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Single-cell profiling of the pig cecum at various developmental stages

Zoological Research 2024年第1期45卷 55-68页

作者： Yan-Yuan Xiao qing Zhang Fei Huang Lin Rao Tian-Xiong Yao Si-Yu Yang Lei Xie Xiao-Xiao zou Li-Ping Cai Jia-Wen Yang Bin Yang Lu-Sheng Huang National Key Laboratory for Swine Genetic Improvement and Germplasm Innovation Ministry of Science and Technology of ChinaJiangxi Agricultural UniversityNanchangJiangxi 330045China

The gastrointestinal tract is essential for food digestion,nutrient absorption,waste elimination,and microbial ***-cell transcriptome profiling of the intestinal tract has greatly enriched our understanding of cellular diversity,functional heterogeneity,and their importance in intestinal tract development and *** such profiling has been extensively conducted in humans and mice,the single-cell gene expression landscape of the pig cecum remains ***,single-cell RNA sequencing was performed on 45572 cells obtained from seven cecal samples in pigs at four different developmental stages(days(D)30,42,150,and 730).Analysis revealed 12 major cell types and 38 subtypes,as well as their distinctive genes,transcription factors,and regulons,many of which were conserved in *** increase in the relative proportions of CD8^(+)T and Granzyme A(low expression)natural killer T cells(GZMA^(low)NKT)cells and a decrease in the relative proportions of epithelial stem cells,Tregs,RHEX^(+)T cells,and plasmacytoid dendritic cells(pDCs)were noted across the developmental ***,the post-weaning period exhibited an up-regulation in mitochondrial genes,COX2 and ND2,as well as genes involved in immune activation in multiple cell ***-cell crosstalk analysis indicated that IBP6^(+)fibroblasts were the main signal senders at D30,whereas IBP6^(−)fibroblasts assumed this role at the other *** cells established interactions with epithelial cells and IBP6^(+)fibroblasts in the D730 cecum through mediation of GZMA-F2RL1/F2RL2 *** study provides valuable insights into cellular heterogeneity and function in the pig cecum at different development stages.

关键词： Single-cell RNA-seq Cecum Bama Xiang pigs Various developmental stages Cellular heterogeneity

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Breeding maize of ideal plant architecture for high-density planting tolerance through modulating shade avoidance response and beyond

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Journal of Integrative Plant Biology 2024年第5期66卷 849-864页

作者： Fereshteh Jafari Baobao Wang Haiyang Wang Junjie zou Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China Graduate School of Chinese Academy of Agricultural Sciences Beijing 100081China National Nanfan Research Institute CAASSanya 572025China State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources College of Life SciencesSouth China AgriculturalUniversityGuangzhou 510642China

Maize is a major staple crop widely used as food,animal feed,and raw materials in industrial ***-density planting is a major factor contributing to the continuous increase of maize ***,high planting density usually triggers a shade avoidance response and causes increased plant height and ear height,resulting in lodging and yield *** plant height and ear height,more erect leaf angle,reduced tassel branch number,earlier flowering,and strong root system architecture are five key morphological traits required for maize adaption to high-density *** this review,we summarize recent advances in deciphering the genetic and molecular mechanisms of maize involved in response to high-density *** also discuss some strategies for breeding advanced maize cultivars with superior performance under high-density planting conditions.

关键词： flowering time high-density planting leaf angle maize plant architecture plant height/ear height root architecture tasselbranch

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Pressure-induced emission(PIE)in halide perovskites toward promising applications in scintillators and solid-state lighting

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Aggregate 2024年第1期5卷 9-15页

作者： Wenya Zhao Guanjun Xiao Bo zou State Key Laboratory of Superhard Materials College of PhysicsJilin UniversityChangchunChina

High-pressure chemistry has provided a huge boost to the development of scientific ***-induced emission(PIE)in halide perovskites is gradually showing its unique charm in both pressure sensing and optoelectronic device ***,the PIE retention of halide perovskites under ambient conditions is of great commercial ***,we mainly focus on the potential applications of PIE and PIE retention in metal halide perovskites for scintillators and solid-state *** on the performance requirements of scintillator and single-component white light-emitting diodes(WLEDs),the significance of PIE and PIE retention is critically clarified,aiming to design and synthesize materials used for high-performance optoelectronic *** perspective not only demonstrates promising applications of PIE in the fields of scintillators and WLEDs,but also provides potential applications in display imaging and anti-counterfeiting of PIE ***,solving the scientific disputes that exist under ambient conditions is also simply discussed as an outlook by introducing high-pressure dimension to produce PIE.

关键词： halide perovskites high pressure light-emitting diode pressure-induced emission scintillators solidstate lighting

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In situ photocatalytically enhanced thermogalvanic cells for electricity and hydrogen production

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Chinese Journal of Structural Chemistry 2024年第1期43卷 1-2页

作者： Tianhao Li Wenguang Tu Zhigang zou School of Science and Engineering The Chinese University of Hong KongShenzhenGuangdong518172PR China

Converting low-grade thermal energy into electricity through ther-mogalvanic cells offers a promising approach to addressing environ-mental challenges[1].However,thermogalvanic cells face obstacles,due to limited thermopower,connected to differences in solvent-dependent entropy(ΔS)among redox anions and varying concentration ratios(ΔC)between hot and cold sides[2,3].A typical strategy to enhance the thermopower involves the improvement ofΔS of the redox ***-fortunately,ΔC tends to approach zero spontaneously due to the ther-modynamic instability and redox ion ***,the challenge is to maintain significantΔC for both redox ions and unravel the intricate modulation mechanisms[4].

关键词： redox maintain entropy

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Allosterically activating SHP2 by oleanolic acid inhibits STAT3-Th17 axis for ameliorating colitis

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2598-2612页

作者： Jinbo Hu Wen Liu Yi zou Chenyang Jiao Jiazhen Zhu Qiang Xu Jianjun zou Yang Sun Wenjie Guo State Key Laboratory of Pharmaceutical Biotechnology Nanjing Drum Tower HospitalSchool of Life SciencesNanjing UniversityNanjing 210093China Department of Clinical Pharmacology Nanjing First HospitalNanjing Medical UniversityNanjing 210006China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhou 221004China

Src homology 2 domain-containing tyrosine phosphatase 2(SHP2)is an essential tyrosine phosphatase that is pivotal in regulating various cellular signaling pathways such as cell growth,differentiation,and *** activation of SHP2 has been shown to have a therapeutic effect in colitis and Parkinson's ***,the identification of SHP2 activators and a complete understanding of their mechanism is *** used a two-step screening assay to determine a novel allosteric activator of SHP2 that stabilizes it in an open *** acid was identified as a suitable *** binding to R362,K364,and K366 in the active center of the PTP domain,oleanolic acid maintained the active open state of SHP2,which facilitated the binding between SHP2 and its *** oleanolic acid-activated SHP2 hindered Th17 differentiation by disturbing the interaction between STAT3 and IL-6Rαand inhibiting the activation of ***,via the activation of SHP2 and subsequent attenuation of the STAT3-Th17 axis,oleanolic acid effectively mitigated colitis in *** protective effect was abrogated by SHP2 knockout or administration of the SHP2 inhibitor *** findings underscore the potential of oleanolic acid as a promising therapeutic agent for treating inflammatory bowel diseases.

关键词： Oleanolic acid SHP2 STAT3 Th17 Colitis Allosteric activator

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Pressure effects on metal/covalent-organic frameworks: structural and optical properties

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Science China Chemistry 2024年第9期67卷 2890-2903页

作者： Yixuan Wang Yunfeng Yang Xinyi Yang Bo zou Synergetic Extreme Condition High-Pressure Science Center State Key Laboratory of Superhard Materials College of Physics Jilin University

Metal-organic frameworks(MOFs) and covalent organic frameworks(COFs) with highly ordered porous structure, tunable bandgap, large specific surface area and structural diversity, provide an appealing platform for the development of stimulus response, sensing, imaging and optoelectronics. Among various tuning methods, pressure engineering using the diamond anvil cell is a highly powerful in-situ technique, which can efficiently modulate the structural and optical properties of MOFs/*** is beyond the realization of traditional chemical methods. This review outlines the research progress in the experimentoriented discovery of new phases or unique properties under high pressure, including phase transition, abnormal compression,photoluminescence(PL) discoloration and enhancement. Notably, the improvement of PL quantum yield in MOFs could be achieved by pressure-treated engineering and hydrogen-bonding cooperativity effect. We also propose and establish the relationship between structure and optical properties under high pressure. Finally, the challenge and outlook of the current fields are summarized. We hope that this review will supply guidance for comprehending the development of high-pressure MOF/COF-related research fields, and offer novel strategies for designing more high-performance MOF/COF materials to ultimately expand their applications.

关键词： metal/covalent-organic frameworks pressure engineering phase transition abnormal compressive behaviors piezochromic behaviors emission enhancement

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MEMS reservoir computing system with stiffness modulation for multi-scene data processing at the edge

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Microsystems & Nanoengineering 2024年第3期10卷 421-432页

作者： Xiaowei Guo Wuhao Yang Xingyin Xiong Zheng Wang Xudong zou The State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijingChina School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijingChina QILU Aerospace Information Research Institute JinanChina

Reservoir computing(RC)is a bio-inspired neural network structure which can be implemented in hardware with *** has been applied across various fields such as memristors,and electrochemical reactions,among which the microelectro-mechanical systems(MEMS)is supposed to be the closest to sensing and computing *** previous MEMS RCs have demonstrated their potential as reservoirs,the amplitude modulation mode was found to be inadequate for computing directly upon *** achieve this objective,this paper introduces a novel MEMS reservoir computing system based on stiffness modulation,where natural signals directly influence the system stiffness as *** this innovative concept,information can be processed locally without the need for advanced data collection and *** present an integrated RC system characterized by small volume and low power consumption,eliminating complicated setups in traditional MEMS RC for data discretization and *** simulation and experiment were conducted on our *** performed nonlinearity tuning for the resonator and optimized the post-processing algorithm by introducing a digital mask ***,our MEMS RC is capable of both classification and forecasting,surpassing the capabilities of our previous non-delay-based *** method successfully processed word classification,with a 99.8%accuracy,and chaos forecasting,with a 0.0305 normalized mean square error(NMSE),demonstrating its adaptability for multi-scene data *** work is essential as it presents a novel MEMS RC with stiffness modulation,offering a simplified,efficient approach to integrate sensing and *** approach has initiated edge computing,enabling emergent applications in MEMS for local computations.

关键词： computing hardware stiffness

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Temperature-dependent self-trapped exciton emission in Cu(I)doped zinc-based metal halides from well-resolved excited state structures

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Nano Research 2024年第8期17卷 7768-7775页

作者： Yunlong Bai Shuai Zhang Nengneng Luo Bingsuo zou Ruosheng Zeng State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

Zero-dimensional metal halides are of unique structures and tunable photoluminescence properties,showing great potential applications such as light-emitting diodes(LEDs)and ***,we successfully synthesized Cu^(+)doped(MA)_(2)ZnCl_(4)metal halides by a slow evaporation solvent *** introduction of Cu^(+)results in sky-blue self-trapped exciton emission in(MA)_(2)ZnCl_(4)at 486 nm at room temperature,and a photoluminescence quantum yield is as high as 54.9%.Interestingly,at low temperatures,Cu^(+)-doped(MA)_(2)ZnCl_(4)exhibits two emission peaks located at 482 and 605 nm,*** temperaturedependent dual emission indicates two excited state structures that exist on the triplet excited-state potential energy *** addition,the temperature sensor we fitted has good performance(Sr=1.65%·K^(−1)),which is the first attempt in Cu^(+)doped Znbased metal *** work enriches the family of sky-blue metal halides and provides a promising strategy for building skyblue LEDs.

关键词： sky-blue emission self-trapped exciton metal halides excited state structures temperature sensor

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CCM-FL:Covert communication mechanisms for federated learning in crowd sensing IoT

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Digital Communications and Networks 2024年第3期10卷 597-608页

作者： Hongruo Zhang Yifei zou Haofei Yin Dongxiao Yu Xiuzhen Cheng Institute of Intelligent Computing School of Computer Science and TechnologyShandong UniversityQingdao266237China

The past decades have witnessed a wide application of federated learning in crowd sensing,to handle the numerous data collected by the sensors and provide the users with precise and customized ***,how to protect the private information of users in federated learning has become an important research *** with the differential privacy(DP)technique and secure multiparty computation(SMC)strategy,the covert communication mechanism in federated learning is more efficient and energy-saving in training the ma-chine learning *** this paper,we study the covert communication problem for federated learning in crowd sensing Internet-of-Things *** from the previous works about covert communication in federated learning,most of which are considered in a centralized framework and experimental-based,we firstly proposes a centralized covert communication mechanism for federated learning among n learning agents,the time complexity of which is O(log n),approximating to the optimal ***,for the federated learning without parameter server,which is a harder case,we show that solving such a problem is NP-hard and prove the existence of a distributed covert communication mechanism with O(log logΔlog n)times,approximating to the optimal solution.Δis the maximum distance between any pair of learning *** analysis and nu-merical simulations are presented to show the performance of our covert communication *** hope that our covert communication work can shed some light on how to protect the privacy of federated learning in crowd sensing from the view of communications.

关键词： Covert communications Federated learning Crowd sensing SINR model

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Bifunctional interstitial phosphorous doping strategy boosts platinum-zinc alloy for efficient ammonia oxidation reaction and hydrogen evolution reaction

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Nano Research 2024年第3期17卷 1182-1189页

作者： Tianqi Yu Kexin Tan Jia Wu Yongjin zou Shibin Yin Guangxi Key Laboratory of Electrochemical Energy Materials School of Chemistry and Chemical EngineeringGuangxi UniversityNanning 530004China Guangxi Key Laboratory of Information Materials Guilin University of Electronic TechnologyGuilin 541004China

It is still a lack of bifunctional catalysts for ammonia oxidation reaction(AOR)and hydrogen evolution reaction(HER)due to their different reaction *** this work,P is doped into PtZn alloy by calcination with NaH_(2)PO_(2) as P source to induce the lattice tensile strain of Pt and the electronic interaction between P and Zn,which optimizes the AOR and HER activity *** sample with the optimal P content can drive the AOR peak current density of 293.6 mA·mgPt^(-1),which is almost 2.7 times of *** HER,the overpotential at^(-1)0 mA·cm^(-2) is only 23 mV with Tafel slope of 34.1 mV·dec^(-1).Furthermore,only 0.59 V is needed to obtain 50 mA·mgPt^(-1) for ammonia electrolysis under a two-electrode ***,this work shows an ingenious method to design bifunctional catalysts for ammonia electrolysis.

关键词： PtZn alloy phosphorous doping ammonia oxidation reaction hydrogen evolution reaction bifunctional catalyst

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