Beneficial Effects of Traditional Chinese Medicine Fuzheng Huayu on the Occurrence of Hepatocellular Carcinoma in Patients with Compensated Chronic Hepatitis B Cirrhosis Receiving Entecavir:A Multicenter Retrospective Cohort Study

作     者：Haina Fan Shujuan Lei Zhimin Zhao Yan Huang Hui Wang Xudong Liu Xiaodong Li Min Xu Wei Zhang Kewei Sun Huichun Xing Yang Mei Jiaquan Huang Chuanwu Zhu Kejun Zhang Yali Zong Xizhong Shen Qing Xie Chenghai Liu 

作者机构：Institute of Liver DiseasesShanghai Key Laboratory of Traditional Chinese Clinical MedicineKey Laboratory of Liver and Kidney Diseases(Ministry of Education)Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Infectious DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Infectious DiseasesRuikang Hospital Affiliated to Guangxi University of Chinese MedicineNanningGuangxiChina Institute of Liver DiseasesHubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Infectious DiseasesHuaian Fourth People’s HospitalHuai’anJiangsuChina Institute of Liver DiseasesShijiazhuang Fifth HospitalShijiazhuangHebeiChina Department of Liver DiseasesThe First Hospital of Hunan University of Chinese MedicineChangshaHunanChina Center of HepatologyCapital Medical University Affiliated Beijing Ditan HospitalBeijingChina Department of HepatologyThe Fifth People’s Hospital of AnyangAnyangHenanChina Department and Institute of Infectious DiseaseTongji Hospital of Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiChina Department of HepatologyThe Fifth People’s Hospital of SuzhouSuzhouJiangsuChina Department of GastroenterologyThe First People’s Hospital of JingmenJingmenHubeiChina Department of Integrated Traditional and Western MedicineThe Ninth Hospital of NanchangNanchangJiangxiChina Department of GastroenterologyZhongshan HospitalFudan UniversityShanghaiChina 

出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)

年 卷 期：2024年第12卷第5期

页      面：505-515页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Shanghai Key Specialty of Traditional Chinese Clinical Medicine(grant number shslczdzk01201) the National Science and Technology Major Project(grant number 2018ZX10302204) Shanghai University of Traditional Chinese Medicine(grant number ZYJK FW201811013) 

主　　题：Entecavir Fuzheng Huayu Hepatitis B virus Cirrhosis Hepatocellular carcinoma Traditional Chinese Medicine 

摘      要：Background and Aims:The application of antifibrotic drugs to treat patients with chronic liver diseases who are receiving antiviral therapies for hepatocellular carcinoma(HCC)has not been ***,we aimed to assess the impact of the Traditional Chinese Medicine Fuzheng Huayu(FZHY)on the occurrence of HCC in patients with hepatitis B virus-related compensated cirrhosis receiving the antiviral drug entecavir(ETV).Methods:A multicenter retrospective cohort study was *** liver cirrhosis patients were divided into the ETV+FZHY group or the ETV group according to *** cumulative incidence of HCC was analyzed using Kaplan-Meier and log-rank *** score matching was used for confounding *** analysis and Cox regression were used to determine the effects of FZHY on the occurrence of HCC and liver function ***:Out of 910 chronic hepatitis B patients,458 were in the ETV+FZHY group and 452 were in the ETV *** propensity score matching,the 5-year cumulative incidence of HCC was 9.8%in the ETV+FZHY group and 21.8%in the ETV group(p36 ***,diabetes,alanine aminotransferase,􀇄-glutamyl transpeptidase,albumin,hepatitis B e-antigen,and fibrosis 4 score were associated with the occurrence of *** decreased the risk of HCC in patients aged45 years with a hepatitis B virus DNA level of􀂕2,000 IU/***:Adjunctive FZHY treatment reduced HCC occurrence in patients with hepatitis B virus cirrhosis who were treated with ETV,possibly due to the antifibrotic properties of FZHY.