检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

施工扬尘空间扩散规律研究

环境科学 2008年第1期29卷 259-262页

作者：田刚李钢闫宝林黄玉虎秦建平北京市环境保护科学研究院北京100037

通过检测建筑工地边界附近同一平面坐标1.5-4.1 m范围内不同高度处的降尘浓度变化，研究了建筑工地边界施工扬尘垂直扩散规律；通过监测建筑工地外同方向0-210 m范围内不同距离、相同高度（3 m）处的降尘浓度变化，研究了建筑工地施工... 详细信息

通过检测建筑工地边界附近同一平面坐标1.5-4.1 m范围内不同高度处的降尘浓度变化，研究了建筑工地边界施工扬尘垂直扩散规律；通过监测建筑工地外同方向0-210 m范围内不同距离、相同高度（3 m）处的降尘浓度变化，研究了建筑工地施工扬尘水平扩散规律，通过数据回归分别得出了施工扬尘垂直、水平的扩散模型.结果表明，建筑工地边界同一平面坐标上方的施工降尘浓度与高度的2次方成反比关系，边界外部同一高度、同一方向的施工降尘浓度与监测点距工地中心距离的2次方成反比关系，施工活动和自然条件等因素主要影响垂直和水平扩散常数的大小.

关键词：施工扬尘降尘扩散模型

Comparing the efficacy and safety of low,medium,and high dosages of selexipag for treating pulmonary hypertension:A systematic review and meta-analysis

在线全文

学校读者我要写书评

暂无评论

Animal Models and Experimental Medicine 2024年第1期7卷 56-70页

作者： Shang Wang Yi Yan jian Zhang ping Yuan Ci-Jun Luo Hong-Ling Qiu Hui-Ting Li jian Xu Lan Wang Tian-Lan Li Rong jiang Department of Cardio-Pulmonary Circulation Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina Heart Center and Shanghai Institute of Pediatric Congenital Heart Disease Shanghai Children's Medical CenterNational Children's Medical CenterShanghai Jiaotong University School of MedicineShanghaiChina Department of Respiratory and Critical Care Medicine The 416 Hospital of Nuclear IndustryThe Second Affiliated Hospital of Chengdu Medical CollegeChengduChina Department of Hematology The Affiliated Hospital of Qingdao UniversityQingdaoChina

Background:The maintenance dosage of selexipag is categorized as low,medium or *** order to assess the efficacy and safety of different dosages of selexipag for the risk stratification of pulmonary arterial hypertension(PAH),we performed a sys-tematic review and ***:Studies assessing PAH risk stratification indices,such as the World Health Organization functional class(WHO-FC),six-minute walk distance(6MWD),N-terminal pro-B-type natriuretic peptide(NT-proBNP)level,right atrial pressure(RAP),cardiac index(CI)and mixed venous oxygen saturation(SvO2),were ***:Thirteen studies were *** led to improvements in the 6MWD(MD:24.20 m,95%CI:10.74-37.67),NT-proBNP(SMD:-0.41,95%CI:-0.79-0.04),CI(MD:0.47 L/min/m^(2),95%CI:0.17-0.77)and WHO-FC(OR:0.564,95%CI:0.457-0.697).Subgroup analysis demonstrated that all three dosages improved the 6MWD.A moderate dosage led to improvements in the CI(MD:0.30 L/min/m^(2),95%CI:0.15-0.46)and WHO-FC(OR:0.589,95%CI:0.376-0.922).Within 6 months of treatment,only the WHO-FC and CI were significantly improved(OR:0.614,95%CI:0.380-0.993;MD:0.30 L/min/m^(2),95%CI:0.16-0.45,respectively).More than 6 months of treatment significantly improved the 6MWD,WHO-FC and NT-proBNP(MD:40.87 m,95%CI:10.97-70.77;OR:0.557,95%CI:0.440-0.705;SMD:-0.61,95%CI:-1.17-0.05,respectively).Conclusions:Low,medium,and high dosages of selexipag all exhibited good *** treatment lasted for more than 6 months,selexipag exerted obvious effects,even in the low-dosage *** finding is important for guiding individualized treatments.

关键词： individualized treatments meta-analysis prostacyclin receptor agonist risk stratification systematic review

Quantifying the impacts of COVID-19 on Sustainable Development Goals using machine learning models

在线全文

学校读者我要写书评

暂无评论

Fundamental Research 2024年第4期4卷 890-897页

作者： Chenyang Shuai Bu Zhao Xi Chen jianguo Liu Chunmiao Zheng Shen Qu jian-ping Zou Ming Xu School of Management Science and Real Estate Chongqing UniversityChongqing 400044China bSchool for Environment and Sustainability University of MichiganAnn ArborMI 489United Stats Michigan Institute for Computational Discovery&Engineering University of MichiganAnn ArborMI 48109United States College of Economics and Management Southwest UniversityChongqing 400044China Center for Systems Integration and Sustainability Department of Fisheries and WildlifeMichigan State UniversityEast LansingMI 48824United States Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China School of Management and Economics Beijing Institute of TechnologyBeijing 100081China Center for Energy&Environmental Policy Research Beijing Institute of TechnologyBejing 100081China Key Laboratory of jiangxi Province for Persistent Plutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063China Department of Civil and Environmental Engineering University of MichiganAnn ArborMI 48109United States

The COvID-19 pandemic has posed severe threats to global sustainable ***,a comprehensive quantitative assessment of the impacts of COVID-19 on Sustainable Development Goals(SDGs)is still *** research quantified the post-COVID-19 SDG progress from 2020 to 2024 using projected GDP growth and population and machine learning models including support vector machine,random forest,and extreme gradient *** results show that the overall SDG performance declined by 7.7%in 2020 at the global scale,with 12 socioeconomic SDG performance decreasing by 3.0%-22.3%and 4 environmental SDG performance increasing by 1.6%-9.2%.By 2024,the progress of 12 SDGs will lag behind for one to eight years compared to their pre-COVID-19 trajectories,while extra time will be gained for 4 environment-related ***,the pandemic will cause more impacts on countries in emerging markets and developing economies than those on advanced economies,and the latter will recover more quickly to be closer to their pre-covID-19 trajectories by ***-COVID-19 economic recovery should emphasize in areas that can help decouple economic growth from negative environmental *** results can help government and non-state stakeholders identify critical areas for targeted policy to resume and speed up the progress to achieve SDGs by 2030.

关键词： Sustainable development goals COVID-19 Machine learning Global development Sustainable development assessment

Changes in the Non-targeted Metabolomic Profile of Three-year-old Toddlers with Elevated Exposure to Polycyclic Aromatic Hydrocarbons

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第5期37卷 479-493页

作者： LI Yang LIN Dan ZHANG Xiu qin JU Guang Xiu SU Ya ZHANG Qian DUAN Hai ping YU Wei Sen WANG Bing Ling PANG Shu Tao Department of Epidemiology and Health Statistics School of Public HealthQingdao UniversityQingdao 266021ShandongChina Department of Environmental Health Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Physicochemical Laboratory Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Section of Child Health Care Huangdao Maternity and Child Health Care Hospital of QingdaoQingdao 266499ShandongChina qingdao Blood Center Qingdao 266071ShandongChina

Objective To investigate changes in the urinary metabolite profiles of children exposed to polycyclic aromatic hydrocarbons(PAHs)during critical brain development and explore their potential link with the intestinal *** Liquid chromatography-tandem mass spectrometry was used to determine ten hydroxyl metabolites of PAHs(OH-PAHs)in 36-month-old ***,37 children were categorized into low-and high-exposure groups based on the sum of the ten ***-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was used to identify non-targeted metabolites in the urine ***,fecal flora abundance was assessed by 16S rRNA gene sequencing using Illumina *** The concentrations of 21 metabolites were significantly higher in the high exposure group than in the low exposure group(variable importance for projection>1,P<0.05).Most of these metabolites were positively correlated with the hydroxyl metabolites of naphthalene,fluorine,and phenanthrene(r=0.336–0.531).The identified differential metabolites primarily belonged to pathways associated with inflammation or proinflammatory states,including amino acid,lipid,and nucleotide ***,these distinct metabolites were significantly associated with specific intestinal flora abundances(r=0.34–0.55),which were mainly involved in *** Higher PAH exposure in young children affected metabolic homeostasis,particularly that of certain gut microbiota-derived *** investigation is needed to explore the potential influence of PAHs on the gut microbiota and their possible association with neurodevelopmental outcomes.

关键词： Child Gut microbiota Non-targeted metabolomics Polycyclic aromatic hydrocarbons Urinary metabolite profile

METTL5 promotes gastric cancer progression via sphingomyelin metabolism

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1925-1946页

作者： Ya-Qiong Zhang jian Li Zhe qin De-Ming Li Fang-Zhou Ye Song-Hua Bei Xiao-Hong Zhang Li Feng Endoscopy Center Minhang Hospital Affiliated to Fudan UniversityShanghai 201100China

BACKGROUND The treatment of gastric cancer(GC)has caused an enormous social burden *** studies have reported that N6-methyladenosine(m6A)is closely related to tumor ***5 is a m6A methyltransferase that plays a pivotal role in maintaining the metabolic stability of ***,its aberrant regulation in GC has not been fully *** To excavate the role of METTL5 in the development of *** METTL5 expression and clinicopathological characteristics were analyzed via The Cancer Genome Atlas dataset and further verified via immunohistochemistry,western blotting and real-time quantitative polymerase chain reaction in tissue microarrays and clinical *** tumor-promoting effect of METTL5 on HGC-27 and AGS cells was explored in vitro by Cell Counting Kit-8 assays,colony formation assays,scratch healing assays,transwell assays and flow *** tumor-promoting role of METTL5 in vivo was evaluated in a xenograft tumor *** EpiQuik m6A RNA Methylation Quantification Kit was used for m6A ***,liquid chromatography-mass spectrometry was used to evaluate the association between METTL5 and sphingomyelin metabolism,which was confirmed by Enzyme-linked immunosorbent assay and rescue *** addition,we investigated whether METTL5 affects the sensitivity of GC cells to cisplatin via colony formation and transwell *** Our research revealed substantial upregulation of METTL5,which suggested a poor prognosis of GC *** METTL5 expression indicated distant lymph node metastasis,advanced cancer stage and pathological *** increased level of METTL5 correlated with a high degree of m6A ***5 markedly promotes the proliferation,migration,and invasion of GC cells in ***5 also promotes the growth of GC in animal ***5 knockdown resulted in significant changes in sphingomyelin metabolism,which implies that METTL5 may impact the development of GC via sphin

关键词： Gastric cancer METTL5 Sphingomyelin metabolism Cisplatin

Impact of metabolic syndrome components on clinical outcomes in hypertriglyceridemia-induced acute pancreatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第35期30卷 3996-4010页

作者： Zhen-Hua Fu Zi-Yue Zhao Yao-Bing Liang Dong-Yu Cheng jian-Ming Luo Hai-Xing jiang Shan-Yu qin Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND The incidence of hypertriglyceridemia(HTG)-induced acute pancreatitis(AP)is steadily increasing in China,becoming the second leading cause of *** complications and outcomes associated with HTG-AP are generally more severe than those seen in AP caused by other ***-AP is closely linked to metabolic dysfunction and frequently coexists with metabolic syndrome or its ***,the impact of metabolic syndrome components on HTGAP clinical outcomes remains *** To investigate the impact of metabolic syndrome component burden on clinical outcomes in *** In this retrospective study of 255 patients diagnosed with HTG-AP at the First Affiliated Hospital of Guangxi Medical University,we collected data on patient demographics,clinical scores,complications,and clinical ***,we analyzed the influence of the presence and number of individual metabolic syndrome components,including obesity,hyperglycemia,hypertension,and low high-density lipoprotein cholesterol(HDL-C),on the aforementioned parameters in HTG-AP *** This study found that metabolic syndrome components were associated with an increased risk of various complications in HTG-AP,with low HDL-C being the most significant risk factor for clinical *** risk of complications increased with the number of metabolic syndrome *** for age and sex,patients with highcomponent metabolic syndrome had significantly higher risks of renal failure[odds ratio(OR)=3.02,95%CI:1.12-8.11)],SAP(OR=5.05,95%CI:2.04-12.49),and intensive care unit admission(OR=6.41,95%CI:2.42-16.97)compared to those without metabolic *** The coexistence of multiple metabolic syndrome components can synergistically worsen the clinical course of HTGAP,making it crucial to monitor these components for effective disease management.

关键词： Hypertriglyceridemia-induced acute pancreatitis Metabolic syndrome High density lipoprotein cholesterol Obesity Hyperglycemia Hypertension Clinical outcomes

Intracellular redox potential-driven live-cell synthesis of CdSe quantum dots in Staphylococcus aureus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第3期67卷 990-999页

作者： Cai-qin Wu An-An Liu Xu Li Jia-Wei Tu Juan Kong Ling-Ling Yang jian-Hong Jia Chuan Wang Bin Hu Zhi-Xiong Xie Dai-Wen Pang The Institute for Advanced Studies College of Chemistry and Molecular SciencesCollege of Life SciencesHubei Key Laboratory of Cell HomeostasisWuhan UniversityWuhan 430072China Research Center for Analytical Sciences College of ChemistryState Key Laboratory of Medicinal Chemical BiologyTianjin Key Laboratory of Biosensing and Molecular RecognitionFrontiers Science Center for New Organic MatterFrontiers Science Center for Cell Responsesand Haihe Laboratory of Sustainable Chemical TransformationsNankai UniversityTianjin 300071China

Biosynthesized semiconductor quantum dots(QDs) have bright fluorescence,adjustable particle sizes,and environmental friendliness,endowing them with convenience and potential for biological *** to the unclear mechanism of the cellular environment on the live-cell synthesis of QDs,it is still difficult to regulate their optical ***,the critical role of the intracellular redox environment in regulating the fluorescence properties of biosynthesized CdSe QDs in Staphylococcus aureus(***) has been *** glutathione peroxidase(GPx) activity directly affects the intracellular H_(2)O_(2) produced in the SeO_(3)^(2-) reduction,which further manipulates the glutathione redox cycle to determine the content of low-valence *** a result,the fluorescence intensity of the synthesized CdSe QDs increases by 60% in the GPx overexpressed *** cellular redox potential that is controlled by the GSH redox cycle provides the driving force for the reduction of SeO_(3)^(2-),facilitating the synthesis of CdSe QDs in *** *** proposed mechanism of the cellular redox state provides a new perspective for regulating the synthesis of semiconductor nanomaterials in live cells.

关键词： redox H_(2)O_(2) peroxidase quantum dot Staphylococcus aureus

Undifferentiated high-grade pleomorphic sarcoma of the common bile duct:A case report and review of literature

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第5期16卷 2253-2260页

作者： Li-ping Zheng Wen-Yan Shen Chun-Dong Hu Chun-Hua Wang Xu-jian Chen Jing Wang Yi-Yu Shen Department of General Surgery The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Pathology The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Undifferentiated pleomorphic sarcoma(UPS)is a rare malignant mesenchymal tumor with a poor *** mainly occurs in the extremities,trunk,head and neck,and retroperitoneum *** to the lack of specific clinical manifestations and imaging features,UPS diagnosis mainly depends on pathological and immunohistochemical examinations for exclusive *** we report an extremely rare case of high-grade UPS in the common bile duct(CBD).There are limited available data on such *** SUMMARY A 70-year-old woman was admitted to our department with yellow eyes and urine accompanied by upper abdominal distending pain for 2 *** laboratory data suggested significantly elevated hepatorenal function *** imaging data revealed calculous cholecystitis,intrahepatic and extrahepatic bile duct dilation with extrahepatic bile duct calculi,and a space-occupying lesion at the distal *** endoscopic biliary stenting and symptomatic support therapy,CBD exploration and biopsy were *** frozen section indicated malignant spindle cell tumor of the CBD mass,and further radical pancreaticoduodenectomy was ***,the neoplasm was diagnosed as a high-grade UPS combined with the light-microscopic morphology and immunohistochemical *** This extremely rare case highlighted the need for increasing physicians'vigilance,reducing the odds of misdiagnosis,and providing appropriate treatment strategies.

关键词： Undifferentiated pleomorphic sarcoma Soft tissue sarcoma Common bile duct Extrahepatic bile duct Immunohistochemistry Case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

辊式矫直机矫直辊的弯辊模型

东北大学学报（自然科学版） 2005年第5期26卷 460-462页

作者：周存龙王国栋刘相华秦建平东北大学轧制技术及连轧自动化国家重点实验室辽宁沈阳110004 太原科技大学材料科学与工程学院山西太原030024

将板材在辊式矫直机矫直辊作用下的弯曲,假设为由压下机构作用的弯曲和由弯辊机构作用的弯曲共同作用的结果·根据梁的弹塑性弯曲理论,通过把板材弯曲当作梁的弯曲,并考虑到矫直机在入口处的压弯量,通常使板材弯曲时塑性变形层高度占厚... 详细信息

将板材在辊式矫直机矫直辊作用下的弯曲,假设为由压下机构作用的弯曲和由弯辊机构作用的弯曲共同作用的结果·根据梁的弹塑性弯曲理论,通过把板材弯曲当作梁的弯曲,并考虑到矫直机在入口处的压弯量,通常使板材弯曲时塑性变形层高度占厚度80%,认为经弯辊作用后塑性变形层高度增加了5%～15%,利用梁的弯曲挠度,建立不同弯曲的弯辊模型,求出了矫直辊的弯辊量·理论计算的弯辊量与实际设定值结果吻合,证明该弯辊量设定模型具有实际应用价值·

关键词：辊式矫直机压弯量挠度弯辊量弹塑性弯曲