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Chinese Journal of Chemistry 2024年第10期42卷 1107-1113页

作者： Guangyu Wang Huaiyuan li Xuebing Leng Long Lu qilong Shen Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of Sciences345 Lingling LuShanghai 200032China

The invention of a well-defined Cu(Ⅲ)fluoride complex Me_(4)N^(+)[Cu(CF_(3))_(3)(F)]^(-)1 enabled to access a versatile of functionalized Cu(Ⅲ)complexes[Me_(4)N]^(+)[Cu(X)(CF_(3))_(3)]^(-)(X=C_(6)F_(5),C_(6)F_(5)C≡C,CN,Cl,N_(3),^(t)BuOO,SCN,OAc,SAr),many of them for the first time.The availability of these complexes allowed us to evaluate the trans-influence order of ligand in Cu(Ⅲ)complexes:Bn>CF_(3)^(-)>C_(6)F_(5)^(-)>N_(3)^(-)>py~CH_(3)^(-)~C_(6)F_(5)C≡C>NO_(2)PhO^(-)~^(t)BuOO^(-)~CH_(3)COO^(-)>F^(-).

关键词： Fluorine Copper Cu(Ⅲ) Cu(Ⅲ)fluoride Trifluoromethyl

Optimized nitrogen application for maximizing yield and minimizing nitrogen loss in film mulching spring maize production on the Loess Plateau,China

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Journal of Integrative Agriculture 2024年第5期23卷 1671-1684页

作者： qilong Song Jie Zhang Fangfang Zhang Yufang Shen Shanchao Yue Shiqing li State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau College of Natural Resources and EnvironmentNorthwestA&FUniversityYangling712100China life Science Department Luoyang Normal UniversityLuoyang 471934China

Excessive use of N fertilizers(driven by high-yield goals)and its consequent environmental problems are becoming increasingly acute in agricultural systems.A 2-year field experiment was conducted to investigate the effects of three N application methods(application of solid granular urea once(OF)or twice(TF),application of solid granular urea mixed with controlled-release urea once(MF),and six N rates(0,60,120,180,240,and 300 kg N ha^(-1))on maize yield,economic benefits,N use efficiency,and soil N balance in the maize(Zea mays L.)film mulching system on the Loess Plateau,China.The grain yield and economic return of maize were significantly affected by the N rate and application method.Compared with the OF treatment,the MF treatment not only increased the maize yield(increased by 9.0-16.7%)but also improved the economic return(increased by 10.9-25.8%).The agronomic N use efficiency(NAE),N partial factor productivity(NPFP)and recovery N efficiency(NRE)were significantly improved by 19.3-66.7,9.0-16.7 and 40.2-71.5%,respectively,compared with the OF treatment.The economic optimal N rate(EONR)of the OF,TF,and MF was 145.6,147.2,and 144.9 kg ha^(-1) in 2019,and 206.4,186.4,and 146.0 kg ha^(-1) in 2020,respectively.The apparent soil N loss at EONR of the OF,TF,and MF were 97.1-100.5,78.5-79.3,and 50.5-68.1 kg ha^(-1),respectively.These results support MF as a one-time N application method for delivering high yields and economic benefits,with low N input requirements within film mulching spring maize system on the Loess Plateau.

关键词： maize yield N management economic optimal N rate Loess Plateau

Persistence of charge density wave against variation of band structures in V_(x)Ti_(1−x)Se_(2)(x=0–0.1)

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Nano Research 2024年第3期17卷 2129-2135页

作者： Zhanfeng liu Tongrui li Wen Zhu Hongwei Shou Mukhtar Lawan Adam qilong Cui Yuliang li Sheng Wang Yunbo Wu Hongen Zhu Yi liu Shuangming Chen Xiaojun Wu Shengtao Cui li Song Zhe Sun National Synchrotron Radiation Laboratory CAS Center for Excellence in NanoscienceUniversity of Science and Technology of ChinaHefei 230029China CAS Key Laboratory of Strongly-coupled Quantum Matter Physics University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012China School of Chemistry and Materials Sciences CAS Key Laboratory of Materials for Energy Conversionand CAS Center for Excellence in NanoscienceUniversity of Science and Technology of ChinaHefei 230026China School Zhejiang Institute of Photonelectronics Jinhua 321004China

Charge density wave(CDW)is a phenomenon that occurs in materials,accompanied by changes in their intrinsic electronic properties.The study of CDW and its modulation in materials holds tremendous significance in materials research,as it provides a unique approach to controlling the electronic properties of materials.TiSe_(2) is a typical layered material with a CDW phase at low temperatures.Through V substitution for Ti in TiSe_(2),we tuned the carrier concentration in V_(x)Ti_(1-x)Se_(2) to study how its electronic structures evolve.Angle-resolved photoemission spectroscopy(ARPES)shows that the band-folding effect is sustained with the doping level up to 10%,indicating the persistence of the CDW phase,even though the band structure is strikingly different from that of the parent compound TiSe_(2).Though CDW can induce the band fold effect with a driving force from the perspective of electronic systems,our studies suggest that this behavior could be maintained by lattice distortion of the CDW phase,even if band structures deviate from the electron-driven CDW scenario.Our work provides a constraint for understanding the CDW mechanism in TiSe_(2),and highlights the role of lattice distortion in the band-folding effect.

关键词： charge density wave band structure lattice distortion

Donkey whey proteins ameliorate dextran sulfate sodium-induced ulcerative colitis in mice by downregulating the S100A8-TRAF6-NF-κB axis-mediated inflammatory response

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Food Science and Human Wellness 2023年第5期12卷 1809-1819页

作者： Mohan li qilong li Rayhnigul Abdlla Jiali Chen Xiqing Yue Siew Young Quek College of Food Science Shenyang Agricultural UniversityShenyang 110866China College of Animal Science and Veterinary Medicine Shenyang Agricultural UniversityShenyang 110866China Food Science School of Chemical SciencesThe University of AucklandAuckland 1010New Zealand Riddet Institute Centre for Research Excellence in Food ResearchPalmerston North 4474New Zealand

Donkey milk has a variety of physiological functions, including antibacterial and anti-inflammatory. Donkey whey proteins(DWPs), as the main functional component in donkey milk, its inhibitory effect on colitis is still unclear. In this study, the inhibitory effect and potential mechanism of DWPs on dextran sulfate sodium(DSS)-induced colitis were investigated. Firstly, the DWPs and bovine milk whey proteins(BWPs)were characterized using proteomics. Then, we administered DWPs and BWPs to mice with colitis via oral gavage. The results of immunohistochemistry and flow cytometry indicated that DWPs increased T regulatory cell accumulation and increased the abundance of the cluster of differentiation 205+(CD205+)macrophages compared to those with BWPs and in model groups. In addition, DWPs exhibited a more remarkable ability to inhibit pro-inflammatory proteins(S100A8, TRAF6, and NF-κB)expression and inflammatory secretion than BWPs. In addition, DWPs significantly decreased NF-κB and CD86 levels more than BWPs or the negative control in both LPS-stimulated human peripheral blood mononuclear cells or cell lines. These findings indicate that DWPs comprise a promising anti-colitis functional food, and this work has established a foundation for future research on these compounds.

关键词： Donkey milk Proteomics Whey proteins NF-κB

Differentially expressed whey proteins of donkey and bovine colostrum revealed with a label-free proteomics approach

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Food Science and Human Wellness 2023年第4期12卷 1224-1231页

作者： Mohan li qilong li Haikun Yu Xiumin Zhang Dehao li Wanying Song Yan Zheng Xiqing Yue College of Food Science Shenyang Agricultural UniversityShenyang 110866China College of Animal Science and Veterinary Medicine Shenyang Agricultural UniversityShenyang 110866China Beijing Academy of Food Sciences Beijing 100068China The Fourth Affiliated Hospital of China Medical University Shenyang 110866China

This study aimed to analyze and compare the differentially expressed whey proteins(DEWPs)of donkey and bovine colostrum using high-performance liquid chromatography with tandem mass spectrometry-based proteomics.A total of 620 and 696 whey proteins were characterized in the donkey and bovine colostrum,respectively,including 383 common whey proteins.Among these common proteins,80 were identified as DEWPs,including 21 upregulated and 59 downregulated DEWPs in donkey colostrum compared to bovine colostrum.Gene Ontology analysis revealed that these DEWPs were mainly related to cellular components,such as extracellular exosome,plasma membrane,and mitochondrion;biological processes,such as oxidation-reduction process,cell-cell adhesion,and small guanosine triphosphate(GTP)ase-mediated signal transduction;and molecular functions,such as GTP binding,GTPase activity,and soluble N-ethylmaleimide-sensitive factor(NSF)attachment protein receptor activity.Metabolic pathway analysis suggested that the majority of the DEWPs were associated with soluble NSF factor attachment protein receptor interactions in vesicular transport,fatty acid biosynthesis,and estrogen signaling pathways.Our results provide a vital insight into the differences between donkey and bovine colostrum,along with important information on the significant components as nutritional and functional factors to be included in infant formula based on multiple milk sources.

关键词： Bovine colostrum Donkey colostrum Proteomics Whey protein Gene Ontology Kyoto Encyclopedia of Genes and Genomes

Endothelial phosphodiesterase 4B inactivation ameliorates endothelial-to-mesenchymal transition and pulmonary hypertension

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1726-1741页

作者： Yanjiang Xing Yangfeng Hou Tianfei Fan Ran Gao Xiaohang Feng Bolun li Junling Pang Wenjun Guo Ting Shu Jinqiu li Jie Yang qilong Mao Ya Luo Xianmei Qi Peiran Yang Chaoyang liang Hongmei Zhao Wenhui Chen Jing Wang Chen Wang State Key Laboratory of Respiratory Health and Multimorbidity Institute of Basic Medical SciencesChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100005China Department of Lung Transplantation National Center for Respiratory MedicineNational Clinical Research Center for Respiratory DiseasesChina–Japan Friendship HospitalInstitute of Respiratory MedicineChinese Academy of Medical SciencesBeijing 100029China Haihe Laboratory of Cell Ecosystem Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300051China The State Key Laboratory of Complex Severeand Rare DiseasesInstitute of Basic Medical SciencesChinese Academy of Medical SciencesDepartment of PathophysiologyPeking Union Medical CollegeBeijing 100005China Department of Pharmacy West China HospitalSichuan UniversityChengdu 610044China

Pulmonary hypertension (PH) is a fatal disorder characterized by pulmonary vascular remodeling and obstruction. The phosphodiesterase 4 (PDE4) family hydrolyzes cyclic AMP (cAMP) and is comprised of four subtypes (PDE4A–D). Previous studies have shown the beneficial effects of pan-PDE4 inhibitors in rodent PH;however, this class of drugs is associated with side effects owing to the broad inhibition of all four PDE4 isozymes. Here, we demonstrate that PDE4B is the predominant PDE isozyme in lungs and that it was upregulated in rodent and human PH lung tissues. We also confirmed that PDE4B is mainly expressed in the lung endothelial cells (ECs). Evaluation of PH in Pde4b wild type and knockout mice confirmed that Pde4b is important for the vascular remodeling associated with PH. In vivo EC lineage tracing demonstrated that Pde4b induces PH development by driving endothelial-to-mesenchymal transition (EndMT), and mechanistic studies showed that Pde4b regulates EndMT by antagonizing the cAMP-dependent PKA–CREB–BMPRII axis. Finally, treating PH rats with a PDE4B-specific inhibitor validated that PDE4B inhibition has a significant pharmacological effect in the alleviation of PH. Collectively, our findings indicate a critical role for PDE4B in EndMT and PH, prompting further studies of PDE4B-specific inhibitors as a therapeutic strategy for PH.

关键词： Phosphodiesterase 4B Pulmonary hypertension Endothelial-to-mesenchymal transition

Dihydroartemisinin beneficially regulates splenic immune cell heterogeneity through the SOD3-JNK-AP-1 axis

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Science China(life Sciences) 2022年第8期65卷 1636-1654页

作者： Yiwei Zhang qilong li Ning Jiang Ziwei Su Quan Yuan Lei Lv Xiaoyu Sang Ran Chen Ying Feng Qijun Chen Key Laboratory of livestock Infectious Diseases in Northeast China Ministry of EducationKey Laboratory of ZoonosisCollege of Animal Science and Veterinary MedicineShenyang Agricultural UniversityShenyang 110866China Research Unit for Pathogenic Mechanisms of Zoonotic Parasites Chinese Academy of Medical SciencesShenyang 110866China

The immunomodulatory potential of dihydroartemisinin(DHA) has recently been highlighted;however, the potential mechanism remains to be clarified. Single-cell RNA sequencing was explored in combination with cellular and biochemical approaches to elucidate the immunomodulatory mechanisms of DHA. In this study, we found that DHA induced both spleen enlargement and rearrangement of splenic immune cell subsets in mice. It was revealed that DHA promoted the reversible expansion of effective regulatory T cells and interferon-γ^(+)cytotoxic CD8^(+)T cells in the spleen via induction of superoxide dismutase 3(SOD3) expression and increased phosphorylation of c-Jun N-terminal kinases(JNK) and its downstream activator protein 1(AP-1) transcription factors. Further, SOD3 knockout mice were resistant to the regulatory effect of DHA. Thus, DHA,through the activation of the SOD3-JNK-AP-1 axis, beneficially regulated immune cell heterogeneity and splenic immune cell homeostasis to treat autoimmune diseases.

关键词： dihydroartemisinin immunomodulatory activity single-cell RNA sequencing AP-1 transcription factor SOD3

Dihydroartemisinin regulates immune cell heterogeneity by triggering a cascade reaction of CDK and MAPK phosphorylation

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Signal Transduction and Targeted Therapy 2022年第8期7卷 3021-3031页

作者： qilong li Quan Yuan Ning Jiang Yiwei Zhang Ziwei Su Lei Lv Xiaoyu Sang Ran Chen Ying Feng Qijun Chen Key Laboratory of livestock Infectious Diseases Ministry of EducationKey Laboratory of ZoonosisCollege of Animal Science and Veterinary MedicineShenyang Agricultural University120 Dongling Road110866 ShenyangChina Research Unit for Pathogenic Mechanisms of Zoonotic Parasites Chinese Academy of Medical Sciences120 Dongling Road110866 ShenyangChina

Artemisinin(ART)and dihydroartemisinin(DHA),apart from their profound anti-malaria effect,can also beneficially modulate the host immune system;however,the underlying molecular mechanisms remain unclear.Here,we report that DHA selectively induced T-cell activation,with an increased proportion of Ki67^(+)CD4^(+)T cells,CD25^(+)CD4^(+)T cells,interferon(IFN)-γ-producing CD8^(+)T cells,Brdu^(+)CD8^(+)T cells and neutrophils,which was found to enhance cellular immunity to experimental malaria and overcome immunosuppression in mice.We further revealed that DHA upregulated the expression of cell proliferation-associated proteins by promoting the phosphorylation of mitogen-activated protein kinase(MAPK),cyclin-dependent kinases(CDKs),and activator protein 1 in the spleen.This study is the first to provide robust evidence that DHA selectively induced the expansion of subsets of splenic T cells through phosphorylated CDKs and MAPK to enhance cellular immune responses under non-pathological or pathological conditions.The data significantly deepened our knowledge in the mechanism underlying DHA-mediated immunomodulation.

关键词： immunity spleen malaria

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康德的建构主义思想及其对教育的影响

湖南师范大学教育科学学报 2024年第3期23卷 1-4页

作者：李其龙华东师范大学国际与比较教育研究所上海200062

康德的先验哲学被视为建构主义的理论基础之一,其将认识过程视为主体性的构建活动,强调了知识的主观性和基于经验的构建。可见,康德虽然不是一个建构主义者,但其毫无疑问具有建构主义认识论的思想倾向,并被广泛引用为建构主义的理论源... 详细信息

康德的先验哲学被视为建构主义的理论基础之一,其将认识过程视为主体性的构建活动,强调了知识的主观性和基于经验的构建。可见,康德虽然不是一个建构主义者,但其毫无疑问具有建构主义认识论的思想倾向,并被广泛引用为建构主义的理论源泉。康德强调了学习者的主观能动性,认为教育应鼓励学生主动探究和理解知识,同时教师应发挥启发和辅助的作用,其思想体系深刻影响了冯·格拉塞斯费尔德等后继建构主义学者。同时,康德的建构主义思想引发了对教育本质的思考,其思想超越激进建构主义,指出了知识的可传授性,认为认识的生存力受范畴和世界普遍秩序的调节性理念保障。

关键词：康德建构主义激进建构主义冯·格拉塞斯费尔德

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可压缩边界层的入口合成湍流生成方法

力学学报 2024年第1期56卷 45-57页

作者：王天孙东郭启龙李辰袁先旭李博中国空气动力研究与发展中心空天飞行空气动力科学与技术全国重点实验室四川绵阳621000

在壁湍流中开展RANS-LES方法混合模拟时,入口处添加合理的湍流脉动能够缩短流场向完全湍流的发展距离,提高数值模拟精度以及节省计算资源.采用SA-IDDES方法对槽道湍流和可压缩湍流边界层开展了数值模拟研究,对比了3种较为常用的合成湍... 详细信息

在壁湍流中开展RANS-LES方法混合模拟时,入口处添加合理的湍流脉动能够缩短流场向完全湍流的发展距离,提高数值模拟精度以及节省计算资源.采用SA-IDDES方法对槽道湍流和可压缩湍流边界层开展了数值模拟研究,对比了3种较为常用的合成湍流方法对流场发展的影响,包括合成湍流生成器(STG)、数字滤波法(DFM)和合成涡方法(SEM);研究了不同合成湍流入口条件下流场壁面摩阻、流场结构、雷诺应力的发展过程,评估了各方法在壁湍流中的表现.其中在不可压槽道湍流和可压缩湍流边界层的模拟中,STG方法展现了较短的摩阻恢复距离,流场结构与雷诺应力发展相比DFM也有一定的优势.在高马赫数湍流边界层的数值模拟中,忽略热力学量脉动可能会降低合成边界层脉动恢复到物理真实脉动的速度.因此,文章进一步基于STG给出的速度脉动,在入口处通过若干强雷诺比拟方法(SRA,GSRA和HSRA)添加热力学脉动量,对比研究了对可压缩湍流边界层流场发展的影响,结果显示是否添加热力学脉动对于流场摩阻和雷诺应力发展影响较小,但对流场中的热力学量影响显著,其中GSRA下流场热力学量恢复得最快.

关键词：合成湍流入口边界条件可压缩性湍流边界层