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Biological nano agent produced by hypoxic preconditioning stem cell for stroke treatment

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Nano Research 2023年第5期16卷 7413-7421页

作者： Xin-Chi Jiang hong-Hui Wu Tianyuan zhang Yun-Fei Dong yao-sheng Li Ting Huang An-Hao Tian Peng-Xiang Chen Xian-ming Lin Ying-zhi Huang Chong Liu Xiang-Nan zhang Zhong Chen Yasuhiko Tabata Jian-qing Gao Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang UniversityHangzhou 310058China Department of Pathology and Pathophysiology and Department of Neurosurgery of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310058China The Third Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310058China SinoCell Biotechnology Ltd. Ningbo 315000China Key Laboratory of Medical Neurobiology of the Ministry of Health of China Institute of Pharmacology&ToxicologyCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Laboratory of Biomaterials Department of Regeneration Science and EngineeringInstitute for Frontier Life and Medical SciencesKyoto UniversityKyoto 606-8501Japan

Exosomes make a significant contribution during stem cell-based therapy due to the abundant *** evidence implies exosomes can act as potential biological nano *** herein propose hypoxic preconditioning for neural stem cells(NSCs)that could produce hypoxic exosomes for efficient treatment of ischemic *** preconditioning on NSCs significantly altered the miRNAs encapsulated in ***,hypoxic exosomes could target the injured brain to regulate the microenvironment to inhibit neuroinflammation and promote blood–brain barrier permeability ***,the autologous NSCs in Nestin-CreER mice could be activated by hypoxic exosomes to facilitate nerve *** hypoxic preconditioning,exosomes further exerted therapeutic effects on both survival(25%)and behavioral outcomes in ischemic stroke ***,hypoxic preconditioning NSCs can produce effective nano agent and may represent a promising strategy for clinical neurorestorative therapy.

关键词： exosomes hypoxia-preconditioning stem cells ischemic stroke microenvironment

Modeling Carbon Dynamics in Paddy Soils in Jiangsu Province of China with Soil Databases Differing in Spatial Resolution

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Pedosphere 2011年第6期21卷 696-705页

作者： XU sheng-Xiang SHI Xue-Zheng ZHAO yong-Cun YU Dong-sheng WANG Shi-Hang zhang Li-ming C. S. LI TAN Man-zhi State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 （China） Graduate University of Chinese Academy of Sciences Beijing 100049 （China） College of Environmental and Resource Sciences Fujian Agriculture and Forestry University Fujian 350002 （China） Institute for the Study of Earth Oceans and Space Complex Systems Research Center University of New Hampshire Durham NH03824 （USA）

A number of process-based models have been developed for quantifying carbon(C)sequestration in *** DeNitrification-DeComposition(DNDC)model was used to simulate and quantify long-term(1980-2008)soil organic carbon(SOC)dynamics in the important rice-producing province,Jiangsu,*** in SOC storages were estimated from two soil databases differing in spatial resolution:a county database consisting of 68 polygons and a soil patch-based database of 701 polygons for all 3.7 Mha of rice fields in *** simulated SOC storage with the coarse resolution county database ranged between 131.0-320.6 Tg C in 1980 and 170.3-305.1 Tg C in 2008,respectively,while that estimated with the fine resolution database was 201.6 and 216.2 Tg C in 1980 and 2008,*** results modeled with the soil databases differing in spatial resolution indicated that using the soil input data with higher resolution substantially increased the accuracy of the modeled results;and when lacking detailed soil datasets,the DNDC model,parameterized with the most sensitive factor(MSF) method to cope with attribute uncertainty,could still produce acceptable results although with deviations of up to 60% for the case study reported in this paper.

关键词： 1:1 000000 soil map C sequestration rate DeNitrification-DeComposition (DNDC) greenhouse gas soil organic carbon (SOC)

张家口市婴幼儿发育性髋关节发育不良流行病学特征及筛查模式探讨

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河北北方学院学报（自然科学版） 2024年第10期40卷 28-31,34页

作者：张慧园刘晨宏张丰经杜海穆桂瑶张永明张涛张家口市第二医院小儿骨科河北张家口075000 张家口市第二医院超声科河北张家口075000 张家口市妇幼保健院儿童保健科河北张家口075000 北京积水潭医院小儿骨科北京102208

目的分析张家口市发育性髋关节发育不良(DDH)患儿的流行病学特征及初筛—复筛—确诊的选择性筛查模式的应用价值。方法应用初筛—复筛—确诊的选择性筛查模式于张家口市妇幼保健院初筛40 330例婴幼儿,查体可疑阳性或高危患儿转诊至张... 详细信息

目的分析张家口市发育性髋关节发育不良(DDH)患儿的流行病学特征及初筛—复筛—确诊的选择性筛查模式的应用价值。方法应用初筛—复筛—确诊的选择性筛查模式于张家口市妇幼保健院初筛40 330例婴幼儿,查体可疑阳性或高危患儿转诊至张家口市第二医院行髋关节超声检查复筛,确诊DDH患儿积极给予干预;分析本地区DDH危险因素及流行病学特点。结果复筛627例(1.5%),超声确诊DDH 145例,张家口地区DDH发病率3.6‰(145/40 330)。女性、臀位产、襁褓史、家族史、羊水少为当地DDH危险因素。结论张家口市DDH发病率与国内相关报道相似,女性、臀位产、襁褓史、家族史、羊水少是DDH危险因素,初筛—复筛—确诊的选择性筛查模式符合当地民情风俗,避免了因假阳性导致的过度治疗,可操作性强。

关键词：发育性髋关节发育不良筛查危险因素

Spatial variability of soil hydraulic conductivity and runoff generation types in a small mountainous catchment

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Journal of Mountain Science 2020年第11期17卷 2724-2741页

作者： YANG yong CHEN Ren-sheng SONG yao-xuan HAN Chun-tan LIU zhang-wen LIU Jun-feng Qilian Alpine Ecology and Hydrology Research Station Key Laboratory of Ecohydrology Inland River BasinNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China College of Urban and Environmental Sciences Northwest UniversityXi'an 710127China

As an important soil property,saturated hydraulic conductivity(Ks)controls many hydrological processes,such as runoff generation types,soil moisture storage and water *** of the extremely harsh natural environmental conditions and soil containing a significant fraction of gravel fragments in high-elevation mountainous catchments,the measurement data of Ks and other soil properties are seriously lacking,which leads to poor understanding on its hydrological processes and water *** this study,the vertical variation(0-150 cm)of Ks and other soil properties from 38 soil profiles were measured under five different land cover types(alpine barren,forest,marshy meadow,alpine shrub and alpine meadow)in a small catchment in Qilian Mountains,northwestern China.A typical characteristic of soil in mountainous areas is widespread presence of rock and gravel,and the results showed that the more rock and gravel in the soil,the higher Ks and bulk density and the lower the soil capillary porosity,field water capacity and total *** Ks of the lower layer with rock and gravel(18.49±10.22 mm·min-1)was significantly higher than that of the upper layer with relatively fine textured soil(0.18±0.18 mm·min-1).The order of values of the Ks in different land cover types was alpine barren,forest,alpine shrub,marshy meadow and alpine meadow,and the values of the Ks in the alpine barren were significantly higher than those of other land *** rainfall events in the research catchment had low rain intensity(<0.04 mm·min-1),and deep percolation(DP)was the dominant runoff generation *** the rainfall intensity increased(0.11 mm·min-1),subsurface stormflow(SSF)appeared in the alpine *** excess overland flow(IOF),SSF and DP existed simultaneously only when the rainfall intensity was extremely high(1.91 mm·min-1).IOF and SSF were almost never appeared in the alpine barren because of high *** alpine barren was the main runoffcontributed area in the

关键词： Saturated hydraulic conductivity Rock fragment Land cover Runoff generation Mountain catchment

CT血管成像及淋巴示踪技术在结肠癌手术中的应用进展

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中国现代普通外科进展 2024年第3期27卷 218-221页

作者：张驰伟丁元升曹明争王永顺吕烁刘乃青潍坊医学院潍坊医学院临床医学院山东潍坊261000 临沂市中心医院普外一科山东临沂276400

结肠癌最常见的转移途径是淋巴转移,出现淋巴结转移则提示肿瘤分期较晚,病情较重,手术中淋巴结清除的彻底性影响着结肠癌患者的预后;吻合口瘘是结肠癌最严重的术后并发症之一。如何在保障淋巴结清除彻底性的同时保障吻合口血运、最大化... 详细信息

结肠癌最常见的转移途径是淋巴转移,出现淋巴结转移则提示肿瘤分期较晚,病情较重,手术中淋巴结清除的彻底性影响着结肠癌患者的预后;吻合口瘘是结肠癌最严重的术后并发症之一。如何在保障淋巴结清除彻底性的同时保障吻合口血运、最大化保留肠道功能,一直是结肠癌根治手术的难点与热点。CT血管成像(CTA)技术可以辅助施术者术前了解患者肿瘤区域血管的解剖分型及走行,淋巴示踪技术可以指引肿瘤周围淋巴结引流情况。笔者整理了CTA及淋巴示踪技术在结肠癌手术中的应用进展,就其优势及局限性进行阐述。

关键词： CT血管成像淋巴示踪技术结肠肿瘤外科手术

Numerical simulation of seasonal snow in Tianshan Mountains

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Journal of Mountain Science 2021年第2期18卷 338-356页

作者： REN Yan-run zhang yao-nan HAO Jian-sheng SHEN yong-ping ZHAO Guo-hui LI Cong Northwest Institute of Eco-Environment and Resources Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China National Cryosphere Desert Data Center Lanzhou 730000China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China Lanzhou University of Technology Lanzhou 730050China

Snowfall in the Tianshan Mountains in China is frequent during winter;thus,avalanches have become a severe issue in snow-covered *** and metamorphosis,as well as hydrothermal exchanges with the environment,considerably affect the stability of snow on ***,a hydrothermal model of snow cover and its underlying surfaces must be developed on the basis of meteorological data to predict and help manage *** study adopted the conceptual model of snow as a porous medium and quantitatively analysed its internal physical processes on the basis of the thermal exchanges amongst its *** effects of local meteorological factors on snow structure and the redistribution of energy and mass inside the snow cover in the Tianshan Mountains were *** results showed that deformation as a result of overlying snow and sublimation of snow cover at the bottom is the main cause of density variation in the vertical profile of snow *** drives water movement in *** low-density area of the bottom snow is the result of temperature *** simulation results of the long-term snow internal mass distribution obtained by the method established in this study are highly consistent with the actual observed trend of *** consistency indicates an accurate simulation of the physical characteristics of snow cover in small and microscale metamorphism in the Tianshan Mountains during the stable period.

关键词： Snow Porous medium Heat and mass transfer Phase change Thermo-hydro-mechanical(THM)coupling Numerical modelling

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豇豆荚螟生物生态学特性与绿色防控研究进展

环境昆虫学报 2024年第5期46卷 1127-1137页

作者：胡静荣史彩华吴明月李瑾吴圣勇张友军谢文湖北文理学院现代农业研究院湖北襄阳441053 三亚中国农业科学院国家南繁研究院海南三亚572019 中国农业科学院蔬菜花卉研究所北京100081

豇豆荚螟Maruca testulalis是世界性害虫,在亚热带地区发生严重。因其具有钻蛀危害特性,使其防治难度巨增。该虫寄主范围广泛,但以豆科作物为主,尤其是豇豆Vigna unguiculata。本文综述豇豆荚螟的形态特征、地理遗传分化、生物生态学特... 详细信息

豇豆荚螟Maruca testulalis是世界性害虫,在亚热带地区发生严重。因其具有钻蛀危害特性,使其防治难度巨增。该虫寄主范围广泛,但以豆科作物为主,尤其是豇豆Vigna unguiculata。本文综述豇豆荚螟的形态特征、地理遗传分化、生物生态学特点、发生危害规律和综合防控进展,同时展望其绿色防控技术的研发与应用,为深入挖掘豇豆荚螟的制约因子并研发新型绿色防控技术奠定基础。

关键词：豇豆荚螟危害规律遗传分化生态调控综合防控

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One-Pot Synthesis of Polysubstituted Pyrroles via Sequential Ketenimine Formation/Ag(l)-Catalyzed Alkyne Cycloisomerisation Starting from Ylide Adducts

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Chinese Journal of Chemistry 2021年第6期39卷 1553-1557页

作者： Jun Xiong zhi-Ying Mu Gang yao Jia-An zhang Qi-Xun Feng Hui-Ting He yong-Long Pang Hang Shi ming-Wu Ding School of Pharmacy Hubei University of Science and TechnologyXianningHubei 437100China Key Laboratory of Pesticide&Chemical Biology of Ministry of Education Hubei International Scientific and Technological Cooperation Base of Pesticide and Green SynthesisCentral China Normal UniversityWuhanHubei 430079China

A simple one pot synthesis of polysubstituted pyrroles via ketenimine formation/Ag(l)-catalyzed alkyne cycloisomerisation has been *** easily accessible phosphorane ylide derivatives reacted with isocyanates,producing highly active ketenimines that were then treated with amines,which afforded substituted pyrroles by a S-exo-dig cyclization/isomerization in the presence of a Ag(l)catalyst in good overall yields.

关键词： Pyrrole Ag⑴-catalysed Ketenimine Ylide One-pot

Discrimination of pp solar neutrinos and^(14)C double pile-up events in a large-scale LS detector

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Nuclear Science and Techniques 2023年第9期34卷 69-81页

作者： Guo-ming Chen Xin zhang Ze-Yuan Yu Si-Yuan zhang Yu Xu Wen-Jie Wu yao-Guang Wang yong-Bo Huang School of Physical Science and Technology Guangxi UniversityNanning 530004China Institute of High Energy Physics Beijing 100049China University of Chinese Academy of Sciences Beijing 100049China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Department of Physics and Astronomy University of CaliforniaIrvineCAUSA

As a unique probe,the precision measurement of pp solar neutrinos is important for studying the sun’s energy mechanism as it enables monitoring the thermodynamic equilibrium and studying neutrino oscillations in the vacuum-dominated *** a large-scale liquid scintillator detector,a bottleneck for pp solar neutrino detection is the pile-up events of intrinsic14C *** paper presents a few approaches to discriminating between pp solar neutrinos and ^(14)C pile-up events by considering the differences in their time and spatial *** this study,a Geant4-based Monte Carlo simulation is *** analysis and deep learning technology are adopted to investigate the capability of ^(14)C pile-up *** BDTG (boosted decision trees with gradient boosting) model and VGG network demonstrate good performance in discriminating pp solar neutrinos and ^(14)C double pile-up *** the ^(14)C concentration assumption of 5×10-18g/g,the signal significance can achieve 10.3 and 15.6 using the statistics of only one *** this case,the signal efficiency for discrimination using the BDTG model while rejecting 99.18% ^(14)C double pile-up events is 51.1%,and that for the case where the VGG network is used while rejecting 99.81%of the ^(14)C double pile-up events is 42.7%.

关键词： Liquid scintillator detector pp solar neutrinos 14C pile-up Multivariate analysis Deep learning