Synthesis and in vitro Antibacterial Activities of 5-（2,3,4,5- Tetrahydro-1 H-chromeno[2,3-dJpyrimidin-5-yl）pyrimidione Derivatives
Synthesis and in vitro Antibacterial Activities of 5-（2,3,4,5- Tetrahydro-1 H-chromeno[2,3-dJpyrimidin-5-yl）pyrimidione Derivatives作者机构：Department of Chemical TechnologyHuaihai Institute of TechnologyLianyungangJiangsu 222005China Jiangsu Key Laboratory of Marine BiotechnologyHuaihai Institute of TechnologyLianyungangJiangsu 222005China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2012年第30卷第2期
页 面：386-390页
核心收录：
学科分类：090603[农学-临床兽医学] 081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 09[农学] 0906[农学-兽医学] 0703[理学-化学]
基 金：The Foundation of Jiangsu Key Laboratory of Marine Biotechnology
主 题：5-(2,3,4,5-tetrahydro-lH-chromeno[2,3-d]pyrimidin-5-yl)pyrimidione antibacterial activity phase transfer catalysis water
摘 要：A series of novel 5-（2,3,4,5-tetrahydro-lH-chromeno[2,3-d]pyrimidin-5-yl）pyrimidione derivatives have been synthesized from substituted salicylaldehydes and barbituric acid or 2-thiobarbituric acid in water catalyzed by phase transfer catalysis of triethylbenzyl ammonium chloride （TEBA）. Elemental analysis, IR, 1HNMR, and 13C NMR elucidated the structures of all the newly synthesized compounds. In vitro antimicrobial activities of synthesized compounds have been investigated against Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and Pseudornonas aeruginosa. These newly synthesized derivatives exhibited significant in vitro antibacterial activity.
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