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Prognostic value of circulating tumor cells combined with neutrophil-lymphocyte ratio in patients with hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 372-385页

作者： Jia-Li chen Lu Guo Zhen-Ying Wu Kun He Han Li Chi Yang Yun-Wei Han Department of Oncology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Ophthalmology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Clinical Research Institute The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Plastic Surgery Meguiar's Medical Beauty HospitalChengdu 610000Sichuan ProvinceChina

BACKGROUND Circulating tumor cell(CTC)count and neutrophil-to-lymphocyte ratio(NLR)are both closely associated with the prognosis of hepatocellular carcinoma(HCC).AIM To investigate the prognostic value of combining these two indicators in *** Clinical data were collected from patients with advanced HCC who received im-mune therapy combined with targeted therapy at the Department of Oncology,the Affiliated Hospital of Southwest Medical University,Sichuan,China,from 2021 to *** optimal cutoff values for CTC programmed death-ligand 1(PD-L1)(+)>1 or CTC PD-L1(+)≤1 and NLR>3.89 or NLR≤3.89 were evaluated using X-Tile *** were categorized into three groups based on CTC PD-L1(+)counts and NLR:CTC-NLR(0),CTC-NLR(1),and CTC-NLR(2).The relationship between CTC-NLR and clinical variables as well as survival rates was *** Patients with high CTC PD-L1(+)expression or NLR at baseline had shorter median progression-free survival(m-PFS)and median overall survival(mOS)than those with low levels of CTC PD-L1(+)or NLR(P<0.001).Mean-while,patients in the CTC-NLR(2)group showed a significant decrease in mPFS and *** regression analysis revealed that alpha-fetoprotein(AFP),CTC PD-L1(+),and CTC-NLR were independent predictors of *** time-dependent receiver operating characteristic curve showed that the area under the curve of CTC-NLR at 12 months(0.821)and 18 months(0.821)was superior to that of AFP and CTC PD-L1(+).CONCLUSION HCC patients with high CTC PD-L1(+)or NLR expression tend to exhibit poor prognosis,and a high baseline CTC-NLR score may indicate low ***-NLR may serve as an effective prognostic indicator for patients with advanced HCC receiving immunotherapy combined with targeted therapy.

关键词： Circulating tumor cells Neutrophil–lymphocyte ratio Hepatocellular carcinoma Prognosis Survival Marker

Enhancing solid-state lithium metal battery performance via indium-based modification of electrolytes and lithium metal surfaces: mechanistic insights and optimization

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Science China Chemistry 2024年

作者： Zhongkai Wu chen Liu Ziling Jiang Lin Li Siwu Li Chaochao Wei Qiyue Luo Xia chen Long Zhang Shijie cheng Chuang Yu State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and Technology School of Chemistry and Chemical Engineering Huazhong University of Science and Technology Interdisciplinary Research Center of Smart Sensors Academy of Advanced Interdisciplinary Research Xidian University College of Physics and Energy Fujian Normal University

Argyrodite-based solid-state lithium metal batteries exhibit significant potential as next-generation energy storage ***,their practical applications are constrained by the intrinsic poor stability of argyrodite towards Li metal and exposure to air/***,an indium-involved modification strategy is employed to address these *** optimized doping yields a high Li-ion conductivity of 7.5 mS cm-1for Li5.54In0.02PS4.47O0.03Cl1.5electrolyte,accompanied by enhanced endurance against air/moisture and bare Li *** retains 92.0%of its original conductivity after exposure to air at a low dew point of-60°C in dry ***,a composite layer comprising Li–In alloy and LiF phases is generated on the surface of lithium metal anode via the reaction between In F3and molten *** layer effectively mitigates Li dendrite growth by creating a physical barrier from the robust LiF phase,while the Li–In alloy induces uniform Li-ion deposition and accelerates Li transport dynamics across the interphase between the solid electrolyte/Li ***,the In-doped electrolyte facilitates the in-situ generation of Li–In alloy within its voids,reducing local current density and further inhibiting lithium dendrite ***,the combination of the Li5.54In0.02PS4.47O0.03Cl1.5electrolyte and the InF3@Li anode provides exceptional electrochemical performances in both symmetric cells and solid-state lithium metal batteries across different operating ***,the LiNbO3@LiNi0.7Co0.2Mn0.1O2/Li5.54In0.02PS4.47O0.03Cl1.5/InF3@Li cell delivers a high discharge capacity of 167.8 mAh g-1at 0.5 C under 25°C and retains 80.0%of its initial value after 400 *** work offers a viable strategy for designing functional interfaces with enhanced stability for sulfide-based solid-state lithium batteries.

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A Big Kiss for You

China Book International 2024年第5期 112-113页

作者： chen Qijing 无不详 Mumian Art Studio

Every day Granny Rabbit wakes up with no memory of what she did the day *** day,Sunny Mouse drops by *** for Granny Rabbit's hospitality,becomes her house *** do a lot of things happily ***,Granny Rabbit always forgets who Sunny Mouse is the next *** Mouse is not in the least worried,because he can find ways to help Granny Rabbit get to know him and love him over and over again,until one day,a miracle happens.

关键词： forget Rabbit before

Mechanisms of resistance to trastuzumab in HER2-positive gastric cancer

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Chinese Journal of Cancer Research 2024年第3期36卷 306-321页

作者： Zhifei Li Huan Zhao Huihui Hu Haili Shang Yongjing Ren Wenhui Qiu Hao Su Huifang Lyu Xiaobing chen Department of Oncology the Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalHenan Engineering Research Center of Precision Therapy of Gastrointestinal CancerZhengzhou Key Laboratory for Precision Therapy of Gastrointestinal CancerZhengzhou 450008China Henan University of Traditional Chinese Medicine Zhengzhou 450046China State Key Laboratory of Esophageal Cancer Prevention&Treatment Key Laboratory of Advanced Drug Preparation TechnologiesMinistry of EducationSchool of Pharmaceutical SciencesZhengzhou UniversityZhengzhou 450001China The First Affiliated Hospital of Xinxiang Medical University Xinxiang 453000China Department of Oncology the Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhou 450008China

Gastric cancer is one of the most prevalent cancers worldwide,and human epidermal growth factor receptor 2(HER2)-positive cases account for approximately 20%of the total ***,trastuzumab+chemotherapy is the recommended first-line treatment for patients with HER2-positive advanced gastric cancer,and the combination has exhibited definite efficacy in HER2-targeted ***,the emergence of drug resistance during treatment considerably reduces its effectiveness;thus,it is imperative to investigate the potential mechanisms underlying *** the present review article,we comprehensively introduce multiple mechanisms underlying resistance to trastuzumab in HER2-positive gastric cancer cases,aiming to provide insights for rectifying issues associated with resistance to trastuzumab and devising subsequent treatment strategies.

关键词： HER2 gastric cancer trastuzumab drug resistance

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Erlotinib combination with a mitochondria-targeted ubiquinone effectively suppresses pancreatic cancer cell survival

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World Journal of Gastroenterology 2024年第7期30卷 714-726页

作者： Pui-Yin Leung Wenjing chen Anissa N Sari Poojitha Sitaram Pui-Kei Wu Susan Tsai Jong-In Park Department of Biochemistry Medical College of WisconsinMilwaukeeWI 53226United States Department of Surgery Medical College of WisconsinMilwaukeeWI 53226United States

BACKGROUND Pancreatic cancer is a leading cause of cancer-related *** activity of the epidermal growth factor receptor(EGFR)is often observed in pancreatic cancer,and the small molecule EGFR inhibitor erlotinib has been approved for pancreatic cancer therapy by the food and drug ***,erlotinib alone is ineffective and should be combined with other drugs to improve therapeutic *** previously showed that certain receptor tyrosine kinase inhibitors can increase mitochondrial membrane potential(Δψm),facilitate tumor cell uptake ofΔψm-sensitive agents,disrupt mitochondrial homeostasis,and subsequently trigger tumor cell *** has not been tested for this *** To determine whether erlotinib can elevateΔψm and increase tumor cell uptake ofΔψm-sensitive agents,subsequently triggering tumor cell ***Δψm-sensitive fluorescent dye was used to determine how erlotinib affectsΔψm in pancreatic adenocarcinoma(PDAC)cell *** viability of conventional and patient-derived primary PDAC cell lines in 2D-and 3D cultures was measured after treating cells sequentially with erlotinib and mitochondria-targeted ubiquinone(MitoQ),aΔψm-sensitive *** synergy between erlotinib and MitoQ was then analyzed using SynergyFinder *** preclinical efficacy of the twodrug combination was determined using immune-compromised nude mice bearing PDAC cell line *** Erlotinib elevatedΔψm in PDAC cells,facilitating tumor cell uptake and mitochondrial enrichment ofΔψm-sensitive *** triggered caspase-dependent apoptosis in PDAC cells in culture if used at high doses,while erlotinib pretreatment potentiated low doses of *** suggested that these drugs synergistically induced tumor cell *** with in vitro data,erlotinib and MitoQ combination suppressed human PDAC cell line xenografts in mice more effectively than single treatments of each *** Our findings suggest tha

关键词： Pancreatic cancer Erlotinib Mitochondria-targeted ubiquinone Mitochondria Combination therapy

Associations of prenatal exposure to bisphenols with BMI growth trajectories in offspring within the first two years:evidence from a birth cohort study in China

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World Journal of Pediatrics 2024年第7期20卷 701-711页

作者： Chao Xiong Kai chen Lu-Li Xu Yi-Ming Zhang Hua Liu Meng-Lan Guo Zhi-Guo Xia Yu-Ji Wang Xiao-Feng Mu Xiao-Xuan Fan Jing-Quan chen Yu-Ru Liu Yuan-Yuan Li Wei Xia You-Jie Wang Ai-Fen Zhou Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital) Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430016China Key Laboratory of Environment and Health Ministry of Education and Ministry of Environmental Protectionand State Key Laboratory of Environmental HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Maternal and Child Health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Background Prenatal bisphenol exposure has been reported to be associated with lower birth weight and obesity-related indicators in early *** findings warrant an investigation of the relationship between prenatal bisphenol exposure and the dynamic growth of *** study aimed to evaluate the relationship of maternal bisphenol concentration in urine with the body mass index(BMI)growth trajectory of children aged up to two years and to identify the critical exposure *** A total of 826 mother–offspring pairs were recruited from Wuhan Children’s Hospital between November 2013 and March *** urine samples collected during the first,second,and third trimesters were analyzed for bisphenol A(BPA),bisphenol S,and bisphenol F(BPF)*** of length and weight were taken at 0,1,3,6,8,12,18,and 24 ***'s BMI was standardized using the World Health Organization reference,and group-based trajectory modeling was used to identify BMI growth *** associations between prenatal bisphenol exposure and BMI growth trajectory patterns were assessed using multinomial logistic regression *** The BMI growth trajectories of the 826 children were categorized into four patterns:low-stable(n=134,16.2%),low-increasing(n=142,17.2%),moderate-stable(n=350,42.4%),and moderate-increasing(n=200,24.2%).After adjusting for potential confounders,we observed that prenatal exposure to BPA during the second trimester[odds ratio(OR)=2.20,95%confidence interval(CI)=1.09–4.43]and BPF during the third trimester(OR=3.28,95%CI=1.55–6.95)at the highest quartile concentration were associated with an increased likelihood of the low-increasing BMI ***,in the subgroup analysis by infant sex,the positive association between the highest quartile of prenatal average urinary BPF concentration during the whole pregnancy and the low-increasing BMI trajectory was found only in girls(OR=2.82,95%CI=1.04–7.68).Conclus

关键词： Birth cohort study Bisphenol A Bisphenol S Bisphenol F Body mass index trajectory Prenatal exposure

再生微粉与矿物掺合料对混凝土力学性能及微观结构的影响

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材料导报 2024年第5期38卷 178-183页

作者：陈立俊李滢陈文浩青海大学土木工程学院西宁810016 青海省建筑节能材料与工程安全重点实验室西宁810016

为了提高再生微粉在混凝土中的利用率,将单掺再生微粉的混凝土与复掺再生微粉、粉煤灰和硅灰的混凝土的力学性能及微观结构进行了对比研究。结果表明,单掺再生微粉和三者复掺对混凝土的抗压强度和孔结构有不同程度的影响,当掺量低于20%... 详细信息

为了提高再生微粉在混凝土中的利用率,将单掺再生微粉的混凝土与复掺再生微粉、粉煤灰和硅灰的混凝土的力学性能及微观结构进行了对比研究。结果表明,单掺再生微粉和三者复掺对混凝土的抗压强度和孔结构有不同程度的影响,当掺量低于20%时,单掺再生微粉的混凝土抗压强度高于同掺量时的复掺混凝土,孔隙率相比于复掺时也有所降低;而掺量高于20%时,复掺效果优于单掺,特别是当复掺掺量为30%时,混凝土28 d抗压强度相比单掺掺量为30%时提高了33.4%,总孔隙率和大孔占总孔隙的比例分别降低了4.4%和17.77%。这说明再生微粉的掺入量较大会给混凝土带来不利影响,但添加粉煤灰与硅灰后,它们可以发挥协同作用,从而改善混凝土的复合水泥基体强度和孔结构。

关键词：再生微粉混凝土微观结构力学性能孔结构协同作用

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Species recognition and the divergences in the chemical and ultrasonic signals between two coexisting Rattus species

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Current Zoology 2024年第4期70卷 531-538页

作者： Wei-Chao Wang Zhi-Ming Li Yi chen Jin-Hua Zhang Jian-Xu Zhang Yao-Hua Zhang The State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAs Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijingChina

The ability to recognize and differentiate between conspecifics and heterospecifics as well as their signals is critical for the coexistence of closely related *** the genus Rattus,species are morphologically similar and multiple species often ***,we investigated the interspecific recognition and signal differentiation of two sympatric rat species,the brown rat(Rattus norvegicus,RN)and the Asian house rat(Rattus tanezumi,RT).In a two-way choice test,both RN and RT females showed a preference for conspecific male rats to heterospecific *** females showed a significant preference for accessible urine of males of same species to those of other species,but not for the inaccessi-ble *** the other hand,there were significant differences in the structural characteristics of the ultrasonic vocalization emitted by males of these two rat *** dodecyl sulphate-polyacrylamide gel electrophoresis(SDS-PAGE)and isoelectric focusing electrophoresis unveiled that major urinary proteins(MUPs)in voided urine were more highly expressed in RN males versus RT *** interspecific dif-ferences of urinary volatile compounds were also *** conclusion,female rats had the ability to distinguish between males of either species.

关键词： Asian house rats brown rats closely related species pheromones ultrasonic vocalization.

WPA1 encodes a vWA domain protein that regulates wheat plant architecture

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The Crop Journal 2024年第4期12卷 992-1000页

作者： Yongxing chen Huixin Xiao Yuange Wang Wenling Li Lingchuan Li Lingli Dong Xuebo Zhao Miaomiao Li Ping Lu Huaizhi Zhang Guanghao Guo Keyu Zhu Beibei Li Lei Dong Peng chen Shuming Wu Yunbo Jiang Fei Lu chengguo Yuan Zhiyong Liu Yusheng Zhao Qiuhong Wu Institute of Biotechnology Xianghu LaboratoryHangzhou 311231ZhejiangChina Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China Hebei Gaoyi Stock Seeds Farm Gaoyi 051330HebeiChina

Plant height,spike,leaf,stem and grain morphologies are key components of plant architecture and related to wheat yield.A wheat(Triticum aestivum L.)mutant,wpa1,displaying temperaturedependent pleiotropic developmental anomalies,was *** WPA1 gene,encoding a von Willebrand factor type A(vWA)domain protein,was located on chromosome arm 7DS and isolated by map-based *** functionality of WPA1 was validated by multiple independent EMS-induced mutants and gene *** analysis revealed that WPA1 is monocotyledon-specific in higher *** identification of WPA1 provides opportunity to study the temperature regulated wheat development and grain yield.

关键词： Wheat plant architecture Map-based cloning vWA Environmental temperature

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