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Visceral adipose volume is correlated with surgical tissue fibrosis in Crohn’s disease of the small bowel

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Gastroenterology Report 2022年第1期10卷 451-459页

作者： Gang Yuan Yao He qing-hua cao Mi-Mi Tang Zong-Lin Xie Yun Qiu Zhi-Rong Zeng Sui Peng Min-Hu Chen Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Pathology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Radiology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Clinical Trial Unit The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Institute of Precision Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background This study explored the diagnostic performance of visceral adiposity to predict the degree of intestinal inflammation and *** The patients with Crohn’s disease(CD)who underwent surgical small bowel resection at the First Affiliated Hospital of Sun Yat-sen University(Guangzhou,China)between January 2007 and December 2017 were *** evaluated the intestinal imaging features of computed tomography enterography(CTE),including mesenteric inflammatory fat stranding,the target sign,mesenteric hypervascularity,bowel wall thickening,lymphadenopathy,stricture diameter,and maximal upstream *** used ***(Artificial Intelligence Kit,version 1.1)to calculate the visceral fat(VF)and subcutaneous fat(SF)volumes at the third lumbar vertebra *** tissue information was *** models were established based on the multivariate regression analysis results,and their effectiveness was evaluated by area under the curve(AUC)and decision curve *** Overall,48 patients with CD were included in this *** abdominal VF/SF volume ratio(odds ratio,1.20;95%confidence interval,1.05–1.38;P=0.009)and the stenosis diameter/upstream intestinal dilatation diameter(ND)ratio(odds ratio,0.90;95%confidence interval,0.82–0.99;P=0.034)were independent risk factors for the severe fibrosis of the small *** AUC values of the VF/SF ratio,the ND ratio,and their combination were 0.760,0.673,and 0.804,*** combination of the VS/SF volume ratio and ND ratio achieved the highest net benefit on the decision *** The VF volume on CTE can reflect intestinal *** combination of the VF/SF volume ratio and ND ratio of CD patients assessed using CTE can help predict severe fibrosis stenosis of the small intestine.

关键词： Crohn’s disease intestinal fibrosis visceral fat computed tomography enterography

等温锻造过程中变形量对TiB_(w)/Ti60复合材料显微组织和力学性能演变的影响

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Transactions of Nonferrous Metals Society of China 2023年第3期33卷 802-815页

作者：张芳洲王博曹清华张利张昊阳上海工程技术大学材料工程学院上海201600

为了研究TiB晶须增强Ti60复合材料在热压缩过程中变形程度对微观结构和力学性能的影响,在1030℃,应变速率为1×10^(-2)s^(-1),变形量为30%、50%和70%的条件下分别进行等温锻造。研究结果表明,随着应变的增加,大角度晶界(HAGBs)的比例在... 详细信息

为了研究TiB晶须增强Ti60复合材料在热压缩过程中变形程度对微观结构和力学性能的影响,在1030℃,应变速率为1×10^(-2)s^(-1),变形量为30%、50%和70%的条件下分别进行等温锻造。研究结果表明,随着应变的增加,大角度晶界(HAGBs)的比例在70%变形量时显著上升到71.47%。由于材料再结晶效率的提高,α_(s)晶粒的织构成分逐渐成为主导织构成分。TiB能够促进再结晶晶粒的形核并且阻碍晶粒长大。经过等温锻造,复合材料在室温和600℃下的力学性能均有所提高,在50%变形量时锻造试样具有最佳的拉伸强度和伸长率。在拉伸试验过程中TiB晶须承受周围基体传递的载荷,从而材料表现出强化效果。

关键词：钛基复合材料等温锻造动态再结晶织构演变力学性能

蒙特卡洛方法研究积分球测量发射率的影响因素

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遥感技术与应用 2017年第1期32卷 149-157页

作者：杨白雪杜永明肖青历华曹彪柳钦火中国科学院遥感与数字地球研究所遥感信息科学重点实验室北京100101 中国科学院大学北京100049

采用理论数值分析和计算机蒙特卡洛光线追迹模拟相结合的方法,研究积分球在设计和操作中影响发射率测量精度的因素,包括积分球开口大小,积分球内壁污损,参考样本与待测样本的发射率,主动光源的功率等。研究结果表明:积分球探测口开口比... 详细信息

采用理论数值分析和计算机蒙特卡洛光线追迹模拟相结合的方法,研究积分球在设计和操作中影响发射率测量精度的因素,包括积分球开口大小,积分球内壁污损,参考样本与待测样本的发射率,主动光源的功率等。研究结果表明:积分球探测口开口比例对发射率的测量无明显影响,当积分球内壁污损时参考样本和待测样本发射率的值相差很大时测量结果会有偏差,积分球自身辐射使发射率测量值偏高。当参考样本与待测样本发射率相差小于0.1,积分球在污损情况下发射率测量误差小于等于4‰。洁净情况下,入射光源功率大于100 W时,积分球自身辐射对发射率的影响低于5‰。

关键词：发射率积分球仿真模拟蒙特卡洛

Universal design of three-dimensional porous graphene-iron based promotors for kinetically rationalized lithium-sulfur chemistry

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Journal of Energy Chemistry 2025年第1期100卷 192-200页

作者： hua Gao Yunfeng Zhang Menglei Wang Ruoxuan Yang Shuai Feng Xuan cao Yaping Zhang Zhongyuan Lu Yingze Song State Key Laboratory of Environment-Friendly Energy Materials School of Materials and Chemistry Southwest University of Science and Technology School of Material Science and Engineering Henan University of Technology College of Chemistry and Chemical Engineering Taishan University

Lithium-sulfur （Li-S） batteries are widely deemed to be one of the most potential candidates for future secondary batteries because of their remarkable energy ***,notorious polysulfide shuttling and retarded sulfur reaction kinetics pose significant obstacles to the further application of Li-S *** rationally designed highly active electrocatalysts can facilitate polysulfide conversion,the universal and scalable synthesis strategies need to be ***,a universal synthetic strategy to construct a series of three-dimensional （3D） porous graphene-iron （3DGr-Fe） based electrocatalysts involving 3DGr-FeP,3DGr-Fe3C,and 3DGr-Fe3Se4is exploited for manipulating the Li-S redox *** has been observed that the implementation of a 3D porous Gr architecture leads to the well-designed conductive networks,while the uniformly dispersed iron nanoparticles introduce an abundance of active sites,fostering the lithium polysulfide conversion,thereby bolstering the overall electrochemical *** Li-S battery with the 3DGr-Fe based electrocatalyst exhibits remarkable capacity retention of 94.8%upon 100 times at 0.2 ***,the soft-packaged Li-S pouch cell based on such a 3DGr-Fe electrocatalyst delivers superior capacity of 1060.71 mA h g-1and guarantees for the continuous 30 min work of fan *** investigation gives comprehensive insights into the design,synthesis,and mechanism of 3DGr-Fe based electrocatalysts with high activity toward efficient and durable Li-S batteries.

关键词： Lithium-sulfur battery Universal synthesis 3D graphene-iron based promotor Electrocatalysis

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

FUNDAMENTAL SOLUTION BASED GRADED ELEMENT MODEL FOR STEADY-STATE HEAT TRANSFER IN FGM

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Acta Mechanica Solida Sinica 2012年第4期25卷 377-392页

作者： Leilei cao Hui Wang qing-hua Qi Key Laboratory for Highway Construction Technology and Equipment of Ministry of Education Chang'an University Xi'an 710064 China School of Engineering Australian National University canberra ACT 0200 Australia College of Civil Engineering and Architecture Henan University of Technology Zhengzhou 450052 China

A novel hybrid graded element model is developed in this paper for investigating thermal behavior of functionally graded materials （FGMs）. The model can handle a spatially varying material property field of FGMs. In the proposed approach, a new variational functional is first constructed for generating corresponding finite element model. Then, a graded element is formulated based on two sets of independent temperature fields. One is known as intra-element temperature field defined within the element domain; the other is the so-called frame field defined on the element boundary only. The intra-element temperature field is constructed using the linear combination of fundamental solutions, while the independent frame field is separately used as the boundary interpolation functions of the element to ensure the field continuity over the interelement boundary. Due to the properties of fundamental solutions, the domain integrals appearing in the variational functional can be converted into boundary integrals which can significantly simplify the calculation of generalized element stiffness matrix. The proposed model can simulate the graded material properties naturally due to the use of the graded element in the finite element （FE） model. Moreover, it inherits all the advantages of the hybrid Trefftz finite element method （HT-FEM） over the conventional FEM and boundary element method （BEM）. Finally, several examples are presented to assess the performance of the proposed method, and the obtained numerical results show a good numerical accuracy.

关键词： graded element hybrid FEM heat conduction functionally graded materials

Hybrid graded element model for transient heat conduction in functionally graded materials

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Acta Mechanica Sinica 2012年第1期28卷 128-139页

作者： Lei-Lei cao qing-hua Qin Ning Zhao Key Laboratory for Road Construction Technology＆ Equipment of MOE Chang＇ an University 710064 Xi＇ an China Research School of Engineering Australian National UniversityCanberra ACT 0200 Australia School of Mechatronics Northwestern Polytechnical University710072 Xi＇an China

This paper presents a hybrid graded element model for the transient heat conduction problem in functionally graded materials （FGMs）. First, a Laplace transform approach is used to handle the time variable. Then, a fundamental solution in Laplace space for FGMs is constructed. Next, a hybrid graded element is formulated based on the obtained fundamental solution and a frame field. As a result, the graded properties of FGMs are naturally reflected by using the fundamental solution to interpolate the intra-element field. Further, Stefest＇s algorithm is employed to convert the results in Laplace space back into the time-space domain. Finally, the performance of the proposed method is assessed by several benchmark examples. The results demonstrate well the efficiency and accuracy of the proposed method.

关键词： Graded element model Functionally graded materials Hybrid FEM Transient heat conduction

Carbon nanotube transistor technology for More-Moore scaling

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Nano Research 2021年第9期14卷 3051-3069页

作者： qing cao Department of Materials Science and Engineering Department of Electrical and Computer EngineeringDepartment of Chemistry Seitz Materials Research LaboratoryUniversity of Illinois at Urbana-ChampaignUrbanaIL 61820USA

Scaling of silicon field-effect transistors has fueled the exponential development of microelectronics in the past 60 years,but is now close to its physical limits with the critical dimensions of state-of-the-art silicon devices approaching the sub-10 nm *** nanotubes have been suggested to hold great promise of replacing the central role of silicon in the next-generation logic switches with their unique geometrical and electrical *** this article,I firstly examine the scaling advantages of carbon nanotubes compared to silicon from technology-development perspective,and then review the latest progress on addressing the manufacturability issues for scaled carbon-nanotube transistors,from materials to device-integration ***,the possible pathways for nanotube transistors to transition into commercial applications are discussed.

关键词： carbon nanotube transistor scaling

Effects of lanthanum(Ⅲ) on nitrogen metabolism of soybean seedlings under elevated UV-B radiation

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Journal of Environmental Sciences 2007年第11期19卷 1361-1366页

作者： cao Rui huaNG Xiao-hua ZHOU qing CHENG Xiao-ying The Key Laboratory of Industrial Biotechnology Ministry of Education Southern Yangtze University Wuxi 214036 China College of Chemistry and Environment Science Nanjing Normal University Nanjing 210097 China

The hydroponic culture experiments of soybean bean seedlings were conducted to investigate the effect of lanthanum （La） on nitrogen metabolism under two different levels of elevated UV-B radiation （UV-B, 280-320 nm）. The whole process of nitrogen metabolism involves uptake and transport of nitrate, nitrate assimilation, ammonium assimilation, amino acid biosynthesis, and protein synthesis. Compared with the control, UV-B radiation with the intensity of low level 0.15 W/m^2 and high level 0.45 W/m^2 significantly affected the whole nitrogen metabolism in soybean seedlings （p 〈 0.05）. It restricted uptake and transport of NO3^-, inhibited activity of some key nitrogen-metabolism-related enzymes, such as： nitrate reductase （NR） to the nitrate reduction, glutamine systhetase （GS） and glutamine synthase （GOGAT） to the ammonia assimilation, while it increased the content of free amino acids and decreased that of soluble protein as well. The damage effect of high level of UV-B radiation on nitrogen metabolism was greater than that of low level. And UV-B radiation promoted the activity of the anti-adversity enzyme glutamate dehydrogenase （GDH）, which reduced the toxicity of excess ammonia in plant. After pretreatment with the optimum concentration of La （20 mg/L）, La could increase the activity of NR, GS, GOGAT, and GDH, and ammonia assimilation, but decrease nitrate and ammonia accumulation. In conclusion, La could relieve the damage effect of UV-B radiation on plant by regulating nitrogen metabolism process, and its alleviating effect under low level was better than that under the high one.

关键词： lanthanum(Ⅲ) UV-B radiation soybean seedlings nitrogen metabolism alleviating effect