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血清尿酸水平与脑血管病因果关系的双向两样本孟德尔随机化研究

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实用临床医药杂志 2025年第1期29卷 66-72页

作者：韩秀燕许华张沁丽长治医学院附属和平医院神经内科山西长治046000 长治医学院研究生院山西长治046000

目的采用两样本双向孟德尔随机化(MR)研究评估血清尿酸(SUA)水平与脑血管病(CVD)的因果关联。方法从全基因组关联研究(GWAS)中获取两样本的单核苷酸多态性(SNPs)作为工具变量。以逆方差加权法(IVW)为主要方法,以加权中位数法、加权模... 详细信息

目的采用两样本双向孟德尔随机化(MR)研究评估血清尿酸(SUA)水平与脑血管病(CVD)的因果关联。方法从全基因组关联研究(GWAS)中获取两样本的单核苷酸多态性(SNPs)作为工具变量。以逆方差加权法(IVW)为主要方法,以加权中位数法、加权模式方法和MR-Egger回归作为补充,进行敏感性分析以验证结果的稳健性。结果正向IVW分析结果显示,SUA升高是中风(OR=1.183, 95%CI:1.081~1.295,P=2.51×10^(-4))、缺血性卒中(OR=1.196, 95%CI:1.084~1.320,P=3.81×10^(-4))、大动脉粥样硬化性卒中(OR=1.466, 95%CI:1.134~1.897,P=0.004)的危险因素,是血管性痴呆(OR=0.451, 95%CI:0.273~0.745,P=0.002)、多发梗死性痴呆(OR=0.372, 95%CI:0.144~0.959,P=0.041)的保护因素。反向IVW分析结果则不支持基因预测的CVD风险对SUA水平存在因果影响。所有显著性结果均经Bonferroni校正P<0.005。敏感性分析进一步证实了本研究结果的可靠性。结论 MR分析显示,SUA水平升高与中风、缺血性卒中、大动脉粥样硬化性卒中的发病风险呈正相关,与血管性痴呆、多发梗死性痴呆的发病风险呈负相关。

关键词：血清尿酸脑血管病孟德尔随机化分析双向因果关联全基因组关联研究

EFFECTS OF THE TAILINGS POSITION IN TAILINGS POND ON THE STRENGTH OF FILL

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中国有色金属学会会刊：英文版 1995年第3期5卷 13-15页

作者： qinli, Zhang Xucheng, Peng Xinmin, Wang Niankai, Ouyang Central South Univ of Technology Changsha China

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关键词： tailings position tailings pond strength of the fill

COST REDUCTION OF CEMENTING FILL IN KANGJIAWAN MINE

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中国有色金属学会会刊：英文版 1997年第1期7卷 6-8页

作者： Wang, Xinmin Zhang, qinli Chen, Changmin Li, Yanping Central South Univ of Technology Changsha China

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关键词： fill cost cement consumption continuous filling time cementing rockfill

Attribute Reduction of Hybrid Decision Information Systems Based on Fuzzy Conditional Information Entropy

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Computers, Materials & Continua 2024年第5期79卷 2063-2083页

作者： Xiaoqin Ma Jun Wang Wenchang Yu qinli Zhang School of Big Data and Artificial Intelligence Chizhou UniversityChizhou247000China Anhui Education Big Data Intelligent Perception and Application Engineering Research Center Chizhou247000China

The presence of numerous uncertainties in hybrid decision information systems(HDISs)renders attribute reduction a formidable *** available attribute reduction algorithms,including those based on Pawlak attribute importance,Skowron discernibility matrix,and information entropy,struggle to effectively manages multiple uncertainties simultaneously in HDISs like the precise measurement of disparities between nominal attribute values,and attributes with fuzzy boundaries and abnormal *** order to address the aforementioned issues,this paper delves into the study of attribute reduction *** of all,a novel metric based on the decision attribute is introduced to solve the problem of accurately measuring the differences between nominal attribute *** newly introduced distance metric has been christened the supervised distance that can effectively quantify the differences between the nominal attribute ***,based on the newly developed metric,a novel fuzzy relationship is defined from the perspective of“feedback on parity of attribute values to attribute sets”.This new fuzzy relationship serves as a valuable tool in addressing the challenges posed by abnormal attribute ***,leveraging the newly introduced fuzzy relationship,the fuzzy conditional information entropy is defined as a solution to the challenges posed by fuzzy *** effectively quantifies the uncertainty associated with fuzzy attribute values,thereby providing a robust framework for handling fuzzy information in hybrid information ***,an algorithm for attribute reduction utilizing the fuzzy conditional information entropy is *** experimental results on 12 datasets show that the average reduction rate of our algorithm reaches 84.04%,and the classification accuracy is improved by 3.91%compared to the original dataset,and by an average of 11.25%compared to the other 9 state-of-the-art reduction *** comprehensive analysis o

关键词： Hybrid decision information systems fuzzy conditional information entropy attribute reduction fuzzy relationship rough set theory(RST)

Characteristics of Hydrogen Storage Alloy Mg_2Ni Produced by Hydriding Combustion Synthesis

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Journal of Materials Science & Technology 2004年第2期20卷 209-212页

作者： QianLI qinli LijunJIANG Kou-chihCHOU FengZHAN QiangZHENG ResearchCenterofEnergyMaterialsandTechnology GeneralResearchInstituteforNonferrousMetalBeijing100088China DepartmentofPhysicalChemistry UniversityofScienceandTechnologyBeijingBeijing100083China

A high activity and large capacity of hydrogen storage alloy Mg2Ni by hydriding combustion synthesis was investigated by means of pressure composition isotherms, X-ray diffraction and scanning electron microscopy. The results showed that the maximum hydrogen absorption capacity of Mg2Ni is 3.25 mass fraction at 523 K, just after synthesis without any activation. The relationships between the equilibrium plateau pressure and the temperature for Mg2Ni were lgp (0.1 MPa)=-3026/T+5.814 (523 K≤T≤623 K) for hydriding and Igp (0.1 MPa)=-3613/T+6.715 (523 K≤T ≤623 K) for dehydriding. The kinetic equation is [-ln(1-a)]3/2 = kt and the apparent activation energy for the nucleation and growth-controlled hydrogen absorption and desorption were determined to be 64.3±2.31kJ/(mol.H2) and 59.9±2.99kJ/(mol.H2)respectively.

关键词： Hydriding combustion Mg2Ni Hydrogen storage property Apparent activation energy

Rheological and physicomechanical properties of rod milling sand-based cemented paste backfill modified by sulfonated naphthalene formaldehyde condensate

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International Journal of Minerals,Metallurgy and Materials 2023年第2期30卷 225-235页

作者： qinli Zhang Hao Wu Yan Feng Daolin Wang Huaibin Su Xiaoshuang Li School of Resource and Safety Engineering Central South UniversityChangsha 410083China School of Civil Engineering Shaoxing UniversityShaoxing 312000China

Rod milling sand(RMS)—a coarse sand aggregate—was recycled for cemented paste backfill(CPB)for the underground mined area at the Jinchuan nickel deposit,named rod milling sand-based cemented paste backfill(RCPB).The adverse effects of coarse particles on the transportation of CPB slurry through pipelines to underground stopes resulting in weakening of the stability of the backfill system are well ***,sulfonated naphthalene formaldehyde(SNF)condensate was used for the performance improvement of *** synergistic effect of solid content(SC),lime-to-sand ratio,and SNF dosage on the rheological and physicomechanical properties,including slump,yield stress,bleeding rate,uniaxial compressive strength(UCS),as well as mechanism analysis of RCPB,have been *** results indicate that the effect of SNF on RCPB performance is related to the SNF dosage,lime-to-sand ratio,and *** slump of fresh RCPB with 0.1wt%-0.5wt%SNF increased by 2.6%-26.2%,whereas the yield stress reduced by 4.1%-50.3%,indicating better workability and improved cohesiveness of the *** bleeding rate of fresh RCPB decreased first and then rose with the increase of SNF dosage,and the peak decrease was 67.67%.UCS of RCPB first increased and then decreased with the increase of SNF *** the optimal SNF addition ratio of 0.3wt%,the UCS of RCPB curing for 7,14 and,28 d ages increased by 31.5%,28.4%,and 29.5%,*** beneficial effects of SNF in enhancing the early UCS of RCPB have been ***,the later UCS increases at a slower *** research findings may guide the design and preparation of RCPB with adequate performance for practical applications.

关键词： rod milling sand sulfonated naphthalene formaldehyde condensate cemented paste backfill rheological properties physicomechanical properties

基于胚珠诱导培育的非洲菊双单倍体花序遗传表现

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北方园艺 2025年第1期 1-7页

作者：单芹丽杨春梅吴丽芳吴旻卢珍红李绅崇云南省农业科学院花卉研究所云南省花卉育种重点实验室云南昆明650205 玉溪云星生物科技有限公司云南玉溪652604

以非洲菊品种及其胚珠诱导培育的双单倍体为试验材料,采用田间完全随机排列方法,对开花植株的花色、花序类型和花心颜色进行观测,解析非洲菊的花序遗传表现,以期为非洲菊定向育种的亲本选择提供参考依据。结果表明:非洲菊的花色和花心... 详细信息

以非洲菊品种及其胚珠诱导培育的双单倍体为试验材料,采用田间完全随机排列方法,对开花植株的花色、花序类型和花心颜色进行观测,解析非洲菊的花序遗传表现,以期为非洲菊定向育种的亲本选择提供参考依据。结果表明:非洲菊的花色和花心表现为偏母性遗传趋势,其中红色品种的后代双单倍体植株花色和母本植株一致的概率达95%以上,花心颜色与母本植株一致的概率达55%以上;单瓣品种后代双单倍体植株的花序类型偏母性遗传倾向明显,和母本植株一致的概率达90%以上;重瓣和半重瓣品种后代双单倍体植株的花序类型未表现出明显的偏母性遗传倾向,和母本植株一致的概率不到35%。

关键词：非洲菊双单倍体育种遗传

Erosion wear at the bend of pipe during tailings slurry transportation:Numerical study considering inlet velocity,particle size and bend angle

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International Journal of Minerals,Metallurgy and Materials 2023年第8期30卷 1608-1620页

作者： Qiusong Chen Hailong Zhou Yunmin Wang Daolin Wang qinli Zhang Yikai Liu School of Resources and Safety Engineering Central South UniversityChangsha 410083China Sinosteel Maanshan General Institute of Mining Research Co. Ltd.Maanshan 243000China Department of Geosciences University of Padova35131 PadovaItaly

Pipeline hydraulic transport is a highly efficient and low energy-consumption method for transporting solids and is commonly used for tailing slurry transport in the mining *** wear(EW)remains the main cause of failure in tailings slurry pipeline systems,particularly at *** is a complex phenomenon influenced by numerous factors,but research in this area has been *** study performs numerical simulations of slurry transport at the bend by combining computational fluid dynamics and fluid particle tracking using a wear *** on the validation of the feasibility of the model,this work focuses on the effects of coupled inlet velocity(IV)ranging from 1.5 to 3.0 m·s^(-1),particle size(PS)ranging from 50 to 650μm,and bend angle(BA)ranging from 45°to 90°on EW at the bend in terms of particle kinetic energy and incidence *** results show that the maximum EW rate of the slurry at the bend increases exponentially with IV and PS and first increases and then decreases with the increase in BA with the inflection point at 60°within these parameter *** comprehensive analysis reveals that the sensitivity level of the three factors to the maximum EW rate is PS>IV>BA,and when IV is 3.0 m/s,PS is 650μm,and BA is 60°,the bend EW is the most severe,and the maximum EW rate is 5.68×10^(-6)kg·m^(-2)·s^(-1).In addition,When PS is below or equal to 450μm,the maximum EW position is mainly at the outlet of the *** PS is greater than 450μm,the maximum EW position shifts toward the center of the bend with the increase in ***,EW at the bend can be reduced in practice by reducing IV as much as possible and using small particles.

关键词： tailings transportation erosion wear pipe wear CFD numerical simulation

Immunolocalization of Arabinogalactan Proteins and Pectins in Floral Buds of Cucumber （Cucumis sativus L.） During Sex Determination

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Journal of Integrative Plant Biology 2005年第2期47卷 194-200页

作者： Yi-BenPENG ChengZOU Hua-QinGONG Shu-NongBAI Zhi-HongXU Yi-qinli PekingUniversity-YaleJointResearchCenterofAgriculturalandPlantMolecularBiology CollegeofLifeSciencesPekingUniversityBeijing100871China ProteinScienceLaboratoryoftheMinistryofEducation SchoolofLifeSciencesandEngineeringTsinghuaUniversityBeijing100084China

Abstract: Arabinogalactan proteins (AGPs) and pectins were detected in the floral buds of cucumber (Cucumis sativus L.) during its sex determination using the following monoclonal antibodies: MAC 207 (recognizes AGP epitopes); JIM 8 (recognizes a subset of AGP epitopes); and JIM 5 and JIM 7 (epitopes of pectins esterified to various degrees). In the stem apex meristem (SAM) of the cucumber, epitopes of MAC 207, JIM 7, and JIM 5 were localized in the cells from second to third peripheral layers when the sex organ primodium began to differentiate; epitopes of MAC 207 and JIM 5 were also detected in the ragged edge cells. A very dense labeling signal with MAC 207 was observed in the carpel and pistil primodium. The AGP epitopes recognized by JIM 8 were localized in the anther of the male flower and the anther-like portion of the stagnant stamen of the female flower. This suggests that the AGPs and pectins in the SAM of the cucumber are closely associated with the differentiation of the SAM, from meristematic cells to floral primodium. The subset of AGPs recognized by JIM 8 may play an important role in stamen formation.

关键词： arabinogalactan proteins cucumber (Cucumis sativus L.) floral buds immunolocalization pectins