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Automatic detection of small bowel lesions with different bleeding risks based on deep learning models

World Journal of Gastroenterology 2024年第2期30卷 170-183页

作者： Rui-Ya Zhang Peng-Peng Qiang Ling-jun Cai Tao Li Yan Qin Yu Zhang Yi-qing Zhao jun-Ping Wang Department of Gastroenterology The Fifth Clinical Medical College of Shanxi Medical UniversityTaiyuan 030012Shanxi ProvinceChina School of Computer and Information Technology Shanxi UniversityTaiyuan 030006Shanxi ProvinceChina School of Life Sciences and Technology Mudanjiang Normal UniversityMudanjiang 157011Heilongjiang ProvinceChina

BACKGROUND Deep learning provides an efficient automatic image recognition method for small bowel(SB)capsule endoscopy(CE)that can assist physicians in diagnosis.However,the existing deep learning models present some unresolved challenges.AIM To propose a novel and effective classification and detection model to automatically identify various SB lesions and their bleeding risks,and label the lesions accurately so as to enhance the diagnostic efficiency of physicians and the ability to identify high-risk bleeding groups.METHODS The proposed model represents a two-stage method that combined image classification with object detection.First,we utilized the improved ResNet-50 classification model to classify endoscopic images into SB lesion images,normal SB mucosa images,and invalid images.Then,the improved YOLO-V5 detection model was utilized to detect the type of lesion and its risk of bleeding,and the location of the lesion was marked.We constructed training and testing sets and compared model-assisted reading with physician reading.RESULTS The accuracy of the model constructed in this study reached 98.96%,which was higher than the accuracy of other systems using only a single module.The sensitivity,specificity,and accuracy of the model-assisted reading detection of all images were 99.17%,99.92%,and 99.86%,which were significantly higher than those of the endoscopists’diagnoses.The image processing time of the model was 48 ms/image,and the image processing time of the physicians was 0.40±0.24 s/image(P<0.001).CONCLUSION The deep learning model of image classification combined with object detection exhibits a satisfactory diagnostic effect on a variety of SB lesions and their bleeding risks in CE images,which enhances the diagnostic efficiency of physicians and improves the ability of physicians to identify high-risk bleeding groups.

关键词： Artificial intelligence Deep learning Capsule endoscopy Image classification Object detection Bleeding risk

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High Speed Sintering:Assessing the Influence of Energy Input on Microstructure and Mechanical Properties of Polyether Block Amide(PEBA)Parts

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Chinese Journal of Polymer Science 2024年第5期42卷 675-682,I0004,I0010页

作者： Jiang-Tao Sun zhi-Yong Fan Yi-Wei Mao Wei Li Wei Zhu Dao-Sheng Cai qing-Song Wei State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan430074China State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430074China National Engineering Research Centre for High Efficiency Grinding Hunan UniversityChangsha410082China Wuhan EasyMFG Technology CO. LTDWuhan430074China

High speed sintering,a new powder-bed fusion additive manufacturing technology,utilizes infrared lights(IR)to intensely heat and melt polymer powders.The presence of defects such as porosity,which is associated with particle coalescence,is highly dependdent on the level of energy input.This study investigate the influcence of energy input on porosity and its subsequent effects on the mechanical properties and microstructures of PEBA parts.The parts were manufactured with a variety of lamp powers,resulting in a range of energy input levels spanning from low to high.Subsequebtly,they underwent testing using Archimedes’method,followed by tensile testing.The porosity,mechanical characteristics,and energy input exhibit a strong correlation;inadequate energy input was the primary cause of pore formation.Using the reduced IR light power resulted in the following outcomes:porosity,ultimate tensile strength,and elongation of 1.37%,7.6 MPa,and 194.2%,respectively.When the energy input was further increased,the porosity was reduced to as low as 0.05%and the ultimate tensile strength and elongation were increased to their peak values of 233.8%and 9.1 MPa,respectively.

关键词： High speed sintering Additive manufacturing Energy input Powder bed fusion PEBA

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Low interleukin-10 level indicates a good prognosis in Salmonella enterica serovar typhimurium-induced pediatric hemophagocytic lymphohistiocytosis:A case report

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World Journal of Clinical Cases 2024年第9期12卷 1660-1668页

作者： Yuan-Yuan Chen Xiang-zhi Xu Xiao-jun Xu Division/Center of Pediatric Hematology Oncology Children’s HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Pediatric Intensive Care Unit Children’s Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Secondary hemophagocytic lymphohistiocytosis(sHLH)triggered by Salmonella enterica serovar Typhimurium is rare in pediatric patients.There is no consensus on how to treat S.typhimurium-triggered sHLH.CASE SUMMARY A 9-year-old boy with intermittent fever for 3 d presented to our hospital with positive results for S.typhimurium,human rhinovirus,and Mycoplasma pneumoniae infections.At the time of admission to our institution,the patient’s T helper 1/T helper 2 cytokine levels were 326 pg/mL for interleukin 6(IL-6),9.1 pg/mL for IL-10,and 246.7 pg/mL for interferon-gamma(IFN-γ),for which the ratio of IL-10 to IFN-γwas 0.04.In this study,the patient received meropenem,linezolid,and cefoperazone/sulbactam in combination with high-dose methylprednisolone therapy(10 mg/kg/d for 3 d)and antishock supportive treatment twice.After careful evaluation,this patient did not receive HLH chemotherapy and recovered well.CONCLUSION S.Typhimurium infection-triggered sHLH patient had a ratio of IL-10 to IFN-γ≤1.33,an IL-10 concentration≤10.0 pg/mL,and/or an IFN-γconcentration≤225 pg/mL at admission.Early antimicrobial and supportive treatment was sufficient,and the HLH-94/2004 protocol was not necessary under these conditions.

关键词： Hemophagocytic lymphohistiocytosis Cytokine pattern Interferon gamma Interleukin-10 Salmonella enterica serovar Typhimurium Case report

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Microstructural characterization and mechanical properties of(TiC+TiB)/TA15 composites prepared by an in-situ synthesis method

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China Foundry 2024年第2期21卷 168-174页

作者： zhi-yong Zhang Jiao-jiao Cheng Jia-qi Xie Shi-bing Liu Kun Shi jun Zhao Shenyang Research Institute of Foundry Co. Ltd.CAMShenyang 110022China National Key Laboratory of Advanced Casting Technologies Shenyang 110022China

Titanium matrix composites reinforced with ceramic particles are considered a promising engineering material due to their combination of high specific strength,low density,and high modulus.In this study,the TA15-based composites reinforced with a volume fraction of 10% to 25%(TiB+TiC)were prepared using powder metallurgy and casting technique.Microstructural characterization and phase constitution were examined using optical microscopy(OM),scanning electron microscopy(SEM),and X-ray diffraction(XRD).In addition,the microhardness,room temperature(RT)and high temperature(HT)tensile properties of the composites were evaluated.Results revealed that the reinforcements are distributed uniformly even in the composites with a high volume of TiB and TiC.However,as the volume fraction exceeds 15%,TiB and TiC particles become coarsening and exhibit rod-like and dendritic-like morphology.Microhardness increases gradually from 321.2 HV for the base alloy to a maximum of 473.3 HV as the reinforcement increases to 25vol.%.Tensile test results indicate that a reinforcement volume fraction above 20% is beneficial for enhancing tensile strength and yield strength at high temperatures,but it has an adverse effect on room temperature elongation.Conversely,if the reinforcement volume fraction is below 20%,it can improve high-temperature elongation when the temperature exceeds 600℃.

关键词： titanium matrix composites microstucture microhardness tensile properties in-situ synthesis

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Yiwei Xiaoyu granules for treatment of chronic atrophic gastritis with deficiency syndrome of the spleen and stomach

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World Journal of Clinical Cases 2024年第13期12卷 2201-2209页

作者： Wan-Qun Chen qing-Feng Fan Yuan-jun He Fei Li Xin Wu Yan-Ping Li Xiao-jun Yang Department of Gastroenterology Chongqing Hospital of Traditional Chinese MedicineChongqing 400000China

BACKGROUND The Correa sequence,initiated by Helicobacter pylori(H.pylori),commonly progresses to gastric cancer through the stage of chronic atrophic gastritis(CAG).Although eradication of H.pylori only reduces the risk of gastric cancer,it does not eliminate the risk for neoplastic progression.Yiwei Xiaoyu granules(YWXY)are a commonly used composite preparation in Chinese clinics.However,the pursuit of excellence in clinical trials and the establishment of standardized animal experiments are still needed to contribute to full understanding and application of traditional Chinese medicine in the treatment of CAG.AIM To demonstrate the effectiveness of YWXY in patients with CAG and spleenstomach deficiency syndrome(DSSS),by alleviating histological scores,improving response rates for pathological lesions,and achieving clinical efficacy in relieving DSSS symptoms.METHODS We designed a double-blind,randomized,controlled trial.The study enrolled seventy-two H.pylori-negative patients(mean age,52.3 years;38 men)who were randomly allocated to either the treatment group or control group in a 1:1 ratio,and treated with 15 g YWXY or 0.36 g Weifuchun(WFC)tablet combined with the respective dummy for 24 wk.The pre-randomization phase resulted in the exclusion of 72 patients:50 participants did not meet the inclusion criteria,12 participants declined to participate,and 10 participants were excluded for various other reasons.Seven visits were conducted during the study,and histopathological examination with target endoscopic biopsy of narrow-band imaging was requested before the first and seventh visits.We also evaluated endoscopic performance scores,total symptom scores,serum pepsinogen and gastrin-17.RESULTS Six patients did not complete the trial procedures.Treatment with YWXY improved the Operative Link on Gastric Intestinal Metaplasia Assessment(OLGIM)stage,compared with WFC(P<0.05).YWXY provided better relief from symptoms of DSSS and better improvement in serum gastric function,compared with WFC(P<0.05).CONCLUSION YWXY

关键词： Chronic atrophic gastritis Yiwei Xiaoyu granules Randomized clinical trial Weifuchun tablet Traditional Chinese medicine Helicobacter pylori

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The reservoir characteristics and their controlling factors of the sublacustrine fan in the Paleogene Dongying Formation, Bohai Sea,China

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Journal of Palaeogeography 2024年第1期13卷 127-148页

作者： Xiao-jun Pang Guan-Min Wang Meng Zhao qing-Bin Wang Xue-Fang Zhang School of Geosciences China University of Petroleum(East China)QingdaoShandong 266580China Tianjin Branch of China National Offshore Oil Corporation Limited Tianjin 300459China

Sublacustrine fan is an important element in continental lacustrine basins and is significant for reservoir exploration. Oil and gas resources have been found in the sublacustrine fan sandstone reservoirs of the Paleogene Dongying Formation in the Bohai Sea. In this study, the characteristics of the sublacustrine fan reservoirs and the controlling factors are studied using information from logging, cores, physical properties,casting thin sections, X-ray diffraction of clay minerals, vitrinite reflectance, rock pyrolysis, manometry data,and 3D seismic data. The sublacustrine fans of the Dongying Formation in the LD10, QHD34, and BZ21 structures show high-quality reservoirs with porosity >15 % and permeability >5 m D. The main controlling factors of the high-quality reservoirs are attributed to the favorable sedimentary facies type and negligible compaction,and cementation, substantial dissolution of K-feldspar, overpressure, and the development of faults and fractures. A high-quality sublacustrine fan reservoir model has been established to explain how these factors affected the physical properties. The favorable targets for oil and gas exploration in the Dongying Formation of Bohai Sea include undercompacted sandy debris flow reservoirs showing the dissolution of K-feldspar, and the reservoirs which are connected to the source rocks by faults. This study provides insights to establish the relationship between sedimentology, diagenesis and reservoir quality. The results of this study are significant for the exploration and development of the sublacustrine fan sandstone reservoirs in the Bohai Sea and analogous sandstone reservoirs elsewhere.

关键词： Sublacustrine fan High-quality reservoir Dissolution Overpressure Fault Bohai Sea

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The role of acute normovolemic hemodilution in reducing allogeneic blood transfusion in glioblastoma surgery:a case-control study

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Chinese Neurosurgical Journal 2024年第1期10卷 35-41页

作者： Ping Chen Xin‑Huang Zhang Ying Wang Xian‑Zhong Lin De‑zhi Kang qing‑Song Lin Department of Anesthesiology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005FujianChina Department of Neurosurgery The First Affiliated Hospital of Fujian Medical UniversityNo.20 Chazhong RdTaijiang DistrictFuzhou 350005FujianChina Department of Neurosurgery Binhai Branch of National Regional Medical CenterThe First Affiliated Hospital of Fujian Medical UniversityFuzhou 350209FujianChina Fujian Provincial Institutes of Brain Disorders and Brain Sciences The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005FujianChina Fujian Provincial Clinical Research Center for Neurological Diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005FujianChina Fujian Provincial Key Laboratory of Precision Medicine for Cancer The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005FujianChina

Background Acute normovolemic hemodilution(ANH)was first introduced in glioblastoma surgery,and its role in reducing allogeneic blood transfusion was investigated in this study.Methods This study enrolled supratentorial glioblastoma patients who received total resection.In the ANH group,the patients were required to draw blood before the operation,and the blood will be transfused back to the patient during the operation.The association between ANH and clinical features was investigated.Results Sixty supratentorial glioblastoma patients were enrolled in this study,25 patients were allocated in the ANH group,and another 35 patients were included in the control group.ANH dramatically reduced the need for allogeneic blood transfusion(3[12%]vs 12[34.3%],P=0.049),and the blood transfusion per total of patients was dramatically decreased by the application of ANH(0.40±1.15 units vs 1.06±1.59 units,P=0.069).Furthermore,ANH also markedly reduced the requirement of fresh frozen plasma(FFP)transfusion(2[8%]vs 11[31.4%],P=0.030)and the volume of FFP transfusion per total of patients(32.00±114.46 mL vs 115.71±181.00 mL,P=0.033).The complication rate was similar between the two groups.Conclusions ANH was a safe and effective blood conservation technique in glioblastoma surgery.

关键词： Glioblastoma Acute normovolemic hemodilution Surgery Blood transfusion

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Warming intensified the effects of nitrogen addition on N_(2)O emissions from alpine meadow in the northern qinghai-Tibet Plateau

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Advances in Climate Change Research 2024年第1期15卷 101-112页

作者： Ming-Jie LI Yi-qing GE Hasbagan GANJURJAV Guo-Zheng HU Hong-Bao WU jun YAN Shi-Cheng HE qing-Zhu GAO Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural SciencesBeijing 100081China National Agricultural Experimental Station for Agricultural Environment Nagqu 852100China Ecology and Nature Conservation Institute Chinese Academy of ForestryBeijing 100091China College of Resource and Environment Anhui Science and Technology UniversityFengyang 233100China Nagqu Agriculture Animal Husbandryand Prataculture Science and Technology Research and Extension CenterNagqu 852100China Tongliao Experimental Middle School Tongliao 028000China

Warming and nitrogen(N)addition may impact soil nitrous oxide(N_(2)O)emissions,but the relationship between plant community composition and soil microbial activities remains unclear.For a two-year field study in the qinghai-Tibet Plateau,open-top chambers were used to quantify the effects of warming,N-addition,and their interactions on N_(2)O emissions.We found that the N-addition greatly increased N_(2)O emissions by 77.4%in 2018 when compared to the control group.In contrast,warming showed little effect on N_(2)0 emissions but did increase the activity of enzymes associated with soil nitrification and denitrification.A combined effect of warming and N-addition of resulted in 208.6%(2018)and 90.8%(2019)increase in N_(2)0 emissions,respectively,compared to the individual treatments of warming or N-addition.Global warming in alpine meadows is causally linked to increased legume biomass which is further intensified with the N-addition.Intensified legume biomass(p<0.05),soil moisture(p<0.001)and enzyme activity(p<0.001)had a positive effect on N_(2)0 emissions,while diminished microbial carbon/nitrogen(MBC/MBN)(p<0.05)correlated with reduced N_(2)O emissions.Final results indicated that N-addition has a positive effect on N_(2)O emissions,and the addition of warming further intensifies this effect.The increased dominance of legumes and microbial N content contributes to this effect.These outcomes suggest that warming and atmospheric N deposition can stimulate N_(2)O emissions of alpine meadows inthefuture.

关键词： Alpine meadow Community composition Nitrogen addition Nitrous oxide flux qinghai-Tibet Plateau Warming

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Design of weak current measurement system and research on temperature impact

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Nuclear Science and Techniques 2024年第4期35卷 46-56页

作者： Chu-Xiang Zhao San-Gang Li Rong-Rong Su Li Yang Ming-Zhe Liu qing-Yue Xue Shan Liao zhi Zhou qing-Shan Tan Xian-Guo Tuo Yi Cheng College of Nuclear Technology and Automation Engineering Chengdu University of Technology1#DongsanluErxianqiaoChengdu 610059China Applied Nuclear Technology in Geosciences Key Laboratory of Sichuan Province Chengdu University of Technology1#DongsanluErxianqiaoChengdu 610059China University of Science and Technology of China Hefei 230026China School of Physics and Electronic Engineering Sichuan University of Science and EngineeringZigong 643000China

A dedicated weak current measurement system was designed to measure the weak currents generated by the neutron ionization chamber.This system incorporates a second-order low-pass filter circuit and the Kalman filtering algorithm to effectively filter out noise and minimize interference in the measurement results.Testing conducted under normal temperature conditions has demonstrated the system's high precision performance.However,it was observed that temperature variations can affect the measurement performance.Data were collected across temperatures ranging from -20 to 70℃,and a temperature correction model was established through linear regression fitting to address this issue.The feasibility of the temperature correction model was confirmed at temperatures of -5 and 40℃,where relative errors remained below 0.1% after applying the temperature correction.The research indicates that the designed measurement system exhibits excellent temperature adaptability and high precision,making it particularly suitable for measuring weak currents.

关键词： Weak current measurement system Neutron ionization chamber Kalman filter algorithm Temperature correction model

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Impact factors and pathways of halonitromethanes formation from aspartic acid during LED-UV_(265)/chlorine disinfection

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Frontiers of Environmental Science & Engineering 2024年第1期18卷 129-144页

作者： Liangwen Zhu Tao Wang Qian Tang qing Wang Lin Deng jun Hu Chaoqun Tan Rajendra Prasad Singh Key Laboratory of Concrete and Prestressed Concrete Structures of Ministry of Education School of Civil EngineeringSoutheast UniversityNanjing 211189China College of Environment Zhejiang University of TechnologyHangzhou 310014China

Light emitting diode (LED-UV)/chlorine disinfection can replace UV/chlorine disinfection in wastewater treatment plants and water supply plants. Halonitromethanes (HNMs) are a class of novel nitrogenous disinfection by-products, which are characterized by higher cytotoxicity and genotoxicity than regulated disinfection by-products. Herein, the impact factors and pathways of HNMs formation from aspartic acid (ASP) were investigated during LED-UV_(265)/chlorine disinfection. The results showed that three types of chlorinated-HNMs (Cl-HNMs) were found during LED-UV265/chlorine disinfection, and their concentrations increased first and then declined as the reaction progressed. Cl-HNMs yields increased with increasing LED-UV_(265) intensity, free chlorine dosage, and ASP concentration, which declined with increasing pH (6.0–8.0). Meantime, the important impact of the coexisting ions contained in water matrices on HNMs formation from ASP was observed during LED-UV_(265)/chlorine disinfection. It was found that copper ions (Cu^(2+)) promoted Cl-HNMs formation. Furthermore, when bromide (Br–) appeared during LED-UV265/chlorine disinfection, nine types of HNMs were detected simultaneously. Moreover, Br– not only converted Cl-HNMs toward brominated (chlorinated)-HNMs and brominated-HNMs but also showed a marked effect on HNMs concentrations and species. Subsequently, the possible pathways of HNMs formation from ASP were proposed during LED-UV_(265)/chlorine disinfection. At last, it was proved that the formation trends of HNMs obtained in the real waters were similar to those in simulated waters. This work elaborated on the influence factors and pathways of HNMs formation, which is conducive to controlling the HNMs produced during LED-UV_(265)/chlorine disinfection.

关键词： LED-UV265 chlorine HNMs Aspartic acid Bromide Copper ions

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