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High Voltage 2024年第1期9卷 81-93页

作者： Jun xie Zhe Zhou Ziqian Liu Haonan Tian Sigang Zhang qing xie Hebei Provincial Key Laboratory of Power Transmission Equipment Security Defense North China Electric Power UniversityBaodingChina State Grid Gansu Electric Power Company LanzhouChina

Fibre-reinforced polymer(FRP)/rigid polyurethane foam(RPUF)interface is susceptible to moisture intrusion in addition to natural ageing during *** study investigated the influence of moisture intrusion on the FRP/RPUF interface under natural ageing using experiments and molecular dynamics(MD)*** absorption,shear strength,and leakage current tests were used to clarify the changes in the interface *** degradation mechanism of moisture intrusion at the interface under natural ageing was revealed by MD simulation and *** results show that the natural ageing of interfacial materials will slightly reduce the quality of the interface but will reduce the water resistance of the material and promote the process of water intrusion into the *** addition,water mainly invades the interface through *** water penetration,the interfacial bonding strength and insulation performance significantly *** and hydrolysis of interfacial materials are the main reasons for decreased interfacial *** can cause irreversible damage to the interface,increasing interface defects and water *** vicious cycle of material hydrolysis is the ultimate cause of interfacial *** polar molecules produced by this process and the water absorbed by the interface caused the degradation of the interface insulation performance.

关键词： interface polyurethane interfacial

Synthesis of Planar-Chiral[2.2]Paracyclophane-Based Oxazole-Pyrimidine Ligands and Application in Nickel-Catalyzed 1,2-Reduction ofα,β-Unsaturated Ketones

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Chinese Journal of Chemistry 2024年第7期42卷 705-710页

作者： Juan Wang qing-Xian xie Xiang Li Chang-Bin Yu Yong-Gui Zhou School of Chemistry Dalian University of Technology2 Linggong RoadDalianLiaoning 116024China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianLiaoning 116023China

The planar-chiral ligands have been widely applied as a class of unique and significant ligands in asymmetric *** them,chiral[2.2]paracycyclophane has emerged as a privileged type of planar-chiral framework and has been utilized as an important toolbox due to their structural ***,we design and synthesize[2.2]paracyclophane-derived oxazole-pyrimidine ligands(abberviated as PYMCOX).These N,N-ligands with stable properties,rigid structure and large steric hindrance performed successfully in nickel-catalyzed asymmetric 1,2-reduction ofα,β-unsaturated ketones,affording the chiral allylic alcohols with up to 99%yield and 99%***,this reduction reaction could be conducted on gram-scale without loss of activity and enantioselectivity,and the chiral ligand could be conveniently recovered with high yield.

关键词： Oxazole-pyrimidine ligands Planar chirality Nickel Hydroboration Asymmetric synthesis

Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions

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World Journal of Gastroenterology 2024年第14期30卷 1968-1981页

作者： Hong-Ju Sun Bo Jiao Yan Wang Yue-Hua Zhang Ge Chen Zi-Xuan Wang Hong Zhao qing xie Xiao-Hua Song Department of General Medicine Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina Department of Gastroenterology Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina Department of Medical Administration Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina qingdao Medical College Qingdao UniversityQingdao 266042Shandong ProvinceChina Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Nonalcoholic fatty liver disease(NAFLD)is the most prevalent type of chronic liver ***,the disease is underappreciated as a remarkable chronic disorder as there are rare managing *** studies have focused on determining NAFLD-caused hepatocyte death to elucidate the disease pathoe-tiology and suggest functional therapeutic and diagnostic ***,ferroptosis,and necroptosis are the main subtypes of non-apoptotic regulated cell deaths(RCDs),each of which represents particular *** the complexity of the findings,the present study aimed to review these types of RCDs and their contribution to NAFLD progression,and subsequently discuss in detail the role of necroptosis in the pathoetiology,diagnosis,and treatment of the *** study revealed that necroptosis is involved in the occurrence of NAFLD and its progression towards steatohepatitis and cancer,hence it has potential in diagnostic and therapeutic ***,further studies are necessary.

关键词： Nonalcoholic fatty liver disease Apoptosis Necroptosis Cell death Diagnosis Treatment

基于DPSR模型的城市水安全评价与保障能力提升

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长江科学院院报 2024年第7期41卷 41-47,56页

作者：谢庆长沙理工大学水利与环境工程学院长沙410114 中共湖南省委党校湖南经济社会发展研究中心长沙410006

水安全评价是水资源开发利用与保护的基础,提升城市水安全有利于促进生态环境保护,支撑经济社会高质量发展。基于驱动-压力-状态-响应(DPSR)模型构建以资源安全、社会安全和经济安全为核心的水安全评价指标体系,运用熵权法确定指标权重... 详细信息

水安全评价是水资源开发利用与保护的基础,提升城市水安全有利于促进生态环境保护,支撑经济社会高质量发展。基于驱动-压力-状态-响应(DPSR)模型构建以资源安全、社会安全和经济安全为核心的水安全评价指标体系,运用熵权法确定指标权重,以长沙市为实例,对“十三五”期间城市水安全状况进行评估与分析。结果表明:长沙市水安全状况尽管从2018年“不安全”等级提升至2020年“安全”等级,但状态不稳定,进而制定了加强保水工程建设、提升水环境质量、加强水灾害防治能力3个方案,综合考虑方案投入成本并对比水安全提升效果,给出了先后实施方案2—方案1—方案3的长沙市水安全提升优化路径。

关键词：城市水安全 DPSR模型熵权法长沙市提升路径

基于非靶向代谢组学的沙枣花、叶片和幼枝的挥发性成分分析

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植物生理学报 2024年第2期60卷 363-376页

作者：解庆刘志红山西农业大学林学院山西晋中030801

本文运用顶空固相微萃取-气相色谱-质谱联用技术(HS-SPME-GC-MS)研究了不同发育阶段沙枣花(花蕾、全开和凋谢)、叶片和幼枝的挥发性成分,并采用主成分分析(PCA)、正交偏最小二乘法判别分析(OPLS-DA)等方法筛选出差异代谢物。结果表明,... 详细信息

本文运用顶空固相微萃取-气相色谱-质谱联用技术(HS-SPME-GC-MS)研究了不同发育阶段沙枣花(花蕾、全开和凋谢)、叶片和幼枝的挥发性成分,并采用主成分分析(PCA)、正交偏最小二乘法判别分析(OPLS-DA)等方法筛选出差异代谢物。结果表明,沙枣挥发油以酯类、烃类、醇类和醛类物质为主,主要成分为肉桂酸乙酯、β-罗勒烯和4-己烯-1-醇乙酸酯等。代谢组学分析共筛选出17种差异代谢物。其中沙枣花蕾中的特征成分为α-橙花叔醇、反式-2-己烯醇、十一醛和β-罗勒烯;沙枣花全开时的特征成分为肉桂酸乙酯和安息香酸乙酯;凋谢后沙枣花的特征成分为癸醛、庚醛、植酮和2-甲基丁酸乙酯;沙枣叶片的特征成分为4-己烯-1-醇乙酸酯和叶醇而沙枣幼枝的特征成分为壬醛、顺式-3-己烯基异戊酸酯、苯乙醇和3-己烯-1-醇。沙枣花、叶片和幼枝挥发性成分的代谢组学分析,可为沙枣精油的综合开发利用提供一定理论依据。

关键词：沙枣挥发性成分顶空固相微萃取气相色谱-质谱联用非靶向代谢组学

Design and prototyping of the readout electronics for the transition radiation detector in the high energy cosmic radiation detection facility

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Nuclear Science and Techniques 2024年第4期35卷 189-199页

作者： Jie-Yu Zhu Yang-Zhou Su Hai-Bo Yang Fen-Hua Lu Yan Yang Xi-Wen Liu Ping Wei Shu-Cai Wan Hao-qing xie Xian-Qin Li Cong Dai Hui-Jun Hu Hong-Bang Liu Shu-Wen Tang Cheng-Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

The high energy cosmic-radiation detection(HERD)facility is planned to launch in 2027 and scheduled to be installed on the China Space *** serves as a dark matter particle detector,a cosmic ray instrument,and an observatory for high-energy gamma rays.A transition radiation detector placed on one of its lateral sides serves dual purpose,(ⅰ)calibrating HERD's electromagnetic calorimeter in the TeV energy range,and(ⅱ)serving as an independent detector for high-energy gamma *** this paper,the prototype readout electronics design of the transition radiation detector is demonstrated,which aims to accurately measure the charge of the anodes using the SAMPA application specific integrated circuit *** electronic performance of the prototype system is evaluated in terms of noise,linearity,and *** the presented design,each electronic channel can achieve a dynamic range of 0–100 fC,the RMS noise level not exceeding 0.15 fC,and the integral nonlinearity was<0.2%.To further verify the readout electronic performance,a joint test with the detector was carried out,and the results show that the prototype system can satisfy the requirements of the detector's scientific goals.

关键词： HERD Dark matter particle detection TRD Readout electronics SAMPA Data acquisition Performance test

Five-year Treatment with Tenofovir Alafenamide Achieves High Rates of Viral Suppression,Alanine Aminotransferase Normalization,and Favorable Bone and Renal Safety in Chinese Chronic Hepatitis B Patients

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Journal of Clinical and Translational Hepatology 2024年第5期12卷 469-480页

作者： Jinlin Hou Qin Ning Zhongping Duan Yu Chen qing xie Lunli Zhang Shanming Wu Hong Tang Jun Li Feng Lin Yongfeng Yang Guozhong Gong Yanwen Luo Shelley xie Hongyuan Wang Roberto Mateo Tahmineh Yazdi Frida Abramov Leland JYee John Flaherty Chengwei Chen Yan Huang Mingxiang Zhang Jidong Jia Nanfang Hospital Southern Medical UniversityGuangzhouGuangdongChina Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Beijing YouAn Hospital Capital Medical UniversityBeijingChina Shanghai Ruijin Hospital Shanghai Jiao Tong University School of MedicineShanghaiChina The First Affiliated Hospital of Nanchang University NanchangJiangxiChina Shanghai Public Health Clinical Center ShanghaiChina West China Hospital Sichuan UniversityChengduSichuanChina The First Affiliated Hospital of Nanjing Medical University NanjingJiangsuChina Hainan General Hospital HaikouHainanChina The Second Hospital of Nanjing Affiliated to Nanjing University of Chinese MedicineNanjingJiangsuChina The Second Xiangya Hospital Central South UniversityChangshaHunanChina Gilead Sciences ShanghaiChina Gilead Sciences Foster CityCAUSA The People’s Liberation Army No.85 Hospital ShanghaiChina Xiangya Hospital Central South UniversityChangshaHunanChina The Sixth People’s Hospital of Shenyang ShenyangLiaoningChina Beijing Friendship Hospital Capital Medical UniversityBeijingChina

Background and Aims:After 3-years(144 week)of double-blind treatment in Chinese chronic hepatitis B patients in two ongoing phase 3 studies,tenofovir alafenamide(TAF)showed similar efficacy to tenofovir disoproxil fumarate(TDF),with improved renal and bone *** this study,we aimed to report the 5-year results from 2 years into the open-label TAF treatment ***:All participants completing the 144-week double-blind treatment were eligible to receive open-label TAF 25 mg once daily up to week *** analysis of viral suppression(hepatitis B virus DNA<29 IU/mL),alanine aminotransferase normalization,serological responses,and safety outcomes at year 5(week 240)was ***:The openlabel phase included 93%(311/334)of the enrolled participants,which included 212 who switched from double-blind TAF to open-label TAF(TAF-TAF)and 99 who switched from double-blind TDF to open-label TAF(TDF-TAF).Baseline characteristics were *** 240 viral suppression rates were similar between groups[93.4%vs.93.9%;difference:-1.5%,(95%CI:-6.4 to-3.5),p=0.857].Alanine aminotransferase normalization and serological response rates were higher in the TAF-TAF group than in the TDF-TAF *** frequencies of adverse events and laboratory abnormalities were low and similar between *** groups had similar small numerical declines from baseline in estimated glomerular filtration rate at year 5(week 240,-2.85 mL/min vs.-3.29 mL/min,p=0.910).The greater declines in renal and bone parameters in the TDF-TAF group through week 144 improved after switching to ***:The 5-year TAF treatment efficacy was high and similar to that of 3-year TDF followed by 2-year TAF in Chinese chronic hepatitis B *** effects on bone and renal parameters were sustained with TAF treatment alone and were observed following the switch from TDF to TAF.

关键词： Chronic hepatitis B Antiviral therapy Bone safety Renal safety Tenofovir alafenamide Tenofovir disoproxil fumarate Chinese

Effects of respiratory muscle training on post-stroke rehabilitation:A systematic review and meta-analysis

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World Journal of Clinical Cases 2024年第20期12卷 4289-4300页

作者： Yong-Tao Liu Xiao-Xin Liu Yi-qing Liu Lei Zhang Lin-Jing Zhang Jian-Hua Wang Yan Shi qing-Fan xie Department of Rehabilitation Xingtai People's HospitalXingtai 054001Hebei ProvinceChina Ophthalmologist Clinic Xingtai People's HospitalXingtai 054001Hebei ProvinceChina Department of Cardiology Xingtai People's HospitalXingtai 054001Hebei ProvinceChina Department of Ultrasound Xingtai People's HospitalXingtai 054001Hebei ProvinceChina

BACKGROUND Stroke often results in significant respiratory dysfunction in *** muscle training(RMT)has been proposed as a rehabilitative intervention to address these challenges,but its effectiveness compared to routine training remains *** systematic review and meta-analysis aim to evaluate the effects of RMT on exercise tolerance,muscle strength,and pulmonary function in post-stroke *** To systematically assess the efficacy of RMT in improving exercise tolerance,respiratory muscle strength,and pulmonary function in patients recovering from a stroke,and to evaluate whether RMT offers a significant advantage over routine training modalities in enhancing these critical health outcomes in the post-stroke *** Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines,a comprehensive search across PubMed,Embase,Web of Science,and the Cochrane Library was conducted on October 19,2023,without temporal *** were selected based on the predefined inclusion and exclusion criteria focusing on various forms of RMT,control groups,and outcome measures[including forced expiratory volume in the first second(FEV1),forced vital capacity(FVC),maximal voluntary ventilation(MVV),peak expiratory flow(PEF),maximal inspiratory pressure(MIP),maximal expiratory pressure(MEP),and 6-min walking test(6MWT)].Only randomized controlled trials(RCTs)were *** extraction and quality assessment were conducted independently by two reviewers using the Cochrane Collaboration's risk of bias *** analyses,including those using the fixed-effect and random-effects models,sensitivity analysis,and publication bias assessment,were performed using Review Manager *** A total of 15 RCTs were *** indicated significant improvements in MIP(12.51 cmH2O increase),MEP(6.24 cmH2O increase),and various pulmonary function parameters(including FEV1,FVC,MVV,and PEF).A substantial i

关键词： Respiratory muscle training Stroke rehabilitation Pulmonary function Exercise tolerance Meta-analysis

水舟隐喻:中西水舟原型的叙事比较与媒介理解差异

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新闻大学 2024年第5期 45-58,118页

作者：谢清果王婕厦门大学新闻传播学院福建厦门361001

水舟隐喻是西方媒介本体论的重要论断。本研究从概念隐喻理论出发,以《圣经》《山海经》《理想国》《周礼》等文本为语料,对灭世洪水与大禹治水、诺亚方舟与番禺制舟、圣人之舟与国家之船三组叙事进行对比分析,从媒介学的视角对人类文... 详细信息

水舟隐喻是西方媒介本体论的重要论断。本研究从概念隐喻理论出发,以《圣经》《山海经》《理想国》《周礼》等文本为语料,对灭世洪水与大禹治水、诺亚方舟与番禺制舟、圣人之舟与国家之船三组叙事进行对比分析,从媒介学的视角对人类文明轴心时代的“水舟”观念原型进行发生学考察。研究发现:“水”“舟”意象的渊源与所指在文明起源之初就已显露端倪,西方水舟的隐喻演进路径与华夏对水舟的认知路径呈现出援舟入水与水舟共生的差异,此差异中又隐含着对“媒介之‘中’”的理解差异,集中体现为中介性隐喻和连接性隐喻的区别。

关键词：水舟论媒介隐喻原型叙事华夏传播

Beneficial Effects of Traditional Chinese Medicine Fuzheng Huayu on the Occurrence of Hepatocellular Carcinoma in Patients with Compensated Chronic Hepatitis B Cirrhosis Receiving Entecavir:A Multicenter Retrospective Cohort Study

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Journal of Clinical and Translational Hepatology 2024年第5期12卷 505-515页

作者： Haina Fan Shujuan Lei Zhimin Zhao Yan Huang Hui Wang Xudong Liu Xiaodong Li Min Xu Wei Zhang Kewei Sun Huichun Xing Yang Mei Jiaquan Huang Chuanwu Zhu Kejun Zhang Yali Zong Xizhong Shen qing xie Chenghai Liu Institute of Liver Diseases Shanghai Key Laboratory of Traditional Chinese Clinical MedicineKey Laboratory of Liver and Kidney Diseases(Ministry of Education)Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Infectious Diseases Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanningGuangxiChina Institute of Liver Diseases Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Infectious Diseases Huaian Fourth People’s HospitalHuai’anJiangsuChina Institute of Liver Diseases Shijiazhuang Fifth HospitalShijiazhuangHebeiChina Department of Liver Diseases The First Hospital of Hunan University of Chinese MedicineChangshaHunanChina Center of Hepatology Capital Medical University Affiliated Beijing Ditan HospitalBeijingChina Department of Hepatology The Fifth People’s Hospital of AnyangAnyangHenanChina Department and Institute of Infectious Disease Tongji Hospital of Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiChina Department of Hepatology The Fifth People’s Hospital of SuzhouSuzhouJiangsuChina Department of Gastroenterology The First People’s Hospital of JingmenJingmenHubeiChina Department of Integrated Traditional and Western Medicine The Ninth Hospital of NanchangNanchangJiangxiChina Department of Gastroenterology Zhongshan HospitalFudan UniversityShanghaiChina

Background and Aims:The application of antifibrotic drugs to treat patients with chronic liver diseases who are receiving antiviral therapies for hepatocellular carcinoma(HCC)has not been ***,we aimed to assess the impact of the Traditional Chinese Medicine Fuzheng Huayu(FZHY)on the occurrence of HCC in patients with hepatitis B virus-related compensated cirrhosis receiving the antiviral drug entecavir(ETV).Methods:A multicenter retrospective cohort study was *** liver cirrhosis patients were divided into the ETV+FZHY group or the ETV group according to *** cumulative incidence of HCC was analyzed using Kaplan-Meier and log-rank *** score matching was used for confounding *** analysis and Cox regression were used to determine the effects of FZHY on the occurrence of HCC and liver function ***:Out of 910 chronic hepatitis B patients,458 were in the ETV+FZHY group and 452 were in the ETV *** propensity score matching,the 5-year cumulative incidence of HCC was 9.8%in the ETV+FZHY group and 21.8%in the ETV group(p36 ***,diabetes,alanine aminotransferase,􀇄-glutamyl transpeptidase,albumin,hepatitis B e-antigen,and fibrosis 4 score were associated with the occurrence of *** decreased the risk of HCC in patients aged>45 years with a hepatitis B virus DNA level of􀂕2,000 IU/***:Adjunctive FZHY treatment reduced HCC occurrence in patients with hepatitis B virus cirrhosis who were treated with ETV,possibly due to the antifibrotic properties of FZHY.

关键词： Entecavir Fuzheng Huayu Hepatitis B virus Cirrhosis Hepatocellular carcinoma Traditional Chinese Medicine