A novel strategy for cancer treatment:Targeting cancer stem cells

作     者：LIU Jia MA LeiNa WANG YiGang LIU XinYuan QIAN QiJun 

作者机构：Xin Yuan Institute of Medicine and Biotechnology College of Life Science Zhejiang Sci-Tech University Hangzhou 310018 China Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Laboratory of Viral and Gene Therapy Eastern Hepatobiliary Surgical Hospital Shanghai 200438 China 

出 版 物：《Chinese Science Bulletin》 (中国科学通报)

年 卷 期：2008年第53卷第12期

页      面：1777-1783页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the National Natural Science Foundation of China (Grant No.30730104) Zhejiang Province Sci-Tech Supporting and Leading Program (Grant No.2007C33027) 

主　　题：肿瘤 治疗方法 干细胞 临床分析 

摘      要：Cancer stem cell/tumor-initiating cell (CSC/TIC) is a subclass of cancer cells possessing parts of properties of normal stem cell. It has a high capacity of proliferation and plays a pivotal role in tumor recurrence and tumor resistance to radiotherapy and chemotherapy. At present, small molecule in-hibitors and fusion proteins are widely used in the CSC-targeting strategy. Gene-virotherapy, which uses oncolytic adenovirus as a vector to mediate the expression of therapeutic gene, shows a signifi-cant superiority to other regimens of cancer treatment and has a good efficacy in the treatment of solid tumors. Thus, it is a promising choice to apply gene-virotherapy into the CSC-targeting treatment. Based on the molecular mechanism underlying CSC self-renewal, a series of effective strategies for targeting CSC have been established. This review will summarize the recent research progresses on CSC-targeting treatment.