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慢性肾脏病患者血清骨硬化蛋白与肌少症相关指标的相关性

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中华肾脏病杂志 2024年第1期40卷 11-17页

作者：邢婷婷李燕文罗娜李春蕾刘岩钟小仕谭荣韶广州市红十字会医院临床病态营养研究所广州510220 广州市红十字会医院肾内科广州510220

目的探讨慢性肾脏病(chronic kidney disease,CKD)患者血清骨硬化蛋白水平与肌少症相关指标的相关性,寻找能兼顾骨质疏松症和肌少症的生物标志物和潜在治疗靶点。方法该研究为单中心横断面研究。收集2021年3月至2023年3月在广州市红十... 详细信息

目的探讨慢性肾脏病(chronic kidney disease,CKD)患者血清骨硬化蛋白水平与肌少症相关指标的相关性,寻找能兼顾骨质疏松症和肌少症的生物标志物和潜在治疗靶点。方法该研究为单中心横断面研究。收集2021年3月至2023年3月在广州市红十字会医院血液透析中心规律治疗的维持性血液透析患者及CKD 1~5期非透析住院患者的临床资料。采用酶联免疫吸附测定法检测血清骨硬化蛋白水平,测量患者的身高、体重、上臂围、上臂肌围、皮褶厚度、握力、捏力等人体学指标,采用人体成分分析仪测量人体成分指标。根据估算肾小球滤过率以及是否透析将患者分为CKD 1~3期组、CKD 4~5期组及CKD 5期血液透析组。采用单因素方差分析、Kruskal-Wallis H检验及χ^(2)检验比较CKD不同分期组间人口学资料和临床特征的差异。Spearman相关分析、多元线性逐步回归法分析CKD患者血清骨硬化蛋白与肌少症相关指标的相关性。结果该研究纳入CKD 5期血液透析患者104例及CKD 1~5期非透析住院患者104例,年龄为(61.8±13.7)岁,男性114例(54.8%),糖尿病肾病89例(42.8%),肌少症67例(32.2%)。随着肾损伤进展,CKD 1~3期、4~5期、5期血液透析患者血清骨硬化蛋白分别为0.4(0.3,0.9)ng/L、0.5(0.3,1.1)ng/L和1.1(0.6,2.3)ng/L(χ^(2)=8.934,Pt=5.675,Pt=-2.143,P=0.033)和体重指数(β=0.474,t=8.090,P<0.001)是lg[四肢骨骼肌质量指数]的相关因素。结论血清骨硬化蛋白可作为评价CKD患者肌少症的良好指标及潜在治疗靶点。

关键词：肌减少症肾功能不全,慢性数据相关性骨硬化蛋白肌肉质量肌肉力量

Emergency medical services use and its association with acute ischaemic stroke evaluation and treatment in Singapore

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Stroke & Vascular Neurology 2020年第2期5卷 121-127页

作者： Hanzhang Xu Ying Xian Fung Peng Woon Janet Prvu Bettger Daniel t Laskowitz Yih Yng ng Marcus Eng Hock Ong David Bruce Matchar Deidre Anne De Silva Department of Family Medicine and Community Health Duke University School of MedicineDurhamNorth CarolinaUnited States Duke University School of Nursing DurhamNorth CarolinaUnited States Duke Clinical Research Institute DurhamNorth CarolinaUnited States Department of Neurology Duke University School of MedicineDurhamNorth CarolinaUnited States Department of Neurology National Neuroscience Institute-Singapore General Hospital CampusSingapore Department of Orthopaedic Surgery Duke University School of MedicineDurhamNorth CarolinaUnited States Hometeam Government of Singapore Ministry of Home AffairsSingapore Department of Emergency Medicine Singapore General HospitalSingapore Program in Health Services and Systems Research Duke-NUS Graduate Medical SchoolSingapore Department of Medicine(General Internal Medicine) Duke University School of MedicineDurhamNorth CarolinaUnited States

Background Emergency medical services(EMS)is a critical link in the chain of stroke *** aimed to assess EMS use for stroke in Singapore,identify characteristics associated with EMS use and the association of EMS use with stroke evaluation and *** the Singapore Stroke Registry combines nationwide EMS and public hospital data for stroke cases in *** regressions with the generalised estimat.ng equations were performed to examine the association between EMS use and timely stroke evaluation and *** Of 3555 acute ischaemic patients with symptom onset within 24 hours admitted to all five public hospitals between 2015 and 2016,68%arrived via *** who used EMS were older,were less likely to be female,had higher stroke severity by National Institute of Health Stroke Scale and had a higher prevalence of atrial fibrillation or peripheral arterial *** transported by EMS were more likely to receive rapid evaluation(door-to imaging time≤25 min 34.3%vs 11.1%,OR=2.74(95%CI 1.40 to 5.38))and were more likely to receive intravenous tissue plasminogen activator(tPA,22.8%vs 4.6%,OR=4.61(95%CI 3.52 to 6.03)).Among patients treated with tPA,patients who arrived via EMS were more likely to receive timely treatment than self-transported patients(door-to needle time≤60 min 52.6%vs 29.4%,OR=2.58(95%CI 1.35 to 4.92)).Conclusions EMS use is associated with timely stroke evaluation and treatment in *** EMS-Hospital stroke pathways and targeted public campaigns to advocate for appropriate EMS use have the potential to improve acute stroke care.

关键词： needle treatment likely

the effect of turbulence on NLOS underwater wireless optical communication channels [Invited]

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Chinese Optics Letters 2019年第10期17卷 80-87页

作者： Mohammed Sait Xiaobin Sun Omar Alkhazragi Nasir Alfaraj Meiwei Kong tien Khee ng Boon S.Ooi Photonics Laboratory King Abdullah University of Science and Technology (KAUST)

Conventional line-of-sight underwater wireless optical communication(UWOC)links suffer from huge signal fading in the presence of oceanic turbulence due to misalignment,which is caused by variations in the refractive index in the ***-line-of-sight(NLOS)communication,a novel underwater communication configuration,which has eased the requirements on the alignment,is supposed to enhance the robustness of the UWOC links in the presence of such *** Letter experimentally and statistically studies the impact of turbulence that arises from temperature gradient variations and the presence of different air bubble populations on NLOS optical *** results suggest that temperature gradient-induced turbulence causes negligible signal fading to the NLOS ***,the presence of air bubbles with different populations and sizes can enhance the received signal power by seizing the scattering phenomena from an ultraviolet 377 nm laser diode.

关键词： communication scattering turbulence

我国流域水环境抗生素与耐药基因的赋存及风险

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科学通报 2024年第6期69卷 759-773页

作者：袁青彬王娜郭欣妍陈则友王小龙李文李曦雷留生罗义南京大学环境学院污染控制与资源化国家重点实验室南京210023 生态环境部南京环境科学研究所南京210042 南开大学环境科学与工程学院天津300350 中国环境科学研究院北京100012

抗生素作为新污染物,被列入我国“十四五”提出的《重点管控新污染物》名单.流域水环境是抗生素的主要环境归宿,我国主要流域普遍检出了抗生素和耐药基因.因此,如何表征流域水环境抗生素的风险是对抗生素这类新污染物管控的科学前提.本... 详细信息

抗生素作为新污染物,被列入我国“十四五”提出的《重点管控新污染物》名单.流域水环境是抗生素的主要环境归宿,我国主要流域普遍检出了抗生素和耐药基因.因此,如何表征流域水环境抗生素的风险是对抗生素这类新污染物管控的科学前提.本文在综述了我国主要流域水环境抗生素的赋存特征及其造成的细菌耐药广泛传播的生态健康问题的基础上,指出了当前普遍采用的抗生素风险评估方法存在的问题,构建了基于细菌耐药的多指标抗生素风险评估技术框架.最后,提出了通过加强抗生素筛选细菌耐药的基础研究创新来支撑抗生素的风险评估,该研究为我国抗生素新污染物的治理和管控提供了科技支撑.

关键词：抗生素风险评估细菌耐药耐药基因流域水环境

Pancreatic lymphangioma:two case reports from an institutional experience with a rare entity and review of literature

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Journal of Pancreatology 2022年第2期5卷 98-109页

作者： Alfonso tan-Garcia Ser Yee Lee Jen San Wong thomas W.t.Ho Keng Sin ng Kiat Hon tony Lim Division of Pathology Department of Anatomical PathologySingapore General HospitalSingapore Surgical Associates Mount Elizabeth Medical CentreSingapore Department of Hepatopancreatobiliary and transplant Surgery Singapore General HospitalSingapore Hepatobiliary and Pancreatic Surgery Centre Mount Elizabeth Medical CentreSingapore Digestive Surgical Oncology Department of Diagnostic Imaging Mount Alvernia HospitalSingapore

Pancreatic lymphangiomas are very rare benign cystic lesions that pose a diagnostic dilemma due to their resemblance to other non-neoplastic and neoplastic pancreatic cystic *** such,pancreatic lymphangiomas are frequently diagnosed only after histological examination of the excised *** present 2 cases of pancreatic lymphangioma,determine its prevalence at our institution and perform a detailed review of published literature since *** 1 is a 36-year-old male and case 2 is a 35-year-old female,both of which presented with abdominal *** were the only cases of pancreatic lymphangiomas reported at our institution since *** reviewed 69 cases of pancreatic lymphangiomas from 52 *** affects predominantly females with a median age of 43 and such patients typically present with abdominal pain(58.8%)or are asymptomatic(27.9%).the median size is 8.6 cm,the most common location is the head of pancreas and the most common imaging finding is that of a multilocular *** of patients underwent surgical resection(69.6%).Endoscopic ultrasound-guided fine-needle aspiration features of pancreatic lymphangiomas include chylous cyst fluid,elevated fluid triglyceride levels(15/16 cases)and numerous lymphocytes on *** majority of patients with elevated fluid triglyceride levels(13/15 cases)were managed *** lymphangiomas are rare pancreatic cystic lesions that may be diagnosed preoperatively using a multidisciplinary and multimodal approach involving clinical,radiological,biochemical and cytological features,allowing greater confidence in the selection of patients who can be managed conservatively.

关键词： Case report Cystic Diagnostic features Literature review Lymphangioma management Pancreas Prevalence

枸橼酸西地那非片在中国健康受试者体内的生物等效性研究

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中国临床药理学杂志 2024年第3期40卷 430-434页

作者：李晓斌陈璐吴秀君葛宇鑫陆文超肖婷谢荷王华伟王文萍辽宁中医药大学附属医院GCP中心Ⅰ期临床病房辽宁沈阳110032 华润双鹤药业股份有限公司北京101100 安徽万邦医药科技股份有限公司安徽合肥230088

目的评估在空腹、餐后条件下健康受试者口服枸橼酸西地那非片(100 mg)受试制剂与参比制剂的生物等效性。方法用单次给药、随机、开放、两周期、双交叉设计。空腹和餐后试验各入组36例健康受试者,每周期单次口服枸橼酸西地那非片受试... 详细信息

目的评估在空腹、餐后条件下健康受试者口服枸橼酸西地那非片(100 mg)受试制剂与参比制剂的生物等效性。方法用单次给药、随机、开放、两周期、双交叉设计。空腹和餐后试验各入组36例健康受试者,每周期单次口服枸橼酸西地那非片受试制剂和参比制剂100 mg。用液相色谱-串联质谱法(LC-MS/MS)检测人血浆中西地那非及N-去甲基西地那非的浓度,用Analyst 1.6.3(AB Sciex)以非房室模型计算药代动力学参数,评价2种制剂的生物等效性,并对试验期间受试者进行相关的安全性评价。结果空腹试验西地那非受试制剂和参比制剂的主要药代动力学参数:C_(max)分别为(494.69±230.94)和(558.78±289.83)ng·mL^(-1),AUC_(0-t)分别为(1 336.21±509.78)和(1 410.82±625.99)h·ng·mL^(-1),AUC_(0-∞)分别为(1 366.49±512.16)和(1 441.84±628.04)h·ng·mL^(-1)。餐后试验西地那非受试制剂和参比制剂的主要药代动力学参数:C_(max)分别为(381.89±126.53)和(432.47±175.91)ng·mL^(-1),AUC_(0-t)分别为(1 366.34±366.99)和(1 412.76±420.37)h·ng·mL^(-1),AUC_(0-∞)分别为(1 403.28±375.32)和(1 454.13±429.87)h·ng·mL^(-1)。空腹和餐后试验受试制剂和参比制剂的C_(max)、AUC_(0-t)和AUC_(0-∞)的几何均值比的90%置信区间均在80%~125%内,判断2种制剂具有生物等效性。空腹和餐后试验的不良事件发生率分别为33.33%和25.00%,未发生严重不良事件。结论枸橼酸西地那非片受试制剂和参比制剂具有生物等效性,安全性良好。

关键词：枸橼酸西地那非片 N-去甲基西地那非生物等效性安全性

Synthesis and Crystal Structure of trans-bis(acesulfamato-O)tetraaquazinc(Ⅱ)

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Chinese Journal of Structural Chemistry 2010年第7期29卷 1047-1050页

作者： SAHIN Onur ICBUDAK Hasan B(U|¨)Y(U|¨)KG(U|¨)ng(O|¨)R Orhan Department of Physics Faculty of Arts and SciencesOndokuz Mayis UniversitySamsunTurkey Department of Chemistry Faculty of Arts and SciencesOndokuz Mayis UniversitySamsunTurkey

the title compound, trans-bis（acesulfamato-O）tetraaquazinc（Ⅱ）（I, C8H16N2O12S2Zn）, crystallizes in the triclinic system, space group P1 with a = 5.1638（5）, b = 8.5338（9）, c = 9.9583（9）A, α = 74.325（8）, β = 81.112（7）, γ = 75.800（8）°, V= 407.77（7） A3, Z = 1, F（000） = 236, Rint = 0.085, t= 296 K, the final R = 0.029 and wR = 0.078 for 1832 observed reflections with I〉 2σ（0. the ZnⅡcentre resides on a centre of symmetry and has a distorted octahedral geometry. the basal plane is defined by two carbonyl O atoms of two monodentate trans-oriented acesulfamato ligands and two trans-aqua ligands. the axial positions in the octahedron are occupied by two trans-aqua ligands. Intermolecular O-H…O hydrogen bonds produce R22（8） and R22（16） rings, which lead to two- dimensional polymeric chains.

关键词： crystal structure zinc(Ⅱ) octahedral complex hydrogen bonds

血清CXCL10、CCCK-18水平对伴糖尿病冠心病患者PCI术后短期预后的预测效能

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海南医学 2024年第12期35卷 1740-1744页

作者：呼庆华郭晓艳宋爱新安阳市第三人民医院心内科河南安阳455000 阜外华中心血管病医院心内科河南郑州451450

目的探讨血清CXC趋化因子配体10(CXCL10)、细胞角蛋白18裂解片段(CCCK-18)水平对伴糖尿病冠心病患者经皮冠状动脉介入术(PCI)后短期预后的预测效能。方法选取2020年12月至2022年12月在安阳市第三人民医院实施相应PCI手术的149例伴糖尿... 详细信息

目的探讨血清CXC趋化因子配体10(CXCL10)、细胞角蛋白18裂解片段(CCCK-18)水平对伴糖尿病冠心病患者经皮冠状动脉介入术(PCI)后短期预后的预测效能。方法选取2020年12月至2022年12月在安阳市第三人民医院实施相应PCI手术的149例伴糖尿病冠心病患者作为研究对象,采用酶联免疫吸附法检测血清CXCL10、CCCK-18水平。术后随访3个月,根据患者是否发生主要心血管不良事件(MACE)分为预后良好组121例和预后不良组28例。采用受试者工作特征曲线(ROC)评估血清CXCL10、CCCK-18水平对伴糖尿病冠心病患者PCI术后短期预后的预测效能,采用二分类Logistic逐步回归分析探讨伴糖尿病冠心病患者PCI术后短期预后的影响因素。结果预后不良组患者冠状动脉评分(Gensini)≥70分和多支血管病变的占比分别为78.57%、89.29%,明显高于预后良好组的43.80%、60.33%,差异均有统计学意义(P0.05);预后不良组患者的血清CXCL10、CCCK-18水平分别为(19.35±2.41)ng/mL、(306.45±33.69)U/L,明显高于预后良好组的(8.63±1.87)ng/mL、(218.36±22.15)U/L,差异均有统计学意义(Png/L、262.47 U/L,而两者联合预测的曲线下面积(AUC)95%置信区间(95%CI)为0.912(0.868~0.957);经多因素Logistic逐步回归分析结果显示:Gensini评分≥70分、多支血管病变、CXCL10、CCCK-18均是伴糖尿病冠心病患者PCI术后短期预后的影响因素(Pt2DM冠心病PCI术后预后不良患者的血清CXCL10、CCCK-18水平较预后良好者明显升高,两者联合检测对术后不良心血管事件具有一定的预测效能。

关键词：冠心病 2型糖尿病 CXC趋化因子配体10 细胞角蛋白18裂解片段短期预后

单纯性肥胖儿童发生代谢相关脂肪性肝病的危险因素分析

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肝脏 2024年第3期29卷 308-312页

作者：张怡崔蕾袁伯稳海安市人民医院儿科江苏226600

目的探讨发生代谢相关脂肪性肝病(MAFLD)的高危因素。方法纳入2021年1月至2023年6月海安市人民医院诊断的140例单纯性肥胖儿童,其中MAFLD组52例,非MAFLD组88例。记录研究对象的基线资料和临床指标。单因素和logistic多因素单纯性肥胖儿... 详细信息

目的探讨发生代谢相关脂肪性肝病(MAFLD)的高危因素。方法纳入2021年1月至2023年6月海安市人民医院诊断的140例单纯性肥胖儿童,其中MAFLD组52例,非MAFLD组88例。记录研究对象的基线资料和临床指标。单因素和logistic多因素单纯性肥胖儿童并发MAFLD高危因素,受试者工作特征曲线下面积(AUC)判断高危因素的预测价值。结果MAFLD组的男性比例、体质量指数(BMI)、脂质蓄积指数(LAP)、丙氨酸转移酶(ALt)、碱性磷酸酶(ALP)、三酰甘油(tG)、尿酸(UA)、铁蛋白(SF)分别为71.54%、27.46 kg/m^(2)、37.98±6.35、68 U/L、56 U/L、1.08 mmol/L、(423.58±27.36)μmol/L、(124.95±13.46)ng/mL,高于非MAFLD组的52.27%、25.19 kg/m^(2)、46.82±7.04、29 U/L、47 U/L、0.81 mmol/L、(346.75±21.08)μmol/L、(95.38±7.45)ng/mL,差异有统计学意义(t/χ^(2)/Z=3.517,6.254,8.472,9.596,6.528,5.329,9.427,9.781,均Ptics回归分析显示,LAP、ALt、UA和SF为单纯性肥胖儿童发生MAFLD的独立影响因素(95%CI为1.047~1.092、1.012~1.157、1.020~1.059、1.017~1.063,OR=1.063、1.084、1.035、1.049)。ROC分析显示,LAP、ALt、UA和SF的AUC分别为0.741、0.849、0.783和0.682,敏感度为86.27%、81.35%、72.86%、87.94%,特异度为73.85%、91.27%、78.13%、70.36%。结论LAP、ALt、UA和SF升高是单纯性肥胖儿童发生MAFLD的独立影响因素,可作为早期识别、诊断和评价单纯性肥胖儿童发生MAFLD的预测指标。

关键词：单纯性肥胖代谢相关脂肪性肝病危险因素儿童保健