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Topologically close-packed intermetallic alloy electrocatalysts for CO_(2) reduction towards high value-added multi-carbon chemicals

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Chinese Chemical Letters 2025年第1期36卷 6-7页

作者： Qiyan wu qing Li State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The continuous combustion of unsustainable carbon-based fossil fuels has dramatically accelerated the increase in carbon dioxide(CO_(2))concentration in the atmosphere(from approximately278.3 ppm in 1750 to 417.9 ppm in 2023),which would exacerbate environmental problems such as greenhouse effect[1].The effective electrosynthesis of high value-added multi-carbon(C_(2+))chemicals(e.g.,ethanol,ethylene)from CO_(2) reduction reaction(CO_(2)RR)is a promising strategy to mitigate these environmental issues mentioned above but remains highly challenging due to the competition of hydrogen evolution reaction(HER)and low selectivity of target products.

关键词： intermetallic alloy carbon

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World Journal of Pediatrics 2022年第4期18卷 271-277页

作者： Yi Cao Wei-Hui Yan Li-Na Lu Yi-Jing Tao Hai-Xia Feng qing-qing wu Yi-Jing Chu Wei Cai Ying Wang Division of Pediatric Gastroenterology and Nutrition Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of MedicineNo.1665Kongjiang Rd.ShanghaiChina Shanghai Institute for Pediatric Research ShanghaiChina Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition No.1665Kongjiang Rd.ShanghaiChina

Background Children with intestinal failure(IF)have frequent catheter-related bloodstream infections(CRBSIs).This study aimed to analyze the clinical presentation and laboratory parameters of CRBSIs in children with *** This 6-year retrospective study was conducted among IF children with CRBSIs at an intestinal rehabilitation center in *** data were collected,including data of temperature and gastrointestinal ***/catheter culture,fecal tests,and calculation of inflammatory index were performed,which were obtained within 1 week since CRBSI *** Fifty children with 87 CRBSIs were identified,of which there were 17 suspected and 70 confirmed ***-two pathogens were cultured from 70 positive blood cultures:63%were Gram-positive organisms,23%were Gram-negative organisms,and 11%were fungal ***,48.6%were enteric organisms;47.2%of bacterial pathogens were consistent between fecal and blood ***,46.3%fecal routines showed abnormalities including increased white blood cells,occult blood positive and the presence of fat *** consistent symptom at onset of CRBSIs was fever and gastrointestinal symptoms including increased stool output,abdominal distension,or both.C-reactive protein(CRP)and procalcitonin(PCT)were elevated,i.e.,16.5 mg/L[interquartile range(IQR)8.7-44.7]and 0.48 ng/mL(IQR 0.2-1.76),*** IF children had a high rate of CRBSIs,of which larger proportions were due to Gram-positive and enteric *** and/or gastrointestinal symptoms,combined with elevated CRP and PCT,is conducive to the early diagnosis of CRBSIs in IF patients.

关键词： Enteric pathogens Fecal examination Gastrointestinal symptoms

Diagnosis and treatment of an inborn error of bile acid synthesis type 4:A case report

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World Journal of Clinical Cases 2021年第26期9卷 7923-7929页

作者： Shou-Hao Wang Tian-Chen Hui Zhe-Wen Zhou Cheng-An Xu Wen-Hao wu qing-qing wu Wei Zheng Qiao-Qiao Yin Hong-Ying Pan Zhejiang Provincial People’s Hospital Qingdao UniversityHangzhou 310014Zhejiang ProvinceChina Department of Infectious Diseases Zhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Inborn error of bile acid synthesis type 4 is a peroxisomal disease with impaired bile acid synthesis caused by a-methylacyl-CoA racemase(AMACR)gene *** disease is usually found in children with mild to severe liver disease,cholestasis and poor fat-soluble vitamin *** present,there is no report of inborn errors of bile acid synthesis type 4 in adults with liver disease and poor fat-soluble vitamin *** SUMMARY A 71-year-old man was hospitalized in our department for recurrent liver *** clinical manifestations were chronic liver disease and yellow skin and *** transaminase,bilirubin and bile acid were abnormally increased;and fat-soluble vitamins *** cirrhosis and ascites were diagnosed by computed *** patient had poor coagulation function and ascites and did not undergo liver *** testing showed AMACR gene missense *** patient was diagnosed with inborn error of bile acid synthesis type *** was treated with ursodeoxycholic acid,liver protection and vitamin supplementation,and jaundice of the skin and sclera was *** indicators of liver function and the quality of life were significantly *** When adults have recurrent liver function abnormalities,physicians should be alert to genetic diseases and provide timely treatment.

关键词： Bile acid synthesis A-methylacyl-CoA racemase gene Gene mutation Inborn error of metabolism Ursodeoxycholic acid Case report

Pneumocystis jirovecii and Legionella pneumophila coinfection in a patient with diffuse large B-cell lymphoma:A case report

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World Journal of Clinical Cases 2021年第28期9卷 8595-8601页

作者： Wen-Hao wu Tian-Chen Hui qing-qing wu Cheng-An Xu Zhe-Wen Zhou Shou-Hao Wang Wei Zheng Qiao-Qiao Yin Xi Li Hong-Ying Pan Department of Infectious Diseases Zhejiang Provincial People’s HospitalHangzhou 310014Zhejiang ProvinceChina Medical College Qingdao UniversityQingdao 266071Shandong ProvinceChina Centre of Laboratory Medicine Zhejiang Provincial People’s HospitalHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Diffuse large B-cell lymphoma(DLBCL)is a common non-Hodgkin's lymphoma.R-CHOP is a protocol for long-term chemotherapy for DLBCL *** chemotherapy can lead to low immunity and increase the risk of opportunistic pathogen infections in immunocompromised *** SUMMARY We report a case of coinfection with Pneumocystis jirovecii(***)and Legionella pneumophila(***)in a patient with *** patient was a 40-year-old female who was diagnosed with DLBCL and was admitted due to pulmonary *** and *** were detected in her bronchoalveolar lavage fluid by hexamine silver staining,isothermal amplification and metagenomic *** To the best of our knowledge,this is the first case of *** and *** coinfection found in a DLBCL *** should be aware of the risk of complicated infection in patients undergoing long-term chemotherapy.

关键词： Legionella pneumophila Pneumocystis jirovecii Next-generation sequencing Diffuse large B-cell lymphoma Case report

Primary bone anaplastic lymphoma kinase positive anaplastic largecell lymphoma: A case report and review of the literature

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World Journal of Clinical Cases 2021年第14期9卷 3403-3410页

作者： Wei Zheng Qiao-Qiao Yin Tian-Chen Hui Wen-Hao wu qing-qing wu Hai-Jun Huang Mei-Juan Chen Rong Yan Yi-Cheng Huang Hong-Ying Pan Department of Infectious Diseases Zhejiang Provincial People’s Hospital People’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina The Graduate School Bengbu Medical CollegeBengbu 233030Anhui ProvinceChina The Graduate School Qingdao UniversityQingdao 266071Shandong ProvinceChina The Second School of Clinical Medicine Zhejiang Chinese Medicinal UniversityHangzhou 310053Zhejiang ProvinceChina

BACKGROUND Primary bone lymphoma(PBL)is an uncommon extranodal disease that represents approximately 1%-3%of *** lymphoma kinase(ALK)positive anaplastic large-cell lymphoma(ALCL)is an extremely rare type of *** aim of this report is describe the symptoms,diagnosis,and treatment of primary bone ALK-positive *** SUMMARY A 66-year-old man presented to our hospital with neck and shoulder pain and intermittent fever that lasted for 1 *** extensive evaluation,positron emission tomography-computed tomography(CT)examination showed multiple osteolytic bone lesions without other sites ***-guided biopsy of the T10 vertebral body was performed,and the pathology results showed that neoplastic cells were positive for ALK-1,CD30,and CD3.A diagnosis of primary bone ALK positive ALCL was ultimately *** patient was in partial response after four cycle soft cyclophosphamide,doxorubicin,vincristine,and prednisone chemotherapy,and we planned to repeat the biopsy and radiological examination after completion of the fifth cycle of *** Primary bone ALK positive ALCL is a rare disease and physicians should keep in mind that ALCL can present with isolated osseous involvement without nodal involvement,and lymphoma should be considered in the differential diagnosis of primary bone lesions.

关键词： Anaplastic large cell lymphoma Anaplastic lymphoma kinase Primary bone lymphoma Bone involvement Osteolysis Case report

Sanguinarine Attenuates Lipopolysaccharide-induced Inflammation and Apoptosis by Inhibiting the TLR4/NF-KB Pathway in H9c2 Cardiomyocytes

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Current Medical Science 2018年第2期38卷 204-211页

作者： Yan-yan MENG Yuan LIU Zhe-fu HU Yao ZHANG Jian NI Zhen-guo MA Hai-han LIAO qing-qing wu Qi-zhu TANG Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 China Cardiovascular Research Institute Wuhan University Wuhan 430060 China Hubei Key Laboratory of Cardiology Wuhan 430060 China

The inflammatory response is involved in the pathogenesis of the most common types of heart disease. Sanguinarine （SAN） has various pharmacological properties such as anti-inflammatory, antioxidant, antibacterial, antitumor, and immune-enhancing properties. However, few studies have investigated the effects of SAN on lipopolysaceharide （LPS）-induced inflammatory and apoptotic responses in H9c2 cardiomyocytes. Therefore, in this study, H9c2 cells were co-treated with SAN and LPS, and the mRNA levels of pro-inflammation markers and the apoptosis rate were measured to clarify the effect of SAN on cardiac inflammation. The underlying mechanism was further investigated by detecting the activation of Toll-like receptor （TLR）4/nuclear faetor-κB （NF-κB） signaling pathways. As a result, increased mRNA expression of interleukin （IL）-1β, IL-6, and TNFα induced by LPS was attenuated after SAN treatment; LPS-induced apoptosis ofHge2 cardiomyocytes and cleaved-caspase 8, 9, 3 were all significantly reduced by SAN. Further experiments showed that the beneficial effect of SAN on blocking the inflammation and apoptosis of H9c2 cardiomyocytes induced by LPS was associated with suppression of the TLR4/NF-κB signaling pathway. It was suggested that SAN suppressed the LPS-induced inflammation and apoptosis of H9c2 cardiomyocytes, which may be mediated by inhibition of the TLR4/NF-κB signaling pathway. Thus, SAN may be a feasible therapy to treat sepsis patients with cardiac dysfunction.

关键词： lipopolysaccharides sanguinarine inflammation H9c2 cardiac cells apoptosis

A Rare Novel Copy Number Variation of Xp22.33-p11.22 Duplication is Associated with Congenital Heart Defects

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Chinese Medical Journal 2015年第20期128卷 2829-2830页

作者： Juan Zhang qing-qing wu Li Wang Li-Juan Sun Department of Ultrasound Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing 100026 China

Congenital heart defect （CHD） is the most common fetal defects. Copy nmnber variations （CNVs） were demonstrated to be involved in the etiology of CHDs. We report three cases from a family diagnosed as CHDs with a rare novel duplication ofXp22.33-p I 1.22. A 30-year-old woman, gmvida 2 para 0. Her first pregnancy at 2012 was diagnosed to be dichorionic twin pregnancy and her second pregnancy at 2014 was a singleton pregnancy. After a routine ultrasound scan at 22 week＇s gestation, all the fetuses were diagnosed with critical CHDs. The first fetus （male） exhibited tetralogy of Fallot, atrial septal defect, persistent left superior vena cava, and coronary sinus dilatation while the examination of the second fetus （male） revealed atrioventricular septal detect and hypoplastic left heart syndrome. The third fetus （t^male） was also diagnosed with an atrioventricular septaI defect and hypoplastic left heart syndrome. The parents decided to terminate the wegnancy.

关键词： Congenital Heart Defects Copy Number Variations Chromosomal Duplication Prenatal Ultrasonic Diagnosis

Predicting fetal weight by three-dimensional limb volume ultrasound (AVol/TVol) and abdominal circumference

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Chinese Medical Journal 2021年第9期134卷 1070-1078页

作者： Li Kang qing-qing wu Li-Juan Sun Feng-Yun Gao Jing-Jing Wang Department of Ultrasound Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing 100026China

Background:Fetal weight is an important parameter to ensure maternal and child *** purpose of this study was to use three-dimensional(3D)limb volume ultrasound combined with fetal abdominal circumference(AC)measurement to establish a model to predict fetal weight and evaluate its ***:A total of 211 participants with single pregnancy(28-42 weeks)were selected between September 2017 and December 2018 in the Beijing Obstetrics and Gynecology Hospital of Capital Medical *** upper arm(AVol)/thigh volume(TVol)of fetuses was measured by the 3D limb volume *** AC was measured by two-dimensional *** cases were excluded due to incomplete information or the interval between examination and delivery>7 *** enrolled 202 participants were divided into a model group(134 cases,70%)and a verification group(68 cases,30%)by mechanical sampling *** linear relationship between limb volume and fetal weight was evaluated using Pearson Chi-squared *** prediction model formula was established by multivariate regression with data from the model *** of the model formula was evaluated with verification group data and compared with traditional formulas(Hadlock,Lee2009,and INTERGROWTH-21st)by paired t-test and residual *** operating characteristic curves were generated to predict ***:AC,AVol,and TVol were linearly related to fetal *** correlation coefficient was 0.866,0.862,and 0.910,*** prediction model based on AVol/TVol and AC was established as follows:Y=-481.965+12.194TVol+15.358AVol+67.998AC,R2adj=*** scatter plot showed that when birth weight fluctuated by 5%(i.e.,95%to 105%),the difference between the predicted fetal weight by the model and the actual weight was small.A paired t-test showed that there was no significant difference between the predicted fetal weight and the actual birth weight(t=-1.015,P=0.314).Moreover,the residual analysis showed

关键词： Fetal weight prediction Limb volume Three-dimensional ultrasound

Establish a normal fetal lung gestational age grading model and explore the potential value of deep learning algorithms in fetal lung maturity evaluation

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Chinese Medical Journal 2021年第15期134卷 1828-1837页

作者： Tai-Hui Xia Man Tan Jing-Hua Li Jing-Jing Wang qing-qing wu De-Xing Kong Department of Ultrasound Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing 100026China The School of Mathematical Sciences Zhejiang UniversityHangzhouZhejiang 310058China

Background:Prenatal evaluation of fetal lung maturity(FLM)is a challenge,and an effective non-invasive method for prenatal assessment of FLM is *** study aimed to establish a normal fetal lung gestational age(GA)grading model based on deep learning(DL)algorithms,validate the effectiveness of the model,and explore the potential value of DL algorithms in assessing ***:A total of 7013 ultrasound images obtained from 1023 normal pregnancies between 20 and 41+6 weeks were analyzed in this *** were no pregnancy-related complications that affected fetal lung development,and all infants were born without neonatal respiratory *** images were divided into three classes based on the gestational week:class I:20 to 29+6 weeks,class II:30 to 36+6 weeks,and class III:37 to 41+6 *** were 3323,2142,and 1548 images in each class,***,we performed a pre-processing algorithm to remove irrelevant information from each ***,a convolutional neural network was designed to identify different categories of fetal lung ultrasound ***,we used ten-fold cross-validation to validate the performance of our *** new machine learning algorithm automatically extracted and classified lung ultrasound image information related to *** was used to establish a grading *** performance of the grading model was assessed using accuracy,sensitivity,specificity,and receiver operating characteristic ***:A normal fetal lung GA grading model was established and *** sensitivity of each class in the independent test set was 91.7%,69.8%,and 86.4%,*** specificity of each class in the independent test set was 76.8%,90.0%,and 83.1%,*** total accuracy was 83.8%.The area under the curve(AUC)of each class was 0.982,0.907,and 0.960,*** micro-average AUC was 0.957,and the macro-average AUC was ***:The normal fetal lung GA grading model could accurately identify ultraso

关键词： Convolutional neural network Deep learning algorithms Grading model Normal fetal lung Fetal lung maturity Gestational age Artificial intelligence