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NUMERICAL COMPUTATION OF PRESSURE GRADIENT FOR THE FLOW OF POWER-LAW FLUID IN ANNULUS WITH INNER CYLINDER EXECUTING A PLANETARY MOTION

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Journal of Hydrodynamics 2009年第5期21卷 699-704页

作者： CUI Hai-qing cai Meng ZHANG Shu-yun XIU De-yan Key Laboratory for Enhanced Oil and Gas Recovery of Ministry of Education Daqing Petroleum Institute Daqing 163318 China Exploration and Development Research Institute of Jidong Oilfield PetroChina Tangshan 063000 China

With the governing equations for the flow of the power-law fluid in annulus with the inner cylinder executing a planetary motion being transformed by using the undetermined coefficient method, the formula of pressure gradient for this flow under the given flow rate and the relevant numerical calculation method are given in this article. Through the experiments on the flow of Hydrolyzed Polyacrylamide （HPAM） aqueous solution which can be regarded as a power-law fluid, the calculated results of the pressure gradient values are compared with measured data, the mean relative error between them is smaller than 5%, which verifies the results presented in this article.

关键词： power-law fluid planetary motion annulus pressure gradient numerical calculation

IL-2Rα up-regulation is mediated by latent membrane protein 1 and promotes lymphomagenesis and chemotherapy resistance in natural killer/T-cell lymphoma

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Cancer Communications 2018年第1期38卷 667-676页

作者： Liang Wang Xi-wen Bi Yu-jia Zhu Ying-zhi He Qiu-yu Lai Zhong-jun Xia qing-qing cai Department of Hematology ZhuJiang HospitalSouthern Medical UniversityGuangzhou 510280GuangdongP.R.China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangzhou 510060GuangdongP.R.China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060Guang-dongP.R.China Department of Radiation Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Hematologic Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China

Background:Natural killer/T-cell lymphoma(NKTCL)is a highly aggressive non-Hodgkin lymphoma often resistant to *** level of soluble IL-2 receptorα(IL-2Rα)is elevated in NKTCL patients and correlates signifi-cantly with treatment response and *** the current study we examined the potential role of IL-2Rαby over-expressing IL-2Rαin representative cell ***:Levels of IL-2Rαwere evaluated in the human natural killer cell line NK-92 and the NKTCL cell line *** vectors were used to express latent membrane protein 1(LMP1)in NK-92 cells,and IL-2Rαin both NK-92 and SNK-6 *** biological effects of these genes on proliferation,apoptosis,cell cycle distribution,and chemosensitiv-ity were ***:Expression of IL-2Rαwas significantly higher in SNK-6 cells than in NK-92 *** LMP1 in NK-92 cells remarkably up-regulated IL-2Rαlevels,whereas selective inhibitorss of the proteins in the MAPK/NF-κB pathway significantly down-regulated IL-2Rα.IL-2Rαoverexpression in SNK-6 cells promoted cell proliferation by altering cell cycle distribution,and induced resistance to gemcitabine,doxorubicin,and *** effects were reversed by an anti-IL-2Rα***:Our results suggest that LMP1 activates the MAPK/NF-κB pathway in NKTCL cells,up-regulating IL-2Rα***-2Rαoverexpression promotes growth and chemoresistance in NKTCL,making this interleukin receptor a potential therapeutic target.

关键词： Natural killer/T-cell lymphoma Latent membrane protein 1 Epstein-Barr virus Interleukin-2 receptor alpha

Expression of SOCS-1 in the liver tissues of chronic hepatitis B and its clinical significance

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World Journal of Gastroenterology 2008年第4期14卷 607-611页

作者： Zhi-Xin Zhao qing-xian cai Xiao-Mou Peng Yu-Tian Chong Zhi-Liang Gao Department of Infectious Diseases of The ThirdAffiliated Hospital of Sun Yat-Sen University Guangzhou 510630Guangdong Province China

AIM： To study the expression of suppressor of cytokine signaling-1 （SOCS-1） in the liver tissues of chronic hepatitis 13 （CHB） and the clinical significance of this expression. METHODS： The expression of SOCS-1 in liver tissues of 45 cases of CHB was investigated by immunohistochemical staining, and its correlations with inflammation grades and fibrosis stage were analyzed by SPSS statistics software. RESULTS： The result showed SOCS-1 expressing could be observed in the liver tissue of CriB. The expression of SOCS-1 was mainly distributed near the portal area in the liver tissue of mild inflammation CriB group, and was diffusely distributed in the liver tissue of moderate and severe inflammation groups. SOCS-1 positive stains mainly appear in the hepatocytes, only a few of liver interstitial cells were involved. Inside the hepatocyte, SOCS-1 positive stains are mainly distributed in the plasma. Some of the staining was observed on the membrane. The inclusion bodies in the plasma of hepatocytes were observed occasionally. There were both obvious correlations between the expression of SOCS-1 and the inflammatory grade, and that between the expression of SOCS-1 and the fibrosis stage, CONCLUSION： The distribution of SOCS-1 in the liver tissue of CriB is variable. This expression was correlated with the inflammation grade and fibrosis stage.

关键词： Suppressor of cytokine signaling-I, Janus kinase-signal transducer and activator of transcription Chronic hepatitis B Inflammation Fibrosis

Preparation and Characterization of New Type Ionic Liquids

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Chinese Chemical Letters 2003年第5期14卷 523-524页

作者： qing Hai cai Yong Kui SHAN Li Yi DAI Bi Xia SU Ming Yuan HE Center for chemistry of ionic liquid East China Normal UniversityShanghai 200062

A new type of ionic liquids containing cation of diacetone acrylamide [or N-(1,1- bismethyl-3-oxo-butyl)acrylamide] and anions such as CH3COO- (Ac), CF3COO- (TF), BF4-(BF), PF6-(PF), HSO4-(SO) and Cl-(Cl) were prepared by normal neutralization. The obtained ionic liquids were identified by FT-IR and 1H NMR spectroscopy. However, their properties such as melting point, conductivity, viscosity etc. were determined.

关键词： Ionic liquid diacetone acrylamide preparation characterization.

New risk factors and new tendency for central nervous system relapse in patients with diffuse large B-cell lymphoma:a retrospective study

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Chinese Journal of Cancer 2016年第12期35卷 713-724页

作者： qing-qing cai Li-Yang Hu Qi-Rong Geng Jie Chen Zhen-Hai Lu Hui-Lan Rao qing Liu Wen-Qi Jiang Hui-Qiang Huang Tong-Yu Lin Zhong-Jun Xia State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuang-zhou 510060GuangdongP.R.China. Department of Medical Oncology Sun Yat-sen University Cancer Center651 Dongfeng Road EastGuang-zhou 510060GuangdongP.R.China. Department of Hematology Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China. Guangdong Province Key Laboratory of Arrhythmia and Elec-trophysiology Guangzhou 510120GuangdongP.R.China. Department of Radiotherapy Sun Yat-sen Memorial Hospital of Sun Yat-sen UniversityGuangzhou 510120GuangdongP.R.China. Department of Colorectal Carci-noma Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China. Department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China. Department of Cancer Preven-tion Research Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China.

Background: In patients with difuse large B?cell lymphoma(DLBCL), central nervous system(CNS) relapse is uncom?mon but is nearly always fatal. This study aimed to determine the risk factors for CNS relapse in DLBCL patients and to evaluate the eicacy of rituximab and intrathecal chemotherapy prophylaxis for CNS relapse ***: A total of 511 patients with newly diagnosed DLBCL treated at the Sun Yat?sen University Cancer Center between January 2003 and December 2012 were included in the study. Among these patients, 376 received R?CHOP regimen(rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) as primary treatment, and 135 received CHOP regimen(cyclophosphamide, doxorubicin, vincristine, and prednisone) as primary treatment. Intrathe?cal chemotherapy prophylaxis(methotrexate plus cytarabine) was administered to those who were deemed at high risk for CNS relapse. In the entire cohort and in the R?CHOP set in particular, the Kaplan–Meier method coupled with the log?rank test was used for univariate analysis, and the Cox proportional hazards model was used for multivariate analysis. Diferences were evaluated using a two?tailed test, and P 110 U/L(HR = 3.59, 95% CI 1.25–10.34), serum albumin(ALB) <35 g/L(HR = 3.63, 95% CI 1.25–10.51), treatment with rituxi?mab(HR = 0.34, 95% CI 0.12–0.96), and a time to complete remission ≤ 108 days(HR = 0.22, 95% CI 0.06–0.78) were independent p

关键词： Diffuse large B?cell lymphoma Central nervous system relapse Risk factor Rituximab Intrathecal chemotherapy prophylaxis

Full recovery from chronic headache and hypopituitarism caused by lymphocytic hypophysitis:A case report

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World Journal of Clinical Cases 2022年第3期10卷 1041-1049页

作者： Mao-Guang Yang Han-qing cai Si-Si Wang Lin Liu Chun-Mei Wang Department of Endocrinology The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Radiology The First Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina

BACKGROUND Lymphocytic hypophysitis(LYH)is an important condition to consider in the differential diagnosis of patients with a pituitary *** main clinical manifestations of LYH include headache,symptoms related to sellar compression,hypopituitarism,diabetes insipidus and ***,which is a frequent complaint of patients with LYH,is thought to be related to the occupying effect of the pituitary mass and is rapidly resolved with a good outcome after timely and adequate glucocorticoid treatment or *** SUMMARY Here,we report a patient with LYH whose initial symptom was headache and whose pituitary function assessment showed the presence of secondary hypoadrenalism,central hypothyroidism and hypogonadotropic *** magnetic resonance imaging showed symmetrical enlargement of the pituitary gland with suprasellar extension in a dumbbell shape with significant homogeneous enhancement after gadolinium *** size of the gland was approximately 17.7 mm×14.3 mm×13.8 *** pituitary stalk was thickened without deviation,and there was an elevation of the optimal *** lesion grew bilaterally toward the cavernous sinuses,and the parasternal dural caudal sign was *** patient presented with repeatedly worsening and prolonged headaches three times even though the hypopituitarism had fully resolved after glucocorticoid treatment during this *** This rare headache regression suggests that patients with chronic headaches should also be alerted to the possibility of LYH.

关键词： Lymphocytic hypophysitis Magnetic resonance imaging Hypopituitarism Headache Glucocorticoid Case report

Discussion on the Method of Land Quality Geochemical Evaluation Database : A Case Study of Diao Town and Xinzhai Town of Zhangqiu City

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Agricultural Biotechnology 2021年第2期10卷 107-112页

作者： qing cai Shandong Institute of Geological Survey Jinan250013China Land Quality Geochemistry and Pollution Prevevtion Engineering Technology Research Center of Shandong Province Jinan 250013China

The land quality geochemical evaluation database was mainly based on soil geochemical *** its construction process,geochemical survey data involving atmospheric dry(wet)sediments,irrigation water,fertilizers and crops was simultaneously collected,analyzed and compiled into result maps using *** was used to manage standardized result data to establish an evaluation *** database included a basic spatial database involving regional geography,topography,soil type and land use,a spatial evaluation database centered on the sampling layout of the work areas of soil,irrigation water,crops and other media,the distribution and changes of soil chemical elements,the classification of soil pollution and the classification of soil element environment and nutrients,and an evaluation database of various result maps such as land planning map,characteristic agricultural product planting plan suggestion map and fertilization suggestion *** database realized the scientific and effective management of the samples and corresponding numerous laboratory analysis data,and provides basic information for the geochemical survey and evaluation of the land quality in the evaluation areas and the overall comprehensive research,and an important basis for promoting the adjustment of agricultural economic planning,the development of modern green agriculture and the development and utilization of high-quality characteristic land resources.

关键词： Land quality Geochemical evaluation Database Zhangqiu City

Progress on AlGaN-based solar-blind ultraviolet photodetectors and focal plane arrays

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Light(Science & Applications) 2021年第6期10卷 976-1006页

作者： qing cai Haifan You Hui Guo Jin Wang Bin Liu Zili Xie Dunjun Chen Hai Lu Youdou Zheng Rong Zhang Key Laboratory of Advaneed Photonic and Electronic Materials School of Electronic Science and EngineeringNanjing UniversityNanjing 210093China Collaborative In novation Center for Optoelectronic Semiconductors and Efficient Devices Department of PhysicsXiamen UniversityXiamen 361005China lnstitute of Future Display Tech no logy Tan Kah Kee Inno vati on LaboratoryXiamen 361102China

Solar-blind ultraviolet(UV)photodetectors(PDs)have attracted tremendous attention in the environmental,industrial,military,and biological *** a representative Ill-nitride material,AlGaN alloys have broad development prospects in the field of solar-blind detection due to their superior properties,such as tunable wide bandgaps for intrinsic UV *** recent decades,a variety of AlGaN-based PDs have been developed to achieve high-precision solar-blind UV *** integrated optoelectronic technology advances,AlGaN-based focal plane arrays(FPAs)are manufactured and exhibit outsta nding solar-blind imaging *** sidering the rapid development of AlGaN detection techniques,this paper comprehensively reviews the progress on AlGaN-based solar-blind UV PDs and ***,the basic physical properties of AlGaN are *** epitaxy and p-type doping problems of AlGaN alloys are then *** PDs,including photoconductors and Schottky,metal-semiconductor-metal(MSM),p-i-n,and avalanche photodiodes(APDs),are dem on strated,and the physical mechanisms are analyzed to improve device ***,this paper summarizes imaging technologies used with AlGaN FPAs in recent ***!ng from the development of AlGaN materials and optoelectronic devices,solar-blind UV detection technology is greeted with significant revolutions.

关键词： optoelectronic arrays ultraviolet

BRD2 induces drug resistance through activation of the RasGRP1/Ras/ERK signaling pathway in adult T-cell lymphoblastic lymphoma

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Cancer Communications 2020年第6期40卷 245-259页

作者： Xiao-Peng Tian Jun cai Shu-Yun Ma Yu Fang Hui-Qiang Huang Tong-Yu Lin Hui-Lan Rao Mei Li Zhong-Jun Xia Tie-Bang Kang Dan Xie qing-qing cai State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Pathology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Hematology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China

Background:Adult patients with T-cell lymphoblastic lymphoma(T-LBL)are treated with high-intensity chemotherapy regimens,but the response rate is still unsatisfactory because of frequent drug *** aimed to investigate the potential mechanisms of drug resistance in adults with ***:Gene expression microarray was used to identify differential mRNA expression profiles between chemotherapy-resistant and chemotherapy-sensitive adult T-LBL ***-time PCR and immunohistochemistry were performed to detect the expression of bromodomain-containing protein 2(BRD2)and c-Myc in fresh-frozen T-LBL tissues from 85 adult *** Ras pull-down assay was performed to monitor Ras *** immunoprecipitation assays were used to analyze the binding of E2F transcription factor 1(E2F1)/BRD2 to the RAS guanyl releasing protein 1(RasGRP1)promoter *** drug resistance effect and mechanism of BRD2 were determined by both in vivo and in vitro ***:A total of 86 chemotherapy resistance-related genes in adult T-LBL were identified by gene expression *** them,BRD2 was upregulated in chemotherapy-resistant adult T-LBL tissues and associated with worse progressionfree survival and overall survival of 85 adult T-LBL ***,BRD2 suppressed doxorubicin(Dox)-induced cell apoptosis both in vitro and in *** activation of RasGRP1/Ras/ERK signaling might contribute to the Dox resistance effect of ***,OTX015,a bromodomain and extra-terminal(BET)inhibitor,reversed the Dox resistance effect of ***-derived tumor xenograft demonstrated that the sequential use of OTX015 after Dox showed superior therapeutic ***:Our data showed that BRD2 promotes drug resistance in adult T-LBL through the RasGRP1/Ras/ERK signaling *** BRD2 may be a novel strategy to improve the therapeutic efficacy and prolong survival of adults with TLBL.

关键词： T-cell Lymphoblastic Lymphoma drug resistance BRD2 MEK ERK c-Myc RasGRP1 doxorubicin OTX015 sequential treatment simultaneous treatment