Living near a Major Road in Beijing： Association with Lower Lung Function, Airway Acidification, and Chronic Cough

作     者：Zhan-Wei Hu Yan-Ni Zhao Yuan Cheng Cui-Yan Guo Xi Wang Nan Li Jun-Qing Liu Hui Kang Guo-Guang Xia Ping Hu Ping-Ji Zhang Jing Ma Ying Liu Cheng Zhang Li Su Guang-Fa Wang Hu Zhan-Wei;Zhao Yan-Ni;Cheng Yuan;Guo Cui-Yan;Wang Xi;Li Nan;Liu Jun-Qing;Kang Hui;Xia Guo-Guang;Hu Ping;Zhang Ping-Ji;Ma Jing;Liu Ying;Zhang Cheng;Su Li;Wang Guang-Fa

作者机构：Department of Respiratory and Critical Care Medicine Peking University First Hospital Beijing 100034 China Department of Internal Medicine Shichahai Community Health Care Center Beijing 100035 China Department of Respiratory and Critical Care Medicine Beijing Jishuitan Hospital Beijing 100035 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2016年第129卷第18期

页      面：2184-2190页

核心收录：

学科分类：1002[医学-临床医学] 07[理学] 070602[理学-大气物理学与大气环境] 0706[理学-大气科学] 10[医学] 

基　　金：supported by the grants from Capital Medical Development and Scientific Research Fund 国家自然科学基金 the Peking University Clinical Research Project 

主　　题：Air Pollution Airway Inflammation Chronic Cough Exhaled Breath Condensate Lung Function 

摘      要：Background： The effects of near-road pollution on lung function in China have not been well studied. We aimed to investigate the effects of long-term exposure to traffic-related air pollution on lung function, airway inflammation, and respiratory symptoms. Methods： We enrolled 1003 residents aged 57.96 ± 8.99 years living in the Shichahai Community in Beijing. Distances between home addresses and the nearest major roads were measured to calculate home-road distance. We used the distance categories 1, 2, and 3, representing 〈100 m, 100-200 m, and 〉200 m, respectively, as the dose indicator for traffic-related air pollution exposure. Lung function, exhaled breath condensate （EBC） pH, and interleukin 6 levels were measured. As a follow-up, 398 participants had a second lung function assessment about 3 years later, and lung function decline was also examined as an outcome. We used regression analysis to assess the impacts of home-road distance on lung function and respiratory symptoms. As the EBC biomarker data were not normally distributed, we performed correlation analysis between home-road distance categories and EBC biomarkers. Results： Participants living a shorter distance from major roads had lower percentage of predicted value of forced expiratory volume in 1 s （FEV1% -1.54, 95% confidence interval [CI]： -0.20 to -2.89）. The odds ratio for chronic cough was 2.54 （95% CI： 1.57-4.10） for category 1 and 1.97 （95% CI： 1.16-3.37） for category 2, compared with category 3. EBC pH was positively correlated with road distance （rank correlation coefficient of Spearman [rs] = 0.176, P 〈 0.001 ）. Conclusions： Long-term exposure to traffic-related air pollution in people who live near major roads in Beijing is associated with lower lung function, airway acidification, and a higher prevalence of chronic cough. EBC pH is a potential useful biomarker for evaluating air pollution exposure.