Recent advances in isolation,identification,and culture of mammalian spermatogonial stem cells
作者机构：Key Laboratory of Animal GeneticsBreeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest Agriculture and Forestry UniversityYangling 712100China
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2022年第24卷第1期
页 面：5-14页
核心收录：
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学]
基 金：This work was supported by the National Natural Science Foundation of China(No.31672425)
主 题：culture identification isolation male germline stem cell spermatogonial stem cell transplantation
摘 要：Continuous spermatogenesis depends on the self-renewal and differentiation of spermatogonial stem cells(SSCs).SSCs,the only male reproductive stem cells that transmit genetic material to subsequent generations,possess an inherent self-renewal ability,which allows the maintenance of a steady stem cell *** eventually differentiate to produce ***,in an in vitro culture system,SSCs can be induced to differentiate into various types of germ *** SSCs are well defined,and a culture system has been successfully established for *** contrast,available information on the biomolecular markers and a culture system for livestock SSCs is *** review summarizes the existing knowledge and research progress regarding mammalian SSCs to determine the mammalian spermatogenic process,the biology and niche of SSCs,the isolation and culture systems of SSCs,and the biomolecular markers and identification of *** information can be used for the effective utilization of SSCs in reproductive technologies for large livestock animals,enhancement of human male fertility,reproductive medicine,and protection of endangered species.
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