检索结果-南通市图书馆

DP1180和S700MC异种高强钢激光焊接接头的组织和性能

在线全文

学校读者我要写书评

暂无评论

上海金属 2024年第2期46卷 64-70页

作者：汪杨王山刘成杰黎其俊恺博座椅机械部件有限公司上海201315 宝山钢铁股份有限公司中央研究院汽车用钢研究所上海201900

采用激光搭接焊对DP1180和S700MC异种高强钢进行焊接,研究了焊接接头的微观组织和力学性能,并与DP1180同种钢焊接接头进行了对比。结果表明:DP1180和S700MC异种钢焊缝的横截面呈Y形,而DP1180同种钢焊缝的横截面呈V形;异种钢搭接焊接头的... 详细信息

采用激光搭接焊对DP1180和S700MC异种高强钢进行焊接,研究了焊接接头的微观组织和力学性能,并与DP1180同种钢焊接接头进行了对比。结果表明:DP1180和S700MC异种钢焊缝的横截面呈Y形,而DP1180同种钢焊缝的横截面呈V形;异种钢搭接焊接头的DP1180钢侧热影响区分别出现了软化和硬化现象,而S700MC钢侧热影响区只出现了较为严重的硬化现象,并没有明显的软化现象;在相同的熔宽条件下,DP1180和S700MC异种钢接头的拉剪力明显小于DP1180同种钢接头,但仍高于S700MC钢母材;所有接头的拉伸性能稳定,力学性能良好,并且同种钢和异种钢焊接均可通过增加焊长来提升焊接接头的承载性能。

关键词： DP1180钢异种材料激光搭接焊显微组织力学性能

Light field salient object detection:A review and benchmark

在线全文

学校读者我要写书评

暂无评论

Computational Visual Media 2022年第4期8卷 509-534页

作者： Keren Fu Yao Jiang Ge-Peng Ji Tao Zhou qijun Zhao Deng-Ping Fan College of Computer Science Sichuan Universityand National Key Laboratory of Fundamental Science on Synthetic VisionSichuan UniversityChengdu 610065China School of Computer Science Wuhan UniversityWuhan 430072China PCA Lab School of Computer Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China Computer Vision Lab ETH ZürichZürichSwitzerland

Salient object detection(SOD)is a long-standing research topic in computer vision with increasing interest in the past *** light fields record comprehensive information of natural scenes that benefit SOD in a number of ways,using light field inputs to improve saliency detection over conventional RGB inputs is an emerging *** paper provides the first comprehensive review and a benchmark for light field SOD,which has long been lacking in the saliency ***,we introduce light fields,including theory and data forms,and then review existing studies on light field SOD,covering ten traditional models,seven deep learning-based models,a comparative study,and a brief *** datasets for light field SOD are also ***,we benchmark nine representative light field SOD models together with several cutting-edge RGB-D SOD models on four widely used light field datasets,providing insightful discussions and analyses,including a comparison between light field SOD and RGB-D SOD *** to the inconsistency of current datasets,we further generate complete data and supplement focal stacks,depth maps,and multi-view images for them,making them consistent and *** supplemental data make a universal benchmark ***,light field SOD is a specialised problem,because of its diverse data representations and high dependency on acquisition hardware,so it differs greatly from other saliency detection *** provide nine observations on challenges and future directions,and outline several open *** the materials including models,datasets,benchmarking results,and supplemented light field datasets are publicly available at https://***/kerenfu/LFSOD-Survey.

关键词： light field salient object detection(SOD) deep learning benchmarking

A novel strategy for cancer treatment:Targeting cancer stem cells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2008年第12期53卷 1777-1783页

作者： LIU Jia MA LeiNa WANG YiGang LIU XinYuan QIAN qijun Xin Yuan Institute of Medicine and Biotechnology College of Life Science Zhejiang Sci-Tech University Hangzhou 310018 China Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Laboratory of Viral and Gene Therapy Eastern Hepatobiliary Surgical Hospital Shanghai 200438 China

Cancer stem cell/tumor-initiating cell (CSC/TIC) is a subclass of cancer cells possessing parts of properties of normal stem cell. It has a high capacity of proliferation and plays a pivotal role in tumor recurrence and tumor resistance to radiotherapy and chemotherapy. At present, small molecule in-hibitors and fusion proteins are widely used in the CSC-targeting strategy. Gene-virotherapy, which uses oncolytic adenovirus as a vector to mediate the expression of therapeutic gene, shows a signifi-cant superiority to other regimens of cancer treatment and has a good efficacy in the treatment of solid tumors. Thus, it is a promising choice to apply gene-virotherapy into the CSC-targeting treatment. Based on the molecular mechanism underlying CSC self-renewal, a series of effective strategies for targeting CSC have been established. This review will summarize the recent research progresses on CSC-targeting treatment.

关键词：肿瘤治疗方法干细胞临床分析

Monitoring checkpoint inhibitors:predictive biomarkers in immunotherapy

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2019年第1期13卷 32-44页

作者： Min Zhang Jingwen Yang Wenjing Hua Zhong Li Zenghui Xu qijun Qian ShangHai Cell Therapy Group Co. Ltd.Shanghai 201805China

Immunotherapy has become the fourth cancer therapy after surgery, chemotherapy, and radiotherapy. In particular, immune checkpoint inhibitors are proved to be unprecedentedly in increasing the overall survival rates of patients with refractory cancers, such as advanced melanoma, non-small cell lung cancer, and renal cell carcinoma. However, inhibitor therapies are only effective in a small proportion of patients with problems, such as side effects and high costs. Therefore, doctors urgently need reliable predictive biomarkers for checkpoint inhibitor therapies to choose the optimal therapies. Here, we review the biomarkers that can serve as potential predictors of the outcomes of immune checkpoint inhibitor treatment, including tumor-specific profiles and tumor microenvironment evaluation and other factors.

关键词： immune checkpoint companion diagnosis PD-L1 tumor mutation burden immune score

Helium ion irradiation effects on neodymium and cerium co-doped Gd_2.r_2._7 pyrochlore ceramic

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rare Earths 2018年第4期36卷 398-403页

作者： qijun Hu Junsen Zeng Lan Wang Xiaoyan Shu Dadong Shao Haibin Zhang Xirui Lu School of Civil Engineering and Architecture Southwest Petroleum University Fundamental Science on Nuclear Wastes and Environmental Safety Laboratory Southwest University of Scienoe and Technology Institute of Plasma Physics Chinese Academy of Sciences Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics

This paper studies the helium ions irradiation effects on Nd and Ce co-doped Gd_2.Zr_2.O_7 ceramics. where Nd replaces the Gd site and Ce replaces the Zr site respectively. A series of（Gd_（1-x）Nd_x）_2.Zr_（1-y）Ce_y）_2.O_7（0 ≤ x, y ≤ 1） ceramics were irradiated with a 500 keV He ions at room temperature at fluences ranging from 1 × 10^（15） to 1 × 10^（17） ions/cm^2. The irradiated samples were characterized using GIXRD, Raman and SEM measurements. From the GIXRD and Raman observations, the results indicate that all the samples display a deficient fluorite structure after irradiation. The irradiation toleration increases with the irradiation depth increasing under experimental conditions, and Nd_2.Ce_2.O_7 has the best irradiation stability in the（Gd_（1-x）Nd_x）_2.Zr_（1-y）Ce_y）_2.O_7（0≤ x. y≤1）. Based on SEM results, the irradiated samples are still relatively dense and uniform, and no second phase exists.

关键词： Helium ion irradiation Ceramic Pyrochlore Co-doping Rare earths

贵州省某三甲公立医院1093例糖尿病患者住院费用结构及西药费影响因素分析

在线全文

学校读者我要写书评

暂无评论

江苏卫生事业管理 2024年第2期35卷 237-240,244页

作者：吕轶娟陶婉菊梁启君贵州中医药大学第一附属医院财务科贵州贵阳550001 贵州中医药大学第一附属医院信息科贵州贵阳550001

目的:分析贵州省某三甲医院糖尿病患者住院费用及西药费影响因素,以期为减轻患者经济负担、进一步优化医保政策、提高公众防病意识提供参考依据。方法:收集该医院2.2.年1093例糖尿病患者信息,对住院总费用构成进行逐步回归分析,对西药... 详细信息

目的:分析贵州省某三甲医院糖尿病患者住院费用及西药费影响因素,以期为减轻患者经济负担、进一步优化医保政策、提高公众防病意识提供参考依据。方法:收集该医院2.2.年1093例糖尿病患者信息,对住院总费用构成进行逐步回归分析,对西药费影响因素进行K-W检验分析。结果:糖尿病患者住院总费用的中位数为17158.2.元,对住院总费用影响最大的费用是西药费(P<0.05),不同性别、年龄、住院天数、诊断、是否有并发症等住院西药费的差异存在统计学意义(P<0.05)。结论:该院糖尿病患者住院费用较高,可从实施临床路径管理、完善医保政策等方面控制西药费,合理控制疾病直接经济负担,并努力提高公众预防糖尿病的意识。

关键词：糖尿病住院费用西药费影响因素贵州

Engineering FeS_(2. nanoparticles on tubular g-C_(3)N_(4) for photo-Fenton treatment of paint wastewater

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第6期33卷 3073-3077页

作者： Chan Wang Bangqi Wei Han Zhu Yimin He Guoxia Ran qijun Song Key Laboratory of Synthetic and Biological Colloids Ministry of EducationInternational Joint Research Center for Photoresponsive Molecules and MaterialsSchool of Chemical&Material EngineeringJiangnan UniversityWuxi 214122China

An efficient photo-Fenton catalyst(Fe S_(2.@HTCN)was designed by maximizing the synergistic effect of Fe S_(2.nanoparticles and hollow tubular g-C_(3)N_(4)(HTCN).Molecule self-assembly and molten salts-assisted calcination were used to engineering the hollow structured g-C_(3)N_(4)before anchoring Fe S_(2.nanoparticles on the walls of HTCN via reflux *** to bulk g-C_(3)N_(4),the unique structure of HTCN and heterojunction in the composite endowed FeS_(2.@HTCN with more active sites and abundant channels for electron transfer and charge *** enriched electrons can improve the Fe^(3+) recycling and boost Fe^(2.) catalyzed ^(·)OH production via H_(2.O_(2..As-prepared photo-Fenton catalyst was successfully applied to the treatment of industrial paint *** paint wastewater with its COD as high as 82.0 mg/L can be effectively degraded with 0.2.mol/L H_(2.O_(2.in 90 min under visible light *** photoFenton system was further evaluated according to the process stability and economic benefit,proving that the strategy presented in this work would be applicable to the treatment of real wastewater.

关键词： Photo-Fenton catalysts FeS_(2.nanoparticles Hollow tubular g-C_(3)N_(4) Heterojunction Reactive oxygen species Paint wastewater degradation

4味归肺经中药的黄酮成分簇“印迹模板”特征分析及其体外归经研究方法建立

在线全文

学校读者我要写书评

暂无评论

中国实验方剂学杂志 2024年第9期30卷 141-147页

作者：贺琪珺盛丹丹陈宇霞欧阳少琴邓凯文贺福元陈新宇湖南中医药大学第一附属医院长沙410007 湖南中医药大学药学院中药炮制与制剂制备工程技术实验室中医药超分子机理与数理特征化实验室中药成药性与制剂制备湖南省重点实验室中药药性与药效国家中医药管理局重点实验室长沙410208

目的:对归肺经4味中药黄酮成分簇的“印迹模板”特征进行研究,建立中药体外归肺经的研究方法。方法:以普通高等教育“十三五”国家级规划教材《中药学》中只归肺经的苍耳子、鱼腥草、金荞麦、射干等13味中药为基础,确定鱼腥草、金荞麦... 详细信息

目的:对归肺经4味中药黄酮成分簇的“印迹模板”特征进行研究,建立中药体外归肺经的研究方法。方法:以普通高等教育“十三五”国家级规划教材《中药学》中只归肺经的苍耳子、鱼腥草、金荞麦、射干等13味中药为基础,确定鱼腥草、金荞麦、射干、桑白皮4味代表中药,通过高效液相色谱法(HPLC)建立指纹图谱,并计算4味中药中所含各类成分的分子连接性指数,运用夹角余弦法计算其与平均分子连接性指数的相似性,以此建立构印定量关系,确定各成分归肺经次序。选择绿原酸、芦丁、槲皮苷、异槲皮苷、金丝桃苷、表儿茶素、野鸢尾苷共7种对照品验证模型的黄酮类成分整体的构印关系及其预测能力。结果:鱼腥草、金荞麦、射干和桑白皮共含有437种化学成分,其平均分子连接性指数相似度为0.9956,4味中药共含黄酮类成分2.4个,平均分子连接性指数相似度为0.9780,仅次于生物碱的0.9851。7个对照品的保留时间(t_(R))与分子连接性指数相似度(S)呈良好构印关系(t_(R)=831.4×S-790.3,r=0.8614,P2.0位为绿原酸,分子连接性指数相似度为0.9582.tR为6.36 min;按指纹图谱的总量统计矩法算得的4味中药的总量一阶矩为2..2. min,列位2.,能表征整体的99.19%,7种对照品的药材峰面积总量一阶矩为2..00 min,列位46,能表征整体的98.68%。结论:黄酮类成分簇是研究归肺经的“印迹模板”特征的适宜探针,据此能建立起定量结构信息与tR关系的体外中药归经研究方法。

关键词：中药归经肺经印迹模版定量构印关系分子连接性指数经络相似度

ZnO形貌及粒径对EP复合材料表面电荷传输及沿面闪络性能的影响

在线全文

学校读者我要写书评

暂无评论

绝缘材料 2024年第3期57卷 50-57页

作者：尹国华段祺君邵帅夏国巍李经纬钟昱尧谢庆华北电力大学新能源电力系统国家重点实验室河北保定071003 国网长春供电公司吉林长春130000

无机填料的形貌及粒径是影响环氧树脂(EP)复合材料沿面耐压性能的关键因素。本研究采用ZnO纳米纤维和不同粒径的颗粒状ZnO掺杂改性环氧树脂制备EP复合材料,并对复合材料进行了直流沿面闪络性能与电荷消散速率测试。结果表明:ZnO填料掺... 详细信息

无机填料的形貌及粒径是影响环氧树脂(EP)复合材料沿面耐压性能的关键因素。本研究采用ZnO纳米纤维和不同粒径的颗粒状ZnO掺杂改性环氧树脂制备EP复合材料,并对复合材料进行了直流沿面闪络性能与电荷消散速率测试。结果表明:ZnO填料掺杂能有效提升EP复合材料的闪络电压,其中纤维状ZnO填料的提升效果要明显优于颗粒状ZnO填料,颗粒状ZnO/EP复合材料的闪络电压随填料粒径的减小呈现上升趋势。当ZnO纳米纤维的质量分数为15%时,EP复合材料的闪络电压相比纯EP提高了2..1%。构建了有限元仿真模型,计算结果表明纤维状ZnO使得EP内部电场非均匀系数提升,提高了复合材料的电流密度。

关键词：环氧树脂氧化锌形貌粒径沿面闪络表面电荷