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非酒精性脂肪性肝病患者2054例肝纤维化状况的评估

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中华全科医师杂志 2017年第3期16卷 219-223页

作者：刘安楠赵小兰陈志恒张群洪海鸥王瑜黄守清王启斌夏燕妮朱玲北京医院国家老年医学中心特需医疗部 100730 第三军医大学西南医院健康管理中心重庆400038 中南大学湘雅三医院健康管理中心长沙410013 江苏省人民医院体检中心南京210029 安徽省立医院体检中心合肥230001 解放军第一八0医院健康管理中心福建省泉州362000 福建省第二人民医院健康管理中心福州350003 山东电力中心医院健康管理中心济南250001 湖北省中山医院健康体检亚健康管理中心武汉430032

目的探讨应用AST／血小板计数值（APRI）初步评估体检人群中非酒精性脂肪性肝病（NAFLD）患者的肝脏纤维化的患病状况及相关危险因素。方法采用回顾分析方法，对2014年3月至2015年1月全国9家体检中心根据体检彩超检查与病史诊断为NAFLD... 详细信息

目的探讨应用AST／血小板计数值（APRI）初步评估体检人群中非酒精性脂肪性肝病（NAFLD）患者的肝脏纤维化的患病状况及相关危险因素。方法采用回顾分析方法，对2014年3月至2015年1月全国9家体检中心根据体检彩超检查与病史诊断为NAFLD的2054例（男性1598、女性456例），按APRI评分分为3组：APRI〈0．43组（1475例）、APRl0．43～0．53组（261例）、APRI≥0．54组（318例），比较3组患者的临床资料，以APRI〉0．98为诊断进展性纤维化标准，分析APRI与各指标相关性；二元logistic回归计算肝纤维化与血糖、血脂代谢的风险性。结果①2054例中，APRI≥0．98者61例（2．97％），APRI≥0．54者占15．48％（318／2054），APRI〈0．43者占71．81％（1475／2054），APRI为0．43～0．53者占12．71％（261／2054）。②logistic回归分析，TG、餐后2h血糖、尿素氮是进展性纤维化的危险因素（P=0．002，OR=1．095，95％CI：1．033～1．161；P=0．000，OR=1．103，95％CI：1．058～1．151；P=0．034，OR=1．215，95％CI：1．014～1．454）：HDL—C是进展性纤维化的保护性因素（P=0．034，OR=0．353，95％CI：0．135～0．924）。结论根据APRI预测体检人群中NAFLD患者进展性纤维化的可能患病率为2．97％，与血糖血脂代谢紊乱密切相关。

关键词：脂肪肝诊断天冬氨酸转氨酶/血小板值纤维化

Determination of responses of liquid xenon to low energy electron and nuclear recoils using a PandaX-Ⅱ detector

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Chinese Physics C 2021年第7期45卷 273-282页

作者： Binbin Yan Abdusalam Abdukerim Wei Chen Xun Chen Yunhua Chen Chen Cheng xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Di Huang Peiyao Huang Yan Huang Yanlin Huang Zhou Huang xiangdong Ji Yonglin Ju Shuaijie Li Jianglai Liu Zhuoqun Lei Wenbo Ma Yugang Ma Yajun Mao Yue Meng Kaixiang Ni Jinhua Ning Xuyang Ning xiangxiang Ren Changsong Shang Lin Si Guofang Shen Andi Tan Anqing Wang Hongwei Wang Meng Wang Qiuhong Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Shiyong Wu Weihao Wu Jingkai xia Mengjiao xiao Pengwei Xie Rui Yan Jijun Yang Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Jianfeng Yue Xinning Zeng Dan Zhang Tao Zhang Li Zhao qibin Zheng Jifang Zhou Ning Zhou xiaopeng Zhou School of Physics and Astronomy Shanghai Jiao Tong UniversityMOE Key Laboratory for Particle Astrophysics and CosmologyShanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Tsung-Dao Lee Institute Shanghai 200240China School of Physics Nankai UniversityTianjin 300071China School of Physics Peking UniversityBeijing 100871China School of Physics Beihang UniversityBeijing 100191China International Research Center for Nuclei and Particles in the Cosmos&Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Physics University of MarylandCollege ParkMaryland 20742USA School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Physics and Key Laboratory of Particle Physics and Particle Irradiation(MOE) Shandong UniversityJinan 250100China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Center for High Energy Physics Peking UniversityBeijing 100871China

We present a systematic determination of the responses of PandaX-Ⅱ,a dual phase xenon time projection chamber detector,to low energy *** electron recoil(ER) and nuclear recoil(NR) responses are calibrated,respectively,with injected tritiated methane or 220Rn source,and with 241Am-Be neutron source,in an energy range from 1-25 keV(ER) and 4-80 keV(NR),under the two drift fields,400 and 317 V/*** empirical model is used to fit the light yield and charge yield for both types of *** best fit models can describe the calibration data *** systematic uncertainties of the fitted models are obtained via statistical comparison to the data.

关键词： dark matter liquid xenon time projection chamber calibration electron recoil nucleon recoil NEST2.0

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豫北地区小麦籽粒矿质元素含量分析

核农学报 2017年第3期31卷 516-523页

作者：夏瑞雪魏帅郭波莉曹冬梅黑龙江八一农垦大学食品学院黑龙江大庆163319 中国农业科学院农产品加工研究所/农业部农产品加工与质量控制重点开放实验室北京100193

为了解豫北地区小麦籽粒中矿物元素的含量,指导小麦区域种植,本研究采集了河南安阳、鹤壁、新乡等3个地市9个粮食主产县区的81份小麦籽粒样品,并分析其钙、铁、锌、硒、铜、镁、钠、钾、铬等9种元素含量。结果表明,豫北地区小麦籽粒中... 详细信息

为了解豫北地区小麦籽粒中矿物元素的含量,指导小麦区域种植,本研究采集了河南安阳、鹤壁、新乡等3个地市9个粮食主产县区的81份小麦籽粒样品,并分析其钙、铁、锌、硒、铜、镁、钠、钾、铬等9种元素含量。结果表明,豫北地区小麦籽粒中铜、铬元素含量均符合国家相关标准要求,锌元素存在少量超标样品,被测元素除镁、铬元素可满足一般人群的每日摄入量外,其余元素均需通过食用其他食品补充人体矿质元素营养需求。豫北地区矿质元素呈不均一分布,鹤壁市淇滨区周边小麦籽粒中锌含量较高,新乡市市区周边的硒含量较高,铁元素含量较高地区为安阳市内黄县、滑县东部,硒元素含量较低地区为安阳市滑县、新乡市延津县。本研究结果为保障豫北地区消费者营养元素均衡摄取提供了数据参考。

关键词：小麦矿物元素豫北地区

Neutron-induced nuclear recoil background in the PandaX-4T experiment

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Chinese Physics C 2022年第11期46卷 262-274页

作者： Zhou Huang Guofang Shen Qiuhong Wang Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Yunshan Cheng xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Chencheng Han Ke Han Changda He Jinrong He Di Huang Yanlin Huang Ruquan Hou xiangdong Ji Yonglin Ju Chenxiang Li Mingchuan Li Shu Li Shuaijie Li Qing Lin Jianglai Liu xiaoying Lu Lingyin Luo Wenbo Ma Yugang Ma Yajun Mao Yue Meng Xuyang Ning Ningchun Qi Zhicheng Qian xiangxiang Ren Nasir Shaheed Changsong Shang Lin Si Wenliang Sun Andi Tan Yi Tao Anqing Wang Meng Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Weihao Wu Jingkai xia Mengjiao xiao xiang xiao Pengwei Xie Binbin Yan Xiyu Yan Jijun Yang Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Dan Zhang Minzhen Zhang Peng Zhang Tao Zhang Li Zhao qibin Zheng Jifang Zhou Ning Zhou xiaopeng Zhou Yong Zhou School of Physics and Astronomy Shanghai Jiao Tong UniversityKey Laboratory for Particle Astrophysics and Cosmology(MoE)Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China School of Physics Beihang UniversityBeijing 102206China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary SciencShandong UniversityQingdao 266237China Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao 266237China Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai200240China School of Physics Nankai UniversityTianjin 300071China School of Physics Peking UniversityBeijing 100871China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing102206China School of Physics and Microelectronics Zhengzhou UniversityZhengzhouHenan 450001China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Physics University of MarylandCollege ParkMaryland 20742USA School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China SJTU Paris Elite Institute of Technology Shanghai Jiao Tong UniversityShanghai200240China

Neutron-induced nuclear recoil background is critical to dark matter searches in the PandaX-4T liquid xenon *** this study,we investigate the features of neutron background in liquid xenon and evaluate its contribution in single scattering nuclear recoil events using three *** first method is fully based on Monte Carlo *** last two are data-driven methods that also use multiple scattering signals and high energy signals in the *** the PandaX-4T commissioning data with an exposure of 0.63 tonne-year,all these methods give a consistent result,i.e.,there are 1.15±0.57 neutron-induced backgrounds in the dark matter signal region within an approximated nuclear recoil energy window between 5 and 100 keV.

关键词： dark matter neutron background multiple scattering high energy gamma

Erratum:A Search for Solar Axions and Anomalous Neutrino Magnetic Moment with the Complete PandaX-Ⅱ Data[***.38(2021)011301]

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Chinese Physics Letters 2021年第10期38卷 71-72页

作者： xiaopeng Zhou Xinning Zeng Xuyang Ning Abdusalam Abdukerim Wei Chen Xun Chen Yunhua Chen Chen Cheng xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Di Huang Yan Huang Yanlin Huang Zhou Huang xiangdong Ji Yonglin Ju Shuaijie Li Huaxuan Liu Jianglai Liu † xiaoying Lu Wenbo Ma Yugang Ma Yajun Mao Yue Meng Kaixiang Ni Jinhua Ning xiangxiang Ren Changsong Shang Guofang Shen Lin Si Andi Tan Anqing Wang Hongwei Wang Meng Wang Qiuhong Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Shiyong Wu Weihao Wu Jingkai xia Mengjiao xiao Pengwei Xie Binbin Yan Jijun Yang Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Dan Zhang Tao Zhang Li Zhao qibin Zheng Jifang Zhou Ning Zhou INPAC School of Physics and AstronomyShanghai Jiao Tong Universityand Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China School of Physics Beihang UniversityBeijing 100191China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China School of Physics Nankai UniversityTianjin 300071China Key Laboratory of Nuclear Physics and Ion-Beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Peking UniversityBeijing 100871China International Research Center for Nuclei and Particles in the Cosmos&Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Physics University of MarylandCollege ParkMaryland 20742USA School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Physics and Key Laboratory of Particle Physics and Particle Irradiation(MOE) Shandong UniversityJinan 250100China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Center for High Energy Physics Peking UniversityBeijing 100871China

In our published letter,[1]we have identified a minor error in Figs.2 and ***,we have 2111 events in these two plots with 646,249,382,and 834 events in Run 9(20.0 ton·day),Run 10(19.4 ton·day),Run 11–1(24.2 ton·day),and Run 11–2(37.1 ton·day).The mistake is due to an incorrect application of a small energy non-linearity(known as the BLS non-linearity)in making plots,but has no impact to the final *** 2 and 3 are now updated in this note.

关键词： letter error

不同秸秆还田方式对冬小麦田土壤含水量的影响

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农业技术与装备 2024年第8期 83-85页

作者：王怀苹赵丽萍郭宇程玉红夏海东梅兹君王国祥鹤壁市农业科学院河南鹤壁458030 焦作市山阳区农业综合行政执法大队河南焦作454150 河南永优种业科技有限公司河南鹤壁458030 鹤壁市淇滨区春晖农作物种植合作社河南鹤壁458030

为进一步探索不同秸秆还田方式对冬小麦田土壤含水量的影响,结合生产实际设置了免耕覆盖(Ⅰ)、无秸秆翻耕(Ⅱ)、翻耕还田(Ⅲ)、旋耕还田(Ⅳ)等4个处理,进行试验。结果表明,不同秸秆还田方式对不同土层具有不同的影响。在冬小麦生育期的... 详细信息

为进一步探索不同秸秆还田方式对冬小麦田土壤含水量的影响,结合生产实际设置了免耕覆盖(Ⅰ)、无秸秆翻耕(Ⅱ)、翻耕还田(Ⅲ)、旋耕还田(Ⅳ)等4个处理,进行试验。结果表明,不同秸秆还田方式对不同土层具有不同的影响。在冬小麦生育期的前期,各处理0~20 cm和20~40 cm的土壤含水量的高低顺序是Ⅱ>Ⅲ>Ⅳ>Ⅰ,即在这两层中处理I的土壤含水量都是最低的,但到了冬小麦生育期的后期处理Ⅰ的含水量却变成了最高的,尤其是在20~40 cm表现得尤为突出,比对照高出4.4个百分点,说明免耕覆盖具有显著的后期保水性;40~60 cm土层各处理间土壤含水量的高低顺序变化不太稳定;60~80 cm和80~100 cm土层,各处理土壤含水量变化趋势相似,但二者处理间的高低顺序略有变化,60~80 cm的土壤含水量的高低排列顺序是Ⅲ>Ⅱ>Ⅳ>Ⅰ,80~100 cm的土壤含水量的高低顺序是Ⅲ>Ⅳ>Ⅱ>Ⅰ,显示出处理Ⅲ在深层明显的保水优势。

关键词：冬小麦秸秆还田土壤水分

Detecting neutrinos from supernova bursts in PandaX-4T

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Chinese Physics C 2024年第7期48卷 14-21页

作者：庞彬宇阿布都沙拉木·阿布都克力木薄子豪陈葳谌勋程晨成兆侃崔祥仪樊英杰方德清符长波付孟婷耿立升 Karl Giboni 顾琳慧郭绪元韩晨成韩柯何昶达何金荣黄迪黄彦霖黄俊挺黄周侯汝全侯钰季向东巨永林李晨翔李家富李名川李帅杰李涛林箐刘江来陆聪聪芦晓盈罗棱尹罗云阳马文博马余刚冒亚军孟月宁旭阳祁宁春钱志成任祥祥 Nasir Shaheed 尚晓凤邵熙元申国防司琳孙文良谈安迪陶奕王安庆王萌王秋红王少博王思广王为王秀丽王舟魏月环武蒙蒙邬维浩夏经铠肖梦姣肖翔谢鹏伟燕斌斌颜玺雨杨继军杨勇姚玉坤喻纯旭袁影苑哲鑫宁张丹张敏桢张鹏张世博张澍张涛张洋张瀛心张园园赵力郑其斌周济芳周宁周小朋周永周钰博 New Cornerstone Science Laboratory Tsung-Dao Lee InstituteShanghai Jiao Tong UniversityShanghai200240China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237ShandongChina Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao 266237ShandongChina School of Physics and Astronomy Shanghai Jiao Tong UniversityKey Laboratory for Particle Astrophysics and Cosmology(MoE)Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai519082China Department of Physics Yantai UniversityYantai 264005China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Peking UniversityBeijing 100871China School of Physics Beihang UniversityBeijing 102206China International Research Center for Nuclei and Particles in the Cosmos&Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China School of Physics and Microelectronics Zhengzhou UniversityZhengzhouHenan 450001China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Physics University of MarylandCollege ParkMaryland 20742USA State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Physics Nankai UniversityTian

Neutrinos from core-collapse supernovae are essential for understanding neutrino physics and stellar ***-phase xenon dark matter detectors can be used to track explosions of galactic supernovae by detecting neutrinos through coherent elastic neutrino-nucleus *** this study,a variation of progenitor masses and explosion models are assumed to predict neutrino fluxes and spectra,which result in the number of expected neutrino events ranging from 6.6 to 13.7 at a distance of 10 kpc over a 10-s duration with negligible backgrounds at *** specialized triggering alarms for monitoring supernova burst neutrinos are *** efficiency of detecting supernova explosions at various distances in the Milky Way is *** alarms will be implemented in the real-time supernova monitoring system at PandaX-4T in the near future,which will provide supernova early warnings for the astronomical community.

关键词： core-collapse supernovae neutrinos liquid xenon detectors supernova early warnings

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临床肿瘤学杂志 2017年第2期22卷 97-106页

作者：秦叔逵杨柳青王科明夏黎明周晋华郑义同李玉杨成喜崔同健汪森明肖明星王红兵白莉刘汉峰安永辉宋启斌张明智韩北秋华东陈玉强陈锦飞杜楠陈文晟冯国生李永强熊建萍欧阳铭刘超英王彩莲张华钟美佐谢绍建无南京中医药大学附属八一医院全军肿瘤中心 210002 南京医科大学附属第二医院肿瘤科 210011 安徽中医学院第一附属医院肿瘤科 230038 连云港市第一人民医院放疗科 222002 福建省立医院肿瘤内科 350001 南方医科大学珠江医院肿瘤中心 510282 徐州医科大学附属医院肿瘤中心 221002 解放军总医院(301医院)肿瘤科 100853 广西医科大学附属第一医院肿瘤内科 530021 河北医科大学附属第一医院肿瘤内科 050000 武汉大学人民医院肿瘤中心 430060 郑州大学第一附属医院肿瘤科 450052 哈尔滨医科大学第四附属医院肿瘤中心 150001 无锡市第四人民医院肿瘤内科 214000 厦门174医院肿瘤中心 361004 南京市第一医院肿瘤内科 210006 解放军总医院第一附属医院(304医院)肿瘤科 100048 广州医科大学附属肿瘤医院肿瘤内科 510095 广西壮族自治区人民医院肿瘤科 530021 广西医科大学附属肿瘤医院消化肿瘤内科 530021 南昌大学第一附属医院肿瘤内科 330006 广州医科大学附属第一医院呼吸内科 510120 无锡市人民医院肿瘤科 214023 东南大学附属中大医院肿瘤科 210009 新疆医科大学第一附属医院耳鼻喉科 830054 中南大学湘雅医院肿瘤科 410008 河北医科大学附属第二医院肿瘤科 050000 MAGIC-301临床研究协作组

目的抗肿瘤细胞毒性药物是引起药物性肝损伤(DILI)最常见的药物之一。本研究旨在观察和评价在大样本恶性肿瘤患者人群中采用异甘草酸镁注射液预防抗肿瘤化疗相关性急性肝损伤的有效性和安全性。方法采取前瞻性、开放性、随机对照、全国... 详细信息

目的抗肿瘤细胞毒性药物是引起药物性肝损伤(DILI)最常见的药物之一。本研究旨在观察和评价在大样本恶性肿瘤患者人群中采用异甘草酸镁注射液预防抗肿瘤化疗相关性急性肝损伤的有效性和安全性。方法采取前瞻性、开放性、随机对照、全国多中心的临床协作研究(简称MAGIC-301研究)。对使用含顺铂(≥60 mg/m^2)、奥沙利铂(≥85mg/m^2)、环磷酰胺(≥600 mg/m^2)或吉西他滨(≥2000 mg/m^2)四种细胞毒药物中任意一种或数种进行化疗的恶性肿瘤患者,随机分为两组。试验组于随机化疗的前1天起,给予异甘草酸镁注射液200 mg/d,静脉滴注,连续使用≥5天;对照组仅给予常规化疗。至1个化疗疗程结束,参照NCI-CTC AE 4.0版标准,严格观察和比较患者化疗前、后肝损伤的发生情况,包括发生率和严重程度,必要时给予解救性保肝方案治疗。结果全国28家研究中心共同参与,2013年2月28日至2015年12月31日共入组病例1200例,其中1146例(95.50%)纳入全分析集(FAS)分析,试验组和对照组分别为766例和380例。两组患者入组前的人口学信息,包括年龄、性别、体重、既往肝病史、癌种以及化疗方案等情况均衡可比(P>0.05)。FAS分析显示,化疗后对照组的肝损伤发生率达62.63%,试验组为52.81%(P=0.0004);根据肝损伤严重程度NCI分级分析显示,化疗后,对照组2级以上肝功能异常率为12.37%,而试验组为10.07%(P=0.0008),且对照组有32.37%的患者上升了至少1个肝损伤等级,相较于试验组高出11.17%(P<0.0001)。分别统计含铂类、含环磷酰胺和含吉西他滨的不同化疗方案,试验组的肝损伤发生率较对照组分别降低7.11%(P=0.0188)、22.36%(P=0.0033)和18.71%(P=0.0380)。化疗后肝功能指标ALT和AST的异常率,试验组也显著低于对照组;化疗第2周(13~15天)试验组的ALT及AST异常率较对照组均降低近50%(ALT异常率:8.63%vs.16.58%,P<0.0001;AST异常率:10.72%vs.20.05%,P<0.0001)。在整个试验过程中,试验组发生解救用药情况的解救率为1.3%,而对照组高达9.2%(P<0.0001)。两组其他不良事件和不良反应的发生率基本相当。结论上述大样本研究结果和数据分析表明,含铂类、含环磷酰胺和含吉西他滨化疗引起的DILI发生率较高、危害程度较重,在临床实践过程中应该高度重视,加强对肝功能的全程监控与肝损伤的防治。在化疗前和化疗同时,预防性应用异甘草酸镁注射液可以明显降低以上药物化疗相关性急性肝损伤的发生率及其严重程度,值得进一步深入研究和临床推广应用。

关键词：肿瘤药物性肝损伤化学治疗急性肝损伤异甘草酸镁注射液预防性应用

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen xiang Chen xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise