检索结果-南通市图书馆

Discussion on Power Market Mode of Central China

在线全文

学校读者我要写书评

暂无评论

Electricity 2007年第2期18卷 31-33,41页

作者： He Zhaocheng ye qing（译） Central China Bureau the State Electricity Regulatory Commission 不详

Central China power system is one of the large regional power grids carrying out power market demonstrative *** of lacking power market experience,a lot of problems need to be thoroughly discussed.

关键词：中国能源模式电力网电力市场

Annoyances in Growing Up

在线全文

学校读者我要写书评

暂无评论

Electricity 2007年第2期18卷 15-17页

作者： Peng Yuanchang ye qing（译） Journalist of China Electric Power 不详

Annoyances in growing up seem to be unavoidable. Many problems still face the Chinese power industry just climbing onto a new level of 600-GW installed capacity. It has to search practicable solutions for problems wit... 详细信息

关键词：中国能源工业能源利用环境保护

Polymeric nanoparticles developed by vitamin E-modified aliphatic polycarbonate polymer to promote oral absorption of oleanolic acid

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2017年第6期12卷 586-593页

作者： Wenjuan Zhang Chufan Liang Hao Liu Zhenbao Li Rui Chen Mei Zhou Dan Li qing ye Cong Luo Jin Sun School of Pharmacy Shenyang Pharmaceutical UniversityNo.103Wenhua RoadShenyang 110016China HAISCO(Shenyang)Pharmaceutical Co.Ltd. ShenyangChina School of Pharmacy BioMolecular Sciences DepartmentThe University of MississippiOxfordMS 38677USA School of Continuing Education Shenyang Pharmaceutical UniversityNo.103Wenhua RoadShenyang 110016China Municipal Key Laboratory of Biopharmaceutics School of PharmacyShenyang Pharmaceutical UniversityNo.103Wenhua RoadShenyang 110016China

Oleanolic acid (OA) exhibited good pharmacological activities in the clinical treatment of hypoglycemia, immune regulation, acute jaundice and chronic toxic hepatitis. However, the oral delivery of OA is greatly limited by its inferior water solubility and poor intestinal mucosa permeability. Herein, we developed a novel polymeric nanoparticle (NP) delivery system based on vitamin E modified aliphatic polycarbonate (mPEG-PCC-VE) to facilitate oral absorption of OA. OA encapsulated mPEG-PCC-VE NPs (OA/mPEG-PCC-VE NPs) showed uniform particle size of about 170 nm with high drug loading capability (8.9%). Furthermore, the polymeric mPEG-PCC-VE NPs, with good colloidal stability and pH-sensitive drug release characteristics, significantly enhanced the in vitro dissolution of OA in the alkaline medium. The in situ single pass intestinal perfusion (SPIP) studies performed on rats demonstrated that the OA/m PEG-PCC-VE NPs showed significantly improved permeability in the whole intestinal tract when compared to OA solution, especially for duodenum and colon. As a result, the in vivo pharmacokinetics study indicated that the bioavailability of OA/m PEG-PCC-VE NPs showed 1.5-fold higher than commercially available OA tablets. These results suggest that mPEGPCC-VE NPs are a promising platform to facilitate the oral delivery of OA.

关键词： Oleanolic acid Polymeric nanoparticles mPEG-PCC-VE Oral delivery

Co-amorphous solid dispersion systems of lacidipine-spironolactone with improved dissolution rate and enhanced physical stability

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2019年第1期14卷 95-103页

作者： Zhaomeng Wang Mengchi Sun Tian Liu Zisen Gao qing ye Xiao Tan Yanxian Hou Jin Sun Dun Wang Zhonggui He Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyang 110016China

Co-amorphous solid dispersion(C-ASD)systems have attracted great attention to improve the solubility of poorly soluble drugs,but the selection of an appropriate stabilizer to stabilize amorphous forms is still a huge ***,C-ASD system of two clinical combined used drugs(lacidipine(LCDP)and spironolactone(SPL))as stabilizers to each other,was prepared by solvent evaporation *** effects of variation in molar ratio of LCDP and SPL(3:1,1:1,1:3,1:6,and 1:9)on the drug release characteristics were *** light microscopy(PLM),powder X-ray diffraction(PXRD),differential scanning calorimetry(DSC)and thermogravimetric analysis(TGA)were employed to evaluate the solid *** C-ASDs were further studied for their stability under the high humidity(RH 92.5%).Further analysis of C-ASDs via Fourier-transform infrared spectroscopy(FTIR)and Raman spectroscopy confirmed that hydrogen bond interactions between the two drugs played a significant role in maintaining the stability of the C-ASDs ***,molecular dynamic(MD)simulations provided a clear insight into the stability mechanism at the molecular *** study demonstrated the novel drug-drug C-ASDs systems is a promising formulation strategy for improved dissolution rate and enhanced physical stability of poorly soluble drugs.

关键词： Co-amorphous solid dispersion Lacidipine Spironolactone Stability Molecular dynamic(MD) simulations

Effects on newborns of applying bupivacaine combined with different doses of fentanyl for cesarean section

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第23期9卷 6698-6704页

作者： Yun Wang Wen-Xun Liu Xiao-Hong Zhou Min Yang Xin Liu Yuan Zhang Ke-Rong Hai qing-Shan ye The First Hospital of Northwest Minzu University(Department of Anesthesiology People's Hospital of Ningxia Hui Autonomous Region)Yinchuan 750002Ningxia Hui Autonomous RegionChina Department of Anesthesiology The Central Hospital of Enshi Tujia and Miao Autonomous PrefectureEnshi 445000Hubei ProvinceChina

BACKGROUND The choice of anesthesia for cesarean section is very *** To compare the effects of applying bupivacaine combined with different doses of fentanyl on newborns after cesarean *** We randomly divided one hundred and twenty patients undergoing cesarean section into the following 4 groups:group B(bupivacaine group),group BF10(bupivacaine combined with 10μg fentanyl),group BF30(bupivacaine combined with 30μg fentanyl)and group BF50(bupivacaine combined with 50μg fentanyl).The heart rate,mean arterial pressure,block plane fixation time and sensory block time were *** artery blood was then collected immediately after fetal delivery for blood gas analysis and qualitative detection of ***,data on the neonatal 1-min and 5-min Apgar scores,results of umbilical artery blood gas analysis and qualitative detection of fentanyl in umbilical artery blood were *** Although the mean arterial pressure decreased in all four groups at 3 min after anesthesia,the percentage of the decrease was less than 20%of the *** addition,there were no significant differences in the 1-min or 5-min Apgar scores or the umbilical artery blood gas analysis among the four groups(P>0.05).Moreover,the concentration of fentanyl in umbilical artery blood was qualitatively detected using an ELISA kit,and the results in the four groups were *** Bupivacaine combined with fentanyl spinal anesthesia is effective in cesarean section.

关键词： Bupivacaine Fentanyl Spinal anesthesia Cesarean section Newborn

Enhanced 1.54-μm photo-and electroluminescence based on a perfluorinated Er(Ⅲ) complex utilizing an iridium(Ⅲ) complex as a sensitizer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2020年第1期9卷 1706-1715页

作者： Hong-Fei Li Xiao-Qi Liu Chen Lyu Jelena Gorbaciova Li-Li Wen Guo-Gang Shan Peter B.Wyatt Huan-qing ye William P.Gillin Materials Research Institute and School of Physics and Astronomy Queen Mary University of LondonMile End RoadE14NS LondonUK Institute of Functional Material Chemistry Faculty of ChemistryNortheast Normal UniversityChangchun 130024China Materials Research Institute and School of Biological and Chemical Sciences Queen Mary University of LondonMile End RoadE14NS LondonUK Chromosol Ltd The Walbrook Building25 WalbrookLondon EC4N 8AUK

Advanced 1.5-μm emitting materials that can be used to fabricate electrically driven light-emitting devices have the potential for developing cost-effective light sources for integrated silicon *** erbium(Er^(3+))in organic materials can give bright 1.5-μm luminescence and provide a route for realizing 1.5-μm organic light emitting diodes(OLEDs).However,the Er3+electroluminescence(EL)intensity needs to be further improved for device ***,an efficient 1.5-μm OLED made from a sensitized organic Er3+co-doped system is realized,where a“traditional”organic phosphorescent molecule with minimal triplet–triplet annihilation is used as a chromophore *** chromophore provides efficient sensitization to a co-doped organic Er^(3+) complex with a perfluorinatedligand *** large volume can protect the Er^(3+) 1.5-μm luminescence from vibrational *** average lifetime of the sensitized Er^(3+) 1.5-μm luminescence reaches ~0.86 ms,with a lifetime component of 2.65 ms,which is by far the longest Er^(3+) lifetime in a hydrogen-abundant organic environment and can even compete with that obtained in the fully fluorinated organic Er^(3+) *** optimal sensitization enhances the Er^(3+) luminescence by a factor of 1600 even with a high concentration of the phosphorescent molecule,and bright 1.5-μm OLEDs are obtained.

关键词： electroluminescence lifetime luminescence

A molecular framework underlying low-nitrogeninduced early leaf senescence in Arabidopsis thaliana

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2023年第4期16卷 756-774页

作者： Hongmei Fan Shuxuan Quan qing ye Lei Zhang Wei Liu Ning Zhu Xiaoqi Zhang Wenyuan Ruan Keke Yi Nigel M.Crawford Yong Wang State Key Laboratory of Crop Biology College of Life SciencesShandong Agricultural UniversityTai'anShandong 271018China Key Laboratory of Plant Nutrition and Fertilizer Ministry of AgricultureInstitute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 10081China Section of Cell and Developmental Biology Division of Biological ScienceUniversity of California at San DiegoLa JollaCA 92093-0116USA

Nitrogen(N)deficiency causes early leaf senescence,resulting in accelerated whole-plant maturation and severely reduced crop ***,the molecular mechanisms underlying N-deficiency-induced early leaf senescence remain unclear,even in the model species Arabidopsis *** this study,we identified Growth,Development and Splicing 1(GDS1),a previously reported transcription factor,as a new regulator of nitrate(NO3)signaling by a yeast-one-hybrid screen using a NO3enhancer fragment from the promoter of *** showed that GDS1 promotes NO3 signaling,absorption and assimilation by affecting the expression of multiple NO3 regulatory genes,including Nitrate Regulatory Gene2(NRG2).Interestingly,we observedthat gds1mutants show early leaf senescence as well as reduced NO3-contentand Nuptake under N-deficient *** analyses indicated that GDS1 binds to the promoters of several senescence-related genes,including Phytochrome-lnteracting Transcription Factors 4 and 5(PIF4 and PIF5)and represses their ***,we found that N deficiency decreases GDS1 protein accumulation,and GDS1 could interact with Anaphase Promoting Complex Subunit 10(APC10).Genetic and biochemical experiments demonstrated that Anaphase Promoting Complex or Cyclosome(APC/C)promotes the ubiquitination and degradation of GDS1 under N deficiency,resulting in loss of PIF4 and PiF5 repression and consequent early leaf ***,we discovered that overexpression of GDS1 could delay leaf senescence and improve seed yield and N-use efficiency(NUE)in *** summary,our study uncovers a molecular framework illustrating a new mechanism underlying low-N-induced early leaf senescence and provides potential targets for genetic improvement of crop varieties with increased yield and NUE.

关键词： nitrate signaling GDS1 nitrogen-deficiency-induced leaf senescence PIF4/PIF5 APC/C ubiquitina-tion NUE

Changes in three-dimensional power Doppler ultrasound features before and after neoadjuvant chemotherapy for cervical cancer and their relationship with malignant molecule expression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Hainan Medical University 2019年第11期25卷 69-74页

作者： Ju-Hua Pan ye-qing Ren qing-Lian Ma Department of Ultrasound Wuhan Red Cross Hospital in Hubei ProvinceWuhanHubei Province430000China

Objective:To study the changes in three-dimensional power Doppler ultrasound features before and after neoadjuvant chemotherapy for cervical cancer and their relationship with malignant molecule ***: The patients who were diagnosed with cervical cancer and received neoadjuvant chemotherapy in Wuhan Red Cross Hospital between March 2015 and October 2017 were selected as the cervical cancer group, and the patients who received cervical biopsy and were diagnosed with stage I cervical intraepithelial neoplasia by pathological findings during the same period were selected as the control group. Before biopsy, three-dimensional power Doppler ultrasonography was performed to measure VI, FI and VFI;the tissues of cervical cancer group before and after chemotherapy as well as the biopsy tissues of control group were collected to measure the expression of proliferation genes, invasion genes and angiogenesis ***: The VI, FI and VFI levels as well as the Piwil2 gene (Piwil2), CyclinD1, N-Myc downstream regulated gene 3 (NDRG3), CXC chemokine ligand 5 (CXCL5), cathepsin-L (CAT-L), EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1), angiotensin (Ang)1, Ang2 and angiopoietin-like protein 4 (ANGPTL4) mRNA expression levels in the tissues of cervical cancer group before and after chemotherapy were all significantly higher than those of control group whereas the thrombospondin 2 (THBS2), Smac gene (Smac), large tumor suppressor kinase 1 (LATS1), reversion-inducing-cysteine-rich protein with kazal motifs (RECK) and plas minogen activator inhibitor 1 (PAI-1) mRNA expression levels in the tissues were all significantly lower than those of control group, and the VI, FI and VFI levels as well as the Piwil2, CyclinD1, NDRG3, CXCL5, CAT-L, EFEMP1, Ang1, Ang2 and ANGPTL4 mRNA expression levels in the tissues of cervical cancer group after chemotherapy were all significantly lower than those before chemotherapy whereas the THBS2, Smac, LATS1, RECK and

关键词： Cervical cancer Three-dimensional power Doppler ultrasound Proliferation Invasion Angiogenesis

Recent advances in isolation,identification,and culture of mammalian spermatogonial stem cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2022年第1期24卷 5-14页

作者： Hua-Ming Xi Yi-Jie Ren Fa Ren Yu Li Tian-Yu Feng Zhi Wang ye-qing Du Li-Kun Zhang Jian-Hong Hu Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest Agriculture and Forestry UniversityYangling 712100China

Continuous spermatogenesis depends on the self-renewal and differentiation of spermatogonial stem cells(SSCs).SSCs,the only male reproductive stem cells that transmit genetic material to subsequent generations,possess an inherent self-renewal ability,which allows the maintenance of a steady stem cell *** eventually differentiate to produce ***,in an in vitro culture system,SSCs can be induced to differentiate into various types of germ *** SSCs are well defined,and a culture system has been successfully established for *** contrast,available information on the biomolecular markers and a culture system for livestock SSCs is *** review summarizes the existing knowledge and research progress regarding mammalian SSCs to determine the mammalian spermatogenic process,the biology and niche of SSCs,the isolation and culture systems of SSCs,and the biomolecular markers and identification of *** information can be used for the effective utilization of SSCs in reproductive technologies for large livestock animals,enhancement of human male fertility,reproductive medicine,and protection of endangered species.

关键词： culture identification isolation male germline stem cell spermatogonial stem cell transplantation