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不同持续时间俯卧位通气对急性呼吸窘迫综合征患者疗效的影响——一项小型Meta分析

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中华危重病急救医学 2024年第5期36卷 508-513页

作者：何娟刘颖李璐杨金凤张习靖陈启敏刘娇洋子沈锋贵州医科大学附属医院重症医学科贵阳550004

目的系统评价不同持续时间俯卧位通气对急性呼吸窘迫综合征(ARDS)患者治疗效果的影响。方法计算机检索美国国立医学图书馆PubMed、Cochrane Library、荷兰医学文摘Embase、中国知网、万方数据库、维普数据库、中国生物医学文献数据库等... 详细信息

目的系统评价不同持续时间俯卧位通气对急性呼吸窘迫综合征(ARDS)患者治疗效果的影响。方法计算机检索美国国立医学图书馆PubMed、Cochrane Library、荷兰医学文摘Embase、中国知网、万方数据库、维普数据库、中国生物医学文献数据库等,从建库至2023年9月发表的关于俯卧位通气治疗成人ARDS患者的研究,根据每次俯卧位通气持续时间分为≤24 h组和>24 h组。结局指标包括:病死率、重症监护病房(ICU)住院时间、压疮发生率及气管切开术操作。由2名研究员独立筛选文献、提取资料,评价纳入文献的偏倚风险。采用NOS量表对纳入的文献进行质量评估,Meta分析不同持续时间俯卧位通气对ARDS疗效的影响。结果最终纳入4篇文献共517例患者,其中俯卧位通气持续时间≤24 h者249例,>24 h者268例。4项研究均为队列研究,总体纳入文献经方法学质量评估后表明研究质量较高,存在偏倚风险性较低。Meta分析结果显示,俯卧位通气持续时间≤24 h组与>24 h组之间ARDS患者的病死率〔相对危险度(RR)=1.02,95%可信区间(95%CI)为0.79~1.31,P=0.88〕、ICU住院时间〔均数差(MD)=-2.68,95%CI为-5.30~-0.05,P=0.05〕差异无统计学意义。与俯卧位通气持续时间≤24 h组相比,俯卧位通气持续时间>24 h组ARDS患者的压疮发生率(RR=0.76,95%CI为0.59~0.98,P=0.04)及气管切开术操作(RR=0.71,95%CI为0.53~0.94,P=0.02)显著增加。结论俯卧位通气持续时间对ARDS患者病死率和ICU住院时间无明显影响,但俯卧位通气时间>24 h会增加压疮发生率及气管切开术操作,由于纳入研究数量少,该结论仍需大量研究进一步验证。

关键词：急性呼吸窘迫综合征俯卧位通气病死率不良事件 Meta分析

新疆典型绿洲农田防护林健康诊断与评价——以阿克苏市防护林为例

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防护林科技 2024年第3期 7-10,18页

作者：桑巴叶陈启民古丽米娜·吐尔孙江新疆林科院造林治沙研究所新疆乌鲁木齐830063

以阿克苏市防护林为例,对典型绿洲农田防护林的健康状况进行诊断与评估。采用样线法和样带法进行样地布设,调查树种组成、生物量、年龄结构及退化成因等。结果表明:阿克苏市防护林体系相对健全,林网完整度较高,但仍存在一些问题,主要体... 详细信息

以阿克苏市防护林为例,对典型绿洲农田防护林的健康状况进行诊断与评估。采用样线法和样带法进行样地布设,调查树种组成、生物量、年龄结构及退化成因等。结果表明:阿克苏市防护林体系相对健全,林网完整度较高,但仍存在一些问题,主要体现在年度防护林造林任务分配不均、空间分布上呈现出显著的不合理性、农田防护林在不同土壤立地条件下的生长状况差异显著以及树种选择较单一等方面。

关键词：农田防护林健康诊断评价

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一种基于萘酰亚胺并噁嗪的CN-探针

山东化工 2024年第3期53卷 23-26页

作者：柳锦琦夏仁汝袁丽媛陆靖一陈骑敏任家强王薇湖北工业大学材料与化学工程学院湖北武汉430068 湖北大学生命科学学院湖北武汉430062

虽然氰离子的检测分析方法有多种,但仍存在着一些不足的地方,如响应时间较长、灵敏度不高,离子选择性也有待改善,或者在检测前须采取其他方法先处理干扰离子等。合成了一类含有萘酰亚胺基团的噁嗪光致变色化合物,表现出良好的光致变色性... 详细信息

虽然氰离子的检测分析方法有多种,但仍存在着一些不足的地方,如响应时间较长、灵敏度不高,离子选择性也有待改善,或者在检测前须采取其他方法先处理干扰离子等。合成了一类含有萘酰亚胺基团的噁嗪光致变色化合物,表现出良好的光致变色性能,同时也对氰离子具有很好的识别性能、高选择性、良好的抗干扰能力、很低的检测极限和快速的响应时间,对于氰离子的在线检测也有着潜在的应用价值。

关键词：氰离子噁嗪萘酰亚胺

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农田防护林对库尔勒香梨火疫病影响的初步研究

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防护林科技 2024年第2期 4-6,11页

作者：桑巴叶陈启民新疆林科院造林治沙研究所新疆乌鲁木齐830063

为了解农田防护林对香梨火疫病的影响,对尉犁县6块农田库尔勒香梨树的感病情况进行调查,探究农田防护林对梨火疫病传播蔓延的限制作用。结果表明:靠近防护林带的香梨树感病率最低,具有一定规模、林相完整的防护林可以减少或隔绝园区梨... 详细信息

为了解农田防护林对香梨火疫病的影响,对尉犁县6块农田库尔勒香梨树的感病情况进行调查,探究农田防护林对梨火疫病传播蔓延的限制作用。结果表明:靠近防护林带的香梨树感病率最低,具有一定规模、林相完整的防护林可以减少或隔绝园区梨火疫病原菌的传播,在一定程度上降低了病害发生;梨火疫病病情在农田内的发生并不均匀,呈现团块结构分布。在规划梨园防护林时,需要充分考虑主风向,特别是主要害风的方向。此外,在防治过程中应采取分区定点、强化防治的策略。

关键词：库尔勒香梨农田防护林梨火疫病

AKT2^(S128)/CCTα^(S315/319/323)-positive cancer-associated fibroblasts (CAFs) mediate focal adhesion kinase (FAK) inhibitors resistance via secreting phosphatidylcholines (PCs)

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Signal Transduction and Targeted Therapy 2024年第2期9卷 782-796页

作者： Jie chen Lingyuan Zhang Yuheng Zhu Di Zhao Jing Zhang Yanmeng Zhu Jingyuan Pang Yuanfan Xiao Qingnan Wu Yan Wang qimin Zhan Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital&Institute100142 BeijingChina Peking University International Cancer Institute Peking University100191 BeijingChina Research Unit of Molecular Cancer Research Chinese Academy of Medical SciencesBeijingChina Soochow University Cancer Institute Suzhou 215000China Institute of Cancer Research Shenzhen Bay LaboratoryShenzhen 518107China

Abnormal metabolism is regarded as an oncogenic hallmark related to tumor progression and therapeutic *** study employed multi-omics,including phosphoproteomics,untargeted metabolomics and lipidomics,to demonstrate that the pAKT2 Ser128 and pCCTαSer315/319/323-positive cancer-associated fibroblasts(CAFs)substantially release phosphatidylcholines(PCs),contributing to the resistance of focal adhesion kinase(FAK)inhibitors in esophageal squamous cell carcinoma(ESCC)***,we observed extremely low levels of FAK Tyr397 expression in CAFs,potentially offering no available target for FAK inhibitors playing their anti-growth role in ***,FAK inhibitor increased the intracellular concentration of Ca2+in CAFs,promoting the formation of AKT2/CCTαcomplex,leading to phosphorylation of CCTαSer315/319/323 sites and eventually enhancing stromal PC *** activation could stimulate the intratumoral Janus kinase 2(JAK2)/Signal transducer and activator of transcription 3(STAT3)pathway,triggering resistance to FAK *** of clinical samples demonstrated that stromal pAKT2 Ser128 and pCCTαSer315/319/323 are related to the tumor malignancy and reduced patient ***-targeted lipidomics and further validation cohort quantitatively showed that plasma PCs enable to distinguish the malignant extent of ESCC *** conclusion,inhibition of stroma-derived PCs and related pathway could be possible therapeutic strategies for tumor therapy.

关键词： CAFs metabolism resistance

Borf-1 protein identified as a transcriptional trans-activator of bovine foamy virus

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Chinese Science Bulletin 1999年第11期44卷 1017-1021页

作者： Jiajian Liu Shuhong Liu qimin chen Yunqi Geng Nankai Univ Coll Life Sci Tianjin 300071 Peoples R China

Bovine foamy virus (BFV), a member of the spumavirus subfamily of retroviruses,contains two open reading frames (ORF-1 and ORF-2) in addition to the genes coding for gag,po/and env. Borf-1 protein, encoded by BFV ORF-1, is identified as a transcriptional transactivator, which augments gene expression directed by the viral long terminal repeat (LTR).Further investigations in transient expression assays reveal that the Borf-1 responsive elements are located in the U3 domain of the LTR, upstream from position -140 ( + 1 represents the transcription initiation site), and the BFV RU5 region has an inhibitory effect in LTR-directed gene expression.

关键词： bovine foamy virus (BFV )3026 China Strain transcriptional trans-activator transient expression assay.

MicroRNAs and their role in viral infection

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Frontiers in Biology 2007年第1期2卷 15-20页

作者： MU Junjie YAO Xue chen qimin GENG Yunqi QIAO Wentao College of Life Science and Tianjin State Laboratory of Microbial Functional Genomics Nankai UniversityTianjin 300071China

Recently,a class of about 22 nucleotides(nt)small RNA has been discovered in many eukaryotes,termed microRNAs(miRNAs),which have a variety of *** recent findings have demonstrated that viruses can also encode their own ***,other findings reveal a relationship between host miRNA and viral *** findings suggest a tight relationship between host and viral infection via miRNA *** article introduces the miRNAs encoded by viruses and reviews the advances of the interaction of the mammalian host miRNAs and viral infection.

关键词： microRNA(miRNA) viral infection small RNA

Membrane-spanning domain of bovine foamy virus transmembrane protein having cytotoxicity

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Frontiers in Biology 2006年第4期1卷 353-356页

作者： MA Yonggang YU Hong WANG Jinzhong chen qimin GENG Yunqi College of Life Sciences Nankai UniversityTianjin 300071China

Foamy viruses(FVs)have broad cellular tropism infecting vertebrates from fish to human being,which indicates that Env protein has a high capability for membrane *** features in all FV transmembrane(TM)proteins include a region of hydrophobic domain called membrane-spanning domain(MSD),which contains several stretches of hydrophobic amino *** investigate whether these features were associated with the cytotoxicity effect of TM on Escherichia coli,a series of mutants were constructed and expressed in the *** BL21(DE3)using pET-32a(+)as expressing *** results showed that only TM3 without MSD was expressed in ***,whereas the other two containing full or part of the MSD(TM1 and TM2)could not be ***,the bacterial amount and living bacteria analysis revealed that the cytotoxicity of TM was dependent on its MSD,especially on the stretches of hydrophobic amino *** blotting analysis showed that TM3 protein was purified with affinity purification.

关键词： bovine foamy virus(BFV) membrane-spanning domain(MSD) cytotoxicity

cis-acting element located in the bovine foamy virus internal promoter possesses the properties of a transcrip-tional enhancer

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Chinese Science Bulletin 2002年第13期47卷 1108-1112页

作者： Wentao Qiao Chunguang Guo Shuhui Wang Jinzhong Wang qimin chen Yunqi Geng Nankai Univ Coll Life Sci Tianjin 300071 Peoples R China

Bovine foamy virus encodes a transcriptional transactivitor, Tas or Borf-1, which governs the level of viral transcripts initiated by both the promoter in the long terminal repeat (LTR) and the internal promoter (IP) located in the env gene through their cis-acting targets. We have identified and characterized a 72 bp TBS (Borf-1) responsive element located in BFV3026, internal promoter (TREIP) by deletion mutant and transient expression assay. This cis-acting target element in the internal promoter has the properties of a transcriptional enhancer which functions independently of its orientation, position and also in heterologous promoters (BFV LTR and bovine immunodeficiency virus, BIV LTR). Alignments reveal that there are positional similarity and sequence homology among BFV TREIP, SFV-1 TREIP proximal element and SFV-3 TREIPH, which suggests that this kind of cis-acting elements possesses some common functional character.

关键词： bovine foamy virus (BFV) internal promoter (IP) Tas responsive element (TRE) enhancer.