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Surface Diffusion on Stressed Solid Surface

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Communications in Computational Physics 2007年第1期2卷 73-86页

作者： Xiaofan Li qing nie Department of Applied Mathematics Illinois Institute of TechnologyChicagoIL 60616USA Center for Mathematical and Computational Biology Department of MathematicsUniversity of CaliforniaIrvineCA 92697-3875USA

The surface diffusion of an axi-symmetric solid,a whisker,subject to applied uniaxial stress,is studied numerically based on a new boundary integral formulation for periodic stress *** efficient semi-implicit time-stepping scheme is developed to treat the serve stiffness due to high-order *** the initial perturbation is small the effect of the stress on the motion of the whisker is found to agree with the linear stability *** simulations of a fully nonlinear case are also presented,and a potential break-up of the whisker is observed.

关键词： Surface diffusion elastic stress boundary integral method semi-implicit scheme.

2013—2022年武威市凉州区丙型病毒性肝炎流行特征分析

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预防医学情报杂志 2025年第1期41卷 45-51页

作者：张润聂清杨秉银武威市凉州区疾病预防控制中心甘肃武威733000

目的通过对2013—2022年武威市凉州区丙型病毒性肝炎(简称丙肝)发病报告数据进行流行病学特征分析,为相关部门有效控制丙肝疫情、制定防控措施提供参考依据。方法通过中国疾病预防控制信息系统收集2013—2022年武威市凉州区丙肝发病报... 详细信息

目的通过对2013—2022年武威市凉州区丙型病毒性肝炎(简称丙肝)发病报告数据进行流行病学特征分析,为相关部门有效控制丙肝疫情、制定防控措施提供参考依据。方法通过中国疾病预防控制信息系统收集2013—2022年武威市凉州区丙肝发病报告数据,采用描述性流行病学方法对丙肝的发病现状和流行病学特征进行分析,各种率和构成差异采用χ^(2)检验,以P<0.05为差异有统计学意义。结果2013—2022年武威市凉州区共报告丙肝病例8490例,年均发病率为(85.76/10万),丙肝发病率2013—2016年呈逐年上升趋势(χ_(趋势)^(2)=506.280,P<0.001),2017—2022年呈逐年下降趋势(χ_(趋势)^(2)=933.983,P<0.001),丙肝发病主要集中于城区8个街道和邻近城区周边8个乡镇,累计报告数4204例,占总发病数的49.52%。发病年龄主要集中于40~69岁年龄组,占66.11%;男性发病数和发病率均低于女性;职业分布主要以农民、家务及待业、离休人员为主。结论2013—2016年武威市凉州区丙肝疫情总体呈逐年上升趋势,2017—2022年总体呈逐年下降趋势;今后应加强各级医疗机构医务人员关于丙肝诊断标准和报告质量的培训;强化公众丙肝预防知识的宣传教育,有效控制丙肝的发病和流行。

关键词：丙型病毒性肝炎流行特征疫情分析

Expression of Nogo-A on the retina in rat model with chronic ocular hypertension

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International Journal of Ophthalmology(English edition) 2010年第2期3卷 112-113页

作者： qing-Zhu nie, Dian-Wen Gao Department of Ophthalmology Shengjing Hospital Affiliated to China Medical University Shenyang 110004 Liaoning Province China Heilongjiang Eye Hospital Harbin 150001 Heilongjiang Province China

AIMTo study the expressive variation of Nogo-A on rat retina in the process of chronic ocular hypertension.

关键词： retina chronic hypertension Nogo-A retinal ganglion cell

Noise control and utility:From regulatory network to spatial patterning

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Science China Mathematics 2020年第3期63卷 425-440页

作者： qing nie Lingxia Qiao Yuchi Qiu Lei Zhang Wei Zhao Department of Mathematics University of California at IrvineIrvineCA 92697USA Department of Developmental and Cell Biology NSF-Simons Center for Multiscale Cell Fate ResearchUniversity of California at IrvineIrvineCA 92697USA Beijing International Center for Mathematical Research Peking UniversityBeijing 100871China Center for Quantitative Biology Peking UniversityBeijing 100871China

Stochasticity(or noise) at cellular and molecular levels has been observed extensively as a universal feature for living systems. However, how living systems deal with noise while performing desirable biological functions remains a major mystery. Regulatory network configurations, such as their topology and timescale, are shown to be critical in attenuating noise, and noise is also found to facilitate cell fate decision. Here we review major recent findings on noise attenuation through regulatory control, the benefit of noise via noise-induced cellular plasticity during developmental patterning and summarize key principles underlying noise control.

关键词： noise attenuation regulatory network design principle spatial patterning

Effects of long non-coding RNA myocardial infarction-associated transcript on retinal neovascularization in a newborn mouse model of oxygen-induced retinopathy

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Neural Regeneration Research 2021年第9期16卷 1877-1881页

作者： Yu Di Yue Wang Xue Wang qing-Zhu nie Department of Ophthalmology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Whether long non-coding RNA myocardial infarction-associated transcript is involved in oxygen-induced retinopathy remains poorly understood. To validate this hypothesis, we established a newborn mouse model of oxygen-induced retinopathy by feeding in an oxygen concentration of 75 ± 2% from postnatal day 8 to postnatal day 12, followed by in normal air. On postnatal day 11, the mice were injected with the myocardial infarction-associated transcript siRNA plasmid via the vitreous cavity to knockdown long non-coding RNA myocardial infarction-associated transcript. Myocardial infarction-associated transcript siRNA transcription significantly inhibited myocardial infarctionassociated transcript mRNA expression, reduced the phosphatidylinosital-3-kinase, phosphorylated Akt and vascular endothelial growth factor immunopositivities, protein and mRNA expression, and alleviated the pathological damage to the retina of oxygen-induced retinopathy mouse models. These findings suggest that myocardial infarction-associated transcript is likely involved in the retinal neovascularization in retinopathy of prematurity and that inhibition of myocardial infarction-associated transcript can downregulate phosphatidylinosital-3-kinase, phosphorylated Akt and vascular endothelial growth factor expression levels and inhibit neovascularization. This study was approved by the Animal Ethics Committee of Shengjing Hospital of China Medical University, China(approval No. 2016 PS074 K) on February 25, 2016.

关键词： long non-coding RNA myocardial infarction-associated transcript neovascularization neurovascular prematurity retinopathy vascular development vascular endothelial growth factor

A new strength criterion for structured soils

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Journal of Rock Mechanics and Geotechnical Engineering 2013年第2期5卷 156-161页

作者： Enlong Liu qing nie Jianhai Zhang State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and Hydropower Sichuan University

Existing strength criteria are mostly formulated to describe the mechanical properties of reconstituted soils. However, the engineering characteristics of structured soils are different from those of reconstituted soils in many aspects, especially in their strength properties, Thus, the influence of soil structure （bonding and fabric） on the mechanical properties of structured soils cannot be correctly described, By analyzing the breakage mechanism of natural soils, the structured soils can be conceptualized as binary medium materials consisting of bonded blocks and weakened bands. On this basis, a new strength criterion is pro- posed for structured soils, The expressions of the strength criterion on both meridian and deviator planes are given to describe the strength properties of structured soils on these planes. The proposed strength criterion is compared with available test data under conventional and true triaxial stress conditions in the literature. It is observed that the proposed strength criterion agrees well with the test data.

关键词： Strength criterion Structured soils Binary medium model Breakage mechanism

Matrix metalloproteinase-9 and vascular endothelial growth factor expression change in experimental retinal neovascularization

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International Journal of Ophthalmology(English edition) 2016年第6期9卷 804-808页

作者： Yu Di qing-Zhu nie Xiao-Long Chen Department of Ophthalmology Shengjing Hospital of China Medical University

AIM： To investigate the signal transduction mechanism of matrix metalloproteinase-9 （MMP-9） mediatedvascular endothelial growth factor （VEGF） expression and retinal neovascularization （RNV） in oxygen-induced retinopathy （OIR） model. METHODS： C57BL/6J mice were divided into four groups： control group, OIR group, OIR control group （phosphatebuffered saline by intravitreal injection） and treated group [tissue inhibitor of matrix metalloproteinase-1 （TIMP-1） by intravitreal injection]. OIR model was established in C57BIJ6J mice exposed to 75% ＋2% oxygen for 5d. mRNA level and protein expression of MMP-9, TIMP-1 and VEGF were measured by real-time polymerase chain reaction and Western blotting, and located by immunohistochemistry. RESULTS： Levels of MMP-9 and VEGF in retina were significantly increased in animals with OIR and OIR control group. Levels of TIMP -1 in retina was significantly reduced in animals with OIR and OIR control group. Furthermore, a significant correlation was found between MMP-9 and VEGF. Intravitreal injection of TIMP- 1 significantly reduced MMP-9 and VEGF expression of the OIR mouse model （all P〈0.05）. CONCLUSION： These results demonstrate that MMP- 9-mediated up-regulation of VEGF promotes RNV in retinopathy of prematurity （ROP）. TIMP-1 may be a potential target for the prevention and treatment of ROP.

关键词： retinal neovascularization matrixmetalloproteinase-9 vascular endothelial growth factor oxygen-induced retinopathy

Harvesting random embedding for high-frequency change-point detection in temporal complex systems

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National Science Review 2022年第4期9卷 92-104页

作者： Jia-Wen Hou Huan-Fei Ma Dake He Jie Sun qing nie Wei Lin Research Institute of Intelligent Complex Systems Fudan University Centre for Computational Systems Biology Institute of Science and Technology for Brain-Inspired IntelligenceFudan University School of Mathematical Sciences Soochow University Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine School of Mathematical Sciences and Shanghai Center for Mathematical Sciences Fudan University Department of Mathematics Department of Developmental and Cell Biologyand NSF-Simons Center for Multiscale Cell Fate ResearchUniversity of California Shanghai Key Laboratory for Contemporary Applied Mathematics LNMS (Fudan University)and LCNBI (Fudan University) State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceInstitutes of Brain ScienceFudan University

Recent investigations have revealed that dynamics of complex networks and systems are crucially dependent on the temporal structures. Accurate detection of the time instant at which a system changes its internal structures has become a tremendously significant mission, beneficial to fully understanding the underlying mechanisms of evolving systems, and adequately modeling and predicting the dynamics of the systems as well. In real-world applications, due to a lack of prior knowledge on the explicit equations of evolving systems, an open challenge is how to develop a practical and model-free method to achieve the mission based merely on the time-series data recorded from real-world systems. Here, we develop such a model-free approach, named temporal change-point detection(TCD), and integrate both dynamical and statistical methods to address this important challenge in a novel way. The proposed TCD approach, basing on exploitation of spatial information of the observed time series of high dimensions, is able not only to detect the separate change points of the concerned systems without knowing, a priori, any information of the equations of the systems, but also to harvest all the change points emergent in a relatively high-frequency manner, which cannot be directly achieved by using the existing methods and *** effectiveness is comprehensively demonstrated using the data from the representative complex dynamics and real-world systems from biology to geology and even to social science.

关键词： temporal systems time series change-point detection complex dynamical systems

Identification of suitable reference genes for quantitative gene expression analysis in clam Cyclina sinensis under salinity stress and Vibrio infection

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Journal of Oceanology and Limnology 2023年第1期41卷 352-363页

作者： Fengjuan JIANG qingyao WANG Jingjing DU Fu LÜ qing nie Weihong ZHAO College of Marine and Biological Engineering Yancheng Institute of TechnologyYancheng 224051China

The appropriate reference gene is a prerequisite for accurate normalization of gene expression level,and research on suitable reference genes in clam Cyclina sinensis is *** improve the situation,we selected five commonly used housekeeping genes,including β-actin,Elongation factor 1-α(EF1-α),Glyceraldehyde-3-pho sphate dehydrogenase(GAPDH),40S ribosomal protein S18(RPS18),and Tubulin a(TUB-α),then evaluated their expression stability in different adult tissues and under different experimental treatments(salinity stress and Vibrio parahaemolyticus infection).Their expression stability was analyzed by three frequently used programs,geNorm,NormFinder,and *** analysis indicated that multiple genes should be used for normalization,and we concluded that the reference gene combination GAPDH-RPS18-β-actin,should be used for qRT-PCR analysis in different tissues of *** under normal physiological *** the clams under salinity stress and Vibrio infection,EF1-α-GAPDHRPS18 was recommended as the gene combination for qRT-PCR ***-αwas generally poorly ranked by all programs,and should not be used in future *** study should provide fundamental support for accurate quantitative gene expression analysis of this species.

关键词： Cyclina sinensis reference gene different tissues salinity stress Vibrio infection