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Application of Computed Tomography Virtual Noncontrast Spectral Imaging in Evaluation of Hepatic Metastases： A Preliminary Study

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Chinese Medical Journal 2015年第5期128卷 610-614页

作者： Shi-Feng Tian Ai-Lian liu Jing-Hong liu Mei-Yu Sun He-qing Wang Yi-jun liu Department of Radiology First Affiliated Hospital of Dalian Medical University Dalian Shenyang 116011 China

Objective：The objective was to qualitatively and quantitatively evaluate hepatic metastases using computed tomography （CT） virtual noncontrast （VNC） spectral imaging in a retrospective ***：Forty hepatic metastases patients underwent CT scans including the conventional true noncontrast （TNC） and the tri-phasic contrast-enhanced dual energy spectral scans in the hepatic arterial,portal venous,and equilibrium *** tri-phasic spectral CT images were used to obtain three groups of VNC images including in the arterial （VNCa）,venous （VNCv）,and equilibrium （VNCe） phase by the material decomposition process using water and iodine as a base material *** image quality and the contrast-to-noise ratio （CNR） of metastasis of the four groups were compared with ANOVA *** metastasis detection rates with the four nonenhanced image groups were calculated and compared using the Chisquare ***：There were no significant differences in image quality among TNC,VNCa and VNCv images （P 〉 0.05）.The quality of VNCe images was significantly worse than that of other three groups （P 〈 0.05）.The mean CNR of metastasis in the TNC and VNCs images was 1.86,2.42,1.92,and 1.94,respectively; the mean CNR of metastasis in VNCa images was significantly higher than that in other three groups （P 〈 0.05）,while no statistically significant difference was observed among VNCv,VNCe and TNC images （P 〉 0.05）.The metastasis detection rate of the four nonenhanced groups with no statistically significant difference （P 〉 0.05）.Conclusions：The quality of VNCa and VNCv images is identical to that of TNC images,and the metastasis detection rate in VNC images is similar to that in TNC *** images obtained from arterial phase show metastases more ***,VNCa imaging may be a surrogate to TNC imaging in hepatic metastasis diagnosis.

关键词： Contrast-to-noise Ratio Hepatic Metastasis Virtual Noncontrast Imaging

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2013年前郭M_s5.8震群矩张量研究

地球物理学报 2017年第9期60卷 3418-3431页

作者：刘俊清刘财雷建设甘卫军杨清福张晨侠吉林大学地球探测科学与技术学院长春130026 吉林省地震局长春130117 中国地震局地壳应力研究所(地壳动力学重点实验室) 北京100085 中国地震局地质研究所地震动力学国家重点实验室北京100029

2013年吉林前郭M_s5.8震群为爆发性震群,目前余震活动仍然在持续.基于吉林、辽宁、黑龙江、内蒙古四省地震台网记录的前郭震群波形资料,利用波形信噪比、震源类型、台站及速度模型组合的指标选择最佳的反演方案,应用矩张量的三种反演模... 详细信息

2013年吉林前郭M_s5.8震群为爆发性震群,目前余震活动仍然在持续.基于吉林、辽宁、黑龙江、内蒙古四省地震台网记录的前郭震群波形资料,利用波形信噪比、震源类型、台站及速度模型组合的指标选择最佳的反演方案,应用矩张量的三种反演模式,对序列中5个M_s≥5.0地震进行矩张量反演研究,获得了全矩张量、偏矩张量和纯双力偶的矩张量.使用F-test对地震的三种模式的矩张量反演结果进行显著性检验来确定最佳反演模式.结果显示,5个地震的最优矩张量解均为全矩张量模式反演获得的结果,其双力偶分量仅有20%~65%,矩心深度位于地下3~4 km处,地震在Hudson震源类型图上的投影远离双力偶震源类型区域.这些结果表明,震源类型并非典型的构造地震,推断前郭地震可能是与人类活动有关的诱发地震.

关键词：震源机制, 全矩张量解, F-test, 前郭5.8级震群

Progress in the application of Meleis transition theory in the nursing field

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Nursing Communications 2022年第1期6卷 79-83页

作者： Lian-Jie Zhan Yong-Chao He qing-jun liu Meng-Yuan Pei Lu-Xin Yu Xiao-Yu liu The Affiliated Yantai Yuhuangding Hospital of qingdao University Yantai 264000China Northwest Minzu University Lanzhou 730000China The Affiliated Children’s Hospital of Shandong University Jinan 250022China.

This paper reviews the development of Meleis transition theory,explores the trajectory of the development of transition theory,analyses of the transition theory at home and abroad and research status,discusses the research prospect of transition theory,in order to better apply Meleis transition theory to clinical nursing work,provide a certain basis for discipline development and nursing research.

关键词： transition theory situation-specific theory nursing

The Therapeutic Effectiveness of Hybrid Renal Replacement (HRRT) in Patients with Severe Snakebite

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Chinese Journal of Biomedical Engineering(English Edition) 2012年第2期21卷 47-51页

作者： HU Shou-liang CHENG jun-zhang LU Hong-zhu LEI qing-feng liu jun-cheng YUAN Fan-li CHEN Rong Department of Nephrology the First Hospital of JingZhou Yangtze University Hubei Province Jingzhou 434000 China

Objective:To investigate the therapeutic effects of hybrid renal replacement therapy (HRRT) in patients with severe snake bite. Methods: 15 patients treated with HRRT from July in 2005 to August in 2009 were involved in the study, all patients were established ascular access by central venous catheter, polysulfone membrane connected absorption hemoperfusion cartridge, the blood flow rate was 200 ml/min, the dialysate flow rate was 300 ml/min, heparin or low molecular heparin was used as anticoagulant, treatment time was 6 to 12 hours. Observe the biochemical indicators and APACHE II score before and after HRRT and clinical outcomes of the patients. Results: The level of serum creatinine, glutamic-oxalacetic transaminease, glutamic-pyruvic transaminease, creatine kinase isozyme MB, and creatine kinase were significantly lower than the level before HRRT(P<0.05); the level of cholinesterase was significantly higher than the level before HRRT (P<0.01); the APACHE II score before HRRT was 14.1±3.8, but decreased significantly to 7.9±1.4, 6.2±1.1 and 4.2±0.8 at the first, second and seventh day after HRRT, respectively (P<0.01). There are 3 patients died at the first, third, and fourth HRRT, respectively, the rest 12 patients were cured or improved when discharged, the survival rate was 80%, and the mortality was 20%. Conclusion: HRRT may be an effective treatment method for severe snake bite patients, which can reduce the mortality rate and increase the survival rate.

关键词： hybrid renal replacement therapy snakebite effectiveness

油砂混合水体后向散射系数光谱贡献分离算法Ⅰ:实验理论

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光谱学与光谱分析 2017年第1期37卷 205-211页

作者：黄妙芬邢旭峰宋庆君刘远广东海洋大学数学与计算机学院广东湛江524088 国家海洋局国家卫星海洋应用中心北京100081 大连海洋大学海洋科技与环境学院辽宁大连116023

在石油类污染水体中,油会吸附在悬浮颗粒物表面而形成一个双层结构,影响水体后向散射系数光谱特征,分离水体石油类物质与悬浮颗粒物对后向散射系数光谱的贡献,能提高水体石油类污染后向散射理论模型的准确性。将美国Wyatt公司生产DAWN H... 详细信息

在石油类污染水体中,油会吸附在悬浮颗粒物表面而形成一个双层结构,影响水体后向散射系数光谱特征,分离水体石油类物质与悬浮颗粒物对后向散射系数光谱的贡献,能提高水体石油类污染后向散射理论模型的准确性。将美国Wyatt公司生产DAWN HELEOSⅡ18角度散射测量仪、美国SEQUOIA公司生产的LISST-100xB粒径仪和美国Hobilabs公司的后向散射仪HydroScat-6Sprctral Backscattering Sensor(HS6)联动观测,构成后向散射系数光谱测量系统,分别测量不同水样的散射强度电压值、粒径分布及粒径浓度、后向散射系数等参数,提出了利用Mie散射理论计算未知折射系数物质的体散射函数β(λ,θ)的新思路及分离后向散射系数光谱的算法。选择已知折射系数m的石英砂作为颗粒物与采自不同油田区域的油污水进行配比,获取不同特性水样,测定相关数据。首先,根据Mie散射理论计算出各样本对应的水体体积散射函数β(λ,θ);其次,建立的DAWN HELEOSⅡ18角度激光散射仪测定散射强度对应的电压值V(θ)转化为体积散射函数β(λ,θ)的关系式;再次,根据最优化方法估算出油砂混合的等效折射系数mos以及油的折射系数mo;最后,利用β(λ,θ)和估算的mos值及mo计算出各类样本的后向散射系数bb(λ),分别建立油污水bb,o(λ)和石英砂bb,s(λ)与油砂混合总bb,os(λ)的分离算法。分离算法的建立一方面提高了水体石油类污染后向散射理论模型的准确性,另外一方面拓展了米散射理论在海洋水色遥感中的应用。

关键词：油砂混合水体后向散射测量仪 Mie散射理论体积散射函数分离算法

Remote Sensing CO,CO_2 in Vehicle Emissions Based on TDLAS

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光机电信息 2007年第5期24卷 25-30页

作者： WANG Tie-dong liu Wen-qing ZHANG Yu-jun liu Jian-guo DONG Feng-zhong WANG Min WANG Xiao-mei XU Min Key Laboratory of Environment Optics and Technology Anhui Institute of Optics and Fine Mechanics Chinese Academy of SciencesHefei 230031China

Knowing the quantity of pollutants that the vehicle fleet is emitting to the air has become a vital problem in almost every major city in China. Finding and fixing gross polluters is therefore very important to control the urban air quality and protect the human health and the environment. Remote sensing is an important advance in the technology of on-road vehicle emissions testing because it is fast, mobile, and unobtrusive. This on-road vehicle emissions remote system is designed to measure the carbon monoxide, carbon dioxide and opacity from the vehicles's tailpipe based on the Tunable Diode Laser Absorption Spectroscopy (TDLAS). There are several advantages of this system such as compact design and easy of use. The measurement principle and optical layout of the instrument has been described in this paper. Field testing at Beijing and Hefei were conducted over one year, more than 6 000 vehicles were tested. This vehicle emissions remote system has been shown to be able to measure CO,CO2 and opacity from individual at highway speeds. In parallel, the plate license, speed, acceleration and length of vehicle are recognised by computer so that the owners of vehicles exceeding the permissible level of emissions can be identified.

关键词：车辆排放一氧化碳排放二氧化碳排放遥感 TDLAS

用免疫酶法对油桐尺蠖、家蚕核型多角体病毒的测定

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昆虫学报 1982年第2期25卷 223-226页

作者：祝庆荃刘军刘宇兰中国科学院武汉病毒研究所

免疫酶法(ELISA)是在萤光抗体和组织化学的基础上将抗原——抗体的免疫反应同酶的高效催化作用有机地结合起来而形成的一种新技术。在不破坏酶活性和免疫球蛋白的免疫反应的情况下,酶分子和免疫球蛋白共价结合形成标记抗体,成为保持免... 详细信息

免疫酶法(ELISA)是在萤光抗体和组织化学的基础上将抗原——抗体的免疫反应同酶的高效催化作用有机地结合起来而形成的一种新技术。在不破坏酶活性和免疫球蛋白的免疫反应的情况下,酶分子和免疫球蛋白共价结合形成标记抗体,成为保持免疫学与生物化学活性的指示剂。这种指示剂与待检物呈特异性结合,借助于酶对底物的作用而产生可见的不溶性反应产物。免疫酶法不仅能在光学显微镜下进行细胞水平上的抗原、抗体的定位研究,而且可用电子显微镜在分子水平上进行抗原、抗体超微结构的观察。本文试图应用ELISA对昆虫核型多角体病毒进行检测,并且在研究昆虫病毒的感染机制方面作出病原定位。

关键词：豚鼠血清抗血清油桐尺蠖免疫酶法家蚕核型多角体病毒细胞酶标记免疫标记阳性反应二氨基联苯胺辣根过氧化物酶抗体

Living near a Major Road in Beijing： Association with Lower Lung Function, Airway Acidification, and Chronic Cough

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Chinese Medical Journal 2016年第18期129卷 2184-2190页

作者： Zhan-Wei Hu Yan-Ni Zhao Yuan Cheng Cui-Yan Guo Xi Wang Nan Li jun-qing liu Hui Kang Guo-Guang Xia Ping Hu Ping-Ji Zhang Jing Ma Ying liu Cheng Zhang Li Su Guang-Fa Wang Department of Respiratory and Critical Care Medicine Peking University First Hospital Beijing 100034 China Department of Internal Medicine Shichahai Community Health Care Center Beijing 100035 China Department of Respiratory and Critical Care Medicine Beijing Jishuitan Hospital Beijing 100035 China

Background： The effects of near-road pollution on lung function in China have not been well studied. We aimed to investigate the effects of long-term exposure to traffic-related air pollution on lung function, airway inflammation, and respiratory symptoms. Methods： We enrolled 1003 residents aged 57.96 ± 8.99 years living in the Shichahai Community in Beijing. Distances between home addresses and the nearest major roads were measured to calculate home-road distance. We used the distance categories 1, 2, and 3, representing 〈100 m, 100-200 m, and 〉200 m, respectively, as the dose indicator for traffic-related air pollution exposure. Lung function, exhaled breath condensate （EBC） pH, and interleukin 6 levels were measured. As a follow-up, 398 participants had a second lung function assessment about 3 years later, and lung function decline was also examined as an outcome. We used regression analysis to assess the impacts of home-road distance on lung function and respiratory symptoms. As the EBC biomarker data were not normally distributed, we performed correlation analysis between home-road distance categories and EBC biomarkers. Results： Participants living a shorter distance from major roads had lower percentage of predicted value of forced expiratory volume in 1 s （FEV1% -1.54, 95% confidence interval [CI]： -0.20 to -2.89）. The odds ratio for chronic cough was 2.54 （95% CI： 1.57-4.10） for category 1 and 1.97 （95% CI： 1.16-3.37） for category 2, compared with category 3. EBC pH was positively correlated with road distance （rank correlation coefficient of Spearman [rs] = 0.176, P 〈 0.001 ）. Conclusions： Long-term exposure to traffic-related air pollution in people who live near major roads in Beijing is associated with lower lung function, airway acidification, and a higher prevalence of chronic cough. EBC pH is a potential useful biomarker for evaluating air pollution exposure.

关键词： Air Pollution Airway Inflammation Chronic Cough Exhaled Breath Condensate Lung Function

A full-length 3D structure for MAPK/ERK kinase 1（MEKl）

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A full-length 3D structure for MAPK/ERK kinase 1（MEKl）