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Optimization of polyurethane-bonded thin overlay mixture designation for airport pavement

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Frontiers of Structural and Civil Engineering 2022年第8期16卷 947-961页

作者： Xianrui LI Ling XU qidi ZONG Fu JIANG Xinyao YU Jun wang Feipeng XIAO Key Laboratory of Road and Traffic Engineering of Ministry of Education Tongji UniversityShanghai 201804China CAAC East China Regional Administration Shanghai 200335China Ningbo Airport Group Co. Ltd.Ningbo 315154China

This research explored the application potential of PUM thin-overlay technology on airport rapid *** rapid curing process of polyurethane binder determines the limited time window for mixing and construction of polyurethane-bonded mixture(PUM),which presents significant difference with hot-mix asphalt(HMA)***,this research investigated and optimized the mix design of PUM for airport thin-overlay technology based on its thermosetting ***,limestone and basalt were comprehensively compared as an aggregate for ***,the effects of molding and curing conditions were studied in terms of mixing time,molding method,molding parameters and curing *** analysis was also conducted to evaluate the effects of gradation and particle size on PUM performances based on gray relational analysis(GRA),thus determining the key particle size to control PUM ***,the internal structural details of PUM were captured by X-ray CT scan *** results demonstrated that it only took 12 hours to reach 75%of maximum strength at a curing temperature of 50°C,indicating an efficient curing process and in turn allowing short traffic *** internal structural details of PUM presented distribution of tiny pores with few connective voids,guaranteeing waterproof property and high strength.

关键词： polyurethane-bonded mixture mix design optimization airport pavement thin overlay gray relational analysis

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外显子组测序探究原发性干燥综合征相关基因

免疫学杂志 2019年第11期35卷 997-1002页

作者：王启迪杜蒙安莉莎王景邱月高丹马旭宣磊曹小芳国家卫生健康委科学技术研究所北京 100081 北京协和医院中医科 100730

目的探究编码区变异在原发性干燥综合征遗传机制中的作用。方法对11例pSS患者和6例健康对照进行全外显子测序,经过位点的多重过滤筛选、基因的功能分析和变异位点的有害性分析获得与疾病相关的变异位点。结果经过筛选分析获得2个变异位... 详细信息

目的探究编码区变异在原发性干燥综合征遗传机制中的作用。方法对11例pSS患者和6例健康对照进行全外显子测序,经过位点的多重过滤筛选、基因的功能分析和变异位点的有害性分析获得与疾病相关的变异位点。结果经过筛选分析获得2个变异位点:IFIH1 c.2115A>C和SIDT1 c.1216G>A,Sanger测序证实为患者样本中真实存在的变异。结论IFIH1c.2115A>C和SIDT1 c.1216G>A可能与原发性干燥综合征存在相关性。

关键词：原发性干燥综合征全外显子测序 IFIH1 SIDT1

pIL-12 delivered by polymer based nanovector for anti-tumor genetherapy

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Chinese Chemical Letters 2023年第11期34卷 209-213页

作者： Lianbin Wen Xin Zan qidi Pang Yuzhu Hu Songping Zheng Mengni Ran Xiang Gao Xiang wang Bilan wang Department of Geriatrics Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengdu 610072China Department of Neurosurgery West China HospitalSichuan UniversityChengdu 610041China Department of Infection Management Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072China Department of Radiation Oncology Cancer CenterWest China HospitalWest China Medical SchoolSichuan UniversityChengdu 610041China Department of Pharmacy West China Second University Hospital of Sichuan UniversityChengdu 610041China Pharmaceutical Department Chongqing University Three Gorges HospitalChongqing 404000China

Finding more effective and safe non-viral vectors to transfer genes into cancer cells has become the key of immune gene therapy for *** a triblock compound MPEG_(2000)-PDLLA_(4000)-MPEG_(2000) modified by cationic liposome DOTAP was used as a non-viral vector DOTAP/MPEG_(2000)-PDLLA_(4000)-MPEG_(2000)(DMPM)to effectively transfer interleukin(IL)-12 plasmid(pIL-12)into tumor ***-12 produced by transfected tumor cells successfully inducing lymphocyte proliferation and promoting interferon-γ(IFN-γ)secretion,which resulted in tumor cells *** ability of DMPM to transfer pIL-12 and the immune effect induced by IL-12 in cells had been *** anti-tumor effect,mechanism and safety of pIL-12/DMPM in mice cancer model were investigated in this *** results showed that the pIL-12 transferred by DMPM was highly expressed both in CT26 cells and B16-F10 ***-12 expressed in the culture supernatant of transfected tumor cells stimulated lymphocyte proliferation and promoted IFN-γ*** experimental result confirmed that pIL-12/DMPM therapy significantly reduced tumor growth in mice *** designed the nanocomposite DMPM to deliver pIL-12 for cancer treatment and explored its therapeutic efficacy and the underlying anti-tumor *** study suggested pIL-12 loaded by DMPM complex would be an effective strategy for cancer treatment.

关键词： Non-viral vector Cancer gene therapy pIL-12 Immune response Nanocomposite

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人血清转铁蛋白标准物质纯化

过程工程学报 2018年第2期18卷 387-392页

作者：孔金隆全灿王启迪罗坚周俊波孙永跃李增兰天津理工大学化学化工学院天津300384 中国计量科学研究院化学计量与分析科学研究所北京100029 北京化工大学机电工程学院北京100029 中国科学院过程工程研究所生化工程国家重点实验室北京100190

建立了一种从Cohn血浆分离副产物组分IV中纯化高纯度转铁蛋白（Tf）标准物质的技术,对Cohn组分IV进行复溶、离心和过滤,采用Capto DEAE阴离子交换色谱进行初分离,再通过穿透式Octyl-Sepharose 4 Fast Flow疏水色谱进一步精制;对纯化产... 详细信息

建立了一种从Cohn血浆分离副产物组分IV中纯化高纯度转铁蛋白（Tf）标准物质的技术,对Cohn组分IV进行复溶、离心和过滤,采用Capto DEAE阴离子交换色谱进行初分离,再通过穿透式Octyl-Sepharose 4 Fast Flow疏水色谱进一步精制;对纯化产品进行了结构、纯度、活性等表征,采用十二烷基磺酸钠-聚丙烯酰胺凝胶电泳、基质辅助激光解吸电离飞行时间质谱、高效液相色谱及酶联免疫吸附法对Tf标准物质进行了分析.结果表明,Tf产品纯度大于99%,收率为79%;圆二色光谱分析显示Tf的二级结构未发生改变,铁离子结合能力实验表明Tf可结合2个铁离子,保持活性.

关键词：人血清转铁蛋白标准物质离子交换色谱疏水色谱 Cohn组分Ⅳ 纯化

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辣椒雄性不育分子研究进展

中国农学通报 2024年第13期40卷 27-35页

作者：徐晓美衡周王恒明孙启迪徐小万广东省农业科学院蔬菜研究所/广东省蔬菜新技术研究重点实验室广州510640 茂名市茂蔬种业科技有限公司广东茂名525000

为对辣椒雄性不育分子研究取得的进展有更直观、系统、深入的了解,梳理已鉴定的辣椒核雄性不育(NMS)基因及部分NMS基因分子标记开发,重点阐述近年来核雄性不育基因精细定位及候选基因探究工作;同时回顾辣椒胞质雄性不育(CMS)相关的线粒... 详细信息

为对辣椒雄性不育分子研究取得的进展有更直观、系统、深入的了解,梳理已鉴定的辣椒核雄性不育(NMS)基因及部分NMS基因分子标记开发,重点阐述近年来核雄性不育基因精细定位及候选基因探究工作;同时回顾辣椒胞质雄性不育(CMS)相关的线粒体不育基因及其关联分子标记和CMS恢复基因分子标记开发,重点概述近年来恢复基因精细定位研究取得的进展。研究指出,精细定位NMS基因,明确候选基因并开发功能标记是辣椒NMS研究的重点,既能为探明辣椒NMS机理奠定基础又可为育种提供高效利用的分子标记。而CMS相较于NMS更为复杂,表现在遗传机制多样且更易受环境影响等方面,因此,从对CMS育性恢复基因的精细定位到基因克隆以及功能研究并探明CMS分子机制还有很长的一段路要走。

关键词：辣椒核雄性不育胞质雄性不育恢复基因分子标记

烟酰胺核苷酸转氢酶基因突变对C57BL／6小鼠糖代谢稳态的影响

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中华内分泌代谢杂志 2017年第8期33卷 673-679页

作者：尹庆磊谢运沈艳张宏利倪启程汪启迪顾燕云上海交通大学医学院附属瑞金医院内分泌代谢病科上海市内分泌代谢病中心上海市内分泌代谢病研究所200025 瑞金医院心内科瑞金医院实验医学研究中心上海市第七人民医院

目的探讨烟酰胺核苷酸转氢酶（NNT）基因突变对于C57BL/6小鼠糖代谢稳态的影响。方法将无NNT突变的野生型C57BL/6N与携带NNT突变C57BL/6J小鼠交配，F1代杂合小鼠继续交配，得到NNT纯合野生型，NNT纯合突变型，及NNT突变杂合子3种不同NN... 详细信息

目的探讨烟酰胺核苷酸转氢酶（NNT）基因突变对于C57BL/6小鼠糖代谢稳态的影响。方法将无NNT突变的野生型C57BL/6N与携带NNT突变C57BL/6J小鼠交配，F1代杂合小鼠继续交配，得到NNT纯合野生型，NNT纯合突变型，及NNT突变杂合子3种不同NNT基因型的F2代。小鼠4周龄起分别给予高脂饮食或对照饮食4周，每周监测小鼠体重。在小鼠8周时称重，并通过经腹糖耐量试验（IPGTT）检测小鼠糖代谢水平，通过经腹胰岛素耐量试验（ITT）检测小鼠胰岛素敏感性。结果正常饮食或高脂饮食喂养4周后，不同F2代小鼠基因型三者体重并无差异，但是NNT突变小鼠糖耐量显著受损，并且在高脂饮食诱导下NNT突变小鼠胰岛素敏感性相对NNT野生型显著下降。而NNT杂合子小鼠糖代谢及胰岛素敏感性异常不显著。结论NNT基因突变对C57BL/6小鼠的糖代谢表型具有重要影响，杂合突变和纯合突变表型迥异。C57BL/6J和C57BL/6N小鼠不同遗传背景对高脂饮食有不同反应，这是在进行实验设计时需要充分考虑的因素，可能与不同NNT基因型有关。在研究代谢的实验中尽量保持受试小鼠遗传背景的一致，将对实验结果的解释具有重要作用。

关键词：烟酰胺核苷酸转氢酶高脂糖耐量 C57BL/6小鼠

限定晶粒取向差的多晶马氏体相变行为的相场法研究

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上海金属 2024年第3期46卷 89-94页

作者：姚启迪王传军刘振智黄琪琦刘文月赵彦上海大学材料科学与工程学院上海200444 海洋装备用金属材料及其应用国家重点实验室辽宁鞍山114009 鞍钢集团北京研究院有限公司北京102200

基于Welch-Powell算法限定多晶体取向,采用相场法研究了晶粒取向差对多晶马氏体相变的影响。结果表明:大晶粒较小晶粒马氏体的板条形貌更规则,晶界降低了马氏体的生长速度;晶粒取向角比晶粒尺寸对马氏体相变体积分数的影响更大。马氏体... 详细信息

基于Welch-Powell算法限定多晶体取向,采用相场法研究了晶粒取向差对多晶马氏体相变的影响。结果表明:大晶粒较小晶粒马氏体的板条形貌更规则,晶界降低了马氏体的生长速度;晶粒取向角比晶粒尺寸对马氏体相变体积分数的影响更大。马氏体相变初期ω值越大,马氏体生长速度越快,ω=60°时的平衡马氏体体积分数高于其他ω值下的平衡马氏体体积分数,随ω值的增大平衡马氏体体积分数减小。

关键词：相场法 Welch-Powell 算法多晶体马氏体相变

A Task-oriented Modular and Agent-based Collaborative Design Mechanism for Distributed Product Development

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Chinese Journal of Mechanical Engineering 2014年第3期27卷 641-654页

作者： LIU Jinfei CHEN Ming wang Lei WU qidi School of Electronics and Information Engineering Tongji University School of Mechanical Engineering Tongji University

The rapid expansion of enterprises makes product collaborative design （PCD） a critical issue under the distributed heterogeneous environment, but as the collaborative task of large-scale network becomes more complicated, neither unified task decomposition and allocation methodology nor Agent-based network management platform can satisfy the increasing demands. In this paper, to meet requirements of PCD for distributed product development, a collaborative design mechanism based on the thought of modularity and the Agent technology is presented. First, the top-down 4-tier process model based on task-oriented modular and Agent is constructed for PCD after analyzing the mapping relationships between requirements and functions in the collaborative design. Second, on basis of sub-task decomposition for PCD based on a mixed method, the mathematic model of task-oriented modular based on multi-objective optimization is established to maximize the module cohesion degree and minimize the module coupling degree, while considering the module executable degree as a restriction. The mathematic model is optimized and simulated by the modified PSO, and the decomposed modules are obtained. Finally, the Agent structure model for collaborative design is put forward, and the optimism matching Agents are selected by using similarity algorithm to implement different task-modules by the integrated reasoning and decision-making mechanism with the behavioral model of collaborative design Agents. With the results of experimental studies for automobile collaborative design, the feasibility and efficiency of this methodology of task-oriented modular and Agent-based collaborative design in the distributed heterogeneous environment are verified. On this basis, an integrative automobile collaborative R＆D platform is developed. This research provides an effective platform for automobile manufacturing enterprises to achieve PCD, and helps to promote product numeralization collaborative R＆D and manag

关键词： collaborative design task-oriented modular multi-agent collaboration mechanism collaborative platform

基于图神经网络GraphVAE的兵棋态势预测方法

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指挥控制与仿真 2023年第5期45卷 129-136页

作者：余晓晗王启迪于坤中国人民解放军陆军工程大学指挥控制工程学院江苏南京210007

在战场上敌我双方作战的过程中,准确地预测敌方的兵力部署将有利于我方的作战。基于兵棋推演的态势数据,通过训练图神经网络,提出了预测敌方未知算子位置的方法。首先,在对数据进行预处理后,实现了态势到图结构数据的转化,构造了兵棋态... 详细信息

在战场上敌我双方作战的过程中,准确地预测敌方的兵力部署将有利于我方的作战。基于兵棋推演的态势数据,通过训练图神经网络,提出了预测敌方未知算子位置的方法。首先,在对数据进行预处理后,实现了态势到图结构数据的转化,构造了兵棋态势的图结构数据集,用于图神经网络的训练。其次,根据兵棋态势及其数据的特点改造了GraphVAE模型,实现了兵棋态势图结构数据的补全。最后设计了基于补全后的图结构数据,计算敌方算子位置的方法。通过实验证实了该方法的有效性和可行性。

关键词：态势预测图结构数据图神经网络兵棋态势

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