检索结果-南通市图书馆

Survivin、PTEN在舌鳞状细胞癌中的表达及其与血管内皮生长因子的相关性和临床意义

在线全文

学校读者我要写书评

暂无评论

中国医师进修杂志 2012年第18期35卷 1-3页

作者：江涌冯庆亮朱聪山东省聊城市第四人民医院口腔科 252000 山东省聊城市肿瘤医院肿瘤二科天津医科大学附属肿瘤医院硕士研究生

目的探讨Survivin、PTEN在舌鳞状细胞癌中的表达及其与血管内皮生长因子（VEGF）的相关性和临床意义。方法72例舌鳞状细胞癌标本和15例正常舌组织标本采用免疫组织化学SABC法检测Survivin、PTEN和VEGF的表达情况。结果舌鳞状细胞癌组织... 详细信息

目的探讨Survivin、PTEN在舌鳞状细胞癌中的表达及其与血管内皮生长因子（VEGF）的相关性和临床意义。方法72例舌鳞状细胞癌标本和15例正常舌组织标本采用免疫组织化学SABC法检测Survivin、PTEN和VEGF的表达情况。结果舌鳞状细胞癌组织中Survivin、PTEN、VEGF的阳性表达率分别为66．7％（48/72）、61．1％（44／72）、70．8％（51，72），正常舌组织分别为0、100．0％（15／15）、0，两者比较差异均有统计学意义（P〈0．01）。在舌鳞状细胞癌组织中Survivin和VEGF的表达与TNM分期、组织分化程度和颈淋巴结转移呈正相关（P〈0．05或〈0．01），PTEN的表达则与其呈负相关（P〈0．05或〈0．01）。在舌鳞状细胞癌组织畔tSurvivin与VEGF表达呈正相关（r=0．6482，P〈0．01），PTEN与VEGF表达呈负相关（r=-0．4027，P〈0．01）。结论在舌鳞状细胞癌组织中Survivin和PTEN表达与肿瘤的发生和发展密切相关，两者与VEGF呈明显相关，三者的联合检测在临床上对舌鳞状细胞癌的诊断、转移和预后判断有重要参考价值。

关键词：舌肿瘤血管内皮生长因子A Survivin PTEN

在线全文

学校读者我要写书评

暂无评论

混输管道数据库压降插值计算方法研究

数学的实践与认识 2017年第18期47卷 107-110页

作者：杨树人廖震敖娟范恩庆冯亮东北石油大学提高油气噼收率教育部重点实验室黑龙江大庆163318 大庆油田采气分公司输气大队101工区黑龙江大庆163712

在计算压降的经验公式与理论公式的基础上,提出了基于混输管道数据库水力插值计算方法,采用SQLServer2008与***软件建立油气水混输管道数据库并开发数据库管理平台,实现水力插值计算,以环道试验数据作为基础数据对插值预测法计算结果进... 详细信息

在计算压降的经验公式与理论公式的基础上,提出了基于混输管道数据库水力插值计算方法,采用SQLServer2008与***软件建立油气水混输管道数据库并开发数据库管理平台,实现水力插值计算,以环道试验数据作为基础数据对插值预测法计算结果进行验证,并与PIPEPHASE软件及OLGA软件计算结果进行对比分析,结果表明:插值预测法计算误差在PIPEPHASE软件及OLGA软件最小误差基础上降低30%以上.

关键词：油气混输数据库 PIPEPHASE 水力插值计算环道试验

Superhydrophobic and corrosion-resistant siloxane-modified MgAl-LDHs coatings on magnesium alloy prepared under mild conditions

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 450-463页

作者： Wenxi Zhang Zhangzelong Zhuo Dan Xu liang Wu Zhihui Xie Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province College of Chemistry and Chemical EngineeringChina West Normal UniversityNanchong 637002China College of Materials Science and Engineering/National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China

We have developed a superhydrophobic and corrosion-resistant LDH-W/PFDTMS composite coating on the surface of Mg *** composite comprised a tungstate-intercalated(LDH-W)underlayer that was grown at low temperature(relative to hydrothermal reaction conditions)under atmospheric pressure and an outer polysiloxane layer created from a solution containing perfluorodecyltrimethoxysilane(PFDTMS)using a simple immersion *** successful intercalation of tungstate into the LDH phase and the following formation of the polysiloxane layer were confirmed through X-ray diffraction(XRD),Fourier transform infrared(FTIR)spectroscopy,and X-ray photoelectron spectroscopy(XPS).The corrosion resistance of the LDH-W film,both before and after the PFDTMS modification,was evaluated using electrochemical impedance spectroscopy(EIS),Tafel curves,and immersion *** results showed that Mg coated with LDH-W/PFDTMS exhibited significantly enhanced corrosion protection compared to the unmodified LDHW film,with no apparent signs of corrosion after exposure to 3.5wt%NaCl solution for 15 ***,the LDH-W/PFDTMS coating demonstrated superior superhydrophobicity and self-cleaning properties against water and several common beverages,as confirmed by static contact angle and water-repellency *** results offer valuable insights into preparing superhydrophobic and corrosion-resistant LDH-based composite coatings on Mg alloy surfaces under relatively mild reaction conditions.

关键词： Mg alloy corrosion coating layered double hydroxide

微创改良脑室-心房分流术后患者的观察及护理

在线全文

学校读者我要写书评

暂无评论

中国实用护理杂志 2009年第17期25卷 21-23页

作者：刘艳君冯清亮马树红曾喜云广东省东莞市黄江医院神经外科

目的总结微创改良脑室-心房分流术后观察要点及护理经验。方法45例微创改良脑室-心房分流术患者,术前做好心理护理及术前准备工作,术后密切观察生命体征、意识、瞳孔、有无颅内高压症、分流不足或过度症状、感染症状,做好专科护理及基... 详细信息

目的总结微创改良脑室-心房分流术后观察要点及护理经验。方法45例微创改良脑室-心房分流术患者,术前做好心理护理及术前准备工作,术后密切观察生命体征、意识、瞳孔、有无颅内高压症、分流不足或过度症状、感染症状,做好专科护理及基础护理,及时发现或预防术后并发症,详细的出院指导及随访工作。结果分流后半个月苏醒28例,意识障碍明显减轻9例,意识障碍无变化8例;分流管堵塞5例,分流过度3例,分流不足5例,血源性感染1例,分流管外露1例,无颅内感染、气栓、心内膜炎等并发症。结论充分术前准备,密切的术后观察,有效的专科护理及基础护理,可以提高脑室-心房分流术成功率,提高患者的生存质量。

关键词：脑室-心房分流术术后观察护理

微波消融联合放疗治疗ⅡA期非小细胞肺癌的疗效研究

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国医疗设备 2016年第10期31卷 110-113页

作者：冯庆亮董林李永杰聊城市肿瘤医院肿瘤科山东聊城252000

目的观察影像引导下微波消融联合放疗治疗ⅡA期非小细胞肺癌（Non-Small Cell Lung Cancer,NSCLC）的临床疗效及其安全性。方法选取我院2009年2月~2015年2月收治的不适宜外科手术或拒绝手术的ⅡA期NSCLC患者共计36例（36个肿瘤）,采用C... 详细信息

目的观察影像引导下微波消融联合放疗治疗ⅡA期非小细胞肺癌（Non-Small Cell Lung Cancer,NSCLC）的临床疗效及其安全性。方法选取我院2009年2月~2015年2月收治的不适宜外科手术或拒绝手术的ⅡA期NSCLC患者共计36例（36个肿瘤）,采用CT引导下冷循环微波消融治疗,消融7 d后序贯放射治疗。治疗前后增强CT观察肿瘤局部坏死率,随访疾病进展时间、生存期,观察治疗中及治疗后的不良事件发生以及处理和转归情况。结果治疗后CT表现为肿瘤消融区可见气化,肺窗可见肿瘤边界模糊呈毛玻璃样改变。36个肿瘤中完全坏死率88.9%（32/36）,不完全坏死率11.1%（4/36）。治疗后3、6、12个月随访,肿瘤体积逐渐缩小,平均缩小率为（8.2±6.1）%、（34.1±7.4）%及（52.6±8.3）%。治疗后1、2、3年患者生存率分别为83.3%（30/36）、58.3（21/36）、38.9%（14/36）。术中及术后未出现严重并发症。结论 CT引导下微波消融序贯放射治疗ⅡA期非小细胞肺癌可获得较好的局部控制效果和较高的3年生存率,适用于不适宜或拒绝接受手术的NSCLC患者。

关键词：非小细胞肺癌微波消融放疗 CT引导

NEUROBIOLOGICAL EFFECTS OF NRCF DERIVED FROM DISTAL STUMPS OF MOTOR NERVE AND SENSORY NERVE AND b-FGF ON CULTURED MOTONEURON IN VITRO

在线全文

学校读者我要写书评

暂无评论

Journal of Shanghai Second Medical University(Foreign Language Edition) 2001年第2期13卷 91-95页

作者：张涤生干季良李青峰平萍 Department of Plastic and Reconstructive surgery The Ninth People's Hospital SSMU

Objective: To explore the mechanism of neurotropism in peripheral nerve regeneration by assessing the bioactivity of regeneration microcircumstance on motoneurons. Methods The motor branch Of femoral nerve to quadriceps was incised and the distal stump was sutured with one-end silicone chamber. The nerve regeneration chamber fluids from distal motor nerve stumps (motor branch of femoral nerve ) (MD-NRCF) was collected 7d post-operatively, and with the same method, nerve regeneration conditioned fluids from distal stumps nerve stumps (saphenous nerve ) (SD-NRCF) was collected. The dissociated rat’s motoneurons were co-cultured with MD-NRCF, SD-NRCF, basic fibroblast growth factor (b-FGF) and serum-free medium for 72h respectively and then were photographed under phase-contrast microscope. The longest neurites and cellbody areas of motoneurons from each group were measured by cell image processing computer system. MTT colorimetric assay was also used to measure cell activation. Results The cells of MD-NRCF group had significantly longer neurites than the other 3 groups, and their activation was also superior to those of the other groups. Conclusion These results indicate that MD-NRCF has more significant neurite-promoting and neurobiological effects on motoneuron than SD-NRCF and b-FGF.

关键词： neurotropism nerve regeneration conditions fluid nerve regeneration cultured motoneuron

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao feng Lai Yangfan liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

新型经皮气管扩张器行经皮气管切开术28例报告

在线全文

学校读者我要写书评

暂无评论

实用临床医学（江西） 2015年第5期16卷 19-21,34页

作者：王伟金冯清亮江勇豪东莞市黄江医院神经外科广东东莞523750

目的使用拥有专利技术的新型经皮气管扩张器实施经皮气管切开,论证其可行性及安全性。方法根据Ciaglia经皮扩张气管切开技术的原理,对Ciaglia经皮扩张器械进行改良,8例患者使用拥有专利技术的新型经皮气管扩张器在纤支镜观察下行经皮气... 详细信息

目的使用拥有专利技术的新型经皮气管扩张器实施经皮气管切开,论证其可行性及安全性。方法根据Ciaglia经皮扩张气管切开技术的原理,对Ciaglia经皮扩张器械进行改良,8例患者使用拥有专利技术的新型经皮气管扩张器在纤支镜观察下行经皮气管切开,观察扩张、造口、置管全过程,证实手术成功后,20例患者按上述方法在无纤支镜协助下完成操作。结果 28例均成功置入一次性气管套管,平均手术时间2min 15s,其中扩张、置管时间平均38s,出血约2mL,未出现气胸、大出血、气管食道瘘、喉返神经损伤等严重并发症。结论新型经皮扩张器能顺利实施经皮气管切开,手术快速安全。

关键词：新型经皮气管扩张器经皮气管切开术气管切开

在线全文

学校读者我要写书评

暂无评论

脑挫裂伤伴弥漫性脑肿胀的治疗

实用临床医学（江西） 2014年第6期15卷 38-40页

作者：王伟金冯清亮江勇豪东莞市黄江医院神经外科广东东莞523750

目的探讨脑挫裂伤伴弥漫性脑肿胀的临床特点和治疗。方法对48例脑挫裂伤合并弥漫性脑肿胀患者的临床表现、影像学特点、治疗情况及预后进行回顾性分析。结果 28例患者(58.3%)行保守治疗,其中恢复良好26例,死亡2例;20例(41.7%)行手术治疗... 详细信息

目的探讨脑挫裂伤伴弥漫性脑肿胀的临床特点和治疗。方法对48例脑挫裂伤合并弥漫性脑肿胀患者的临床表现、影像学特点、治疗情况及预后进行回顾性分析。结果 28例患者(58.3%)行保守治疗,其中恢复良好26例,死亡2例;20例(41.7%)行手术治疗,其中恢复良好9例,中度残疾5例,重度残疾2例,死亡4例。结论脑挫裂伤伴弥漫性脑肿胀早期病情多不严重,但变化快,突然恶化;观察环池的变化,把握好手术时机,可以提高治愈率,降低致残率及病死率。

关键词：脑损伤环池脑肿胀脑挫裂伤手术时机