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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang qing yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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Poorly controlled type II diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage III colon cancer

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World Journal of Gastroenterology 2025年第3期31卷 29-41页

作者： Ruo-Yu Guan Jia-Wei Wu Zi-Yun Yuan Zhi-Yuan Liu Zi-Zhu Liu Zhi-Cong Xiao Jing-Hui Li Cheng-Zhi Huang Jun-Jiang Wang Xue-qing yao Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastrointestinal Surgery Department of General SurgeryGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of General Surgery Guangdong Provincial People’s Hospital Ganzhou Hospital(Ganzhou Municipal Hospital)Ganzhou 341000Jiangxi ProvinceChina Shantou University Medical College Shantou 515041Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Gannan Medical University Ganzhou 341000Jiangxi ProvinceChina

BACKGROUND Type II diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with *** effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage III CC who receive curative resection remain *** To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage III *** This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage III CC from 2018 to *** on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic ***,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk *** Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,P<0.001;OS:HR=2.105,P=0.019;CRR:HR=2.214,P=0.005]and glycosylated hemoglobin levels(DFS:HR=2.344,P=0.006;OS:HR=2.119,P=0.021;CRR:HR=2.449,P=0.009)indicated significantly poor prognosis and high CRR,while T2DM history did not(DFS:HR=1.178,P=0.327;OS:HR=0.933,P=0.739;CRR:HR=0.997,P=0.581).CONCLUSION Increased preoperative fasting plasma glucose and glycosylated hemoglobin levels,but not T2DM history,were identified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage III CC.

关键词： Colon cancer Chemoresistance Diabetes mellitus Prognosis Type II diabetes mellitus

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Existence,Multiplicity and Infinite Solvability of Positive Solutions for One-Dimensional p-Laplacian

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Acta Mathematica Sinica,English Series 2005年第4期21卷 691-698页

作者： qing Liu yao Department of Applied Mathematics Nanjing University of Finance and Economics Nanjing 210003 P. R. China

The existence, multiplicity and infinite solvability of positive solutions are established for some two-point boundary value problems of one-dimensional p-Laplacian. In this paper, by multiplicity we mean the existenc... 详细信息

关键词： One-dimensional p-Laplacian Positive solution Existence Multiplicity Infinite solvability

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Triple Positive Periodic Solutions of Nonlinear Singular Second-order Boundary Value Problems

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Acta Mathematica Sinica,English Series 2014年第2期30卷 361-370页

作者： qing Liu yao Department of Applied Mathematics Nanjing University of Finance and Economics

This paper studies the positive solutions of the nonlinear second-order periodic boundary value problem u″（t）＋ λ（t）u（t） = f（t,u（t））,a.e.t ∈ [0,2π],u（0） = u（2π）,u′（0） = u′（2π）,where f（t,u） is a local Carath′eodory *** shows that the problem is singular with respect to both the time variable t and space variable *** applying the Leggett-Williams and Krasnosel＇skii fixed point theorems on cones,an existence theorem of triple positive solutions is *** order to use these theorems,the exact a priori estimations for the bound of solution are given,and some proper height functions are introduced by the estimations.

关键词： Periodic boundary value problem singular nonlinearity triple positive solutions fixedpoint theorem

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A Possible Explanation of the O'Connell Effect in Close Binary Stars

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Chinese Journal of Astronomy and Astrophysics 2003年第2期3卷 142-150页

作者： qing-yao Liu YU-Lan Yang NationalAstronomicalObservatories YunnanObservatoryChineseAcademyofSciencesKunming650011Bily UnitedLaboratoryofOpticalAstronomy ChineseAcademyofSciences

A theoretical model for explaining the O'Connell effect of close binary stars is given based on the hypothesis that the circumstellar material of a binary system is captured by its components. The results inferred from the model suggest that late-type and/or short-period binaries can easily produce obvious O'Connell effect and that the occurrence of O'Connell effect has no relation with the type of binaries. These conclusions are in agreement with the observed results. The observed O'Connell effects of six binary systems are examined by the model. For three W-subtype W UMa binaries (YY Eri, BX Per and SW Lac), the densities of the materials captured by the two components are assumed to be equal, and the calculated O'Connell effect is found to be almost equal to the observed effect. For three A-subtype W UMa systems (CN And, FG Hya and AU Ser), the two densities are assumed to be different, and are calculated separately. The calculated O'Connell effect turns out to agree better with the observed effect than that was formerly obtained.

关键词： binaries: close - star: W UMa - circumstellar matter

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On the Period Variation of the W UMa-type Contact Binary V502 Ophiuchi

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Chinese Journal of Astronomy and Astrophysics 2006年第3期6卷 331-337页

作者： qing-yao Liu Yu-Lan Yang National Astronomical Observatories/Yunnan Observatory Chinese Academy of Sciences Kunming 650011

The variation in the orbital period of the W UMa type contact binary V502 Oph is analyzed. The orbital period exhibits a wavelike variation with a periodicity of 23.0 years and an amplitude of AP = 1.24 ×10^-5 days superimposed on secular decrease of dP/dt = 1.68× 10^-7 day per year. The long-term decrease may be accompanied by the contraction of the secondary at a rate of 83 m per year and a mass transfer rate from the primary to the secondary of 4.28×10^-8M· per year. The short-term oscillation may be explained by the presence of a third component. Orbital elements of the third body and its possible mass are presented.

关键词： stars: contact binary - period change - star: individual: V502 Oph

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New method for high performance multiply-accumulator design

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第7期10卷 1067-1074页

作者： Bing-jie XIA Peng LIU qing-dong yao Department of Information Science and Electronic Engineering Zhejiang University Hangzhou 310027 China

This study presents a new method of 4-pipelined high-performance split multiply-accumulator (MAC) architecture, which is capable of supporting multiple precisions developed for media processors. To speed up the design further, a novel partial product compression circuit based on interleaved adders and a modified hybrid partial product reduction tree (PPRT) scheme are proposed. The MAC can perform 1-way 32-bit, 4-way 16-bit signed/unsigned multiply or multiply-accumulate operations and 2-way parallel multiply add (PMADD) operations at a high frequency of 1.25 GHz under worst-case conditions and 1.67 GHz under typical-case conditions, respectively. Compared with the MAC in 32-bit microprocessor without interlocked piped stages (MIPS), the proposed design shows a great advantage in speed. Moreover, an improvement of up to 32% in throughput is achieved. The MAC design has been fabricated with Taiwan Semiconductor Manufacturing Company (TSMC) 90-nm CMOS standard cell technology and has passed a functional test.

关键词： Multiply-accumulator (MAC) Pipeline Compressor Partial product reduction tree (PPRT) Split structure

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Effect of MgO on structure and crystallization behavior of CaO–SiO_(2)–Al_(2)O_(3) inclusions in Si–Mn deoxidized steel

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Journal of Iron and Steel Research International 2024年第11期31卷 2774-2787页

作者： Qi Xu yao-qing Meng Jian-li Li The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan430081HubeiChina

To avoid coarse crystallization of glassy inclusions in Si–Mn deoxidized steel during hot rolling, the effect of MgO on the structure and crystallization behavior of CaO–SiO_(2)–Al_(2)O_(3) inclusions was investigated. The results showed that the crystallization temperature of the oxide melts decreased with increasing MgO content from 0 to 15.7 wt.%, which suggested that the addition of MgO would increase the temperature range of the crystalline transition. The increase in MgO content could decrease the crystallization activation energy of inclusions. With the increase in MgO content, the relative fractions of O_(Si)^(0) and O_(Si)^(1) structure units increased, and those of structure units O_(Si)^(2), O_(Si)^(3), and O_(Si)^(4) decreased, increasing the depolymerization degree of the silicate structure. The crystallization ratio of glassy inclusions in the steel crucible increased from 19.7% to 98.3% with increasing MgO content from 0 to 15.7 wt.%. The addition of MgO improved the crystallization ability of inclusions, because MgO provides free oxygen O_(2−) to destroy the bridging oxygens and form non-bridging oxygens O^(−), which depolymerizes silicate network structure and simplifies the [SiO_(4)]-tetrahedral structure. In addition, MgO would promote the precipitation of the Mg-containing phases with a high melting point. When the MgO content was increased above 12.1 wt.%, MgO·Al_(2)O_(3) and 2MgO·SiO_(2) crystalline phases would precipitate from the inclusions.

关键词： Si-Mn deoxidized steel Glassy inclusion Structure Crystallization Plasticization

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Development of combined transitional pavement structure for urban tram track-road grade crossings

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Frontiers of Structural and Civil Engineering 2023年第8期17卷 1199-1210页

作者： Boshun GAO Xin XIAO Jiayu WANG Ligao JIANG qing yao Key Laboratory of Road and Traffic Engineering of Ministry of Education Tongji UniversityShanghai 201804China Shanghai Urban Construction Municipal Engineering(Group)Co. Ltd.Shanghai 200065China

The grade crossings and adjacent pavements of urban trams are generally subjected to complex load conditions and are susceptible to ***,in this study,a novel pavement structure between tram tracks and roads constructed using polyurethane(PU)elastic concrete and ultra-high-performance concrete(UHPC),referred to as a track-road transitional pavement(TRTP),is ***,its performance and feasibility are evaluated using experimental and numerical ***,the mechanical properties of the PU elastic concrete are *** performance of the proposed structure is investigated using a three-dimensional finite element model,where vehicleinduced dynamic and static loads are *** results show that PU elastic concrete and the proposed combined TRTP are applicable and functioned as ***,the PU elastic concrete achieved sufficient *** recommended width of the TRTP is approximately 50 ***,the application of UHPC under a PU elastic concrete layer significantly reduces vertical *** of numerical calculations confirmed the high structural performance and feasibility of the proposed ***,material performance standards are recommended to provide guidance for pavement design and the construction of tram-grade crossings in the future.

关键词： urban tram track grade crossing combined track-road transitional pavement polyurethane elastic concrete finite element method

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Mechanobiology in vascular remodeling

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National Science Review 2018年第6期5卷 933-946页

作者： Yue Han Kai Huang qing-Ping yao Zong-Lai Jiang Institute of Mechanobiology & Medical Engineering School of Life Sciences & BiotechnologyShanghai Jiao Tong University School of Biological Science & Medical Engineering Beijing Advanced Innovation Center for Biomedical Engineering Beihang University

Vascular remodeling is a common pathological process in cardiovascular diseases and includes changes in cell proliferation, apoptosis and differentiation as well as vascular homeostasis. Mechanical stresses, such as shear stress and cyclic stretch, play an important role in vascular remodeling. Vascular cells can sense the mechanical factors through cell membrane proteins, cytoskeletons and nuclear envelope proteins to initiate mechanotransduction, which involves intercellular signaling, gene expression, and protein expression to result in functional regulations. Non-coding RNAs, including micro RNAs and long non-coding RNAs, are involved in the regulation of vascular remodeling processes. Mechanotransduction triggers a cascade reaction process through a complicated signaling network in cells. High-throughput technologies in combination with functional studies targeting some key hubs and bridging nodes of the network can enable the prioritization of potential targets for subsequent investigations of clinical translation. Vascular mechanobiology, as a new frontier field of biomechanics, searches for principles of stress-growth in vasculature to elucidate how mechanical factors induce biological effects that lead to vascular remodeling,with the goal of understanding the mechanical basis of the pathological mechanism of cardiovascular diseases at the cellular and molecular levels. Vascular mechanobiology will play a unique role in solving the key scientific problems of human physiology and disease, as well as generating important theoretical and clinical results.

关键词： mechanobiology vascular remodeling cardiovascular disease mechanotransduction endothelial cell vascular smooth muscle cell nuclear envelope microRNA

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