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Adiponectin and metabolic cardiovascular diseases:Therapeutic opportunities and challenges

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Genes & Diseases 2023年第4期10卷 1525-1536页

作者： Xiaotian Lei Sheng Qiu Gangyi Yang qinan wu Endocrinology Department The Second Affiliated Hospital of the Chongqing Medical UniversityChongqing 400000China Endocrinology Department The First Affiliated Hospital of the Army Medical UniversityChongqing 400038China Endocrinology Department Dazu Hospital of Chongqing Medical UniversityThe People’s Hospital of DazuChongqing 402360China

Metabolic cardiovascular diseases have become a global health concern,and some of their risk factors are linked to several metabolic *** are the leading causes of death in developing *** tissues secrete a variety of adipokines that participate in regulating metabolism and various pathophysiological *** is the most abundant pleiotropic adipokine and can increase insulin sensitivity,improve atherosclerosis,have anti-inflammatory properties,and exert a cardioprotective *** adiponectin con-centrations are correlated with myocardial infarction,coronary atherosclerotic heart disease,hypertrophy,hypertension,and other metabolic cardiovascular ***,the relationship between adiponectin and cardiovascular diseases is complex,and the specific mechanism of action is not fully *** summary and analysis of these issues are ex-pected to contribute to future treatment options.

关键词： Adipokine Adiponectin Inflammation Metabolic cardiovascular disease Obesity

Autophagic dysfunction of β cell dysfunction in type 2 diabetes,a double-edged sword

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Genes & Diseases 2021年第4期8卷 438-447页

作者： Ding Yao Yang GangYi wu qinan Endocrinology and Nephrology Department Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer HospitalChongqing400030PR China Endocrinology Department The Second Affiliated Hospital of the Chongqing Medical UniversityChongqing400010PR China

Diabetes is an age-related disease,most of which is type 2 diabetes,and islet β cell dysfunction and insulin resistance are the main mechanisms of type 2 *** studies have revealed that autophagy plays an important role in maintaining the structure and func-tion of islet beta cells and inhibiting insulin resistance and apoptosis induced by oxidative *** this review,we discussed the positive and negative effects of autophagy and its dysfunction on type 2 diabetes mellitus,which is the so-called double-edged sword,analysed its possible mechanism,and identifed possible research hot spots.

关键词： Apoptosis Autophagic dysfunction Insulin resistance Islet beta cell dysfunction Type 2 diabetes mellitus

基于COI条形码的市售蝉蜕及其混淆品DNA分子鉴定研究

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中草药 2024年第6期55卷 2057-2065页

作者：张欢欢徐金娣周静贾聪玲吴啟南郭梦斐沈纪晨伍城颖李松林毛茜南京中医药大学附属中西医结合医院中药质量研究室江苏南京210028 江苏省中医药研究院/中国中医科院江苏分院中药代谢组研究室江苏南京210028 南京中医药大学药学院江苏南京210023

目的利用COI序列对中药材蝉蜕Cicadae Periostracum及其混淆品进行DNA条形码鉴定研究,为蝉蜕药材的快速准确鉴定提供新的技术手段。方法收集全国市售蝉蜕药材、基地自采蝉蜕及其混淆品总45份样本,同时采集江苏徐州黑蚱养殖基地不同树种... 详细信息

目的利用COI序列对中药材蝉蜕Cicadae Periostracum及其混淆品进行DNA条形码鉴定研究,为蝉蜕药材的快速准确鉴定提供新的技术手段。方法收集全国市售蝉蜕药材、基地自采蝉蜕及其混淆品总45份样本,同时采集江苏徐州黑蚱养殖基地不同树种中蝉卵样品5份作为对照。提取DNA,进行PCR扩增及双向测序,测序结果采用DNAMAN和SnapGene进行拼接校对,运用MEGA11.0进行比对分析,计算种内及种间Kimura 2-Parameter(K2P)遗传距离并构建邻接法(neighbor-joining,NJ)系统发育树。结果黑蚱种内遗传距离远小于种间最小遗传距离,NJ树结果显示,黑蚱蝉蜕样品全部聚集为独立的一支,支持率为99%。混淆品样品分别聚集为单独的一支,支持率均大于90%,表明基于COI序列的DNA条形码技术可以有效鉴别蝉蜕药材真伪。结论应用COI序列作为DNA条形码能够准确有效地鉴别蝉蜕及其混淆品。

关键词：蝉蜕混淆品 DNA条形码 COI序列分子鉴定

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单宁酸增强水凝胶的制备及其性能

林业工程学报 2024年第4期9卷 87-92页

作者：吴启楠康希彤刘珍珍刘焕生赵喜阳刘涛王清文华南农业大学生物质工程研究院农业农村部能源植物资源与利用重点实验室广州510642 华南农业大学材料与能源学院生物基材料与能源教育部重点实验室广州510642 华南农业大学食品学院广州510642

单宁酸(TA)作为一种典型的农林生物质多酚,具有抗菌、抗氧化、抗紫外、生物相容性好等优点。水凝胶是一种具有三维交联网络结构的湿软材料,但传统的水凝胶存在机械性能较差、不具备黏附性等问题,很大程度上限制了其应用。TA分子上的苯... 详细信息

单宁酸(TA)作为一种典型的农林生物质多酚,具有抗菌、抗氧化、抗紫外、生物相容性好等优点。水凝胶是一种具有三维交联网络结构的湿软材料,但传统的水凝胶存在机械性能较差、不具备黏附性等问题,很大程度上限制了其应用。TA分子上的苯三酚和儿茶酚基团会以氢键、π-π相互作用、疏水相互作用等方式与聚合物形成物理交联,从而提升水凝胶的机械性能与黏附性。以甘氨酸(Gly)为原料合成聚合单体N-丙烯酰基-2-甘氨酸(ACG),引入TA作为物理交联剂,成功制备单宁酸增强聚甘氨酸水凝胶,并测试分析其力学、黏附、电导率以及应变传感性能。研究结果表明,TA的引入使水凝胶交联网络更加致密,其应力逐渐增大,韧性值、黏附能则是呈现先增大后减小的规律。当TA/ACG质量比为1∶100时,制备的单宁酸增强水凝胶综合性能最优,断裂拉伸应变达到162%,应力为196 kPa,韧性值为143 kJ/m^(3),电导率为1.48 mS/cm,对猪皮的黏附能达到17.68 kPa,且对不同基材具备黏附性能。因此,TA的引入有效增强了水凝胶网络,使其力学、黏附等性能均得到提升。将制备的单宁酸增强水凝胶组装成柔性电阻式传感器,该传感器对水凝胶的形变具有较好的灵敏度,实现了将手指、手肘等运动信号转变为稳定的电信号。本研究为开发绿色可持续、自黏附的生物基柔性电子传感器件提供了一种十分有前景的策略。

关键词：单宁酸水凝胶制备方法机械性能黏附性能

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Inwardly rectifying potassium channel 5.1:Structure,function,and possible roles in diseases

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Genes & Diseases 2021年第3期8卷 272-278页

作者： Junhui Zhang Jian Han Lingfei Li Qiong Zhang Yanhai Feng Youzhao Jiang Fang Deng Yuping Zhang qinan wu Bing Chen Jiongyu Hu Institute of Burn Research Southwest HospitalThird Military Medical University(Army Medical University)Chongqing400038PR China State Key Laboratory of Trauma Burns and Combined InjurySouthwest HospitalThird Military Medical University(Army Medical University)Chongqing400038PR China Department of Obstetrics and Gynecology Daping HospitalThird Military Medical University(Army Medical University)Chongqing400042PR China Department of Dermatology Daping HospitalThird Military Medical University(Army Medical University)Chongqing400042PR China Department of Endocrinology People’s Hospital of Banan DistrictChongqing401320PR China Department of Endocrinology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing400038PR China Department of Endocrinology Chongqing Cancer Hospital(Chongqing University Cancer Hospital)Chongqing40030PR China

Inwardly rectifying potassium(Kir)channels make it easier for K^(+)to enter into a cell and subsequently regulate cellular biological ***5.1(encoded by KCNJ16)alone can form a homotetramer and can form heterotetramers with Kir4.1(encoded by KCNJ10)or Kir4.2(encoded by KCNJ15).In most cases,homomeric Kir5.1 is non-functional,while hetero-meric Kir5.1 on the cell membrane contributes to the inward flow of K^(+)ions,which can be regulated by intracellular pH and a variety of signaling *** the form of a heterotetramer,Kir5.1 regulates Kir4.1/4.2 activity and is involved in the maintenance of nephron ***,homomeric Kir5.1 may also play a very important role in diseases,including in the ventilatory response to hypoxia and hypercapnia,hearing impairment,cardio-vascular disease and *** an increase in the number of studies into the roles of Kir channels,researchers are paying more attention to the pathophysiological functions of *** minireview provides an overview regarding these Kir5.1 roles.

关键词： Cancer Cardiovascular disease Cochlea Kir5.1 heterotetramer Ventilatory response

Evaluation of the physicochemical properties and antioxidant activities of polysaccharides from Semen Euryales

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Journal of Chinese Pharmaceutical Sciences 2014年第8期23卷 578-587页

作者：陈蓉薛满陈伟吴启南苏州市食品药品检验所江苏苏州215104 苏州市中医医院江苏苏州215009 南京中医药大学江苏省中药方剂重点实验室江苏南京210046

Polysaccharides were isolated from Semen Euryales by water extraction, alcohol precipitation and deproteinization. A refined polysaccharide, named EPJ, was separated into nine fractions by DEAE-52 cellulose chromatography and one of them was separated into two fractions by Sephadex G-100 column. The molecular weight of EPJ was determined to 15 367 Da and the monosaccharide composition was mainly glucose and rhamnose with the molar ratio of 5.46：1. The FT-IR spectra showed carbohydrate-related absorbance of polysaccharide functional groups. In vitro assay showed EPJ could significantly scavenge DPPH radical, superoxide anion, hydrogen peroxide and exhibited a strong reducing power. In vivo assay indicated that EPJ was effective in a D-galactose induced aging mice model. Results showed EPJ significantly inhibited formation of MDA and increased the activities of SOD, CAT, GSH-Px in a dose-dependent manner in mice tissues. The findings obtained from this study indicated that polysaccharides from Semen Euryales could be explored for a wide prospect of benefit.

关键词： Semen Euryales Polysaccharide Physicochemical properties Antioxidant activities

法国内分泌协会关于免疫治疗的内分泌副反应指导意见解读

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重庆医科大学学报 2019年第12期44卷 1529-1534,F0002页

作者：吴绮楠重庆大学附属肿瘤医院内分泌肾脏病科

由于免疫检查点抑制剂(immune checkpoint inhibitor,ICPI)在临床上使用频率增高及适应证不断扩展,对于内分泌及肿瘤医师来说,应该知道如何去诊断和治疗ICPI内分泌方面的副反应。鉴于此,法国内分泌学会起草了关于免疫治疗相关内分泌副... 详细信息

由于免疫检查点抑制剂(immune checkpoint inhibitor,ICPI)在临床上使用频率增高及适应证不断扩展,对于内分泌及肿瘤医师来说,应该知道如何去诊断和治疗ICPI内分泌方面的副反应。鉴于此,法国内分泌学会起草了关于免疫治疗相关内分泌副反应的指导意见。该指导意见介绍了关于ICPI内分泌副反应的研究进展,并就ICPI导致内分泌副反应的筛查、管理、监控方法提出共识意见。本文就该指导意见作一解读。

关键词：免疫治疗免疫检查点抑制剂内分泌副反应

A chromosome-level genome assembly reveals that a bipartite gene cluster formed via an inverted duplication controls monoterpenoid biosynthesis in Schizonepeta tenuifolia

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Molecular Plant 2023年第3期16卷 533-548页

作者： Chanchan Liu Samuel J.Smit Jingjie Dang Peina Zhou Grant T.Godden Zheng Jiang wukun Liu Licheng Liui Wei Lin Jinao Duan qinan wu Benjamin R.Lichman School of Pharmacy Nanjing University of Chinese MedicineNanjingChina Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization Nanjing University of Chinese MedicineNanjingChina Centre for Novel Agricultural Products Department of BiologyUniversity of YorkYork YO105DDUK Florida Museum of Natural History University of FloridaGainesileFLUSA Department of Pathogen Biology School of Medicine and Holistic Integrative MedicineNanjing University of Chinese MedicineNanjngChina

Biosynthetic gene clusters(BGCs)are regions of a genome where genes involved in a biosynthetic pathway are in *** origin and evolution of plant BGCs as well as their role in specialized metabolism remain largely *** this study,we have assembled a chromosome-scale genome of Japanese catnip(Schizonepeta tenuifolia)and discovered a BGC that contains multiple copies of genes involved in four adjacent steps in the biosynthesis of p-menthane *** BGC has an unprecedented bipartite structure,with mirrored biosynthetic regions separated by 260 *** bipartite BGC includes identical copies of a gene encoding an old yellow enzyme,a type of flavin-dependent *** vitro assays and virus-induced gene silencing revealed that this gene encodes the missing isopiperitenone *** enzyme evolved from a completely different enzyme family to isopiperitenone reductase from closely related Mentha spp.,indicating convergent evolution of this pathway *** analysis revealed that this bipartite BGC has emerged uniquely in the *** lineage and through insertion of pathway genes into a region rich in monoterpene *** cluster gained its bipartite structure via an inverted *** discovered bipartite BGC for p-menthane biosynthesis in *** has similarities to the recently described duplicated p-menthane biosynthesis gene pairs in the Mentha longifolia genome,providing an example of the convergent evolution of gene *** work expands our understanding of plant BGCs with respect to both form and evolution,and highlights the power of BGCs for gene discovery in plant biosynthetic pathways.

关键词： specialized metabolism monoterpenoids biosynthetic gene cluster Lamiaceae biosynthesis chromosomal inversion

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儿童文学是一种保守的文学?

吉首大学学报（社会科学版） 2019年第5期40卷 110-115页

作者：吴其南温州大学人文学院

成人看儿童和儿童文学类似殖民者看殖民地的人民和文化。成人为了确证自己文明、理性的现代人身份而创造了具有野蛮、幼稚、不文明、未开化等特征的原始人/乡野人/儿童这个他者形象,以将自己和他们、自己的文学和他们的文学区分开来,这... 详细信息

成人看儿童和儿童文学类似殖民者看殖民地的人民和文化。成人为了确证自己文明、理性的现代人身份而创造了具有野蛮、幼稚、不文明、未开化等特征的原始人/乡野人/儿童这个他者形象,以将自己和他们、自己的文学和他们的文学区分开来,这自然赋予儿童文学某种保守性质。保守于儿童文学并非都是负面的。现代“并喻社会”“后喻社会”的到来也为儿童文学挣脱保守主义的羁绊提供了契机。

关键词：儿童文学审美保守主义儿童文学理论