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Synthesis and in vitro Antibacterial Activities of 5-（2,3,4,5- Tetrahydro-1 H-chromeno[2,3-dJpyrimidin-5-yl）pyrimidione Derivatives

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Chinese Journal of Chemistry 2012年第2期30卷 386-390页

作者： Cheng,Qingfang wang,qifa Tan,Ting wang,Mingxiao Chen,Na Department of Chemical Technology Huaihai Institute of TechnologyLianyungangJiangsu 222005China Jiangsu Key Laboratory of Marine Biotechnology Huaihai Institute of TechnologyLianyungangJiangsu 222005China

A series of novel 5-（2,3,4,5-tetrahydro-lH-chromeno[2,3-d]pyrimidin-5-yl）pyrimidione derivatives have been synthesized from substituted salicylaldehydes and barbituric acid or 2-thiobarbituric acid in water catalyzed by phase transfer catalysis of triethylbenzyl ammonium chloride （TEBA）. Elemental analysis, IR, 1HNMR, and 13C NMR elucidated the structures of all the newly synthesized compounds. In vitro antimicrobial activities of synthesized compounds have been investigated against Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and Pseudornonas aeruginosa. These newly synthesized derivatives exhibited significant in vitro antibacterial activity.

关键词： 5-(2,3,4,5-tetrahydro-lH-chromeno[2,3-d]pyrimidin-5-yl)pyrimidione antibacterial activity phase transfer catalysis water

Augmenting photoluminescence of monolayer MoS_(2) using high order modes in a metal dimer-on-film nanocavity

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Photonics Research 2021年第4期9卷 501-506页

作者： Shiyin Cao Liping Hou qifa wang Chenyang Li Weixing Yu Xuetao Gan Kaihui Liu Malin Premaratne Fajun Xiao Jianlin Zhao MOE Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions and Shaanxi Key Laboratory of Optical Information TechnologySchool of Physical Science and TechnologyNorthwestern Polytechnical UniversityXi’an 710129China Key Laboratory of Spectral Imaging Technology of Chinese Academy of Sciences Xi’an 710119China State Key Laboratory for Mesoscopic Physics Collaborative Innovation Centre of Quantum MatterSchool of PhysicsPeking UniversityBeijing 100871China Advanced Computing and Simulation Laboratory(AχL) Department of Electrical and Computer Systems EngineeringMonash UniversityClaytonVIC 3800Australia

Plasmonic particle-on-film nanocavities,supporting gap modes with ultra-small volume,provide a great solution to boost light–matter interactions at the *** this work,we report on the photoluminescence(PL)enhancement of monolayer MoS_(2) using high order modes of an Au nanosphere dimer-on-film nanocavity(DoFN).The high order plasmon modes,consisting of two bonding quadrupoles in the dimer and their images in the Au film,are revealed by combining the polarization-resolved scattering spectra with the numerical *** integrating the monolayer MoS_(2) into the DoFN,these high order modes are used to enhance PL intensity through simultaneously boosting the absorption and emission processes,producing a 1350-fold enhancement *** opens an avenue to enhance the light–matter interaction with high order plasmon modes and may find applications in future optoelectronics and nanophotonics devices.

关键词： cavity high integrating

A new fluorocarbon adhesive:Inhibiting agglomeration during combustion of propellant via efficient F-Al_(2)O_(3) preignition reaction

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Carbon Energy 2024年第6期6卷 292-305页

作者： qifa Yao Min Xia Chao wang Fanzhi Yang Wei Yang Yunjun Luo School of Materials Science and Engineering Beijing Institute of TechnologyBeijingChina Key Laboratory of High Energy Density Materials Ministry of EducationBeijing Institute of TechnologyBeijingChina School of Aerospace Engineering Beijing Institute of TechnologyBeijingChina Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijingChina

Inhibiting the agglomeration of molten aluminum particles packed in the binder network is a promising scheme to achieve efficient combustion of solid *** this investigation,the hydroxyl-terminated structured fluorinated alcohol compound(PFD)was introduced to modify the traditional polyethylene glycol/polytetrahydrofuran block copolymerization(HTPE)binder;that is,a unique fluorinated polyether(FTPE)binder was synthesized by embedding fluorinated organic segments into the HTPE binder via crosslinking *** FTPE was applied in aluminum-based propellants for the first *** to the complete release of fluorinated organic active segments in the range of 300℃to 400℃,the burning rate of FTPEbased propellant increased from 4.07(0%PFD)to 6.36 mm/s(5%PFD),increased by 56.27%under 1 *** reaction heat of FTPE propellants increased from 5.95(0%PFD)to 7.18 MJ/kg(5%PFD)under 3.0 MPa,indicating that HTPE binder modified with PFD would be conducive to inhibiting the D90 of condensed combustion products(CCPs)dropped by 81.84%from 75.46(0%PFD)to 13.71μm(5%PFD)under 3.0 MPa,in consistent with the significant reduction of aluminum agglomerates observed on the quenched burning surface of the *** results demonstrated that a novel FTPE binder with PFD can release fluorinated organic active segments,which motivate preignition reaction with the alumina shell in the early stage of aluminum combustion,and then enhance the melting diffusion effect of aluminum to inhibit the agglomeration.

关键词： agglomeration characteristics aluminum particles combustion fluorine alcohol compounds HTPE propellants

miR‑423 sponged by lncRNA NORHA inhibits granulosa cell apoptosis

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Journal of Animal Science and Biotechnology 2024年第2期15卷 632-644页

作者： Yuqi Li Zhuofan Zhang Siqi wang Xing Du qifa Li College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China

Background Atresia and degeneration,a follicular developmental fate that reduces female fertility and is triggered by granulosa cell(GC)apoptosis,have been induced by dozens of ***,we report a miRNA,miR-423,that inhibits the initiation of follicular atresia(FA),and early apoptosis of *** We showed that miR-423 was down-regulated during sow FA,and its levels in follicles were negatively correlated with the GC density and the P4/E2 ratio in the follicular fluid in *** in vitro gain-of-function experiments revealed that miR-423 suppresses cell apoptosis,especially early apoptosis in *** speaking,the miR-423 targets and interacts with the 3’-UTR of the porcine SMAD7 gene,which encodes an apoptosis-inducing factor in GCs,and represses its expression and pro-apoptotic ***,FA and the GC apoptosis-related lncRNA NORHA was demonstrated as a ceRNA of ***,we showed that a single base deletion/insertion in the miR-423 promoter is significantly associated with the number of stillbirths(NSB)trait of *** These results demonstrate that miR-423 is a small molecule for inhibiting FA initiation and GC early apoptosis,suggesting that treating with miR-423 may be a novel approach for inhibiting FA initiation and improving female fertility.

关键词： Granulosa cell apoptosis miR-423 NORHA SMAD7 Sow fertility traits

Nonlinear Flap-Wise Vibration Characteristics ofWind Turbine Blades Based onMulti-Scale AnalysisMethod

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Energy Engineering 2024年第2期121卷 483-498页

作者： qifa Lang Yuqiao Zheng Tiancai Cui Chenglong Shi Heyu Zhang School of Mechanical and Electrical Engineering Lanzhou University of TechnologyLanzhou730050China

This work presents a novel approach to achieve nonlinear vibration response based on the Hamilton *** chose the 5-MW reference wind turbine which was established by the National Renewable Energy Laboratory(NREL),to research the effects of the nonlinear flap-wise vibration *** turbine wheel is simplified by treating the blade of a wind turbine as an Euler-Bernoulli beam,and the nonlinear flap-wise vibration characteristics of the wind turbine blades are discussed based on the simplification ***,the blade’s large-deflection flap-wise vibration governing equation is established by considering the nonlinear term involving the centrifugal ***,it is truncated by the Galerkin method and analyzed semi-analytically using the multi-scale analysis method,and numerical simulations are carried out to compare the simulation results of finite elements with the numerical simulation results using Campbell diagram analysis of blade *** results indicated that the rotational speed of the impeller has a significant impact on blade *** the wheel speed of 12.1 rpm and excitation amplitude of 1.23 the maximum displacement amplitude of the blade has increased from 0.72 to *** the amplitude-frequency curve,it can be seen that the multi-peak characteristic of blade amplitude frequency is under centrifugal *** phase trajectories in blade nonlinear vibration,exhibiting periodic motion characteristics,are found through phase diagrams and Poincare section diagrams.

关键词： Wind turbine blades nonlinear vibration Galerkin method multi-scales method

侯外庐对中国封建社会史及近世思想史研究的学术贡献——纪念侯外庐诞辰120周年

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中国史研究动态 2023年第3期 60-73页

作者：王启发中国社会科学院古代史研究所北京100101

侯外庐是20世纪中国重要的马克思主义史学家之一,在马克思主义中国化的历史进程中有着突出的理论贡献和学术成就。侯外庐在早年对中国古代社会和古代思想史的早期阶段进行了系统研究之后(参见王启发《侯外庐早期思想史研究的特色及学术... 详细信息

侯外庐是20世纪中国重要的马克思主义史学家之一,在马克思主义中国化的历史进程中有着突出的理论贡献和学术成就。侯外庐在早年对中国古代社会和古代思想史的早期阶段进行了系统研究之后(参见王启发《侯外庐早期思想史研究的特色及学术史意义》,《晋阳学刊》2016年第5期),又继续对中国封建社会长时段的历史,以及与之有着密切关联的思想发展史,进行了相互结合、互相照应的深入考察和系列研究与论述。

关键词：学术史意义学术贡献思想史研究侯外庐思想发展史中国古代社会学术成就研究与论述

The genetic basis and process of inbreeding depression in an elite hybrid rice

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Science China(Life Sciences) 2024年第8期67卷 1727-1738页

作者： Xiaodong Xu Yawen Xu Jian Che Xu Han Zhengji wang Xianmeng wang Qinghua Zhang Xu Li Qinglu Zhang Jinghua Xiao Xianghua Li qifa Zhang Yidan Ouyang National Key Laboratory of Crop Genetic Improvement and National Centre of Plant Gene Research(Wuhan) Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China

Inbreeding depression refers to the reduced performance arising from increased homozygosity,a phenomenon that is the reverse of heterosis and exists among plants and *** a natural self-pollinated crop with strong heterosis,the mechanism of inbreeding depression in rice is largely *** understand the genetic basis of inbreeding depression,we constructed a successive inbreeding population from the F_(2)to F_(4)generation and observed inbreeding depression of all heterotic traits in the progeny along with the decay of heterozygosity in each *** expected depression effect was largely explained by 13 QTLs showing dominant effects for spikelets per panicle,11 for primary branches,and 12 for secondary branches,and these loci constitute the main correlation between heterosis and inbreeding ***,the genetic basis of inbreeding depression is also distinct from that of heterosis,such that a biased transmission ratio of alleles for QTLs with either dominant or additive effects in four segregation distortion regions would result in minor effects in expected ***,two-locus interactions may change the extent and direction of the depression effects of the target loci,and overall interactions would promote inbreeding depression among *** an F_(2:3)variation population,the actual performance of the loci showing expected depression was evaluated considering the heterozygosity decay in the background after *** found inconsistent or various degrees of background depression from the F_(2)to F_(3)generation assuming different genotypes of the target locus,which may affect the actual depression effect of the locus due to *** results suggest that the genetic architecture of inbreeding depression and heterosis is closely linked but also differs in their intrinsic mechanisms,which expand our understanding of the whole-genome architecture of inbreeding depression.

关键词： rice inbreeding depression spikelet development dominance segregation distortion epistasis

Investigation on photonic crystal nanobeam cavity based on mixed diamond–circular holes

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Nanotechnology and Precision Engineering 2024年第1期7卷 63-70页

作者： Jingtong Bin Kerui Feng Shang Ma Ke Liu Yong Cheng Jing Chen qifa Liu College of Telecommunication and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing 210003China College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210003China State Key Laboratory of Advanced Optical Communication Systems and Networks Shanghai Jiao Tong UniversityShanghai 200240China

A photonic crystal nanobeam cavity(M-PCNC)with a structure incorporating a mixture of diamond-shaped and circular air holes is *** performance of the cavity is simulated and studied *** theﬁnite-difference time-domain method,the parameters of the M-PCNC,including cavity thickness and width,lattice constant,and radii and numbers of holes,are optimized,with the quality factor Q and mode volume Vm as performance *** modulation of the lattice constant and hole radius enable the proposed M-PCNC to realize outstanding *** optimized cavity possesses a high quality factor Q 1.45105 and an ultra-small mode=×volume Vm 0.01(λ/n)[Zeng et al.,Opt Lett 2023:48;3981–3984]in the telecommunications wavelength *** can be progres-=sively squeezed in both the propagation direction and the perpendicular in-plane direction by a series of interlocked anti-slots and slots in the diamond-shaped hole ***,the energy can be conﬁned within a small mode volume to achieve an ultra-high Q/Vm ratio.

关键词： Photonic crystal nanobeam cavity Mixed diamond–circular holes Slots and anti-slots FDTD simulation Quality factor Mode volume

稻草还田对土壤钾,磷,锌的吸附—解吸及其有效性的影响

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华中农业大学学报 2000年第3期19卷 227-232页

作者：李学垣王启发华中农业大学资源环境与农业化学系

就长期肥料田间试验的红壤性水稻土、黄棕壤性水稻土和灰潮土性水稻土，用热呼学稀吸附法和流行法分别进行了土壤钾、磷、锌的吸附－解吸试验和土壤钾吸附动力学试验，测定了土壤钾吸附动力学试验，测定了土诉粘接矿物组成，基本性质和... 详细信息

就长期肥料田间试验的红壤性水稻土、黄棕壤性水稻土和灰潮土性水稻土，用热呼学稀吸附法和流行法分别进行了土壤钾、磷、锌的吸附－解吸试验和土壤钾吸附动力学试验，测定了土壤钾吸附动力学试验，测定了土诉粘接矿物组成，基本性质和有效钾、磷的含量，研究了稻草还田对土壤钾、磷、锌吸附量、吸附钾、磷、锌解吸率的影响。结果表明稻草还田：（１）能减小土壤对钾的吸附，增加其解吸率，提高土壤有效钾量和土壤对钾的缓冲能力；（

关键词：水稻土吸附-解吸钾磷锌有效性稻草还田