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Acetylcholinesterase inhibition ameliorates retinal neovascularization and glial activation in oxygen-induced retinopathy

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1361-1367页

作者： Qiu-Ping Liu Xian Zhang Ya-zhou qin Jing-Lin Yi Jing-Ming Li Affiliated Eye Hospital of Nanchang University Nanchang 330006Jiangxi ProvinceChina Department of Ophthalmology First Affiliated Hospital of Xi'an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

AIM:To investigate whether inhibition of acetylcholinesterase(AChE)by donepezil ameliorate aberrant retinal neovascularization(RNV)and abnormal glial activation in oxygen-induced retinopathy(OIR).METHODS:A mouse model of RNV was induced in postnatal day 7(P7)mice by exposure to 75%*** was administrated to P12 mice by intraperitoneal *** and localization of AChE in mouse retinas were determined by *** was evaluated by paraffin sectioning and hematoxylin and eosin(HE)*** of retinal M uller glial cells were examined by immunoblot of glial fibrillary acidic protein(GFAP).rMC-1.a retinal Muller cell line,was used for in vitro *** of hypoxia-induced factor 1α(HIF-1α)and vascular endothelial growth factor(VEGF)were determined by Western-blot analysis,enzyme-linked immunosorbent assay(ELISA)or ***:Aberrant RNV and glial activation was observed after *** note,retinal AChE was mainly expressed by retinal Muller glial cells and markedly increased in OIR *** administration of donepezil significantly reduced RNV and abnormal glial activation in mice with ***,ischemia-induced HIF-1αaccumulation and VEGF upregulation in OIR mouse retinas and cultured rMC-1 were significantly inhibited by donepezil ***:AchE is implicated in RNV with *** of AChE by donepeizl is likely to be a potential therapeutic approach for retinal neovascular diseases.

关键词： acetylcholinesterase oxygen-induced retinopathy neovascularization glosis mice

An Analysis of the Development of Middle Leaders in Chinese Secondary Schools:The Role of the Principal

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Journal of Contemporary Educational Research 2022年第10期6卷 98-108页

作者： qin zhou Department of Administration School of Economics and Social WelfareZhejiang Shuren UniversityHangzhou 310000Zhejiang ProvinceChina

Numerous studies conducted on educational leadership have generally emphasized the role of principal,whereas,research on middle leadership remains limited[1].The purpose of this paper is to explore and investigate the development of middle leadership and seeks to fill in the gap by providing the analysis from a Chinese *** author found that middle leaders are positioning at a challenging role,in which they are required to take charge of responsibilities of both a leader and a teacher,and in the meantime,they also need to negotiate between the senior leader,the *** ***,personal factors such as self-awareness and resilience are discovered to be pivotal for middle-leadership *** from that,the principal plays a critical role in establishing collaborative school culture that facilitates the development of middle leaders based on the influences from the school’s history,culture,and policies.

关键词： Educational leadership Middle leadership Leader Principal Self-awareness Resilience School culture Leading learning Trust Distributed leadership

Discourse Analysis Based on Face-Threatening Theory-A Case Study of TucaodahuiⅢ

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Sino-US English Teaching 2024年第4期21卷 188-193页

作者： zhou qin Hunan Applied Technology University ChangdeChina

Face and politeness are very important parts in people’s daily *** people will violate the principle of politeness for protecting their own ***,they usually choose to use more humorous words or jocular words to communicate in order to avoid direct *** from the face-threatening acts in the face theory and politeness principle,this paper briefly analyzes the face-threatening acts and its humorous usage in the TucaodahuiⅢ.

关键词： face theory face-threatening acts TucaodahuiⅢ

Brillouin gain spectrum characterization in Ge-doped large-mode-area fibers

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Chinese Physics B 2021年第12期30卷 418-423页

作者： Xia-Xia Niu Yi-Feng Yang Zhao Quan Chun-Lei Yu qin-Ling zhou Hui Shen Bing He Jun zhou Shanghai Key Laboratory of All Solid-State Laser and Applied Techniques Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

The dependence of Brillouin gain spectrum(BGS)characteristics,including the Brillouin frequency shift(BFS)and the BGS bandwidth,on germanium concentration in large-mode-area Ge-doped passive fibers is investigated theoretically and *** simulation results show that the BFS is inversely proportional to GeO_(2)concentration,and the BGS bandwidth initially increases with the augment of GeO_(2)concentration,and then *** BGSs of four fibers with core diameters of 10μm and 20μm for different GeO_(2)concentrations are compared *** results demonstrate that with the same core diameter,the variations of BFS and BGS bandwidths with GeO_(2)concentration accord with the simulation ***,the BGS characteristics of three large-mode-area passive fibers with diameters of 10μm,25μm,and 30μm are measured,which confirm that the increasing of the fiber diameters will cause the BGS bandwidth to *** believe that these results can provide valuable references for modulating the high-power narrowlinewidth fiber lasers and Brillouin fiber amplifiers.

关键词： stimulated Brillouin scattering Brillouin gain spectrum large-mode-area fibers fiber laser

Defect-induced magnetism in χ_(3) borophene

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Rare Metals 2022年第10期41卷 3486-3494页

作者： Qiao-Lu Lin Hao Liang Can-qin zhou Zheng-Fang Qian Yi-Ling Sun Xue-Yuan Wang Ren-Heng Wang Key Laboratory of Optoelectronic Devices and Systems of the Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen518060China Department of Materials Science and Engineering City University of Hong KongHong Kong999077China

Borophene is an emerging and promising twodimensional material for spintronics ***,the origin and controllability of its magnetism remain poorly understood,thereby hindering the further development of borophene-based *** this study,it is demonstrated that χ_(3) borophene with vacancy defects,which contains zigzag edges and dangling bonds,exhibits spin *** understand the origin and characteristics of its magnetism,a magnetic study of vacancy defects in χ_(3) borophene using first-principles calculations was *** is determined that the unpaired dangling bond electrons in the σ state contribute to its magnetism,and the zigzagged vacancy structure helps to maintain the localization and stability of unpaired *** coupling is completed by the s-p orbital interaction and mediated by p-orbital itinerant *** magnetic coupling energy difference oscillates with the distance of magnetic atoms because of the indirect magnetic exchange by itinerant electrons and electronic shielding,in accordance with the Ruderman-Kittel-Kasuya-Yosida(RKKY)***,the causality between the dangling bonds and magnetism is identified by saturating magnetic B atoms using H,C and N *** study provides a reference for the regulation of borophene in magnetic semiconductors.

关键词： Two-dimensional(2D)materials Borophene Vacancy Magnetic properties First-principles Nanostructure

SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response

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Cellular & Molecular Immunology 2021年第3期18卷 613-620页

作者： Yu-Zhi Fu Su-Yun Wang zhou-qin Zheng Yi Huang Wei-Wei Li Zhi-Sheng Xu Yan-Yi Wang Key Laboratory of Special Pathogens and Biosafety Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of Sciences430071 WuhanChina University of Chinese Academy of Sciences 100049 BdjingChina

A novel SARS-related coronavirus(SARS-CoV-2)has recently emerged as a serious pathogen that causes high morbidity and substantial ***,the mechanisms by which SARS-CoV-2 evades host immunity remain poorly ***,we identified SARS-CoV-2 membrane glycoprotein M as a negative regulator of the innate immune *** found that the M protein interacted with the central adaptor protein MAVS in the innate immune response *** interaction impaired MAVS aggregation and its recruitment of downstream TRAF3,TBK1,and IRF3,leading to attenuation of the innate antiviral *** findings reveal a mechanism by which SARS-CoV-2 evades the innate immune response and suggest that the M protein of SARSCoV-2 is a potential target for the development of SARS-CoV-2 interventions.

关键词： SARS-CoV-2 Membrane glycoprotein M MAVS TypeⅠinterferon Innate immunity

Microglia-associated neuroinflammation is a potential therapeutic target for ischemic stroke

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Neural Regeneration Research 2021年第1期16卷 6-11页

作者： Wan Zhang Tian Tian Shao-Xin Gong Wen-Qian Huang qin-Yi zhou Ai-Ping Wang Ying Tian Institute of Clinical Research Affiliated Nanhua HospitalUniversity of South ChinaHengyangHunan ProvinceChina Department of Clinical Laboratory the First Hospital of ChangshaChangshaHunan ProvinceChina Department of Pathology the First Affiliated Hospital of University of South ChinaHengyangHunan ProvinceChina

Microglia-associated neuroinflammation plays an important role in the pathophysiology of ischemic *** activation and polarization,and the inflammatory response mediated by these cells play important roles in the development,progression and outcome of brain injury after ischemic ***,there is no effective strategy for treating ischemic stroke in clinical ***,it is clinically important to study the role and regulation of microglia in *** this review,we discuss the involvement of microglia in the neuroinflammatory process in ischemic stroke,with the aim of providing a better understanding of the relationship between ischemic stroke and microglia.

关键词： brain cells central nervous system inflammation injury macrophages repair review stroke

The clinical significance of bimodal growth pattern in the treatment of hemangiomas in infancy and children

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上海口腔医学 2009年第5期18卷 555-556页

作者： ZHENG Jia-wei WANG Yan-an YANG Xiu-juan zhou qin Department of Oral and Maxillofacial Surgery Ninth People's Hospital College of Stomatology Shanghai JiaoTong University School of Medicine. Shanghai 200011 China

Hemangiomas are the most common benign vascular neoplasms of infancy and children, the life cycle of which involves a phase of rapid proliferation in the neonatal period, followed by spontaneous involution, usually du... 详细信息

关键词：血管瘤新生儿临床分析治疗方法

Gas in place and its controlling factors of deep shale of the Wufeng–Longmaxi Formations in the Dingshan area, Sichuan Basin

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Frontiers of Earth Science 2023年第1期17卷 322-336页

作者： Ping GAO Xianming XIAO Dongfeng HU Ruobing LIU Fei LI qin zhou Yidong CAI Tao YUAN Guangming MENG School of Energy Resources China University of Geosciences(Beijing)Beijing 100083China Sinopec Exploration Branch Company Chengdu 610041China State Key Laboratory of Organic Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China

Recently, deeply-buried shale (depth > 3500 m) has become an attractive target for shale gas exploration and development in China. Gas-in-place (GIP) is critical to shale gas evaluation, but the GIP content of deep shale and its controlling factors have rarely been investigated. To clarify this issue, an integrated investigation of deep gas shale (3740–3820 m depth) of the Lower Paleozoic Wufeng–Longmaxi Formations (WF–LMX) in the Dingshan area, Sichuan Basin had been carried out. Our results show that the GIP content of the studied WF–LMX shale in the Dingshan area ranges from 0.85 to 12.7 m^(3)/t, with an average of 3.5 m^(3)/t. Various types of pores, including organic matter (OM) pore and inorganic pore, are widely developed in the deep shale, with total porosity of 2.2 to 7.3% (average = 4.5%). The OM pore and clay-hosted pore are the dominant pore types of siliceous shale and clay-rich shale, respectively. Authigenic quartz plays a critical role in the protection of organic pores in organic-rich shales from compaction. The TOC content controls the porosity of shale samples, which is the major factor controlling the GIP content of the deep shale. Clay minerals generally play a negative role in the GIP content. In the Sichuan Basin, the deep and ultra-deep WF–LMX shales display the relatively high porosity and GIP contents probably due to the widespread of organic pores and better preservation, revealing great potentials of deep and ultra-deep shale gas. From the perspective of rock mechanical properties, deep shale is the favorable exploration target in the Sichuan Basin at present. However, ultra-deep shale is also a potential exploration target although there remain great challenges.

关键词： Deep shale porosity organic pore gas potential authigenic quartz