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Journal of Advanced Ceramics 2013年第3期2卷 252-259页

作者： qiming hang Wenke ZHOU Xinhua ZHU Jianmin ZHU Zhiguo LIU Talaat AL-KASSAB National Laboratory of Solid State Microstructures School of PhysicsNanjing UniversityNanjing 210093China National Laboratory of Solid State Microstructures Department of Materials Science and EngineeringNanjing UniversityNanjing 210093China King Abdullah University of Science&Technology(KAUST) Physical Sci.and Eng.Thuwal 23955-6900Kingdom of Saudi Arabia

0.67BiFeO_(3)-0.33BaTiO_(3)multiferroic ceramics doped with x mol%MnO_(2)(x=2-10)were synthesized by solid-state *** formation of a perovskite phase with rhombohedral symmetry was confirmed by X-ray diffraction(XRD).The average grain sizes were reduced from 0.80mm to 0.50mm as increasing the Mn-doped *** crystalline nature of the grains was revealed by high-resolution transmission electron microscopy(HRTEM)images and electron diffraction *** nano-sized ferroelectric domains with an average size of 9 nm randomly distributed in the ceramic samples were revealed by TEM *** domain lamellae(71°ferroelectric domains)with an average width of 5 nm were also *** modes were examined by Raman spectra,where only four Raman peaks at 272 cm^(-1)(E-4 mode),496 cm^(-1)(A_(1)-4 mode),639 cm^(-1),and 1338 cm^(-1)were *** blue shifts in the E-4 and A_(1)-4 Raman mode frequencies were interpreted by a spring oscillator *** dieletric constants of the present ceramics as a function of the Mn-doped levels exhibited a V-typed *** were in the range of 350-700 measured at 10^(3)Hz,and the corresponding dielectric losses were in range of 0.43-0.96,approaching to 0.09 at 10^(6)Hz.

关键词： multiferroic ceramics dielectric properties Raman spectra microstructure

Synthesis, Microstructure, and Dielectric Properties of Mn-doped 0.33BaTiO3-0.67BiFeO3 Multiferroic Solid Solutions

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Synthesis, Microstructure, and Dielectric Properties of Mn-d...

GLP-1 receptor agonists and myocardial metabolism in atrial fibrillation

中国材料大会2012

作者： qiming hang Feng Shan Jianmin Zhu Xinhua Zhu National Laboratory of Solid State Microstructures School of Physics Nanjing University

ISBN: (纸本)9783037856079

In this work, 0.33BaTiO3-0.67BiFeO3 multiferroic ceramics doped with x mol% MnO2 （x= 0.1-1.0） were fabricated by solid-state reaction method, and their microstructure and dielectric property were also investigated. The perovskite phase structure of the solid solutions was confirmed by X-ray diffraction patterns, and the formation of minor impure phase of Bi2Fe4O9 was prevent effectively by Mn-doping. With increasing the Mn-doped concentration, the dielectric constants of Mn-doped 0.33BaTiO3-0.67BiFeO3 multiferroic ceramics first increased, and reached a maximum value of 340 （measured @1MHz） at the Mn-doped concentration of 0.60 mol%, and then decreased. On the other hand, the dielectric losses first decreased, and reached the minimum value at the Mn-doped concentration of 0.30 mol%, and then increased along with increasing the Mn-doped concentrations. The ferroelectric domain structures in the Mn-doped 0.33BaTiO3-0.67BiFeO3 multiferroic ceramics with rhombohedral symmetry were also revealed by TEM image and selected area electron diffraction patterns, and tweed-like domain structures were observed.

关键词： Mn-doping BaTiO3 BiFeO3 Multiferroic solid solution Microstructure character Dielectric property

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Journal of Pharmaceutical Analysis 2024年第5期14卷 653-665页

作者： Jiani Zhong hang Chen qiming Liu Shenghua Zhou Zhenguo Liu Yichao Xiao Department of Cardiovascular Medicine Second Xiangya HospitalCentral South UniversityChangsha410011China Xiangya School of Medicine Central South UniversityChangsha410008China Center for Precision Medicine and Division of Cardiovascular Medicine Department of MedicineSchool of MedicineUniversity of MissouriColumbiaMO65211USA

Atrial fibrillation(AF)is the most common cardiac *** medical conditions,including hypertension,diabetes,obesity,sleep apnea,and heart failure(HF),increase the risk for *** have unique metabolic characteristics to maintain adenosine triphosphate *** changes occur in myocardial metabolism in ***-like peptide-1 receptor agonists(GLP-1RAs)have been used to control blood glucose fluctuations and weight in the treatment of type 2 diabetes mellitus(T2DM)and ***-1RAs have also been shown to reduce oxidative stress,inflammation,autonomic nervous system modulation,and mitochondrial *** article reviews the changes in metabolic characteristics in cardiomyocytes in *** the clinical trial outcomes are unsatisfactory,the findings demonstrate that GLP-1 RAs can improve myocardial metabolism in the presence of various risk factors,lowering the incidence of AF.

关键词： Atrial fibrillation Glucagon-like peptide-1 receptor agonists Metabolism

KSHV strategies for host dsDNA sensing machinery

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Virologica Sinica 2016年第6期31卷 466-471页

作者： hang Gao Yanyan Song Chengrong Liu qiming Liang Department of Nephrology The Second Hospital of Jilin University Changchun 130041 China

The innate immune system utilizes pattern recognition receptors cyclic GMP-AMP synthase(cGAS)to sense cytosolic double-stranded(ds) DNA and initiate type 1 interferon signaling and autophagy pathway, which collaborate to limit pathogen infections as well as alarm the adaptive immune response. The genomes of herpesviruses are large dsDNA, which represent a major class of pathogen signatures recognized by cellular DNA sensor cGAS. However, to successfully establish the persistent infection, herpesviruses have evolved their viral genes to modulate different aspects of host immune signaling. This review summarizes the evasion strategies of host cGAS DNA sensing pathway by Kaposi's Sarcoma-associated Herpesvirus(KSHV) and their contributions to KSHV life cycles.

关键词： dsDNA interferon innate autophagy signaling modulate pathogen alarm initiate contributions

Review of deep ultraviolet photodetector based on gallium oxide

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Chinese Physics B 2019年第1期28卷 126-142页

作者： Yuan Qin Shibing Long hang Dong qiming He Guangzhong Jian Ying Zhang Xiaohu Hou Pengju Tan Zhongfang Zhang hangbing Lv Qi Liu Ming Liu Key Laboratory of Microelectronics Devices&Integration Technology Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China School of Microelectronics University of Science and Technology of ChinaHefei 230026China University of Chinese Academy of Sciences Beijing 100049China

Ultraviolet(UV) photodetectors(PDs) have drawn great attention in recent years due to their potential application in civil and military fields. Because of its ultrawide bandgap, low cost, strong radiation hardness, and high thermal and chemical stability with high visible-light transparency, Ga_2O_3 is regarded as the most promising candidate for UV ***, the bandgap of Ga_2O_3 is as high as 4.7–4.9 eV, directly corresponding to the solar-blind UV detection band with wavelength less than 280 nm. There is no need of doping in Ga_2O_3 to tune its bandgap, compared to AlGaN, MgZnO,etc, thereby avoiding alloy composition fluctuations and phase separation. At present, solar-blind Ga_2O_3 photodetectors based on single crystal or amorphous Ga_2O_3 are mainly focused on metal–semiconductor–metal and Schottky *** this work, the recent achievements of Ga_2O_3 photodetectors are systematically reviewed. The characteristics and performances of different photodetector structures based on single crystal Ga_2O_3 and amorphous Ga_2O_3 thin film are analyzed and compared. Finally, the prospects of Ga_2O_3 UV photodetectors are forecast.

关键词： gallium oxide ultrawide bandgap ultraviolet(UV) photodetector

Oxidation-strengthened disulfide-bridged prodrug nanoplatforms with cascade facilitated drug release for synergetic photochemotherapy

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Asian Journal of Pharmaceutical Sciences 2020年第5期15卷 637-645页

作者： Bin Yang Lin Wei Yuequan Wang Na Li Bin Ji Kaiyuan Wang Xuanbo Zhang Shenwu Zhang Shuang Zhou Xiaohui Yao hang Song Yusheng Wu Haotian Zhang qiming Kan Tao Jin Jin Sun Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China Ministry of Education Heilongjiang UniversityHarbin 150500China Sino-Russian Joint Graduate School Heilongjiang UniversityHarbin 150080China Department of Laboratory Medicine The First Affiliated HospitalChina Medical UniversityShenyang 110001China School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China School of Life Sciences Heilongjiang UniversityHarbin 150080China

One of the major barriers in utilizing prodrug nanocarriers for cancer therapy is the slow release of parent drug in *** cells generally display the higher oxidative level than normal cells,and also displayed the heterogeneity in terms of redox homeostasis *** previously found that the disulfide bond-linkage demonstrates surprising oxidationsensitivity to form the hydrophilic sulfoxide and sulphone ***,we develop oxidation-strengthened prodrug nanosystem loaded with pyropheophorbide a(PPa)to achieve light-activatable cascade drug release and enhance therapeutic *** disulfide bond-driven prodrug nanosystems not only respond to the redox-heterogeneity in tumor,but also respond to the exogenous oxidant(singlet oxygen)elicited by *** the prodrug nanoparticles(NPs)are activated under irradiation,they would undergo an oxidative self-strengthened process,resulting in a facilitated drug cascade *** IC50 value of the PPa@PTX-S-S NPs without irradiation was 2-fold higher than those of NPs plus *** vivo,the PPa@PTX prodrug NPs display prolonged systemic circulation and increased accumulation in tumor *** PPa@PTXS-S NPs showed much higher efficiency than free PTX or the PPa@PTX-C-C NPs to suppress the growth of 4 T1 ***,this novel oxidation-strengthened disulfide-bridged prodrug-nanosystem has a great potential in the enhanced efficacy of cancer synergetic photochemotherapy.

关键词： Prodrug nanoplatform Disulfide bond Pyropheophorbide a Redox-heterogeneity Accurate therapy

Progress of power field effect transistor based on ultra-wide bandgap Ga_2O_3 semiconductor material

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Journal of Semiconductors 2019年第1期40卷 17-25页

作者： hang Dong Huiwen Xue qiming He Yuan Qin Guangzhong Jian Shibing Long Ming Liu Key Laboratory of Microelectronic Devices & Integration Technology Institute of Microelectronics of Chinese Academy of Sciences University of Chinese Academy of Sciences School of Microelectronics University of Science and Technology of China

As a promising ultra-wide bandgap semiconductor, gallium oxide(Ga_2O_3) has attracted increasing attention in recent years. The high theoretical breakdown electrical field(8 MV/cm), ultra-wide bandgap(～ 4.8 eV) and large Baliga's figure of merit(BFOM) of Ga_2O_3 make it a potential candidate material for next generation high-power electronics, including diode and field effect transistor(FET). In this paper, we introduce the basic physical properties of Ga_2O_3 single crystal, and review the recent research process of Ga_2O_3 based field effect transistors. Furthermore, various structures of FETs have been summarized and compared, and the potential of Ga_2O_3 is preliminary revealed. Finally, the prospect of the Ga_2O_3 based FET for power electronics application is analyzed.

关键词： gallium oxide(Ga_2O_3) ultra-wide bandgap semiconductor power device field effect transistor(FET)

Multiband mucosectomy versus endoscopic submucosal dissection for management of early esophageal squamous cell neoplasems

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Multiband mucosectomy versus endoscopic submucosal dissectio...

第十七届西南地区消化病学术会议暨2014贵州省消化病及消化内镜学术年会

作者： hang Yi Yi Mou Wei Liu qiming Wang Hongze Zeng Chengwei Tang Bing Hu Department of Gastroenterology West China HospitalSichuan University

Objectives:Endoscopic submucosal dissection(ESD)is an important treatment option of early esophageal squamous cellcarcinoma(ESCC)and high grade intraepithelial neoplasia(HGIN).ESD achieves complete resection rates superior to EMR,but is technically demanding and comprises higher procedural *** technique multiband mucosectomy(MBM)can be performed in these *** study aims to evaluate the efficacy,safety of ESD versus MBM in the management of ESCC and ***:A

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协方差矩阵重构的稳健自适应波束形成算法

声学学报 2019年第2期44卷 170-176页

作者：王昊马启明杭州应用声学研究所杭州310023

针对协方差矩阵含有期望信号成分以及波束指向角失配时,传统自适应波束形成器性能严重下降的问题,提出了协方差矩阵重构的稳健自适应波束形成算法。该算法将全空域划分成若干互不重叠的区域,分别对应干扰区域与信号区域,先利用Capon波... 详细信息

针对协方差矩阵含有期望信号成分以及波束指向角失配时,传统自适应波束形成器性能严重下降的问题,提出了协方差矩阵重构的稳健自适应波束形成算法。该算法将全空域划分成若干互不重叠的区域,分别对应干扰区域与信号区域,先利用Capon波束形成器对干扰区域积分,由此构造出干扰协方差矩阵。然后,利用标准Capon波束形成器的波束域MUSIC谱估计法对信号区域积分,重构出信号协方差矩阵,以其主特征向量作为期望信号导引向量估计。由于算法重构了干扰加噪声协方差矩阵并对导引向量进行了修正,保证了自适应波束形成器的性能。理论分析和仿真实验结果表明,算法在训练数据含有期望信号成分和波束指向角度失配情况下具有良好的性能。

关键词：协方差矩阵期望信号稳健自适应波束形成导引向量波束形成器

Mg-9.5Li-2.56Al-2.58Zn合金组织及室温变形行为

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稀有金属材料与工程 2021年第4期50卷 1359-1364页

作者：张金龙路恩皓朱均张莹姜行尹晨张祺铭西安航空学院材料工程学院陕西西安710077

以Mg-9.5Li-2.56Al-2.58Zn合金为对象,研究其组织形貌及相组成。并利用UTM5305电子万能试验机对其进行了不同应变速率以及不同变形量的室温压缩实验,获得真应力-应变曲线,构建合金的室温变形本构方程。研究压缩前后合金的微观组织和压... 详细信息

以Mg-9.5Li-2.56Al-2.58Zn合金为对象,研究其组织形貌及相组成。并利用UTM5305电子万能试验机对其进行了不同应变速率以及不同变形量的室温压缩实验,获得真应力-应变曲线,构建合金的室温变形本构方程。研究压缩前后合金的微观组织和压缩性能演变规律。结果表明,Mg-9.5Li-2.56Al-2.58Zn合金包含α-Mg、β-Li、Al_(12)Mg_(17)、AlLi和MgLiAl_(2) 5相,β-Li为基体相,α-Mg相呈条状或块状,纤维状Al_(12)Mg_(17)相位于α-Mg相内部,颗粒状MgLiAl_(2)相分布在晶界上,晶内相AlLi呈颗粒状。固溶处理后合金组织中析出相的数量明显减少,合金强度得到提升。根据Mg-9.5Li-2.56Al-2.58Zn合金真应力-应变曲线分析了应变速率对流变应力的影响,挤压态和固溶态合金室温压缩都存在峰值应力和峰值后的软化现象,有利于室温成形;并通过线性回归的方式获得不同状态下的材料本构方程常数n以及ln A–(Q/RT)的值,构建了基于Arrhenius模型的本构方程。合金组织随压缩变形量增加被逐渐压扁、拉长,AlLi相有所增多。

关键词： Mg-Li合金显微组织室温变形行为本构方程