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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第6期11卷 437-442页

作者： Xiu-ju DU Jing-song ZHANG Yan YANG qing-jiu tang Wei JIA Ying-jie PAN Institute of Edible Fungi Shanghai Academy of Agricultural Sciences Shanghai 201106 China College of Life Science Liaocheng University Liaocheng 252059 China College of Food Science Shanghai Ocean University Shanghai 200090 China

Ultrafiltration and a series of chromatographic steps were used to isolate and purify polysaccharides from Tremella aurantialba fruit *** crude fractions(TAP50w,TAP10-50w,and TAP1-10w),five semi-purified fractions(TAPA-TAPE),and one purified fraction(TAPA1) were obtained.A sulfated derivative of TAPA1(TAPA1-s) was prepared by chemical *** immunostimulating activity of the polysaccharide fractions in vitro was determined using the mouse spleen lymphocyte proliferation *** the three crude fractions tested,cell prolifera-tion rates were increased most by ***,TAPA1-s was markedly more stimulatory than TAPA1,indicating that sulfonation was an effective way to enhance the immunostimulating activity of polysaccharide.

关键词： Tremella aurantialba Purification Polysaccharide Sulfation Immunostimulating activity

Mechanisms and Efficacy of Chinese Herbal Medicines in Benign Prostatic Hyperplasia

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Chinese Journal of Integrative Medicine 2025年第1期31卷 73-82页

作者： WANG Fu MA Dong-yue YANG jiu-tian LYU Dong-fang GAO qing-he LI Chun-lei ZHONG Chong-fu Department of Andrology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing100091China Graduate School Beijing University of Chinese MedicineBeijing100029China Department of Andrology The Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan250014China Faculty of Medicine Linyi UniversityLinyiShandong Province276000China

Benign prostatic hyperplasia(BPH) is one of the most common diseases in elderly men, the incidence of which gradually increases with age and leads to lower urinary tract symptoms(LUTS), which seriously affects the quality of life of patients. Chinese herbal medicines(CHMs) are widely used for the treatment of BPH in China and some other countries. To explore the molecular mechanisms of CHMs for BPH, we conducted a review based on peer-reviewed English-language publications in Pub Med and Web of Science databases from inception to December 31, 2023. This article primarily reviewed 32 papers on the use of CHMs and its active compounds in the treatment of BPH, covering animal and cell experiments, and identified relevant mechanisms of action. The results suggest that the mechanisms of action of CHMs in treating BPH may involve the regulation of sex hormones,downregulation of cell growth factors, anti-inflammatory and antioxidative effects, inhibition of cell proliferation, and promotion of apoptosis. CHMs also exhibit α-blocker-like effects, with the potential to relax urethral smooth muscle and alleviate LUTS. Additionally, we also reviewed 4 clinical trials and meta-analyses of CHMs for the treatment of BPH patients, which provided initial evidence of the safety and effectiveness of CHMs treatment. CHMs treatment for BPH shows advantages as a multi-component, multi-target, and multi-pathway therapy, which can mitigate the severity of the disease, improve LUTS, and may become a reliable treatment option in the future.

关键词： herbal treatment promotion

Chlorination of benzyl group on the terminal unit of A_(2)-A_1-D-A_1-A_(2) type nonfullerene acceptor for high-voltage organic solar cells

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Chinese Chemical Letters 2025年第1期36卷 312-317页

作者： Jinge Zhu Ailing tang Leyi tang Peiqing Cong Chao Li qing Guo Zongtao Wang Xiaoru Xu Jiang Wu Erjun Zhou School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China National Center for Nanoscience and Technology Beijing 100190China Zhongyuan Critical Metals Laboratory Zhengzhou UniversityZhengzhou 450001China Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450003China

Benzotriazole(BTA)-based A_(2)-A_1-D-A_1-A_(2)type wide-bandgap(WBG)non-fullerene acceptors(NFAs)have shown promising potential in indoor photovoltaic,and in-depth investigation of their structure-property relationship is of great ***,we explored the chlorination effect of the side chain on the *** introduced Cl atoms into the benzyl side chains in parent BTA5 to synthesize two NFAs,BTA5-Cl with mono-chlorinated benzyl groups and BTA5-2Cl containing bi-chlorinated benzyl *** chose D18-Cl with deep-energy levels and strong crystallinity to pair with these three acceptors,affording high photovoltage and *** the stepwise chlorination,the open-circuit voltage(V_(OC))values decrease from 1.28,1.22,to 1.20 V,while the corresponding power conversion efficiencies(PCEs)improve from 5.07%,9.15%,to 10.96%.Compared with BTA5-based OSCs,introducing Cl atoms downshifts the energy levels and slightly increases the non-radiative energy loss(0.14<0.17<0.19 e V),resulting in a sequential decrease in VO ***,more chlorine atom replacements produce more effective exciton dissociation,higher charge transfer,and balanced carrier mobility in the blend films,ultimately achieving better *** work indicates that chlorination of the benzyl group on the terminals can improve the device's performance,implying good application potential in indoor photovoltaics.

关键词： High open-circuit voltage Benzotriazole Non-fullerene acceptor Terminal engineering Chlorination

Mixed-charge glycopolypeptides as antibacterial coatings with long-term activity

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Chinese Chemical Letters 2025年第2期36卷 270-278页

作者： Fangping Yang Jin Shi Yuansong Wei qing Gao Jingrui Shen Lichen Yin Haoyu tang Institute of Functional Nano & Soft Materials(FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow University

Planktonic bacteria adhere and subsequently form biofilms on implantable medical devices can cause severe infections that have become the major types of hospital-acquired infections. Traditional coatings for the implants are frequently lack of long-term antifouling and bactericidal activities. It is still a big challenge to simultaneously improve the antifouling and bactericidal activities of the coatings. Herein,we report that mixed-charge glycopolypeptide coatings are of long-term antibacterial activities to efficiently inhibit the biofilm growth. The glycosylation of mixed-charge polypeptides has led to a significant improvement of both antifouling and bactericidal activities. The cooperative effect of the saccharide residues and mixed-charge residues improved the resistance of the polypeptide coatings against protein adsorption. The saccharide and L-glutamic acid(E) residues collectively enhanced the bacterial membrane-disruption of cationic L-lysine(K) residues, leading to potent bactericidal activity. Meanwhile,the glycopolypeptide coatings showed superior biocompatibility, long-term antibiofilm and anti-infection properties in two types of mouse subcutaneous infection models and one type of mouse urinary tract infection model. This work provides a new strategy to achieve antibacterial coatings with long-term activities for preventing implantable medical device associated infections.

关键词： Antibacterial coating Bactericidal activity Biofilm Fouling Glycopolypeptide

Bone marrow mesenchymal stem cells promote uterine healing by activating the PI3K/AKT pathway and modulating inflammation in rat models

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World Journal of Stem Cells 2025年第1期17卷 22-39页

作者： Jing Yang Jun Yuan Yan-qing Wen Li Wu jiu-Jiang Liao Hong-Bo Qi Women and Children’s Hospital of Chongqing Medical University Chongqing 401147China Chongqing Key Laboratory of Maternal and Fetal Medicine Chongqing Medical UniversityChongqing 400016China Obstetrics and Gynecology Guizhou Provincial People’s HospitalGuiyang 557300Guizhou ProvinceChina Research Laboratory of Reproduction and Development of Chinese Ministry of Education Chongqing Medical UniversityChongqing 400016China

BACKGROUND Uterine injury can cause uterine scarring,leading to a series of complications that threaten women’s *** healing is a complex process,and there are currently no effective *** our previous studies have shown that bone marrow mesenchymal stem cells(BMSCs)promote uterine damage repair,the underlying mechanisms remain ***,exploring the specific regulatory roles of BMSCs in uterine injury treatment is crucial for further understanding their functions and enhancing therapeutic *** To investigate the underlying mechanism by which BMSCs promote the process of uterine *** In in vivo experiments,we established a model of full-thickness uterine injury and injected BMSCs into the uterine *** sequencing was per-formed to determine the enrichment of differentially expressed genes at the wound *** in vitro experiments,we isolated rat uterine smooth muscle cells(USMCs)and cocultured them with BMSCs to observe the interaction between BMSCs and USMCs in the *** We found that the differentially expressed genes were mainly related to cell growth,tissue repair,and angiogenesis,while the phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)pathway was highly *** reverse-transcription polymerase chain reaction was used to validate differentially expressed genes,and the results demonstrated that BMSCs can upregulate genes related to regeneration and downregulate genes related to *** BMSCs promoted the migration and proliferation of USMCs,and the USMC microenvironment promoted the myogenic differentiation of ***,we validated the PI3K/AKT pathway in tissues and cells and showed that BMSCs activate the PI3K/AKT pathway to promote the regeneration of uterine smooth muscle both in vivo and in *** BMSCs upregulated uterine wound regeneration and anti-inflammatory factors and enhanced uterine smooth muscle proliferation throu

关键词： Uterine injury Bone marrow mesenchymal stem cells Uterine smooth muscle cells Phosphoinositide 3-kinase/protein kinase B pathway Cell-cell interactions Cell proliferation Immune regulation Wound regeneration

Landscape of four different stages of human gastric cancer revealed by single-cell sequencing

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 179-197页

作者： Xu-Shan tang Chun-Lei Xu Na Li Jian-qing Zhang Yong tang Department of Gastroenterology Tumor Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830011Xinjiang Uighur Autonomous RegionChina Department of Outpatient First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830011Xinjiang Uighur Autonomous RegionChina

BACKGROUND Gastric cancer(GC)poses a substantial risk to human health due to its high prevalence and mortality ***,current therapeutic strategies remain ***-cell RNA sequencing(scRNA-seq)offers the potential to provide comprehensive insights into GC *** To explore the distribution and dynamic changes of cell populations in the GC tumor microenvironment using scRNA-seq *** Cancerous tissues and paracancerous tissues were obtained from patients diagnosed with GC at various stages(I,II,III,and IV).Single-cell suspensions were prepared and analyzed using scRNA-seq to examine transcriptome profiles and cell-cell ***,quantitative real-time polymerase chain reaction(qRT-PCR)and flow cytometry were applied for measuring the expression of cluster of differentiation(CD)2,CD3D,CD3E,cytokeratin 19,cytokeratin 8,and epithelial cell adhesion *** Transcriptome data from 73645 single cells across eight tissues of four patients were categorized into 25 distinct cell clusters,representing 10 different cell *** were observed in these cell type *** adjacent epithelial cells in stages II and III exhibited a degenerative ***,the quantity of CD4 T cells and CD8 T cells were evidently elevated in cancerous *** analysis displayed a remarkable increase in interaction between B cells and other mast cells in stages II,III,and IV of *** findings were further validated through qRT-PCR and flow cytometry,demonstrating elevated T cells and declined epithelial cells within the cancerous *** This study provides a comprehensive analysis of cell dynamics across GC stages,highlighting key interactions within the tumor *** findings offer valuable insights for developing novel therapeutic strategies.

关键词： Gastric cancer Single-cell RNA sequencing Tumor microenvironment Cancer progression Cell-cell interactions

Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang Zhao Yuanjie Liu qinghua Zeng qing tang Zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

When Embodied AI Meets Industry 5.0:Human-Centered Smart Manufacturing

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IEEE/CAA Journal of Automatica Sinica 2025年第3期12卷 485-501页

作者： Jing Xu Qiyu Sun qing-Long Han Yang tang IEEE the Key Laboratory of Smart Manufacturing in Energy Chemical Process Ministry of Education East China University of Science and Technology the School of Science Computing and Engineering Technologies Swinburne University of Technology

As embodied intelligence(EI), large language models(LLMs), and cloud computing continue to advance, Industry5.0 facilitates the development of industrial artificial intelligence(Ind AI) through cyber-physical-social systems(CPSSs) with a human-centric focus. These technologies are organized by the system-wide approach of Industry 5.0, in order to empower the manufacturing industry to achieve broader societal goals of job creation, economic growth, and green production. This survey first provides a general framework of smart manufacturing in the context of Industry 5.0. Wherein, the embodied agents, like robots, sensors, and actuators, are the carriers for Ind AI, facilitating the development of the self-learning intelligence in individual entities, the collaborative intelligence in production lines and factories(smart systems), and the swarm intelligence within industrial clusters(systems of smart systems). Through the framework of CPSSs, the key technologies and their possible applications for supporting the single-agent, multi-agent and swarm-agent embodied Ind AI have been reviewed, such as the embodied perception, interaction, scheduling, multi-mode large language models, and collaborative training. Finally, to stimulate future research in this area, the open challenges and opportunities of applying Industry 5.0 to smart manufacturing are identified and discussed. The perspective of Industry 5.0-driven manufacturing industry aims to enhance operational productivity and efficiency by seamlessly integrating the virtual and physical worlds in a human-centered manner, thereby fostering an intelligent, sustainable, and resilient industrial landscape.

关键词： Embodied AI human-centered manufacturing Industry 5.0 internet of things large multi-mode language models

Determination of Total Flavones in the Medicinal Mushroom Phellinus

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食用菌学报 2006年第2期 49-52页

作者： LIU Yan-fang, YANG Yan~ * , JIA Wei, ZHANG Jing-song, tang qing-jiu, tang Chuan-hong Institute of Edible Fungi, Shanghai Academy of Agriculture Sciences Research and Development Center of Natural Medicinal Resources, Shanghai Academy of Agriculture Sciences, Shanghai 201106, P.R. China

Qualitative and quantitative analyses of the total flavones in ethanol-water extracts of Phellinus spp. have been undertaken using UV- and NaNO_ 2 -Al（NO_ 3 ）_ 3 -based colorimetric assays. Both methods showed high levels of precision, reproducibility and recovery, and a linear relationship between absorbance value and flavone concentration over specified ranges. Both assays appear equally valid for determining the total flavone content of Phellinus spp.

关键词： Flavones Phellinus spp Qualitative and quantitative assay

Investigation of Associated Factors and Microbiota of Different Oral Niches in Early Childhood Caries

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Biomedical and Environmental Sciences 2025年第01期38卷 112-118页

作者： Shuai tang Zejun Zheng Zekun Li qing Wang Shuang Zhu Tong Yang Gang Ding School of Stomatology Shandong Second Medical University Hospital of Stomatology Weifang People's Hospital

Dental caries is a widespread oral disease and is particularly significant during childhood, as it can impact growth and development[1]. Early childhood caries（ECC）, defined as the presence of decayed,missing, or fi... 详细信息

关键词： different oral associated caries childhood early factors investigation microbiota niches