词： J-27H 航空发动机胶粘剂清洗高温固化

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低温等离子体处理的鲜切猕猴桃片货架期预测模型

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中国食品学报 2022年第1期22卷 179-188页

作者：陈月圆赵武奇贾梦科高贵田张清安孟永宏陕西师范大学食品工程与营养科学学院西安710119

研究贮藏温度对低温等离子体处理的鲜切猕猴桃片品质和菌落总数的影响,建立品质指标和菌落总数货架期预测模型。将经低温等离子体处理的鲜切猕猴桃片分别在0,5,10,15,20,25℃贮藏,定期测定VC含量、叶绿素含量、总酚含量、菌落总数、脆... 详细信息

研究贮藏温度对低温等离子体处理的鲜切猕猴桃片品质和菌落总数的影响,建立品质指标和菌落总数货架期预测模型。将经低温等离子体处理的鲜切猕猴桃片分别在0,5,10,15,20,25℃贮藏,定期测定VC含量、叶绿素含量、总酚含量、菌落总数、脆性、色差及固酸比,探讨温度对其的影响,确定各监测指标的拟合方程。结合Arrhenius模型和Belehradck模型,建立鲜切猕猴桃片品质指标和菌落总数的货架期预测模型。结果表明:贮藏温度对固酸比、总酚含量及叶绿素含量的影响不显著,对色差、脆性、VC含量及菌落总数的影响显著。鲜切猕猴桃片贮藏过程中VC含量、脆性、色差及菌落总数的变化分别遵循一级反应、一级反应、零级反应及Logistics方程模型。建立的鲜切猕猴桃片各品质指标货架期预测模型SL脆性、SL色差、SLVC及菌落总数货架期预测模型SL菌落对3℃贮藏的猕猴桃片货架期的预测值与实测值的相对误差分别为4.03%,3.41%,2.4%,2.8%,预测效果好。模型可用于预测0~25℃贮藏的鲜切猕猴桃片的货架期。

关键词：鲜切猕猴桃片货架期预测模型低温等离子体

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Staged angioplasty versus regular carotid artery stenting in patients with carotid artery stenosis at high risk of hyperperfusion:a randomised clinical trial

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Stroke & Vascular Neurology 2021年第1期6卷 95-102页

作者： Dapeng Mo Baixue jia Huaizhang Shi Yaxuan Sun qingan Liu Chengzhe Fan jianping Deng Jinglin Yuan Wei Wu Changchun jiang Guilian Zhang Hanjun Du Ning Ma Feng Gao Xuan Sun Ligang Song Lian Liu Guangge Peng Yongjun Wang Yilong Wang Zhongrong Miao the STEP Study Group Interventional Neuroradiology Beijing Tiantan HospitalBeijingChina Neurosurgery First Affiliated Hospital of Harbin Medical UniversityHarbinChina Neurology Shaanxi Provincial People's HospitalXi'anChina Neurosurgery Harbin Medical University Fourth HospitalHarbinChina Neurology Beijing An Zhen HospitalBeijingChina Neurosurgery Tangdu HospitalThe Second Affiliated HospitalFourth Military Medical UniversityXi'anChina Neurology Daxing Teaching HospitalCapital Medical UniversityBeijingChina Neurology Shandong University Qilu HospitalJinanChina Neurology Baotou Central HospitalBaotouChina Neurology Xi'an Jiaotong University Second Affiliated HospitalXi'anChina Neurology Peking University Shougang HospitalBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalBeijingChina Neurology Beijing Tiantan HospitalBeijingChina 不详

Background and purpose Hyperperfusion(HP)is a devastating complication associated with carotid artery stenting(CAS)or endarterectomy.The efficacy and safety of staged angioplasty(SAP)in patients with CAS at high risk of HP remains unclear.We sought to determine whether SAP is superior to regular CAS in patients with high risk of HP.Methods A randomised,multicentre open-label clinical trial with blinded outcome assessment(STEP)was conducted.Patients with severe carotid stenosis at high risk of HP were randomly assigned(1:1)to the SAP or regular CAS group.The primary endpoint was hyperperfusion syndrome(HPS)and intracerebral haemorrhage(ICH)within 30 days after the procedure.Results From November 2014 to January 2017,a total of 64 patients were enrolled in 11 centres.33 patients were allocated to the SAP group and 31 to the regular CAS group.At 30 days,the rate of primary endpoint was 0.0%(0/33)in the SAP group and 9.7%(3/31)in the regular CAS group(absolute risk reduction(ARR),9.7%;95%CI−20.1% to 0.7%;p=0.11).As one of the secondary endpoints,the incidence of HP phenomenon(HPP)was lower in the SAP group than the regular CAS group(0.0%vs 22.6%,ARR,−22.6%;95% CI−36.8%to−10.2%;p=0.04).Conclusion The rate of HPS and ICH was not significantly lower in SAP group;the extended secondary endpoint of HPP,however,significantly reduced,which suggested that SAP may be a safe and effective carotid revascularisation procedure to prevent HP.

关键词： patients carotid perfusion

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响应面法优化微波辅助提取扁杏仁油工艺及成分分析

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中国粮油学报 2011年第3期26卷 60-63页

作者：贾晓艳张清安张霞张志琪陕西师范大学化学与材料科学学院西安710062 宁夏医科大学药学院银川750004

研究以正己烷为溶剂微波辅助提取扁杏仁油的工艺。采用响应表面优化法(RSM)对扁杏仁油的提取工艺进行了优化,得到的最佳提取工艺参数是:微波功率661 W,提取时间10 min,料液比1∶20。在此条件下,杏仁油的一次提取率达55.31%。利用GC-MS和... 详细信息

研究以正己烷为溶剂微波辅助提取扁杏仁油的工艺。采用响应表面优化法(RSM)对扁杏仁油的提取工艺进行了优化,得到的最佳提取工艺参数是:微波功率661 W,提取时间10 min,料液比1∶20。在此条件下,杏仁油的一次提取率达55.31%。利用GC-MS和HPLC-MS对扁杏仁油进行分析,结果表明扁杏仁油的主要成分为油酸、亚油酸等不饱和脂肪酸,总不饱和脂肪酸占脂肪酸总量的94.53%;还有少量的维生素E和原花青素聚合物。

关键词：扁杏仁油微波辅助提取响应表面法(RSM) 化学成分分析

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气体射流冲击干燥苹果片的响应面试验及多目标优化

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中国农业科学 2019年第15期52卷 2695-2705页

作者：贾梦科吴忠赵武奇卢丹张清安张宝善宋树杰陕西师范大学食品工程与营养科学学院

【目的】探讨气体射流冲击干燥苹果片过程中风温、切片厚度和风速及其交互作用对VC含量、复水比、单位能耗的影响,建立模型并进行多目标优化,以期得到品质好、能耗低的苹果片干燥工艺参数。【方法】以苹果为原料,选取气流温度、切片厚... 详细信息

【目的】探讨气体射流冲击干燥苹果片过程中风温、切片厚度和风速及其交互作用对VC含量、复水比、单位能耗的影响,建立模型并进行多目标优化,以期得到品质好、能耗低的苹果片干燥工艺参数。【方法】以苹果为原料,选取气流温度、切片厚度和气流速度为因素,以苹果片的VC含量、复水比和单位能耗为指标进行三因素的Box-Behnken响应面试验,分析影响各指标的主次因素及各因素间的交互作用,建立VC含量、复水比及单位能耗的二次回归模型。分别用遗传算法、fgoalattain函数法、隶属度综合评价法3种优化方法进行优化,通过比较3种优化方法的结果,得到最佳工艺参数并加以验证。【结果】各因子对VC含量影响的大小次序依次是气流温度>切片厚度>气流速度,气流温度、气流温度与切片厚度及气流温度与气流速度的交互作用极显著,切片厚度作用显著;各因子对复水比影响的大小次序依次是气流温度>气流速度>切片厚度,气流温度、切片厚度及气流速度的影响极显著,切片厚度与气流速度的交互作用影响显著;各因子对单位能耗影响的大小次序依次是切片厚度>气流温度>气流速度,气流温度、切片厚度及气流温度与气流速度的交互作用影响极显著,气流速度及气流温度与切片厚度的交互作用影响显著。建立的VC含量、复水比及单位能耗的回归模型具有统计学意义(P<0.05),可用于对苹果片气体射流冲击干燥指标进行分析和预测;遗传算法优化出苹果片气体射流冲击干燥的最佳工艺参数为:风温63.24℃、切片厚度2.00 mm、风速12.00 m·s-1,该条件下苹果片的VC含量为66.96μg/100 g,复水比为3.83,单位能耗为26.49 kJ·g-1;fgoalattain函数法优化得到的最佳工艺参数为风温71.62℃,切片厚度2.37 mm,风速11.18 m·s-1,其VC含量为64.90μg/100 g,复水比为3.41,单位能耗为25.85 kJ·g-1;隶属度综合评价法优化得到的最佳工艺参数为风温63.57℃,切片厚度2.00 mm,风速12.00 m·s-1,其VC含量为66.94μg/100g,复水比为3.80,单位能耗为26.53 kJ·g-1。以适应度值为评价指标,可以得出遗传算法优化的结果最好。【结论】遗传算法可用于苹果片气体射流冲击干燥工艺中的多目标优化,最佳工艺参数为气流温度63℃,切片厚度2 mm,气流速度12 m·s-1,该参数下VC含量、复水比、单位能耗分别为66.85μg/100 g,3.78,26.59 kJ·g-1,可在苹果片加工中使用。气体射流冲击干燥应用于苹果片干燥具有VC含量高、复水比高、单位能耗低等优点。

关键词：苹果片气体射流冲击干燥品质评价响应面综合优化

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