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吡格列酮对PCOS卵巢颗粒细胞分泌雌激素的影响

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西安交通大学学报（医学版） 2017年第5期38卷 730-733,739页

作者：宋青邹余粮苟文丽西安交通大学第一附属医院妇产科陕西西安710061

目的观察吡格列酮对多囊卵巢综合征(PCOS)患者卵巢颗粒细胞雌激素分泌功能和其上P450芳香化酶(P450arom)、胰岛素受体底物-1(IRS-1)和胰岛素受体底物-2(IRS-2)表达的影响。方法对27例行体外受精-胚胎移植PCOS患者的颗粒细胞进行体外原... 详细信息

目的观察吡格列酮对多囊卵巢综合征(PCOS)患者卵巢颗粒细胞雌激素分泌功能和其上P450芳香化酶(P450arom)、胰岛素受体底物-1(IRS-1)和胰岛素受体底物-2(IRS-2)表达的影响。方法对27例行体外受精-胚胎移植PCOS患者的颗粒细胞进行体外原代培养并分组,A组分别加入不同浓度(0、10、102、103、104nmol/L)吡格列酮、B组为不同浓度吡格列酮与卵泡刺激素(FSH,50ng/L)及C组为不同浓度吡格列酮与胰岛素样生长因子-Ⅰ(IGF-Ⅰ,50ng/L)。用放射免疫法检测培养上清液中雌二醇(E2)浓度,Real-time PCR法检测颗粒细胞上P450arom、IRS-1、IRS-2mRNA的表达变化。结果在A、B、C组中,人PCOS卵巢颗粒细胞培养48h的E2产生量差异有统计学意义(P<0.05),吡格列酮各浓度组间P450arom mRNA表达量差异有统计学意义(P<0.05),随着吡格列酮浓度的增加,E2水平和P450arom mRNA表达也随之下降;人PCOS卵巢颗粒细胞在相同浓度吡格列酮时,C组E2水平和P450arom mRNA表达明显高于B组(P<0.01)及A组(P<0.01),B组E2产生量和P450arom mRNA表达高于A组,差异有统计学意义(P<0.05);人PCOS卵巢颗粒细胞经不同浓度吡格列酮刺激48h,各浓度组间IRS-1、IRS-2mRNA表达差异有统计学意义(P<0.05),随着吡格列酮浓度的增加,IRS-1mRNA表达随之下降,IRS-2mRNA表达随之上升。结论吡格列酮可能直接或间接通过对P450arom的抑制,减少E2的生成,改善颗粒细胞上IRS-1和IRS-2表达的失衡,抑制PCOS卵巢的局部胰岛素抵抗状态;吡格列酮可抑制FSH和IGF-Ⅰ刺激卵巢颗粒细胞分泌雌激素的功能。

关键词：吡格列酮雌激素芳香化酶P450 多囊卵巢综合征(PCOS) 颗粒细胞胰岛素受体底物(IRS)

Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3095-3112页

作者： Fengcheng Deng Dan Yang Lingxi qing Yifei Chen Jilian zou Meiling Jia Qian Wang Runda Jiang Lihua Huang College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina

The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain *** gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine ***,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host *** reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological *** coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological *** study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological *** pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional *** can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage *** findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.

关键词： cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway strategy therapies

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang qing Yao Chubing Long Pengcheng Yi Jiali song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

New types of topological superconductors under local magnetic symmetries

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National Science Review 2021年第5期8卷 85-90页

作者： Jinyu zou qing Xie Zhida song Gang Xu Wuhan National High Magnetic Field Center & School of Physics Huazhong University of Science and Technology Department of Physics Princeton University

We classify gapped topological superconducting(TSC) phases of one-dimensional quantum wires with local magnetic symmetries, in which the time-reversal symmetry T is broken, but its combinations with certain crystalline symmetries, such as MxT, C2zT, C4zT and C6zT, are preserved. Our results demonstrate that an equivalent BDI class TSC can be realized in the MxT or C2zT superconducting wire,which is characterized by a chiral Zcinvariant. More interestingly, we also find two types of totally new TSC phases in the C4zT and C6zT superinducting wires, which are beyond the known AZ class, and are characterized by a helical Z~h invariant and Z~h ⊕Zcinvariants, respectively. In the Z~h TSC phase, Z pairs of Majorana zero modes(MZMs) are protected at each end. In the C6zT case, the MZMs can be either chiral or helical, and even helical-chiral coexisting. The minimal models preserving C4zT or C6zT symmetry are presented to illustrate their novel TSC properties and MZMs.

关键词： topological superconductor magnetic symmetry Majorana zero mode superconducting wire

发展银发经济的战略设计、焦点难点及路径优化

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新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 59-69,F0002页

作者：黄石松胡清中国人民大学国家发展与战略研究院北京100872 中国人民大学老年学研究所北京100872

我国正处于由中度老龄化社会步入重度老龄化社会的进程,银发经济将逐步从“以政府为主导的事业发展”阶段转向“事业和产业协同发展”的新阶段。准确把握这一转型发展特征,适时调整工作重心和节奏,注重运用市场机制推进产业发展迫在眉... 详细信息

我国正处于由中度老龄化社会步入重度老龄化社会的进程,银发经济将逐步从“以政府为主导的事业发展”阶段转向“事业和产业协同发展”的新阶段。准确把握这一转型发展特征,适时调整工作重心和节奏,注重运用市场机制推进产业发展迫在眉睫。对银发产业进行业态划分是制定产业组织政策、产业管理政策、产业发展政策的前提和基础,文本尝试将我国银发产业划分为基础性产业、延伸性产业和战略性产业,并据此分析三类产业在发展中存在的焦点难点问题,按照分类精准施策原则,提出优化我国银发经济发展路径的政策建议。

关键词：银发经济老龄产业老龄事业战略设计业态划分

Peak Dynamic Pressure on Semi-and Quarter-Circular Breakwaters Under Wave Troughs

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China Ocean Engineering 2017年第2期31卷 151-159页

作者： JIANG Xue-lian zou qing-ping song Ji-ning State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin University Tianjin Key Laboratory of Soft Soil Characteristics & Engineering Environment School of Civil EngineeringTianjin Chengjian University Department of Civil and Environmental Engineering The University of Maine State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University

A series of physical tests are conducted to examine the characteristics of the wave loading exerted on circular-front breakwaters by regular waves. It is found that the wave trough instead of wave crest plays a major role in the failure of submerged circular caissons due to seaward sliding. The difference in the behavior of seaward and shoreward horizontal wave forces is explained based on the variations of dynamic pressure with wave parameters. A wave load model is proposed based on a modified first-order solution for the dynamic pressure on submerged circular-front caissons under a wave trough. This wave loading model is very useful for engineering design. Further studies are needed to include model uncertainties in the reliability assessment of the breakwater.

关键词： semicircular breakwater quarter-circular breakwater wave trough load seaward wave force shoreward wave force

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民国报刊视野中的陈方恪研究

湖北科技学院学报 2025年第1期45卷 19-25页

作者：邹艳徐清南昌大学人文学院江西南昌330031

学界多以“才子”与“浪子”评判陈方恪,前者是指他古典诗词创作的才能,以及文献整理与鉴别的学识,后者是指其在年轻时生活上的放纵以及履历上的任伪职。民国报刊收藏了有关陈方恪的图片、诗作、序文等,这些史料有助于打破学界对陈方恪... 详细信息

学界多以“才子”与“浪子”评判陈方恪,前者是指他古典诗词创作的才能,以及文献整理与鉴别的学识,后者是指其在年轻时生活上的放纵以及履历上的任伪职。民国报刊收藏了有关陈方恪的图片、诗作、序文等,这些史料有助于打破学界对陈方恪评价的“定形”。陈方恪不仅追求雅致的风范而且还具有救亡图存的责任意识,并将其书写进文学创作中。而报刊文献中的《适屦集》序文和追和王国维之创作,展现了陈方恪反映本我、追求创新的文学创作理念。

关键词：民国报刊陈方恪《适屦集》

UiLog： Improving Log-Based Fault Diagnosis by Log Analysis

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Journal of Computer Science & Technology 2016年第5期31卷 1038-1052页

作者： De-qing zou Services Computing Technology and System Laboratory Huazhong University of Science and Technology Wuhan ~3007~ China Big Data Technology and System Laboratory Huazhong University of Science and Technology Wuhan 430074 China Cluster and Grid Computing Laboratory Huazhong University of Science and Technology Wuhan 430074 China School of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 China

In modern computer systems, system event logs have always been the primary source for checking system status. As computer systems become more and more complex, the interaction between software and hardware increases frequently. The components will generate enormous log information, including running reports and fault information. The sheer quantity of data is a great challenge for analysis relying on the manual method. In this paper, we implement a management and analysis system of log information, which can assist system administrators to understand the real-time status of the entire system, classify logs into different fault types, and determine the root cause of the faults. In addition, we improve the existing fault correlation analysis method based on the results of system log classification. We apply the system in a cloud computing environment for evaluation. The results show that our system can classify fault logs automatically and effectively. With the proposed system, administrators can easily detect the root cause of faults.

关键词： fault diagnosis system event log log classification fault correlation analysis

Adenovirus-mediated wild-type p53 gene transfer in combination with bronchial arterial infusion for treatment of advanced non-small-cell lung cancer,one year follow-up

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第5期10卷 331-340页

作者： Yong-song GUAN Yuan LIU qing zou qing HE Zi LA Lin YANG Ying HU Department of Oncology West China Hospital of Sichuan University Chengdu 610041 China State Key Laboratory of Biotherapy West China Medical School Sichuan University Chengdu 610041 China

Objective： In the present study, we have examined the safety and efficacy of recombinant adenovirus encoding human p53 tumor suppressor gene （rAd-p53） injection in patients with advanced non-small-cell lung cancer （NSCLC） in the combination with the therapy of bronchial arterial infusion （BAI）. Methods： A total of 58 patients with advanced NSCLC were enrolled in a non-randomized, two-armed clinical trial. Of which, 19 received a combination treatment of BAI and rAd-p53 （the combo group）, while the remaining 39 were treated with only BAI （the control group）. Patients were followed up for 12 months, with safety and local response evaluated by the National Cancer lnstitute＇s Common Toxicity Criteria and response evaluation criteria in solid tumor （RECIST）, respectively. Time to progression （TTP） and survival rates were also analyzed by Kaplan-Meier method. Results In the combo group, 19 patients received a total of 49 injections ofrAd-p53 and 46 times of BAI, respectively, while 39 patients in the control group received a total of 113 times of BAI. The combination treatment was found to have less adverse events such as anorexia, nausea and emesis, pain, and leucopenia （P〈0.05） but more arthralgia, fever, influenza-like symptom, and myalgia （P〈0.05）, compared with the control group. The overall response rates （complete response （CR）＋partial response （PR）） were 47.3% and 38.4% for the combo group and the control group, respectively （P〉0.05）. Patients in the combo group had a longer TTP than those in the control group （a median 7.75 vs 5.5 months, P-0.018）. However, the combination treatment did not lead to better survival, with survival rates at 3, 6, and 12 months in the combo group being 94.74%, 89.47%, and 52.63%, respectively, com- pared with 92.31%, 69.23%, and 38.83% in the control group （P=0.224）. Conclusion： Our results show that the combination of rAd-p53 and BAI was well tolerated in patients with NSCLC and may have improved the quality of life and delayed the

关键词： RAd-p53 gene therapy Clinical trial Non-small-cell lung cancer (NSCLC) Bronchial arterial infusion (BAI)