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Investigating the Mechanism of Qu Du Qiang Fei 1 Hao Fang Formula against Coronavirus Disease 2019 Based on Network Pharmacology Method

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 93-103页

作者： yuan-Hua Wang He-Yang Zhou Jin-Yun Ma Gui-qing Ding Hua Yu Yong-Sheng Jin Xiao-Dong Cheng Institute of Clinical Immunology Yue-Yang Hospital of Integrative MedicineShanghai University of Traditional Chinese MedicineShanghaiChina School of Pharmacy Naval Medical UniversityShanghaiChina

Objective:Qu Du Qiang Fei 1 Hao Fang(QDQF1)is a novel Chinese herbal medicine formula used to treat coronavirus disease 2019(COVID-19).However,the pharmacological mechanisms of action of QDQF1 remain *** objective of this study was to identify the effective ingredients and biological targets of QDQF1 for COVID-19 *** and Methods:The effective ingredients and mechanisms of action of QDQF1 were analyzed by using network pharmacology methods,which included an analysis of the effective ingredients and corresponding targets,COVID-19-related target acquisition,compound-target network analyses,protein-protein interaction network analysis,Kyoto Encyclopedia of Genes and Genomes(KEGG)and Gene Ontology(GO)enrichment analyses,and molecular docking ***:In total,288 effective QDQF1 ingredients were *** identified 51 core targets from the 148 targets through an overlap between putative QDQF1 targets and COVID-19-related *** key components,including formononetin,kaempferol,luteolin,naringenin,quercetin,and wogonin were identified through component-target network *** functional enrichment analysis of the core targets revealed 1296 items,while KEGG pathway enrichment analysis identified 148 signaling *** central targets(CCL2,CXCL8,IL1B,IL6,MAPK1,MAPK3,MAPK8,STAT3,and TNF)related to the COVID-19 pathway were identified in the KEGG pathway enrichment ***,molecular docking analysis suggested that the docking scores of the six key components to the nine central targets were better than those to ***:QDQF1 may regulate multiple immune-and inflammation-related targets to inhibit the progression of severe acute respiratory syndrome coronavirus 2,and thus,may be suitable for the treatment of COVID-19.

关键词： Coronavirus disease 2019 molecular docking molecular mechanism network pharmacology Qu Du Qiang Fei 1 Hao Fang formula

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Embedded high-quality ternary GaAs_(1−x)Sb_(x) quantum dots in GaAs nanowires by molecular-beam epitaxy

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Journal of Semiconductors 2024年第8期45卷 18-24页

作者： Xiyu hou Lianjun Wen Fengyue He Ran Zhuo Lei Liu Hailong Wang qing Zhong Dong Pan Jianhua Zhao State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China

Semiconductor quantum dots are promising candidates for preparing high-performance single photon sources.A basic requirement for this application is realizing the controlled growth of high-quality semiconductor quantum ***,we report the growth of embedded GaAs_(1−x)Sb_(x) quantum dots in GaAs nanowires by molecular-beam *** is found that the size of the GaAs_(1−x)Sb_(x) quantum dot can be well-defined by the GaAs *** dispersive spectroscopy analyses show that the antimony content x can be up to 0.36 by tuning the growth *** GaAs_(1−x)Sb_(x) quantum dots exhibit a pure zinc-blende *** addition,we have developed a new technology to grow GaAs passivation layers on the sidewalls of the GaAs_(1−x)Sb_(x) quantum *** from the traditional growth process of the passivation layer,GaAs passivation layers can be grown simultaneously with the growth of the embedded GaAs_(1−x)Sb_(x) quantum *** spontaneous GaAs passivation layer shows a pure zinc-blende phase due to the strict epitaxial relationship between the quantum dot and the passivation *** successful fabrication of embedded high-quality GaAs_(1−x)Sb_(x) quantum dots lays the foundation for the realization of GaAs_(1−x)Sb_(x)-based single photon sources.

关键词： semiconductor quantum dot nanowire GaAs_(1−x)Sb_(x) molecular-beam epitaxy

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Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation

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Protein & Cell 2024年第7期15卷 512-529页

作者： Kai-Hui Zhang Fei-Fei Zhang Zhi-Ling Zhang Ke-Fei Fang Wen-Xing Sun Na Kong Min Wu Hai-Ou Liu Yan Liu Zhi Li qing-qing Cai Yang Wang Quan-Wei Wei Peng-Cheng Lin Yan Lin Wei Xu Cong-Jian Xu Yi-yuan yuan Shi-Min Zhao The Obstetrics&Gynecology Hospital of Fudan University State Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200090China Shanghai Key Laboratory of Metabolic Remodeling and Children’s Hospital of Fudan UniversityShanghai 200032China School of Life Sciences and Institutes of Biomedical Sciences Fudan UniversityShanghai 200438China Department of Nutrition and Food Hygiene School of Public HealthNantong UniversityNantong 226019China Reproductive Medicine Center The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Shanghai Fifth People’s Hospital of Fudan University Fudan UniversityShanghai 200240China Department of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210014China Key Laboratory for Tibet Plateau Phytochemistry of qinghai Province College of PharmacyQinghai University for NationalitiesXining 810007China Pediatric Research Institute Children’s Hospital Affiliated to Shandong University(Jinan Children’s Hospital)Jinan 250022China

Polycystic ovary syndrome(PCOS)is the leading cause of anovulatory *** understanding of the ovulation drivers hinders PCOS ***,we report that follicle stimulating hormone(FSH)controls follicular fluid(FF)glutamine levels to determine *** ovulation starts from FF-exposing granulosa cell(GC)*** glutamine,which decreases in pre-ovulation porcine FF,elevates in PCOS patients ***-glutamine chow to elevate FF glutamine inhibits mouse GC apoptosis and induces hormonal,metabolic,and morphologic PCOS ***,follicle-development-driving FSH promotes GC glutamine synthesis to elevate FF glutamine,which maintain follicle wall integrity by inhibiting GC apoptosis through inactivating ASK1-JNK apoptotic *** and glutamine inhibit the rapture of cultured murine *** removal or ASK1-JNK pathway activation with metformin or AT-101 reversed PCOS traits in PCOS models that are induced with either glutamine or *** suggest that glutamine,FSH,and ASK1-JNK pathway are targetable to alleviate PCOS.

关键词： ovulation glutamine granulosa cells PCOS FSH

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A lithium–tin fluoride anode enabled by ionic/electronic conductive paths for garnet-based solid-state lithium metal batteries

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Rare Metals 2024年第2期43卷 575-587页

作者： Lei Zhang Qian-Kun Meng Xiang-Ping Feng Ming Shen Yu-qing Zhang Quan-Chao Zhuang Run-Guo Zheng Zhi-yuan Wang Yan-Hua Cui Hong-Yu Sun Yan-Guo Liu School of Materials Science and Engineering Northeastern UniversityShenyang110819China School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao066004China School of Materials and Physics China University of Mining&TechnologyXuzhou221116China Institute of Electronic Engineering China Academy of Engineering PhysicsMianyang621900China

The high energy density and stability of solid-state lithium metal batteries(SSLMBs)have garnered great ***-type oxides,especially Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO),with high ionic conductivity,wide electrochemical window,and stability to Li metal anode,are promising solid-state electrolyte(SSEs)materials for ***,Li/LLZTO interface issues including high interface resistance,inhomogeneous Li deposition,and Li dendrite growth have hindered the practical application of ***,a multi-functional Li–SnF_(2) composite anode with Li,LiF,and Li-Sn alloy was specifically designed and *** composite anode improves the wettability to LLZTO,constructing an intimate contact interface between it and ***,ionic/electronic conductive paths in situ formed at the interface can effectively uniform Li deposition and suppress Li *** solid-state symmetric cell exhibits low interface resistance(11Ω·cm^(2)) and high critical current density(1.3 mA·cm^(−2))at 25℃.The full SSLMB based on LiFePO_(4) or LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2) cathode also shows stable cycling performance and high rate *** work provides a new composite anode strategy for achieving high-energy density and high-safety SSLMBs.

关键词： Solid-state lithium metal batteries(SSLMBs) Lithium-tin fluoride anode Ionic/electronic conductive Interface resistance Lithium dendrite

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1990和2017年中国鼻咽癌疾病负担及其公平性研究

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中华疾病控制杂志 2024年第3期28卷 323-328页

作者：侯宝杰袁萍四川大学华西公共卫生学院流行病与卫生统计学系华西第四医院成都610041

目的分析中国鼻咽癌的疾病负担及公平性,为科学防治提供依据。方法利用2017年全球疾病负担数据,以省级行政区为单位,利用空间自相关分析鼻咽癌疾病负担的空间分布,利用斜率指数(slope index,SI)和集中指数(concentration index,CI)分析... 详细信息

目的分析中国鼻咽癌的疾病负担及公平性,为科学防治提供依据。方法利用2017年全球疾病负担数据,以省级行政区为单位,利用空间自相关分析鼻咽癌疾病负担的空间分布,利用斜率指数(slope index,SI)和集中指数(concentration index,CI)分析鼻咽癌疾病负担的公平性。结果1990和2017年高-高聚集区主要集中在南方,低-低聚集区主要集中在北方,呈南高北低的分布特点。和1990年相比,2017年鼻咽癌的伤残调整寿命年(disability adjusted life year,DALY)总体下降11.20%、标化DALY率下降24.80%,但澳门地区、陕西和新疆等地上升。1990年DALY和标化DALY率的SI为-34.71、-6.00,CI为-0.08、0.14;2017年DALY和标化DALY率的SI为9.74、12.46,CI为0.07、0.04。结论相比1990年,2017年中国鼻咽癌疾病负担有所下降,但各地分布不平衡,存在不平等现象,且仍有一些地区疾病负担上升,应重点关注高疾病负担聚集区和出现上升的地区,改善鼻咽癌疾病负担的不公平性。

关键词：鼻咽癌空间自相关公平性

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晚清“秉笔华士”群体的滥觞——对近代早期传教士中国助手群体及其编译出版活动的考察

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广东社会科学 2024年第4期 146-158,286,287页

作者：元青南开大学历史学院天津300350

在近代中国开埠前的30多年时间里,伴随早期新教传教士的东来,一批中国文士以助手身份及独特工作活跃于广州、澳门地区及南洋地区。其作为一个群体的出现,是早期中西交流的地域特征、传教士对汉语与中国文化知识的需求及中国文士的谋生... 详细信息

在近代中国开埠前的30多年时间里,伴随早期新教传教士的东来,一批中国文士以助手身份及独特工作活跃于广州、澳门地区及南洋地区。其作为一个群体的出现,是早期中西交流的地域特征、传教士对汉语与中国文化知识的需求及中国文士的谋生考量等因素共同促成的。他们协助传教士编纂双语词典等汉语学习书籍,与其合作翻译《圣经》等基督教文献,合力编译出版西学中文期刊及著述,在双方共同演绎的近代早期跨文化传播史上发挥了重要作用。作为传教士的身边人,他们明显受到基督教的不同层面的影响,有的还比较深入,但保守儒家理念的特征同样明显。他们作为下层文士的身份构成,中国传统教育的背景与文化素养,与传教士雇佣合作关系形成的历史动因,在双方合作编译出版活动中的角色作为,徘徊于儒耶之间的文化思想倾向,无不具有后来大规模涌现的“秉笔华士”群体的基本特征。可以说他们是晚清“秉笔华士”群体的滥觞。

关键词：早期传教士中国助手编译出版活动秉笔华士

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Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health

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Chinese Journal of Integrative Medicine 2024年第2期30卷 171-180页

作者： ZHAO Wen-xiao WANG Tong ZHANG Ya-nan CHEN Qian WANG yuan XING Yan-qing ZHENG Jun DUAN Chen-chen CHEN Lijun ZHAO Hai-jun WANG Shijun School of Nursing Shandong University of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJi'nan(250355)China Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula Shandong University of Traditional Chinese MedicineJi'nan(250355)China College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan(250355)China

The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity,type 2 diabetes mellitus,heart failure,and non-alcoholic fatty liver *** extracted from Chinese medicine(CM)can not only alleviate pathological status but also promote health by anti-inflammatory,regulating immunity,lowering blood glucose and lipids,anti-cancer,and *** alterations of gut microbiota composition and metabolism pathways are the potential mechanisms of CM polysaccharides *** addition,they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by gut *** review summarizes the molecular mechanisms of CM polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics forpromoting health.

关键词： Chinese medicine polysaccharides gut microbiota short-chain fatty acids lipopolysaccharides gut-organaxis synergistic actions

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论安大简《仲尼曰》的思想主旨及其“慎独”思想

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孔子研究 2024年第2期 112-119,159页

作者：袁青中山大学哲学系(珠海) 广东珠海519082

安大简《仲尼曰》为孔子正语,文末标明“孔子之正语也”是为了与假托孔子的言论相区别,《仲尼曰》是《论语》结集前的孔子语录,可能是《论语》的来源材料之一。《仲尼曰》认为统治者也必须修身而成为君子,故其主旨是如何成为君子,偏重... 详细信息

安大简《仲尼曰》为孔子正语,文末标明“孔子之正语也”是为了与假托孔子的言论相区别,《仲尼曰》是《论语》结集前的孔子语录,可能是《论语》的来源材料之一。《仲尼曰》认为统治者也必须修身而成为君子,故其主旨是如何成为君子,偏重的是修身,主要涉及慎言慎行等一系列成为君子的工夫。《仲尼曰》和《中庸》中的“慎独”当释为独处时要慎言慎行,与《大学》中释为“诚其意”的“慎独”含义不同。

关键词：安大简《仲尼曰》慎独

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钢筋混凝土剪力墙抗震滞回性能的多元时序深度神经网络预测

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工程力学 2024年第6期41卷 66-76页

作者：袁程熊青松孔庆钊同济大学土木工程防灾国家重点实验室上海200092

钢筋混凝土剪力墙结构抗震性能优越且造价合理,广泛用于抗震烈度较高的地区。准确地预测剪力墙的滞回性能与骨架曲线,直接决定了结构设计与分析的准确度与可靠性。该文提出了一种基于深度学习的剪力墙结构滞回性能预测方法,可以根据结... 详细信息

钢筋混凝土剪力墙结构抗震性能优越且造价合理,广泛用于抗震烈度较高的地区。准确地预测剪力墙的滞回性能与骨架曲线,直接决定了结构设计与分析的准确度与可靠性。该文提出了一种基于深度学习的剪力墙结构滞回性能预测方法,可以根据结构的基本设计参数(如材料属性、几何尺寸、荷载工况等),直接预测出其承载力。通过3组剪力墙的滞回试验预测1组结构的滞回曲线,结果表明:通过比较时域的特征,深度学习方法具有较高的预测精度。通过与有限元仿真结果对比,深度学习仅需输入不同参数就能够快速预测滞回曲线,其优势还在于具有较高的计算效率,而有限元仿真需要几何建模、本构模型选取、材料属性输入和荷载工况定义,整个过程相较于深度学习耗时耗力。

关键词：钢筋混凝土剪力墙多元时序深度神经网络滞回曲线抗震性能骨架曲线

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Evaluating the performance of genomic selection on purebred population by incorporating crossbred data in pigs

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Journal of Integrative Agriculture 2024年第2期23卷 639-648页

作者： Jun Zhou qing Lin Xueyan Feng Duanyang Ren Jinyan Teng Xibo Wu Dan Wu Xiaoke Zhang Xiaolong yuan Zanmou Chen Jiaqi Li Zhe Zhang Hao Zhang College of Animal Science South China Agricultural University/State Key Laboratory of Swine and Poultry Breeding Industry/National Engineering Research Center for Breeding Swine IndustryGuangzhou 510642China Guangxi State Farms Yongxin Animal Husbandry Group Co. Ltd.Nanning 530022China

Genomic selection(GS)has been widely used in livestock,which greatly accelerated the genetic progress of complex *** population size was one of the significant factors affecting the prediction accuracy,while it was limited by the purebred *** to directly combining two uncorrelated purebred populations to extend the reference population size,it might be more meaningful to incorporate the correlated crossbreds into reference population for genomic *** this study,we simulated purebred offspring(PAS and PBS)and crossbred offspring(CAB)base on real genotype data of two base purebred populations(PA and PB),to evaluate the performance of genomic selection on purebred while incorporating crossbred *** results showed that selecting key crossbred individuals via maximizing the expected genetic relationship(REL)was better than the other methods(individuals closet or farthest to the purebred population,CP/FP)in term of the prediction ***,the prediction accuracy of reference populations combining PA and CAB was significantly better only based on PA,which was similar to combine PA and ***,the rank correlation between the multiple of the increased relationship(MIR)and reliability improvement was *** for individuals with low correlation(Cor(Pi,PA or B),the reliability improvement was significantly lower than other *** findings suggested that incorporating crossbred into purebred population could improve the performance of genetic prediction compared with using the purebred population *** genetic relationship between purebred and crossbred population is a key factor determining the increased reliability while incorporating crossbred population in the genomic prediction on pure bred individuals.

关键词： pigs crossbred population genomic selection reference population construction relationship

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