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Clonality and allelotype analyses of focal nodular hyperplasia compared with hepatocellular adenoma and carcinoma

World Journal of Gastroenterology 2009年第37期15卷 4695-4708页

作者： Yi-Ran Cai Li Gong Xiao-Ying Teng Hong-Tu Zhang Cheng-Feng Wang Guo-Lian Wei Lei Guo Fang Ding Zhi-Hua Liu qin-jing pan qin Su Department of Pathology Cancer Institute and Cancer Hospital Chinese Academy ofMedical Sciences and Peking Union Medical College PanjiayuanNanli 17 Beijing 100021 China Department of Pathology Tangdu Hospital the FourthMilitary Medical University Xi'an 710038 Shaanxi ProvinceChina Department of Abdominal Surgery CancerInstitute and Cancer Hospital Chinese Academy of MedicalSciences and Peking Union Medical College Beijing 100021China State Key Laboratory of Molecular Oncology Cancer Institute Chinese Academy of MedicalSciences and Peking Union Medical College Beijing 100021China

AIM： To identify clonality and genetic alterations in focal nodular hyperplasia （FNH） and the nodules derived from it. METHODS： Twelve FNH lesions were examined. Twelve hepatocellular adenomas （HCAs） and 22 hepatocellular carcinomas （HCCs） were used as references. Nodules of different types were identified and isolated from FNH by microdissection. An X-chromosome inactivation assay was employed to describe their clonality status. Loss of heterozygosity （LOH） was detected, using 57 markers, for genetic ***： Nodules of altered hepatocytes （NAH）, the putative precursors of HCA and HCC, were found in all the FNH lesions. Polyclonality was revealed in 10 FNH lesions from female patients, and LOH was not detected in any of the six FNH lesions examined, the results apparently showing their polyclonal nature. In contrast, monoclonality was demonstrated in all the eight HCAs and in four of the HCCs from females, and allelic imbalances were found in the HCAs （9/9） and HCCs （15/18）, with chromosomal arms 11p, 13q and 17p affected in the former, and 6q, 8p, 11p, 16q and 17p affected in the latter lesions in high frequencies （≥ 30%）. Monodonality was revealed in 21 （40%） of the 52 microdissected NAH, but was not found in any of the five ordinary nodules. LOH was found in all of the 13 NAH tested, being highly frequent at six loci on 8p, 11p, 13q and 17p. CONCLUSION： FNH, as a whole, is polyclonal, but some of the NAH lesions derived from it are already neoplastic and harbor similar allelic imbalances as HCAs.

关键词： Clonality analysis Focal nodular hyperplasia Hepatocellular adenoma Liver tumorigenesis Loss of heterozygosity Nodules of altered hepatocytes

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Real-time distance field acceleration based free-viewpoint video synthesis for large sports fields

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Computational Visual Media 2024年第2期10卷 331-353页

作者： Yanran Dai jing Li Yuqi Jiang Haidong qin Bang Liang Shikuan Hong Haozhe pan Tao Yang School of Telecommunications Engineering Xidian UniversityXi’an 710071China National Engineering Laboratory for Integrated AeroSpace-Ground-Ocean Big Data Application Technology SAIIPthe School of Computer ScienceNorthwestern Polytechnical UniversityXi’an 710129China

Free-viewpoint video allows the user to view objects from any virtual perspective,creating an immersive visual *** technology enhances the interactivity and freedom of multimedia ***,many free-viewpoint video synthesis methods hardly satisfy the requirement to work in real time with high precision,particularly for sports fields having large areas and numerous moving *** address these issues,we propose a freeviewpoint video synthesis method based on distance field *** central idea is to fuse multiview distance field information and use it to adjust the search step size *** step size search is used in two ways:for fast estimation of multiobject three-dimensional surfaces,and synthetic view rendering based on global occlusion *** have implemented our ideas using parallel computing for interactive display,using CUDA and OpenGL frameworks,and have used real-world and simulated experimental datasets for *** results show that the proposed method can render free-viewpoint videos with multiple objects on large sports fields at 25 ***,the visual quality of our synthetic novel viewpoint images exceeds that of state-of-the-art neural-rendering-based methods.

关键词： free-viewpoint video view synthesis camera array distance field sports video

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Aeroengine thrust estimation and embedded verification based on improved temporal convolutional network

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Chinese Journal of Aeronautics 2024年第1期37卷 106-117页

作者： Wanzhi MENG Zhuorui pan Sixin WEN pan qin Ximing SUN Key Laboratory of Intelligent Control and Optimization for Industrial Equipment of Ministry of Education Dalian University of TechnologyDalian 116024China School of Control Science and Engineering Dalian University of TechnologyDalian 116024China

Thrust estimation is a significant part of aeroengine thrust control *** traditional estimation methods are either low in accuracy or large in *** further improve the estimation effect,a thrust estimator based on Multi-layer Residual Temporal Convolutional Network(M-RTCN)is *** solve the problem of dead Rectified Linear Unit(ReLU),the proposed method uses the Gaussian Error Linear Unit(GELU)activation function instead of ReLU in residual *** the overall architecture of the multi-layer convolutional network is adjusted by using residual connections,so that the network thrust estimation effect and memory consumption are further ***,the comparison with seven other methods shows that the proposed method has the advantages of higher estimation accuracy and faster convergence ***,six neural network models are deployed in the embedded controller of the micro-turbojet *** Hardware-in-the-Loop(HIL)testing results demonstrate the superiority of M-RTCN in terms of estimation accuracy,memory occupation and running ***,an ignition verification is conducted to confirm the expected thrust estimation and real-time performance.

关键词： Thrust estimation Temporal convolutional network Embedded deployment Hardware-in-the-loop testing Ignition verification

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High-resolution spatiotemporal mapping:a comprehensive view of eukaryotic cell cycle proteome dynamics

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2354-2356页

作者： jing Zou Ziran qin Long Zhang Life Sciences Institute Second Affiliated Hospital of the Zhejiang University School of MedicineThe MOE Key Laboratory of Biosystems Homeostasis&Protection and Zhejiang Provincial Key Laboratory for Cancer Molecular Cell BiologyZhejiang UniversityHangzhouZhejiangChina The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors The First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchangChina Cancer Center Zhejiang UniversityHangzhouZhejiangChina

In a recent study published in Cell,Litsios et *** a highresolution spatiotemporal map of the eukaryotic cell cycle proteome.1 They identified proteome-level changes in both abundance and spatial distribution throughout the cell cycle and provided a valuable resource for future exploration into the global proteome dynamics that drive cell cycle progression(https://***/cellcycle).

关键词： al. cycle dynamics

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Friction moment calculation method for tapered roller bearings under combined loads

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Science China(Technological Sciences) 2024年第8期67卷 2565-2578页

作者： LI XinBin LIU jing HUANG SuHe pan Guang School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710072China Key Laboratory for Unmanned Underwater Vehicle Northwestern Polytechnical UniversityXi’an 710072China System Engineering Research Institute Beijing 100094China

Tapered roller bearings(TRBs) can withstand axial loads, radial loads, and overturning moments. The performance, safety, and efficiency of rotating machinery are directly influenced by the friction moments within the TRBs. However, most current research has relied on empirical formulas that focus on axial loads. Additionally, the friction coefficient between the rollers and the inner ring rib has been defined using simple empirical methods. In actual applications, the loads on TRBs are not purely axial or radial, and simple empirical friction coefficients do not adequately account for the varying lubrication conditions. To address this challenge, this study proposes an improved method for calculating the friction moments of TRB under combined axial and radial loads. This study employs a calculation method for sliding friction coefficients that can model dry, boundary, elastohydrodynamic, and mixed lubrication conditions. To demonstrate the advantages of the proposed method, the friction moments obtained using the existing and proposed methods are compared. Additionally, the influence of TRB structural parameters on the friction moment is discussed. An experimental study is conducted to validate the effectiveness of the proposed method. The findings provide valuable insights for designing TRB structural parameters to minimize friction moments.

关键词： tapered roller bearing friction moment structural parameters combined loads

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Effect of the yaw angle on turbulent flow structures around the submarine model

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Journal of Hydrodynamics 2024年第3期36卷 421-434页

作者： Yi-jing Hu Yi Qu qin Wu Biao Huang School of Mechanical Engineering Beijing Institute of TechnologyBeijing100081China Beijing Institute of Electronic System Engineering Beijing100854China

The objective of this paper is to investigate the turbulent flow structures around the submarine model and evaluate the effect of the yaw angle on the turbulent flow *** large eddy simulation based on the boundary data immersion method is used to *** computational domain consists of 1.2×10^(8)uniformly distributed Cartesian orthogonal grid nodes to capture the basic flow characteristics around the *** pressure coefficient,friction coefficient and wake velocity distribution are in good agreement with the experimental *** different types of vortex structures were mainly captured around the model,including horseshoe vortex,sail tip vortex and crossflow separation *** the increase of the yaw angle,the asymmetry of the horseshoe vortex and the tip vortex gradually increases,and the vortex strength of the vortex leg on the windward of the horseshoe vortex and the vortex strength of the tip vortex also increase *** the crossflow separation vortex,the flow separation zone gradually expands and migrates downstream with the increase of the yaw angle.

关键词： Vortex structure submarine model boundary data immersion method yaw angle

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Impact of baseline hepatitis B virus viral load on the long-term prognosis of advanced hepatocellular carcinoma treated with immunotherapy

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2504-2519页

作者： Di pan Hao-Nan Liu Zhi-Yuan Yao Xiao-Xiao Chen Yu-Qi Li jing-jing Zhu Zheng-Xiang Han Xiao-Bing qin Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Although the combination of lenvatinib and PD-1 inhibitors has become the standard regimen for the treatment of advanced hepatocellular carcinoma(HCC),real data on the impact of baseline hepatitis B virus(HBV)-DNA levels on the clinical efficacy of this regimen is still *** To evaluate the effectiveness of camrelizumab combined with lenvatinib in patients with HCC at varying levels of *** One hundred and twenty patients with HCC who received camrelizumab and lenvatinib treatment were categorized into two cohorts:HBV-DNA≤2000(n=66)and HBV-DNA>2000(n=54).The main outcomes measured were overall survival(OS)and progression-free survival(PFS),while additional outcomes included the rate of objective response rate(ORR),disease control rate(DCR),and any negative *** proportional hazards regression analysis revealed independent predictors of OS,leading to the creation of a nomogram incorporating these *** The median PFS was 8.32 months for the HBV-DNA≤2000 group,which was similar to the 7.80 months observed for the HBV DNA>2000 group(P=0.88).Likewise,there was no notable variation in the median OS between the two groups,with durations of 13.30 and 14.20 months respectively(P=0.14).The ORR and DCR were compared between the two groups,showing ORR of 19.70%vs 33.33%(P=0.09)and DCR of 72.73%vs 74.07%(P=0.87).The nomogram emphasized the importance of antiviral treatment as the main predictor of patient results,with portal vein tumor thrombus and Barcelona Clinic Liver Cancer staging following closely *** The clinical outcomes of patients with HBV-associated HCC treated with camrelizumab in combination with lenvatinib are not significantly affected by HBV viral load.

关键词： Hepatitis B virus Hepatocellular carcinoma Camrelizumab Lenvatinib Efficacy

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Added Benefit of the Early-Morning-Orbit Satellite Fengyun-3E on the Global Microwave Sounding of the Three-Orbit Constellation

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Advances in Atmospheric Sciences 2024年第1期41卷 39-52页

作者： Juan LI Zhengkun qin Guiqing LIU jing HUANG CMA Earth System Modeling and Prediction Centre Beijing 100081China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Joint Center for Data Assimilation Research and Applications School of Atmospheric SciencesNanjing University of Information Science&TechnologyNanjing 210044China

The three-orbit constellation can comprehensively increase the spatial coverage of polar-orbiting satellites,but the polar-orbiting satellites currently in operation are only mid-morning-orbit and afternoon-orbit ***-3E(FY-3E)was launched successfully on 5 July 2021 in *** an early-morning-orbit satellite,FY-3E can help form a complete three-orbit observation system together with the mid-morning and afternoon satellites in the current mainstream operational *** this study,we investigate the added benefit of FY-3E microwave sounding observations to the midmorning-orbit Meteorological Operational satellite-B(Met Op-B)and afternoon-orbit Fengyun-3D(FY-3D)microwave observations in the Chinese Meteorological Administration global forecast system(CMA-GFS).The results show that the additional FY-3E microwave temperature sounder-3(MWTS-3)and microwave humidity sounder-2(MWHS-2)data can increase the global coverage of microwave temperature and humidity sounding data by 14.8% and 10.6%,*** enables the CMA-GFS to achieve nearly 100% global coverage of microwave-sounding observations at each analysis ***,after effective quality control and bias correction,the global biases and standard deviations of the differences between observations and model simulations are also *** on the Advanced Microwave Sounding Unit A and the Microwave Humidity Sounder onboard Met Op-B,and the MWTS-2 and MWHS-2 onboard FY-3D,adding the microwave sounding data of FY-3E can further reduce the errors of analysis results and improve the global prediction skills of CMA-GFS,especially for the southern-hemisphere forecasts within 96 hours,all of which are significant at the 95% confidence level.

关键词： data assimilation microwave temperature sounder MWTS-3

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Enhanced bright green luminescence from GdOF:Ho^(3+) up-conversion phosphor via Yb^(3+) doping

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Journal of Rare Earths 2024年第2期42卷 263-269,I0002页

作者： Linjun qin Yue Guo jing Xu Lixi Wang Qitu Zhang College of Materials Science and Engineering Nanjing Tech UniversityNanjing211816China

In this paper,a series of GdOF-based green phosphors doped with Ho^(3+) and Yb^(3+) ions was prepared by a simple co-precipitation *** crystal structure s and optical prope rties were investigated in *** intensity of the emission of GdOF:Yb^(3+),Ho^(3+) phosphors is enhanced by the effective energy transfer from Yb^(3+) to Ho^(3+),and the optimal luminescence is achieved with the Ho^(3+)doping amount of 0.1 mol%as well as Yb^(3+) doping amount of 5 mol%.Tunable UC emission of samples is achieved by adjusting the doping concentration of Ho^(3+) or Yb^(3+).The purity of the green UC emission is further improved by enhancing the excitation pumping *** addition,logarithmic functions of green,red and nearinfrared radiation intensities were calculated versus logarithmic function of pump power for further study.A possible UC luminescence mechanism between Yb^(3+) and Ho^(3+) is discussed based on powerdependent UC luminescence spectrum and decay *** results suggest that GdOF:Yb^(3+),Ho^(3+)phosphors with bright and high-purity green UC emission have potential applications in the fields of bioimaging,display and illumination.

关键词： Up-conversion GdOF Lanthanide ions Rare earths

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A deep multimodal fusion and multitasking trajectory prediction model for typhoon trajectory prediction to reduce flight scheduling cancellation

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Journal of Systems Engineering and Electronics 2024年第3期35卷 666-678页

作者： TANG Jun qin Wanting pan qingtao LAO Songyang College of Systems Engineering National University of Defense TechnologyChangsha 410000China

Natural events have had a significant impact on overall flight activity,and the aviation industry plays a vital role in helping society cope with the impact of these *** one of the most impactful weather typhoon seasons appears and continues,airlines operating in threatened areas and passengers having travel plans during this time period will pay close attention to the development of tropical *** paper proposes a deep multimodal fusion and multitasking trajectory prediction model that can improve the reliability of typhoon trajectory prediction and reduce the quantity of flight scheduling *** deep multimodal fusion module is formed by deep fusion of the feature output by multiple submodal fusion modules,and the multitask generation module uses longitude and latitude as two related tasks for simultaneous *** more dependable data accuracy,problems can be analysed rapidly and more efficiently,enabling better decision-making with a proactive versus reactive *** multiple modalities coexist,features can be extracted from them simultaneously to supplement each other’s *** actual case study,the typhoon Lichma that swept China in 2019,has demonstrated that the algorithm can effectively reduce the number of unnecessary flight cancellations compared to existing flight scheduling and assist the new generation of flight scheduling systems under extreme weather.

关键词： flight scheduling optimization deep multimodal fusion multitasking trajectory prediction typhoon weather flight cancellation prediction reliability

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