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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S Y Yau Kwok-Fai So li Zhang Haining ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Early identification of stroke through deep learning with multi-modal human speech and movement data

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Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun ou Haitao Wang Bin Zhang Haobang liang Bei Hu Longlong Ren Yanjuan liu Yuhu Zhang Chengbo Dai Hejun Wu Weifeng li Xin li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke

Interface energetics and engineering of organic heterostructures in organic photovoltaic cells

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Science China Chemistry 2016年第4期59卷 422-435页

作者： Yan-qing li Qian-Kun Wang qing-Dong ou Jian-Xin Tang Institute of Functional Nano & Soft Materials Collaborative Innovation Center of Suzhou Nano Science and TechnologyJiangsu Key Laboratory for Carbon-based Functional Materials & Devices Soochow University

The reliable information about interface energetics of organic materials, especially the energy level alignment at organic heterostructures is of pronounced importance for unraveling the photon harvesting and charge separation process in organic photovoltaic(OPV) cells. This article provides an overview of interface energetics at typical planar and mixed donor-acceptor heterostructures, perovskite/organic hybrid interfaces, and their contact interfaces with charge collection layers. The substrate effect on energy level offsets at organic heterostructures and the processes that control and limit the OPV operation are presented. Recent efforts on interface engineering with electrical doping are also discussed.

关键词： organic photovoltaic cell organic heterostructure energy level alignment substrate effect interface engineering

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贵州的木薯优势区域规划与布局

江西农业学报 2016年第11期28卷 24-29页

作者：罗春芳杨龙黎青欧珍贵罗亚红贵州省亚热带作物研究所贵州兴义562400

阐述了贵州木薯发展的现状与存在问题、优势与机遇。利用气候、海拔、地形等数据,通过3S技术,结合土地利用图、海拔图、坡度图、贵州省气象台站近20年的气象统计数据,综合考虑地理信息、遥感影像等因素,对贵州木薯适宜种植区域进行了规... 详细信息

阐述了贵州木薯发展的现状与存在问题、优势与机遇。利用气候、海拔、地形等数据,通过3S技术,结合土地利用图、海拔图、坡度图、贵州省气象台站近20年的气象统计数据,综合考虑地理信息、遥感影像等因素,对贵州木薯适宜种植区域进行了规划与布局。规划的优势区主要分布于南、北盘江和红水河、赤水河、樟江、都柳江流域,适宜木薯种植总面积为12.69万hm^2;兼顾总量和质量发展的目标,制定了2016~2035年贵州木薯发展的规划与布局,力争到2035年,贵州木薯发展到3.33万hm^2。为了实现总体目标,提出了相应的对策措施及建议。

关键词：木薯贵州优势区域规划与布局

Study on the local time asymmetry of the Earth's ring currents based on multiple low-Earth-orbit satellite magnetic observations

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Science China(Technological Sciences) 2024年第11期67卷 3354-3364页

作者： ou JiaMing JIANG Yi YAN qing State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao 999078China Macao Institute of Space Technology and Application Macao 999078China Zhuhai MUST Science and Technology Research Institute Macao University of Science and TechnologyZhuhai 519085China

The azimuthal morphology of Earth's ring currents has consistently shown asymmetry during extreme space weather events at low latitudes,particularly during geomagnetic storms.A dawn-dusk pattern has been detected during the storm main phase through near-Earth and in-situ magnetic *** asymmetry is believed to arise from asymmetric solar windmagnetosphere coupling and is linked to the closure of the ring *** evidence has confirmed the existence of asymmetric ring currents during quiet times and the storm recovery *** phenomenon may be closely related to the evolution of ring currents,including plasma injection and decay *** this study,the local time asymmetry of the ring current is estimated using data from low-Earth-orbit Swarm and Macao Science Satellite-1(MSS-1)*** harmonics models are developed to quantify the magnetic field of ring currents through external Gauss coefficients during both quiet periods and the storm recovery *** features of dawn-dusk asymmetry are observed in various cases in different months.(1)The maximum difference in magnetic value across local time ranges from 3 to 10 nT,showing relative invariance compared with various Sym-H levels.(2)Stronger magnetic signals are detected at the premidnight sector during quiet times and at the afternoon sector during the storm recovery phase.(3)Magnetic perturbations remain at a lower level during the postmidnight and morning *** the pattern of local time asymmetry differs between quiet times and the recovery phase,dawn-dusk asymmetry remains the most pronounced feature,affecting the trapping and loss of charged particles in the inner *** Swarm and MSS-1 magnetic observations can enable convenient monitoring of the detailed azimuthal local time effects of the ring current at various disturbance levels in the future.

关键词： Earth's ring currents local time asymmetry SHA model Macao Science Satellite-1

Side-channel analysis attacks based on deep learning network

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Frontiers of Computer Science 2022年第2期16卷 35-45页

作者： Yu ou Lang li Hunan Provincial Key Laboratory of Intelligent Information Processing and Application Hengyang Normal UniversityHengyang 421002China College of Information Science and Engineering Hunan Normal UniversityChangsha 410081China College of Computer Science and Technology Hengyang Normal UniversityHengyang 421002China

There has been a growing interest in the sidechannel analysis(SCA)field based on deep learning(DL)*** DL network or model has been developed to improve the efficiency of ***,few studies have investigated the impact of the different models on attack results and the exact relationship between power consumption traces and intermediate *** on the convolutional neural network and the autoencoder,this paper proposes a Template Analysis Pre-trained DL Classification model named TAPDC which contains three *** TAPDC model detects the periodicity of power trace,relating power to the intermediate values and mining the deeper features by the multi-layer convolutional *** implement the TAPDC model and compare it with two classical models in a fair *** evaluative results show that the TAPDC model with autoencoder and deep convolution feature extraction structure in SCA can more effectively extract information from power consumption ***,Using the classifier layer,this model links power information to the probability of intermediate *** completes the conversion from power trace to intermediate values and greatly improves the efficiency of the power attack.

关键词： side-channel analysis template attack machine learning deep learning

Mitochondrial replacement techniques or therapies (MRTs) to improve embryo development and to prevent mitochondrial disease transmission

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Journal of Genetics and Genomics 2017年第8期44卷 371-374页

作者： Xiang-Hong ou qing-Yuan Sun Reproductive Medicine Center The 2nd People＇s Hospital of Guangdong Province Guangzhou 510317 China State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing I00101 China University of Chinese Academy of Sciences Beijing 100101 China

The mitochondrion which contains its own double-stranded circular DNA is a semi-independent organelle that plays critical roles in cell activity. Mitochondrial DNA （mtDNA） is maternally inherited through several mechanisms that have been proposed （Luo et al., 2013） and, if mitochondrial mutations are inherited to the offspring, it is possible to cause mitochondrial diseases such as neuropathy, cardiomyopathy, myopathy, and liver failure.

关键词： mtDNA Mitochondrial replacement techniques or therapies to improve embryo development and to prevent mitochondrial disease transmission

Design approaches for active,semi-active and passive control systems based on analysis of characteristics of active control force

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Earthquake Engineering and Engineering Vibration 2009年第4期8卷 493-506页

作者： ou Jinping li Hui School of Civil ＆ Hydraulic Engineering Dalian University of Technology Dalian 116024 China School of Civil Engineering Harbin Institute of Technology Harbin 150090 China

In this paper, the characteristics of forces in active control systems connected to adjacent levels of a building are analyzed. The following characteristics are observed：（1） active control can provide significantly superior supplemental damping to a building, but causes a small frequency shift; （2） the linear quadratic regulator （LQR）-based control force is composed of an elastic restoring force component and a damping force component, where the damping force is almost identical to the total control force, however, the elastic restoring force is very small; and （3） the active control forces prevent mction most of the time during the entire control process. These three characteristics imply that active control systems connected to adjacent levels of a building behave like passive damping devices with adjustable parameters, namely damping characteristics in an active control, which is the mechanism used by semi-active control devices to reach similar performance as active control systems. Two indices are defined to quantify the damping characteristics of control forces in active control systems. These two indices can also be used to quantify the capacity of semi-active control to achieve the perfonrlance of active control. Based on the above observations, two principles are founded for optimization of parameters of semi-active control devices and passive dampers. The first is that the maximum output force of a semi-active or passive device to be designed is identical to an active device, called ＂design principle＂. The other is the response equivalent principle, which states that the response of a building with semi-active or passive devices is the same as with active devices when the same maximum output force is applied. The design procedure for semi-active control devices and passive dampers is described in detail. Finally, numerical simulations of two benchmark problems is conducted to demonstrate the damping characteristics of active control and investigate the c

关键词： active control: semi-active control smart control damping design approach

中性及酸性条件下不同来源脱脂乳粉的稳定性比较分析

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食品安全质量检测学报 2016年第8期7卷 3155-3160页

作者：舒成亮杨忻怡薛玉清余立意欧凯李言郡马海然杭州娃哈哈饮料有限公司杭州310018

目的对5种不同来源的脱脂乳粉在中性和酸性条件下的稳定性进行比较分析。方法对不同脱脂乳粉的营养组成、乳清蛋白氮、热凝固时间、△p H、离心沉淀率等指标进行检测并进行对比。结果 5种脱脂乳粉在蛋白质、乳糖、钙等影响稳定性的成分... 详细信息

目的对5种不同来源的脱脂乳粉在中性和酸性条件下的稳定性进行比较分析。方法对不同脱脂乳粉的营养组成、乳清蛋白氮、热凝固时间、△p H、离心沉淀率等指标进行检测并进行对比。结果 5种脱脂乳粉在蛋白质、乳糖、钙等影响稳定性的成分上差异不大,脱脂乳粉热凝固时间越长、△p H越小,酸性乳饮料经高温热处理后离心沉淀越少,而脱脂乳粉乳清蛋白氮越高,中性条件下离心沉淀越少。结论本研究对脱脂乳粉在中性和酸性条件下的稳定性评价较为科学,对于乳清蛋白氮、热凝固时间和△p H的测定可应用于产品中脱脂乳粉的选择。

关键词：脱脂乳粉稳定性乳清蛋白氮热凝固时间离心沉淀