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Neuroendoscopic and microscopic transsphenoidal approach for resection of nonfunctional pituitary adenomas

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World Journal of Clinical Cases 2019年第13期7卷 1591-1598页

作者： Zhi-Quan Ding Sheng-Fan Zhang qing-hua wang Department of Neurosurgery Zhujiang Hospital Southern Medical University The National Key Clinical Specialty The Engineering Technology Research Center of Education Ministry of China Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration

BACKGROUND Nonfunctional pituitary adenoma is a common type of pituitary adenoma, which can lead to headache, visual field disturbance, and cranial nerve damage due to increased tumor volume. Neuroendoscopic and microscopic transsphenoidal approaches have been widely used in the resection of nonfunctional pituitary adenomas. However, the clinical efficacy in neuroendoscopic and microscopic surgery is still controversial. AIM To explore the clinical efficacy of neuroendoscopic and microscopic transsphenoidal approach for resection of nonfunctional pituitary adenomas. METHODS We retrospectively analyzed 251 patients with nonfunctional pituitary adenomas;138 underwent neuroendoscopic surgery via transsphenoidal approach, and 113 underwent microscopic surgery via transsphenoidal approach between July 2010 and September 2015. All patients were followed up for > 6 mo. Gender, age, course of disease, tumor diameter, tumor location, and percentage of patients with headache, visual impairment, sexual dysfunction, and menstrual disorders were contrasted between the two groups to compare the difference of preoperative data. Cure rate, symptom improvement rate, recurrence rate, the postoperative hospital stay, operating time, intraoperative blood loss, and the incidence of postoperative complications were compared in order to evaluate the advantages and disadvantages of neuroendoscopic and microscopic *** There was no significant difference in cure rate, symptom improvement rate, and recurrence rate between neuroendoscopy group and microscopy group (82.6% vs 85.8%, P > 0.05;90.6% vs 93.8%, P > 0.05;5.1% vs 9.7%, P > 0.05). In the neuroendoscopy group, the postoperative hospital stay was 8.4 ± 0.6 d;operating time was 167.2 ± 9.6 min;intraoperative blood loss was 83.4 ± 9.3 mL, and the rates of diabetes insipidus and electrolyte imbalance were 4.3% and 8.0%, respectively. The corresponding results in the microscopic group were 11.2 ± 0.6 d, 199.7 ± 9.3 min, 138.8 ± 1

关键词： Nonfunctional pituitary adenomas Neuroendoscopy Microscopy Transsphenoidal approach Clinical efficacy

Facile preparation of antibacterial polymer coatings via thiol-yne click photopolymerization

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Chinese Chemical Letters 2016年第5期27卷 681-684页

作者： Chuan Zhou Yi-He Li Zhen-hua Jiang Kwang-Duk Ahn Tian-Jiao Hu qing-hua wang Chun-hua wang Department of Chemistry and Biology College of Science National University of Defense Technology Polymer Research Center Korea Institute of Science and Technology

Novel antibacterial polymer coatings were prepared by a facile thiol-yne click photopolymerization of 1-propargyl-3-allYl-l,3-diazanyl-2,4-cyclopentadiene bromide （[PAIMIBr） and tetra（3-mercapto-pro- pionate）pentaerythritol （PETMP）（2：1 molar ratio） using 2,2-dimethoxy-2-phenylacetophenone （DMPA） as initiator. The antibacterial activity of the coatings was tested against Staphylococcus aureus （ATCC 292130） and Escherichia coli （ATCC 25922） by the dynamic shake method. The evaluation results revealed the antibacterial polymer coatings exhibited excellent inhibitory activity against S. aureus and E. coil, especially for S. aureus.

关键词： Antibacterial polymer Thiol-yneClick chemistry UV-curing Coatings

Poly[(mercaptopropyl)methylsiloxane](PMMS)-based antibacterial polymer coatings prepared by a two-step sequential thiol–ene click chemistry

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Chinese Chemical Letters 2016年第5期27卷 685-688页

作者： Chuan Zhou Yi-He Li Zhen-hua Jiang Kwang-Duk Ahn Tian-Jiao Hu qing-hua wang Chun-hua wang Department of Chemistry and Biology. College of Science National University of Defense Technology Changsha 410073 China State Key Laboratory of NBC Protection for Civilian Beijing 102205 China Polymer Research Center Korea Institute of Science and Technology Seoul 136-791 Republic of Korea

Poly[（mercaptopropyl）methylsiloxane] （PMMS）-based antibacterial polymer coatings have been prepared through a two-step sequential thiol-ene click chemistry utilizing 1-allyl-3-decylimidazolium bromide （ADIm） as antibacterial monomer and triallyl cyanurate （TAC） as the crosslinker. These films with different content of ADIm were characterized by thermogravimetric analysis （TGA）, dynamic mechanical analysis （DMA） and pencil hardness. It was found that the mechanical and thermal properties of these films were largely influenced by the content of ADIm in the films. Films with imidazolium bromide groups displayed excellent antimicrobial activity against Staphylococcus aureus with 100% killing efficiency.

关键词： Antibacterial polymerThiol-ene UV-curing Click chemistry Coatings

Effect of ion-beam assisted deposition on the film stresses of TiO_2 and SiO_2 and stress control

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Acta Mechanica Sinica 2012年第5期28卷 1382-1388页

作者： Yu-Qiong Li hua-qing wang Wu-Yu wang Zhi-Nong Yu He-Shan Liu Gang Jin National Microgravity Laboratory(NML) Institute of MechanicsChinese Academy of Sciences School of Optoelectronics Beijing Institute of Technology Optical Thin Film Center Daheng New Epoch Technology Inc. Beijing General Research Institute for Nonferrous Metals Division of Mineral Research and Material Energy

Based on Hartmann-Shack sensor technique, an online thin film stress measuring system was introduced to measure the film stresses of TiO2 and SiO2, and comparison was made between the film stresses prepared respectively by the conventional process and the ion-beam assisted deposition. The effect of ion-beam assisted deposition on the film stresses of TiO2 and SiO2 was investigated in details, and the stress control methodologies using on-line adjustment and film doping were put forward. The results show that the film stress value of TiO2 prepared by ion-beam assisted deposition is 40 MPa lower than that prepared by conventional process, and the stress of TiO2 film changes gradually from tensile stress into compressive stress with increasing ion energy; while the film stress of SiO2 is a tensile stress under ion-beam assisted deposition because of the ion-beam sputtering effect, and the film refractive index decreases with increasing ion energy. A dynamic film stress control can be achieved through in-situ adjustment of the processing parameters based on the online film stress measuring technique, and the intrinsic stress of film can be effectively changed through film doping.

关键词： Film stress Stress controlling Ion-beam as-sisted deposition Hartmann-Shack sensor

Synthesis of novel chiral stationary phases for high-performance liquid chromatography

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Chinese Chemical Letters 2007年第4期18卷 461-464页

作者： Xu Lin Tan Shi Cong Hou qing hua Bian Min wang College of Science China Agricultural University Beijing 100094 China

Three novel chiral selectors 4a-c were synthesized from （S）-amino acids and （R）-1-phenyl-2-（4-methylphenyl）ethylamine. 4a-c were connected to 3-aminopropylsilanized silica gel to be used as the chiral stationary phase for HPLC. Five amino acid derivatives and two pyrethroid insecticides were fairly resolved on these three new chiral stationary phases under normal phase condition.

关键词： Enantioseparation Chiral stationary phase Amino acid derivatives Pyrethroid insecticides

Dysregulated liver function in SARS-CoV-2 infection:Current understanding and perspectives

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World Journal of Gastroenterology 2021年第27期27卷 4358-4370页

作者： Yi-Ke huang Yu-Jia Li Bin Li Pan wang qing-hua wang Institute of Blood Transfusion Chinese Academy of Medical Sciences and Peking Union Medical CollegeKey Laboratory for Transfusion-transmitted Infectious Diseases of the Health Commission of Sichuan ProvinceChengdu 610052Sichuan ProvinceChina Joint laboratory on Transfusion-transmitted Diseases between Institute of Blood Transfusion Chinese Academy of Medical Sciences and Nanning Blood CenterNanning 530007Guangxi Zhuang Autonomous RegionChina Department of Emergency The Traditional Chinese Medicine Hospital of Wenjiang DistrictChengdu 611130Sichuan ProvinceChina

Since it was first reported in December 2019,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has spread rapidly around the world to cause the ongoing *** the clinical manifestations of SARS-CoV-2 infection are predominantly in the respiratory system,liver enzyme abnormalities exist in around half of the cases,which indicate liver injury,and raise clinical *** present,there is no consensus whether the liver injury is directly caused by viral replication in the liver tissue or indirectly by the systemic inflammatory *** review aims to summarize the clinical manifestations and to explore the underlying mechanisms of liver dysfunction in patients with SARSCoV-2 infection.

关键词： SARS-CoV-2 COVID-19 Dysregulated liver function Cytokine storm

Exogenous Nitric Oxide Alleviated the Inhibition of Photosynthesis and Antioxidant Enzyme Activities in Iron-Deficient Chinese Cabbage (Brassica chinensis L.)

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Agricultural Sciences in China 2008年第2期7卷 168-179页

作者： DING Fei wang Xiu-feng SHI qing-hua wang Mei-ling YANG Feng-juan GAO qing-hai State Key Laboratory of Crop Biology College of Horticulture Science and Engineering Shandong Agricultural University Tai＇an 271018 P.R. China

The effects of exogenous nitric oxide （NO） on plant growth, chlorophyll contents, photosynthetic and chlorophyll fluorescence parameters as well as lipid peroxidation and activities of antioxidant enzymes were investigated in Chinese cabbage plants exposed to iron （Fe） deficiency. Iron deficiency led to serious chlorosis in Chinese cabbage leaves, and resulted in significant decrease in plant growth, photosynthetic pigments, net photosynthetic rate, Fv/Fm, Ф ps Ⅱ and activities of antioxidant enzymes, and increase in lipid peroxidation. While treatment with SNP, a NO donor, it could revert the iron deficiency symptoms, increased photosynthetic rate as well as activities of antioxidant enzymes, and protected membrane from lipid peroxidation, as a result, the growth inhibition of Chinese cabbage by Fe deficiency was alleviated.

关键词： antioxidant enzyme Chinese cabbage iron deficiency nitric oxide photosynthesis

Pathogenesis,clinical manifestations,diagnosis,and treatment progress of achalasia of cardia

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World Journal of Clinical Cases 2023年第8期11卷 1741-1752页

作者： Ming-Yue Li qing-hua wang Run-Peng Chen Xiao-Fang Su Dong-Yang wang School of Nursing Binzhou Medical UniversityYantai 264003Shandong ProvinceChina Faculty of Nursing Mahidol UniversityNakhon Pathom 73170Thailand

Achalasia cardia,type of esophageal dynamic disorder,is a relatively rare primary motor esophageal disease characterized by the functional loss of plexus ganglion cells in the distal esophagus and lower esophageal *** of function of the distal and lower esophageal sphincter ganglion cells is the main cause of achalasia cardia,and is more likely to occur in the *** changes in the esophageal mucosa are considered pathogenic;however,studies have found that inflammation and genetic changes at the molecular level may also cause achalasia cardia,resulting in dysphagia,reflux,aspiration,retrosternal pain,and weight ***,the treatment options for achalasia focus on reducing the resting pressure of the lower esophageal sphincter,helping to empty the esophagus and relieve *** measures include botulinum toxin injection,inflatable dilation,stent insertion,and surgical myotomy(open or laparoscopic).Surgical procedures are often subject to controversy owing to concerns about safety and effectiveness,particularly in older ***,we review clinical epidemiological and experimental data to determine the prevalence,pathogenesis,clinical presentation,diagnostic criteria,and treatment options for achalasia to support its clinical management.

关键词： Achalasia cardia Pathogenesis Clinical manifestations Diagnosis Treatment

IR STUDY ON MONOMOLECULAR PARTICLE AGGLOMERATES OF POLYSTYRENE OBTAINED BY FREEZE-DRYING OF ITS DILUTE SOLUTION

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Chinese Journal of Polymer Science 2002年第4期20卷 381-383页

作者： Song wang qing-hua wang Rong-shi Cheng Research Center of Materials Beijing Institute of Technology Beijing 100081, China Department of Chemistry Nanjing University Nanjing 210093, China Nanjing Univ Dept Chem Nanjing 210093 Peoples R China Beijing Inst Technol Ctr Mat Res Beijing 100081 Peoples R China

The monomolecular particle agglomerates of polystyrenes were obtained by freeze-drying of its very dilute solutions of 1.3 x 10(-5)-2.0 x 10(-5) g/mL in benzene:cylcohexane (100:1) solvents, and they were annealed at room temperature for hundred days before use. According to C-13-NMR measurement the polystyrenes should be practically atactic. The number average molecular weights of the samples are 2.80 x 10(3), 2.00 x 10(4), and 1.55 x 10(6), respectively. The freeze-dried aPS with a molecular weight higher than 10(4) show two new IR absorption bands at 1098 and 1261 cm(-1), which are absent in the normal aPS and freeze-dried styrene oligomer. It was also found that the low molecular weight samples can only form powders, whereas the freeze-dried aPS with higher molecular weight form a mixture of powders and fibrils, of which the longer fibrils show a much stronger 1261 cm(-1) band than the shorter fibrils and the powder. It seems that the 1261 cm(-1) band corresponds to the stacking behavior of monomolecular particles.

关键词： monomolecular particles atactic polystyrene FTIR spectroscopy