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Improved survival ratios correlate with myeloid dendritic cell restoration in acute-on-chronic liver failure patients receiving methylprednisolone therapy

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Cellular & Molecular Immunology 2012年第5期9卷 417-422页

作者： Juan Zhao Ji-Yuan Zhang Hong-wei Yu Yu-Lan He Jing-Jing Zhao Juan Li Yue-Ke Zhu qin-wei yao Jin-Huan Wang Hai-Xia Liu Shu-Yun Shi Zheng-Sheng Zou Xiang-Sheng Xu Chun-Bao Zhou Fu-Sheng Wang qing-Hua Meng Department of Hepatology Beijing You An HospitalCapital Medical UniversityBeijingChina Research Center for Biological Therapy The Institute of Translational HepatologyBeijing 302 HospitalBeijingChina Department of Infectious Disease Beijing 302 HospitalBeijingChina juan Zhao and Ji-Yuan Zhang contributed equally to this work.

Acute-on-chronic liver failure （ACLF） is a severe life-threatening complication. Liver transplantation is the only available therapeutic option; however, several limitations have restricted its use in patients. The use of corticosteroids as an optional therapy for ACLF has received a great deal of interest. The rationale behind its use is the possible role of the immune system in initiating and perpetuating hepatic damage. In order to assess the relationship between myeloid dendritic cells （mDCs） and the efficacy of methylprednisolone （MP） treatment for hepatitis B virus （H BV）-associated ACLF patients, we recruited 30 HBV-associated ACLF patients who had received MP treatment at lO-day intervals; 26 patients received conservative medical （CM） management as a control. The functionality of DC subsets was lower in these ACLF patients compared with healthy subjects. In addition, compared with survivors, dead/transplanted patients had lower functional mDC in both groups. Furthermore, a decreased numbers of mDC at baseline was associated with high mortality of ACLF patients. Importantly, MP treatment resulted in a significant decrease in 28-day mortality, and all MP patients exhibited an initial rapid decrease in circulating mDC numbers within 10 days of MP treatment. Subsequently, MP survivors displayed a continuous increase in mDC numbers accompanied by a decrease in total bilirubin levels by more than 30%. However, MP dead/ transplanted patients lacked these sequential responses compared with survivors. This evidence suggests strongly that the higher mDC numbers at baseline and the recovery of mDC number at the end of treatment may represent a prognostic marker for favorable response to corticosteroid treatment in ACLF patients.

关键词： acute-on-chronic liver failure methylprednisolone myeloid dendritic cells plasmacytoid dendritic cells

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河南省工业企业创新绩效及影响因素分析

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人文地理 2017年第2期32卷 118-121,160页

作者：安士伟秦耀辰郑州轻工业学院经济与管理学院郑州450002 河南大学环境与规划学院开封475004

创新是经济发展的驱动力,影响区域创新绩效的因素很多,本文从宏观经济、行业、企业、外部力量等四个尺度构建了企业创新模型,利用1991年到2014年统计数据,探讨了人均GDP水平、产业集聚、企业规模、R&D、FDI、技术引进这六个因素对河南... 详细信息

创新是经济发展的驱动力,影响区域创新绩效的因素很多,本文从宏观经济、行业、企业、外部力量等四个尺度构建了企业创新模型,利用1991年到2014年统计数据,探讨了人均GDP水平、产业集聚、企业规模、R&D、FDI、技术引进这六个因素对河南省专利授权量的影响。研究发现:在企业尺度上,企业规模、R&D经费显著正向影响河南工业企业的创新绩效;在中观尺度上,产业集聚还没有发挥很好的集聚效益;反映经济发展水平的人均GDP在统计上并未显著影响创新绩效,甚至是负影响;外部力量尺度上,外商直接投资增强了创新的绩效,而技术引进与创新绩效则呈显著负相关。综合来看,企业创新是一个多尺度因素相互作用的非线性过程,各种力量对创新的影响机理也较为复杂。

关键词：创新工业企业影响因素河南省

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Recent progress in constructing fluorinated solid-electrolyte interphases for stable lithium metal anodes

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 270-291页

作者： Di Zhang Pengfei Lv wei qin Xin He Yuanhua He Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan Province College of Civil Aviation Safety EngineeringCivil Aviation Flight University of ChinaGuanghan 618307China School of Chemical Engineering Sichuan UniversityChengdu 610065China

Lithium metal batteries(LMBs)are emerging as a promising energy storage solution owing to their high energy density and specific ***,the non-uniform plating of lithium and the potential rupture of the solid-electrolyte interphase(SEI)during extended cycling use may result in dendrite growth,which can penetrate the separator and pose significant short-circuit *** a stable SEI is essential for the long-term operation of the ***-rich SEI has garnered significant attention for its ability to effectively passivate electrodes,regulate lithium deposition,and inhibit electrolyte *** the structural components and preparation methods of existing fluorinated SEI is crucial for optimizing lithium metal anode *** paper reviews the research on optimizing LiF passivation interfaces to protect lithium metal *** focuses on four types of compositions in fluorinated SEI that work synergistically to enhance SEI *** instance,combining compounds with LiF can further enhance the mechanical strength and ionic conductivity of the *** metals with LiF significantly improves electrochemical performance at the SEI/anode interface,with a necessary focus on reducing electron tunneling ***,incorporating polymers with LiF offers balanced improvements in interfacial toughness and ionic conductivity,though maintaining structural stability over long cycles remains a critical area for future *** alloys combined with LiF increase surface energy and lithium affinity,challenges such as dendrite growth and volume expansion *** summary,this paper emphasizes the crucial role of interfacial structures in LMBs and offers comprehensive guidance for future design and development efforts in battery technology.

关键词： LiF lithium metal anodes solid-electrolyte interphase interface cycling stability

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The gut-eye axis:from brain neurodegenerative diseases to age-related macular degeneration

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Neural Regeneration Research 2025年第10期20卷 2741-2757页

作者： Qianzi Jin Suyu Wang Yujia yao qin Jiang Keran Li Department of Ophthalmology The Affiliated Eye Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina The Fourth School of Clinical Medicine Nanjing Medical UniversityNanjingJiangsu ProvinceChina

Age-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts ***,the specific pathogenesis remains unclear,and effective early treatment options are consequently *** microbiome is defined as a large ecosystem of microorganisms living within and coexisting with a *** intestinal microbiome undergoes dynamic changes owing to age,diet,genetics,and other *** dysregulation of the intestinal flora can disrupt the microecological balance,resulting in immunological and metabolic dysfunction in the host,and affecting the development of many *** recent decades,significant evidence has indicated that the intestinal flora also influences systems outside of the digestive tract,including the ***,several studies have demonstrated the critical role of the gut-brain axis in the development of brain neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s ***,the role of the“gut-eye axis”has been confirmed to play a role in the pathogenesis of many ocular ***,age-related macular degeneration and many brain neurodegenerative diseases have been shown to share several risk factors and to exhibit comparable *** such,the intestinal flora may play an important role in age-related macular *** the above context,the present review aims to clarify the gut-brain and gut-eye connections,assess the effect of intestinal flora and metabolites on age-related macular degeneration,and identify potential diagnostic markers and therapeutic ***,direct research on the role of intestinal flora in age-related macular degeneration is still relatively limited,while studies focusing solely on intestinal flora are insufficient to fully elucidate its functional role in age-related macular ***-on-a-chip technology has shown promise in clarifying the gut-eye interactions,while integrating analysis of the inte

关键词： age-related macular degeneration biological agents blinding eye disease dietary nutrition fecal microbial transplantation gut-eye axis intestinal flora metabolite microecology neurodegenerative disease

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Prescreening teratogenic potential of chlorinated drinking water disinfection by-products by using Hydra regeneration assay

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Journal of Environmental Sciences 1998年第1期10卷 112-114页

作者： Ji Yuan tang Department of Preventive Medicine, Anhui Medical University, Hefei 230032, China Chen qin yao, wei Xiao fei, Li Yi, Liao Hong mei Department of Biology, Anhui University, Hefei 230039, China

Practicability of method for the Hydra regeneration assay on the prescreening teratogenic potential of chlorinated drinking water disinfection by products was studied through both the assays of toxicity of adult Hydra (T) and inhibition of the growth of regeneration Hydra (I) by using chloroform, dichloromethane and chloroacetic acid. The results showed that T 50 / I 50 ratios of chloroform and chloroacetic acid were 2 77 and 6 16 respectively, with teratogenic potential. T 50 / I 50 ratio of dichloromethane was 1.69, with weaker teratogenic potential. These experimental results indicated preliminarily that the Hydra regeneration assay has certainly applied value as a prescreening assay for developmental toxicity.

关键词： Hydra regeneration assay chlorinated disinfection chloroform dichloromethane chloroacetic acid.

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Boosting Oxygen Evolution Reaction Performance on NiFe‑Based Catalysts Through d‑Orbital Hybridization

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Nano-Micro Letters 2025年第1期17卷 281-292页

作者： Xing Wang wei Pi Sheng Hu Haifeng Bao Na yao wei Luo State Key Laboratory of New Textile Materials and Advanced Processing Technology Key Laboratory of New Textile Materials and Applications of Hubei ProvinceSchool of Materials Science and EngineeringWuhan Textile UniversityWuhan 430200People’s Republic of China College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072People’s Republic of China

Anion-exchange membrane water electrolyzers(AEMWEs)for green hydrogen production have received intensive attention due to their feasibility of using earth-abundant NiFe-based *** introducing a third metal into NiFe-based catalysts to construct asymmetrical M-NiFe units,the d-orbital and electronic structures can be adjusted,which is an important strategy to achieve sufficient oxygen evolution reaction(OER)performance in ***,the ternary NiFeM(M:La,Mo)catalysts featured with distinct M-NiFe units and varying d-orbitals are reported in this *** and theoretical calculation results reveal that the doping of La leads to optimized hybridization between d orbital in NiFeM and 2p in oxygen,resulting in enhanced adsorption strength of oxygen intermediates,and reduced rate-determining step energy barrier,which is responsible for the enhanced OER *** critically,the obtained NiFeLa catalyst only requires 1.58 V to reach 1 A cm^(−2) in an anion exchange membrane electrolyzer and demonstrates excellent long-term stability of up to 600 h.

关键词： NiFe-based catalysts d-orbital coupling Oxygen evolution reaction Anion exchange membrane electrolyzer

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一种磁控型浮地忆阻器模拟器的实现

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电气开关 2017年第3期55卷 51-54页

作者：赵伟钦要航广西大学电气工程学院广西南宁530004

该模拟电路基于磁通控制的浮地忆阻器仿真器,它由常规电路元件组成并应用到MC低通滤波器。仿真结果表明,该模拟器有一个滞后的伏安特性以及其相应的MC低通滤波器具有时变特性。

关键词：忆阻器仿真器浮动终端

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang qing yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu wei Wan Xiuqin Rao Yue Lin Gen wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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D-乳酸跨肺梯度联合P-选择素和血小板参数检测在肺炎疗效评估中的意义

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中国卫生检验杂志 2017年第4期27卷 546-548页

作者：辅桓钦姚伟陆溦湖州市第一人民医院呼吸内科浙江湖州313000

目的探讨D-乳酸跨肺梯度联合P-选择素和血小板参数检测在肺炎疗效评估中的作用。方法收集115例肺炎患者,分为重症肺炎组(50例)和轻症肺炎组(65例),另选60例健康体检者为对照组,检测并比较3组间及重症肺炎患者治疗前后PLT、PDW、MPV、P-... 详细信息

目的探讨D-乳酸跨肺梯度联合P-选择素和血小板参数检测在肺炎疗效评估中的作用。方法收集115例肺炎患者,分为重症肺炎组(50例)和轻症肺炎组(65例),另选60例健康体检者为对照组,检测并比较3组间及重症肺炎患者治疗前后PLT、PDW、MPV、P-LCR的差异。结果重症肺炎组D-乳酸跨肺梯度、P-选择素、PLT均显著高于轻症肺炎组和对照组;PDW、MPV、P-LCR均显著低于轻症肺炎组和对照组;轻症肺炎组D-乳酸跨肺梯度、PLT均显著高于对照组,上述差异均有统计学意义(P<0.05)。与治疗前比,重症肺炎患者治疗后第3 d D-乳酸跨肺梯度显著降低,其余指标治疗后第5 d变化差异有统计学意义(P<0.05)。结论 D-乳酸跨肺梯度联合P-选择素和血小板参数检测可更快、更准确地评价肺炎病情、疗效和判断预后。

关键词：肺炎 D-乳酸 P-选择素血小板参数

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维生素C对亚硝酸盐胁迫下匙吻鲟仔鱼非特异性免疫及抗氧化能力的影响

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河南农业科学 2018年第7期47卷 132-136页

作者：秦国兵熊伟姚俊杰杨通枝贾美香贵州大学动物科学学院/高原山地动物遗传育种与繁殖省部共建教育部重点实验室贵州贵阳550025

为初步探究水体中添加不同剂量维生素C对匙吻鲟内源营养期及混合营养期仔鱼抗亚硝酸盐胁迫能力的影响,采用生化方法测定不同条件下仔鱼溶菌酶(LZM)、酸性磷酸酶(ACP)、碱性磷酸酶(AKP)活性,丙二醛(MDA)含量和总抗氧化能力(T-AOC)在内源... 详细信息

为初步探究水体中添加不同剂量维生素C对匙吻鲟内源营养期及混合营养期仔鱼抗亚硝酸盐胁迫能力的影响,采用生化方法测定不同条件下仔鱼溶菌酶(LZM)、酸性磷酸酶(ACP)、碱性磷酸酶(AKP)活性,丙二醛(MDA)含量和总抗氧化能力(T-AOC)在内源营养期及混合营养期的动态变化。结果显示:以卵黄为营养的内源营养期,LZM、AKP、ACP活性和T-AOC随维生素C质量浓度的增加呈现升高趋势,且90 mg/L和120 mg/L维生素C组显著高于对照组和胁迫组;以卵黄和外源饵料作营养的混合营养期,LZM、AKP、ACP活性随维生素C质量浓度的增加呈现"升高—降低"趋势。90 mg/L维生素C组LZM、AKP、ACP活性和T-AOC从内源营养期到混合营养期显著上升,上升率分别为71.8%、33.7%、48.4%和61.1%。MDA含量随维生素C质量浓度的增加而降低,且在同一取样时间下显著低于胁迫组,维生素C添加组MDA含量从内源营养期到混合营养期无显著变化。综上,在亚硝酸盐胁迫下,90 mg/L维生素C浸泡对匙吻鲟仔鱼内源营养期及混合营养期保护效果较好;亚硝酸盐胁迫可导致匙吻鲟内源营养期及混合营养期仔鱼机体的氧化损伤及抗氧化能力的不平衡,但不同质量浓度维生素C浸泡可以在一定程度上缓解亚硝酸盐胁迫的负面影响。

关键词：匙吻鲟维生素C 亚硝酸盐非特异性免疫抗氧化能力

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