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Mimotope peptide modified pompon mum-like magnetic microparticles for precise recognition,capture and biotransformation analysis of rituximab in biological fluids

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1317-1328页

作者： Jiawen Yang Aixuan Zhou Minyi Li qiaoxian he Jingwei Zhou Jacques Crommen Wentao Wang Zhengjin Jiang Qiqin Wang Institute of Pharmaceutical Analysis College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of ChinaJinan UniversityGuangzhou 510632China Laboratory for the Analysis of Medicines Department of Pharmaceutical SciencesCIRMUniversity of LiegeLiege B-4000Belgium SCIEX Shanghai 200050China

Due to low immobilized ligand density,limited binding capacity,and severe interference from serum proteins,developing ideal peptide-based biomaterials for precise recognition and in vivo analysis of biopharmaceuticals remains a huge *** this study,mimotope peptide modified pompon mum-like biomimetic magnetic microparticles(MMPs,3.8μm)that mimic the specific functionalities of CD20 on malignant B cells were developed for the first *** from the numerous ligand binding sites(Ni^(2+))on the pompon mum-like MMPs,these novel materials achieved≥10 times higher peptide ligand densities(>2300 mg/g)and antibody binding capacities(1380 mg/g)compared to previous reported *** the high specificity of the mimotope peptide,rituximab can be precisely recognized and enriched from cell culture media or serum *** also established an LC-MS/MS method using the MMPs for tracking rituximab biotransformation in patient ***,deamidation of Asn55 and Asn33,as well as oxidation of Met81 and Met34 were observed at the key complementarity determining regions of rituximab,which could potentially influence antibody function and require careful ***,these versatile biomimetic MMPs demonstrate superior recognition and enrichment capabilities for target antibodies,offering interesting possibilities for biotransformation analysis of biopharmaceuticals in patient serum.

关键词： Therapeutic monoclonal antibody Mimotope peptide Precise recognition Peptide-based biomaterials Biotransformation Patient serum

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Combined algorithm of acquisition and anti-jamming based on SFT

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Journal of Systems Engineering and Electronics 2015年第3期26卷 431-440页

作者： Ying Ma Xiangyuan Bu Hangcheng Han qiaoxian Gong School of Information and Electronics Beijing Institute of Technology

A communication and navigation receiver is required to remove hostile jamming signals and synchronize receiving signals effectively especially for satellite communication and navigation whose resources are becoming more and more limited. This paper proposes a novel signal receiving method by combining the pro- cesses of anti-jamming and synchronization to reduce the overall computationa~ complexity at the expense of slightly affecting the detection probability, which is analyzed in detail by derivations. Furthermore, this paper introduces sparse Fourier transformation （SFT） into the proposed algorithm to replace fast Fourier transfor- mation （FFT） so as to further reduce the calculation time especially in large frequency offset environments.

关键词： acquisition anti-jamming navigation sparse Fourier transformation (SFT).

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Buoyancy of convective-scale updrafts in the outer cores of sheared tropical cyclones

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Atmospheric and Oceanic Science Letters 2019年第1期12卷 58-65页

作者： LI Qingqing FANG qiaoxian Pacific Typhoon Research Center Key Laboratory of Meteorological Disaster of the Ministry of Education Nanjing University of Information Science and Technology State Key Laboratory of Severe Weather Chinese Academy of Meteorological Sciences

In this paper,the authors present the statistical characteristics of the buoyancy of outer-core convective-scale updrafts in numerically simulated sheared tropical cyclones(TCs).The total buoyancy is predominantly positive in weak-to-strong ambient vertical shears,whereas much of the total buoyancy under an extreme shear environment becomes *** buoyancy positively contributes to the total buoyancy *** weakly and moderately sheared TCs,the updraft buoyancy is statistically significantly stronger downshear but smaller *** a downshear preference of strong buoyancy becomes less evident as the shear magnitude *** total buoyancy of updrafts shows a decreasing tendency with *** thermal and dynamic buoyancy do not significantly correlate with vertically averaged vertical mass *** also leads to no significant correlation between the total buoyancy and vertical mass fluxes of outer-core updrafts.

关键词： Tropical cyclone vertical wind shear outer core updraft buoyancy

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On island landscape pattern of forests in helan Mountain and its cause of formation

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Science China(Technological Sciences) 2006年第z1期49卷 45-53页

作者： DENG Hongbing WANG Yingming ZHANG qiaoxian YAN Yan State Key Lab of Systems Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China State Key Lab of Systems Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China State Key Lab of Systems Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China State Key Lab of Systems Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Based on the spatial information techniques such as RS, GIS, and GPS, the forest landscape patterns in the helan Mountain, western China, were studied. The Landsat 5 TM data were used to classify the forest landscapes through RS digital cartography, and then, the landscape characteristics and landscape pattern were analyzed quantificationally. Furthermore, through spatial data collection and spatial analysis of the main disturbances in this area, the cause of landscape formation was studied. The results showed that the total 1177 forest landscape patches could be classified into 21 landscape types, and the forest landscape in the helan Mountain was island pattern, which was encircled by deserta as matrix. The values of landscape diversity index and landscape fragmentation index were 2.61 and 0.43, respectively. In this area, the landscape pattern was clearly formed and continuously changed in response to geological processes, climate, activities of organisms, forest fire, desertification, human activities and so on. This landscape pattern had an obviously negative effect on the stability and ecosystem services of forests. So, scientific landscape planning and protection should be adopted to improve the sustainability of forest management in this area.

关键词： landscape pattern, island landscape of forest, disturbance, helan Mountain.

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Electrocatalytic water splitting:Mechanism and electrocatalyst design

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Nano Research 2023年第7期16卷 9142-9157页

作者： Han Wu qiaoxian Huang Yuanyuan Shi Jiangwei Chang Siyu Lu Green Catalysis Center College of ChemistryZhengzhou UniversityZhengzhou 450001China

Hydrogen energy,a new type of clean and efficient energy,has assumed precedence in decarbonizing and building a sustainable carbon-neutral ***,hydrogen production from water splitting has seen considerable advancements owing to its advantages such as zero carbon emissions,safety,and high product *** overcome the large energy barrier and high cost of water splitting,numerous efficient electrocatalysts have been designed and ***,various difficulties in promoting the industrialization of electrocatalytic water splitting ***,as high-performance electrocatalysts that satisfy industrial requirements are urgently needed,a better understanding of water-splitting systems is *** this paper,the latest progress in water electrolysis is reviewed,and experimental evidence from in situ/operando spectroscopic surveys and computational analyses is summarized to present a mechanistic understanding of hydrogen and oxygen evolution ***,some promising strategies,including alloying,morphological engineering,interface construction,defect engineering,and strain engineering for designing and synthesizing electrocatalysts are *** believe that this review will provide a knowledge-guided design in fundamental science and further inspire technical engineering developments for constructing efficient electrocatalysts for water splitting.

关键词： water splitting mechanism operando spectroscopy design strategy

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The Legal Support for the Protection of the Disabled Children's Rights and Interests

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学术界 2014年第9期 293-300页

作者： Chang Xiaoming Xu qiaoxian School of Management Nanjing Normal University of Special Education

How to protect the disabled children’s rights and interests legally has been a very serious,urgent realistic ***,the problems in the protection of the disabled children’s rights and interests become obvious,mainly including that the right to exist is not protected,the right to education is changed,the right to development is not implemented,the right to participate is not respected,and the right to be protected is not safeguarded,*** the legal position of the protection of the disabled children’s rights and interests is absent,it is imperative to choose the legal support ways for the protection of the disabled children’s rights and interests.

关键词：权益保护法律支持残疾儿童儿童保护法律地位权利利益

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响应面法优化红枣沙棘馒头的加工工艺

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中国粮油学报 2022年第8期37卷 237-244页

作者：张巧仙吕梁学院生命科学系吕梁033001

以中筋小麦粉、红枣、沙棘为主要原料研究红枣沙棘馒头的最佳工艺配方。基于单因素实验结果,采用Plackett-Burman(PB)设计结合Box-Behnken Design(BBD)响应面法实验,以质构特性(硬度、弹性、咀嚼性)、比容、色差(L^(*)、b^(*))和感官评... 详细信息

以中筋小麦粉、红枣、沙棘为主要原料研究红枣沙棘馒头的最佳工艺配方。基于单因素实验结果,采用Plackett-Burman(PB)设计结合Box-Behnken Design(BBD)响应面法实验,以质构特性(硬度、弹性、咀嚼性)、比容、色差(L^(*)、b^(*))和感官评分为考察指标评价红枣沙棘馒头的品质,基于主成分分析法优化红枣沙棘馒头的加工工艺。结果表明:红枣沙棘馒头的最佳工艺配方为:以中筋小麦粉质量为基准,红枣泥10%、沙棘汁3.5%、酵母1.5%、水40%、发酵时间50 min、发酵温度38℃。在此工艺条件下,规范化综合评分最高为0.944。验证实验也得出优选出的红枣沙棘馒头工艺条件具有很好的重现性,模型的预测性好。红枣沙棘馒头比单一的中筋小麦粉馒头营养丰富。

关键词：沙棘红枣馒头工艺研究 Box-Behnken响应面法

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铁皮石斛花粉活力与种质创制研究

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中国中药杂志 2011年第6期36卷 755-757页

作者：朱波苑鹤俞巧仙斯金平浙江农林大学亚热带森林培育国家重点实验室培育基地天然药物研究开发中心浙江临安311300 浙江森宇药业有限公司浙江义乌322000

目的:为铁皮石斛杂交育种与野生资源保护提供基础。方法:采用过氧化物酶法测定不同花期与不同贮藏条件的花粉活力;在温室大棚设施栽培条件下开展杂交、自交、自由授粉,野外昆虫辅助授粉。结果:铁皮石斛有活力花粉比例花蕾期为29.4%,开... 详细信息

目的:为铁皮石斛杂交育种与野生资源保护提供基础。方法:采用过氧化物酶法测定不同花期与不同贮藏条件的花粉活力;在温室大棚设施栽培条件下开展杂交、自交、自由授粉,野外昆虫辅助授粉。结果:铁皮石斛有活力花粉比例花蕾期为29.4%,开花当天为70.6%,开花后1周为31.9%,直至花谢花粉仍有活力;离体干燥条件下4℃贮藏20 d后有活力花粉比例仍有21.2%;人工授粉杂交结实率达82.6%,自交结实率7.3%;野外昆虫辅助授粉与温室大棚设施栽培条件下自由授粉结实率均为0。结论:铁皮石斛花粉在整个花期均有活力,石斛花构造的特殊性导致自由授粉与野外昆虫辅助授粉均结实困难,人工杂交授粉是铁皮石斛野生资源的保护与种质创制的有效途径。

关键词：铁皮石斛花粉活力人工授粉果实生长

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多策略改进的蜣螂优化算法及其应用

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计算机科学与探索 2024年第4期18卷 930-946页

作者：郭琴郑巧仙湖北大学计算机与信息工程学院武汉430062 湖北大学网络空间安全学院武汉430062

蜣螂优化算法(DBO)是近年提出的智能优化算法,与其他优化算法一样,DBO也存在收敛精度低、易陷入局部最优等缺点。针对DBO的这些局限性,提出一种多策略改进的蜣螂优化算法(MIDBO)。首先,改进雏球和偷窃蜣螂对局部最优解和全局最优解的接... 详细信息

蜣螂优化算法(DBO)是近年提出的智能优化算法,与其他优化算法一样,DBO也存在收敛精度低、易陷入局部最优等缺点。针对DBO的这些局限性,提出一种多策略改进的蜣螂优化算法(MIDBO)。首先,改进雏球和偷窃蜣螂对局部最优解和全局最优解的接受程度,使其根据自身搜索能力动态变化,既提升了种群质量又保持了适应度高的个体的良好搜索能力;其次,融合麻雀搜索算法中的追随者位置更新机制对算法进行扰动,并用贪婪策略更新位置,提升了算法的收敛精度;最后,当算法陷入停滞时引入柯西高斯变异策略,提高了算法跳出局部最优解的能力。仿真实验基于20个基准测试函数和CEC2019测试函数,验证了3种改进策略的有效性,将所改进算法和对比算法的优化结果进行收敛性分析和Wilcoxon秩和检验,证明了MIDBO具有良好的寻优性能和鲁棒性。将MIDBO运用在汽车碰撞优化问题的求解上,进一步验证了MIDBO在求解实际工程问题中的有效性和可靠性。

关键词：蜣螂优化算法局部最优解麻雀搜索算法柯西高斯变异汽车碰撞优化问题 Wilcoxon秩和检验

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植物种质资源保存

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生物学教学 2009年第2期34卷 3-5页

作者：张巧仙山西省吕梁高等专科学校生命科学系

植物种质资源的保存研究对于生物多样性保护和植物生物技术均具有十分重要的意义。本文综述了植物种质资源的保存办法，同时提出了种质保存中需要注意的几个常见问题。

关键词：植物种质资源椭物生物技术生物多样性保存方法

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