检索结果-南通市图书馆

Reversible li2C2O4 product regulation in li–CO2 batteries using single-atom alloy engineering

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Xinxin Zhang Yu Wang Yafei li Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials School of Chemistry and Materials Science Nanjing Normal University

The efficiency of lithium-carbon dioxide （li–CO2） batteries is limited by the sluggish generation/decomposition kinetics of the discharge products （i.e.,li2CO3and carbon） despite the use of state-of-the-art noble metal （NM） ***2C2O4has emerged as a promising alternative product;however,the thermodynamic instability of li2C2O4causes it to generally appear as an intermediate in li2CO3pathways rather than a product during ***,using comprehensive first-principles calculations,we report tailoring the discharge products of li–CO2batteries to li2C2O4via single-atom alloy （SAA） engineering,in which NM-doped copper SAAs （NM1Cu） are constructed for *** NM1Cu catalysts display a free-atom-like narrow d-band state and unique charge distribution over the solute NM1atom and the surrounding matrix Cu *** an optimized electronic structure is substantial in Ru1Cu and Ir1Cu,which is conducive to the co-activation and coupling of *** lithiation of*CO2intermediate that breaks the charge symmetry of the central C species can further reduce the kinetic barriers of the C–C *** advantages promote li2C2O4generation on Ru1Cu and Ir1Cu while suppress its subsequent ***,they exhibit low theoretical overpotentials and enable facile delithiation under normal charging *** work proposes a universal principle of manipulating electronic structures to achieve li2C2O4product,which provides practical guidance for the development of li–CO2batteries.

关键词：

Design of a cationic accelerator enabling ultrafast ion diffusion kinetics in aqueous zinc-ion batteries

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 377-384页

作者： Yawei Xiao Qianqian Gu Haoyu li Mengyao li Yude Wang National Center for International Research on Photoelectric and Energy Materials School of Materials and Energy Yunnan University Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources School of Chemistry and Chemical Engineering Hainan University College of Chemical Engineering Fuzhou University Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon Technologies Yunnan University

Aqueous zinc-ion batteries are highly favored for grid-level energy storage owing to their low cost and high safety,but their practical application is limited by slow ion *** address this,a strategy has been developed to create a cation-accelerating electric field on the surface of the cathode to achieve ultrafast Zn2+diffusion *** employing electrodeposition to coat MoS2on the surface of BaV6O16·3H2O nanowires,the directional built-in electric field generated at the heterointerface acts as a cation accelerator,continuously accelerating Zn2+diffusion into the active *** optimized Zn2+diffusion coefficient in CC@BaV-6O16·3H2O@MoS2(7.5×10～8cm2s-1) surpasses that of most reported V-based ***,MoS2serving as a cathodic armor extends the cycling life of the Zn-CC@BaV6O16·3H2O@MoS2full batteries to over 10000 *** work provides valuable insights into optimizing ion diffusion kinetics for high-performance energy storage devices.

关键词： Zinc alloys

Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie Z.li Nagendran Ramalingam Shaomin li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

TRMT6 and TRMT61A facilitated acute pancreatitis severity via regulation of neutrophil function

在线全文

学校读者我要写书评

暂无评论

Science China life Sciences 2025年

作者： Yuan dong li Su Sin Man Lam Cen Yan Yalan Deng Guotao Lu Jinkui Yang Guanghou Shui Yingmei Feng Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Department of Science and Development Beijing Youan HospitalCapital Medical University Laboratory for Clinical Medicine Capital Medical University Neuroscience Research Institute Peking University Center of Medical and Health AnalysisPeking University State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of Sciences Pancreatic Center Department of GastroenterologyAffiliated Hospital of Yangzhou UniversityYangzhou University Beijing Key Laboratory of Diabetes Research and Care Department of EndocrinologyBeijing Tongren HospitalCapital Medical University

Dear Editor,Type 2 diabetes mellitus (T2DM) has been identified as a risk factor for increased severity in acute pancreatitis (AP)(Mikóet al,2018).However,to date,no studies have simultaneously included healthy individuals,T2DM patients,and AP patients to investigate which diabetes-associated metabolites are linked to AP severity.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

新加良附方抑制人胃癌细胞增殖的分子机制

世界中医药 2017年第9期12卷 2134-2138页

作者：李亚石凤芹朱陵群田劭丹董青侯丽北京中医药大学东直门医院血液肿瘤科北京100700 北京中医药大学东直门医院中医内科学教育部重点实验室和北京市重点实验室北京100700

目的:探讨新加良附方及其主要成分薯蓣皂苷药物血清对人胃癌细胞BGC-823的增殖抑制作用及可能的作用机制。方法:制备新加良附方及薯蓣皂苷药物血清,并作用于胃癌细胞株BGC-823,使用MTS方法检测细胞增殖抑制率;采取实时PCR方法观察新加... 详细信息

目的:探讨新加良附方及其主要成分薯蓣皂苷药物血清对人胃癌细胞BGC-823的增殖抑制作用及可能的作用机制。方法:制备新加良附方及薯蓣皂苷药物血清,并作用于胃癌细胞株BGC-823,使用MTS方法检测细胞增殖抑制率;采取实时PCR方法观察新加良附方及薯蓣皂苷药物血清对人胃癌细胞BGC-823中caspase-3及p53表达的影响;采取实时PCR方法检测胃癌细胞中miR-34a表达水平。结果:新加良附方药物血清及薯蓣皂苷药物血清对胃癌细胞BGC-823有明显的增殖抑制作用,并且其作用与时间正相关。新加良附方对胃癌细胞的增殖抑制作用在48 h、72 h高于其主要成分薯蓣皂苷;人胃癌BGC-823细胞中caspase-3的表达明显低于其在正常胃黏膜上皮细胞GES-1中的水平,p53基因表达水平高于正常GES-1细胞中的p53表达水平。新加良附方药物血清及薯蓣皂苷药物血清作用于BGC-823细胞后其caspase-3表达水平均明显上升,且随着时间增加其表达量升高;p53基因表达水平下降,并且与时间负相关。新加良附方与其主要成分薯蓣皂苷相比较,两者对caspase-3、p53的调控作用无明显差异;胃癌细胞中miR-34a表达水平高于正常胃黏膜上皮细胞GES-1。结论:新加良附方及其主要成分薯蓣皂苷可以显著抑制胃癌BGC-823细胞的生长,新加良附方对胃癌细胞的抑制作用高于其主要成分薯蓣皂苷。新加良附方及薯蓣皂苷抑制胃癌细胞增殖作用可能与增加凋亡相关蛋白caspase-3表达,抑制突变型p53表达相关。miR-34a可能发挥癌基因的作用,应明确其作用并进行下一步研究。

关键词：新加良附方胃癌 caspase-3 p53 miR-34a

不同贮藏温度下冷却猪肉货架期预测模型的构建

在线全文

学校读者我要写书评

暂无评论

食品科学 2012年第20期33卷 304-308页

作者：董庆利曾静熊成余华星梁娜胡梦涵潘燕上海理工大学医疗器械与食品学院上海200093

建立冷却猪肉中特定腐败菌的货架期预测模型。将气单胞菌接种到经80℃无菌水灭菌的猪精腿肉中,分别密封包装于0、4、7、15℃和20℃温度贮藏,测定各温度下接种猪肉的菌落总数(N)、pH值、TVBN值、TBA值,并进行感官评分。采用Origin 8.0分... 详细信息

建立冷却猪肉中特定腐败菌的货架期预测模型。将气单胞菌接种到经80℃无菌水灭菌的猪精腿肉中,分别密封包装于0、4、7、15℃和20℃温度贮藏,测定各温度下接种猪肉的菌落总数(N)、pH值、TVBN值、TBA值,并进行感官评分。采用Origin 8.0分析软件对数据进行处理,结果表明:修正的Gompertz方程能较好地拟合不同温度下气单胞菌的生长动态,应用平方根模型(B lehrádek)描述温度对最大比生长速率(μmax)和迟滞期(Lag)的影响,均表现出良好的线性关系,R2分别为0.93和0.95。猪肉在0、4、7、15℃和20℃温度下气单胞菌的感官货架期终点菌数对数平均值为(6.33±0.14)(lg(CFU/g)),平均最大菌数对数为(7.36±0.21)(lg(CFU/g)),得到在0～20℃贮藏温度下冷却猪肉的货架期预测模型为SL=[1/(0.026T-0.00048)2]-[(7.36-lgN0)/2.718×(0.0102T+0.148)2]×{ln[-ln(6.33-lgN0)/(7.36-lgN0)]-1}。通过8℃和12℃贮藏温度下冷却猪肉的货架期实测值对构建的预测模型进行验证,相对误差均小于10%,表明建立的模型可以有效地预测冷却猪肉在0～20℃贮藏温度下的货架期。

关键词：特定腐败菌冷却猪肉货架期预测模型

枇杷清肺饮加减联合红蓝光照射治疗中、重度寻常性痤疮疗效观察及安全性评价

在线全文

学校读者我要写书评

暂无评论

中国美容医学 2017年第2期26卷 114-117页

作者：朱珂齐庆李东海李勇杨丽红广州中医药大学第一附属医院皮肤科广东广州510405

目的:观察枇杷清肺饮加减联合红蓝光照射治疗中、重度寻常性痤疮的疗效,并对其安全性进行评估。方法:将2014年1月-2015年12月在笔者科室进行治疗的120例中、重度寻常性痤疮患者纳入研究,随机分为试验组及对照组。对照组:给予红蓝光照射... 详细信息

目的:观察枇杷清肺饮加减联合红蓝光照射治疗中、重度寻常性痤疮的疗效,并对其安全性进行评估。方法:将2014年1月-2015年12月在笔者科室进行治疗的120例中、重度寻常性痤疮患者纳入研究,随机分为试验组及对照组。对照组:给予红蓝光照射加0.1%阿达帕林凝胶外敷;试验组:在对照组治疗的基础上给予枇杷清肺饮加减汤剂口服治疗。疗程均4周。对治疗前后皮损情况及治疗效果进行统计,并对不良反应、安全性及复发情况做评价。结果:两组患者治疗后皮损程度均有所减轻,试验组减轻更为明显,且总有效率更高(92.7%vs 85.5%),差异具有统计学意义(P0.05);治疗后1个月随访,试验组痤疮复发率稍高于对照组(29.2%vs 26.7%),但两组差异无统计学意义(P>0.05)。结论:在红蓝光照射加外敷用药基础上口服枇杷清肺饮治疗中、重度寻常性痤疮疗效佳,不良反应及复发率并无明显上升。

关键词：寻常性痤疮枇杷清肺饮红蓝光疗效安全性

Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Xihan Xu Juan-Juan li Jiamin li Hui-Yan Zhang Yilin Qi Bing-Sen Shi Tianqi li Shan-Shan Su Weitao Zhao Chang Chen Zhongying Gong Huiyu liu Ke-Rang Wang dong-Sheng Guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

关键词：

Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： Hui li Laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid