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Cytogenetic identification and molecular marker development for the novel stripe rust-resistant wheat- Thinopyrum intermedium translocation line WTT11

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aBIOTECH 2021年第4期2卷 343-356页

作者： Guotang Yang Qi Zheng pan Hu Hongwei Li qiaoling Luo Bin Li Zhensheng Li State Key Laboratory of Plant Cell and Chromosome Enginering Institute of Genetics and Developmental Biology The Innovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Stripe rust,caused by Puccinia striformis ***(Pst),is one of the most destructive diseases of wheat(Triticum aestivum L)*** 78829,a partial amphidiploid developed by crossing common wheat with Thinopyrum intermedium,is immune to wheat stripe *** transfer the resis-tance gene of this excellent germplasm resource to wheat,the tr anslocation line WTT11 was produced by pollen irradiation and assessed for immunity to stripe rust races CYR32,CYR33 and CYR34.A novel stripe rust-resistance locus derived from *** was confirmed by linkage and diagnostic marker *** cytogenetic analyses revealed that WTT11 carries a TTh 2DL *** breakpoint of 1B was located at 95.5 MB,and the alien segments were found to be homoeologous to wheat-group chromosomes 6 and 7 according to a wheat660K single-nucleotide polymorphism(SNP)array *** previously developed PCR-based markers were confirmed to rapidly trace the alien segments of WTT11,and 20 kompetitive allele-specific PCR(KASP)markers were developed to enable genotyping of *** and common *** of agronomic traits in two consecutive crop seasons uncovered some favorable agronomic traits in WTT11,such as lower plant height and longer main panicles,that may be applicable to wheat *** a novel genetic resource,the new resistance locus may be useful for wheat disease-resistance breeding.

关键词： Wheat-Thinopyrum intermedium translocation line CYR34 Cytogenetic analyses Wheat660k SNP array PCR-based markers KASP markers

Bile acids evoke placental inflammation by activating Gpbar1/NF-κB pathway in intrahepatic cholestasis of pregnancy

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Journal of Molecular Cell Biology 2016年第6期8卷 530-541页

作者： YouHua Zhang YouDong pan ChangDong Lin YaJuan Zheng Hao Sun HaiLong Zhang JunLei Wang MengYa Yuan Tao Duan qiaoling Du JianFeng Chen State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceInstitute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Department of Obstetrics Shanghai First Maternity and Infant HospitalTongji University School of MedicineShanghai 200040China

Intrahepatic cholestasis of pregnancy(ICP)is a cholestatic disorder with potentially deleterious consequences for *** a clear correlation between the elevated levels of maternal serum bile acids and deficient fetal outcome has been established in clinical practice,the underlying mechanisms remain ***,we report that bile acids induce NF-κB pathway activation via G protein-coupled bile acid receptor 1(Gpbar1),with consequent upregulation of inflammatory genes in trophoblasts,leading to aberrant leukocyte infiltration and inflammation in *** acid(UDCA),a drug used clinically to treat ICP,competes with other bile acids for binding with Gpbar1 and thus inhibits bile acid-induced inflammatory response in trophoblasts and improves fetal survival in pregnant rats with obstructive ***,inhibition of NF-κB by andrographolide is more effective than UDCA in benefiting placentas and ***,anti-inflammation therapy targeting Gpbar1/NF-κB pathway could be effective in suppressing bile acid-induced inflammation and alleviating ICP-associated fetal disorders.

关键词： fetal outcome G protein-coupled receptor maternal cholestasis placental inflammation ursodeoxycholic acid

Mapping of powdery mildew resistance genes transferred to common wheat from wild emmer wheat revealed three functional Pm60 haplotypes

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The Crop Journal 2024年第2期12卷 540-548页

作者： Wenxin Wei Nannan Liu Shengnan Zhang Jing Zhang Wei pan Xiaoming Xie Zuhuan Yang Junna Sun Jun Ma Zhaorong Hu Weilong Guo qiaoling Luo Jingzhong Xie Fei He Yinghui Li Chaojie Xie Qixin Sun Key Laboratory of Crop Heterosis and Utilization(MOE)/Key Laboratory of Crop Genetic Improvement China Agricultural UniversityBeijing 100193China Institute of Advanced Agricultural Science Peking UniversityWeifang 261200ShandongChina Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101China Triticeae Research Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina Institute of Evolution University of HaifaMt.CarmelHaifa 3498838Israel

Powdery mildew(PM),caused by Blumeria graminis ***(Bgt),is one of the destructive wheat diseases *** emmer wheat(Triticum turgidum ***,WEW),a tetraploid progenitor of common wheat,is a valuable genetic resource for wheat disease resistance breeding *** developed three hexaploid pre-breeding lines with PM resistance genes derived from three WEW *** resistant pre-breeding lines were crossed with susceptible common wheat *** in the F2populations were 3 resistant:1 susceptible,suggesting a single dominant allele in each resistant *** of the resistance gene in each line indicated a single locus on the long arm of chromosome 7A,at the approximate location of previously cloned Pm60 from *** sequencing revealed three different Pm60 haplotypes(Hap 3,Hap 5,and Hap 6).Co-segregating diagnostic markers were developed for identification and selection of each *** resistance function of each haplotype was verified by the virus-induced gene silencing(VIGS).Common wheat lines carrying each of these Pm60 haplotypes were resistant to most Bgt isolates and differences in the response arrays suggested allelic variation in response.

关键词： Alleles Blumeria graminus Marker-assisted selection Molecular marker Triticum dicoccoides

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实行学生任职管理制培养学生自我管理能力

护理研究 2007年第29期21卷 2717-2717页

作者：张巧玲胡珊珊潘献梅江苏省淮阴卫生学校

护理学是一门实践性很强的应用性学科,护理实训中心则是训练学生基本操作技能的场所.我校在护理实训中心管理方面大胆创新,借鉴医院护理管理模式,实行学生任职管理制,全员参与,进行分级、分层次管理,成效卓越.现将具体做法报告如下.

关键词：自我管理能力质量实训中心护士护理实训医院护理管理

Bismuth stabilized by ZIF derivatives for electrochemical ammonia production:Proton donation effect of phosphorus dopants

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Nano Research 2023年第4期16卷 4574-4581页

作者： qiaoling Wu Ying Sun Qin Zhao Hui Li Zhengnan Ju Yu Wang Xiaodong Sun Baohua Jia Jieshan Qiu Tianyi Ma Institute of Clean Energy Chemistry Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials of Liaoning ProvinceCollege of ChemistryLiaoning UniversityShenyang 110036China School of Science RMIT UniversityMelbourneVIC 3000Australia College of Chemical Engineering State Key Laboratory of Chemical Resource EngineeringBeijing University of Chemical TechnologyBeijing 100029China

N2 electroreduction reaction(NRR)offers a feasible and promising alternative for NH_(3)production by using clean energy ***,it is still obstructed by the pretty low NH3 yield rate and Faradaic efficiency(FE)primarily due to the undesired competing hydrogen evolution reaction and the extremely stable N≡N ***,bismuth nanoparticles were successfully embedded in N and P co-doped carbon nanoflakes(Bi/NPC)by high-temperature pyrolyzation of Bi-zeolitic imidazole frameworks(ZIF)followed by phosphorization,and used as a high-efficiency catalyst toward N2 electroreduction to *** 0.1 M KHCO_(3)electrolyte,Bi/NPC exhibits excellent NRR performances,including a high NH3 yield rate of 3.12μg·h^(−1)·cm^(−2)(−0.6 V *** hydrogen electrode(RHE)),an outstanding FE of 13.58%(−0.4 V ***),and a remarkable stability up to 36 h under ambient *** outstanding NRR catalytic activity is mainly attributed to the intrinsic electrocatalytic NRR activity combined with the inert hydrogen evolution reaction(HER)activity of Bi,the adsorption and activation of N2 facilitated by N dopants,as well as the superior conductivity and the large specific surface area of the two-dimensional layered carbon ***,the hydrogen source provided by P dopant promotes the hydrogenation of the adsorbed N,which further boosts the NRR performance in alkaline *** ultralong durability of Bi/NPC is attributed to the highly dispersed bismuth catalytic active centers confined in the skeleton of N and P co-doped carbon nanoflakes,which inhibits the agglomeration of bismuth *** work presents a novel avenue for designation and fabrication of high-performance Bi-based electrocatalysts for NRR.

关键词： N2 reduction bismuth N P co-doped carbon nanoflakes electrocatalysis

Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression

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Bone Research 2023年第1期11卷 136-147页

作者： Aoyuan Fan Genbin Wu Jianfang Wang Laiya Lu Jingyi Wang Hanjing Wei Yuxi Sun Yanhua Xu Chunyang Mo Xiaoying Zhang Zhiying pang Zhangyi pan Yiming Wang Liangyu Lu Guojian Fu Mengqiu Ma qiaoling Zhu Dandan Cao Jiachen Qin Feng Yin Rui Yue Department of Joint Surgery Shanghai East HospitalTongji University School of MedicineShanghai200092China Department of Orthopedic Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200240China Institute for Regenerative Medicine Shanghai East HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai200092China Department of Cardiology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai200072China Shanghai Institute of Stem Cell Research and Clinical Translation Shanghai200120China Shanghai Clinical Research Center for Aging and Medicine Shanghai200040China

Fibroblast activation protein(Fap)is a serine protease that degrades denatured type I collagen,α2-antiplasmin and *** is highly expressed in bone marrow stromal cells and functions as an osteogenic suppressor and can be inhibited by the bone growth factor Osteolectin(Oln).Fap is also expressed in synovial fibroblasts and positively correlated with the severity of rheumatoid arthritis(RA).However,whether Fap plays a critical role in osteoarthritis(OA)remains poorly ***,we found that Fap is significantly elevated in osteoarthritic synovium,while the genetic deletion or pharmacological inhibition of Fap significantly ameliorated posttraumatic OA in ***,we found that Fap degrades denatured type II collagen(Col II)and Mmp13-cleaved native Col ***-articular injection of r Fap significantly accelerated Col II degradation and OA *** contrast,Oln is expressed in the superficial layer of articular cartilage and is significantly downregulated in *** deletion of Oln significantly exacerbated OA progression,which was partially rescued by Fap deletion or ***-articular injection of r Oln significantly ameliorated OA *** together,these findings identify Fap as a critical pathogenic factor in OA that could be targeted by both synthetic and endogenous inhibitors to ameliorate articular cartilage degradation.

关键词： cartilage superficial inhibited

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中国粮食作物的过量施肥程度评价及时空分异

经济地理 2018年第10期38卷 201-210+240页

作者：孔凡斌郭巧苓潘丹江西财经大学生态经济研究院江西省社会科学院江西财经大学经济学院

基于2002—2015年全国农产品成本收益数据,采用C-D生产函数从经济学角度测算水稻、小麦和玉米3种主要粮食作物的过量施肥程度,并探索过量施肥程度的时空差异特征。研究结果表明:(1)中国粮食作物的过量施肥程度较高,水稻、小麦和玉米的... 详细信息

基于2002—2015年全国农产品成本收益数据,采用C-D生产函数从经济学角度测算水稻、小麦和玉米3种主要粮食作物的过量施肥程度,并探索过量施肥程度的时空差异特征。研究结果表明:(1)中国粮食作物的过量施肥程度较高,水稻、小麦和玉米的过量施肥程度分别为43.48%、34.58%和32.76%,三者平均过量施肥程度达到36.94%。(2)从时序变化来看,三种粮食作物过量施肥程度的变动态势均经历了先持续下降(2002—2004年)再波动上升(2005—2015年)两个阶段。(3)从空间差异来看,粮食作物过量施肥程度由高到低的区域排序依次为:华南地区>长江中下游地区>黄淮海地区>北部高原地区>西南地区>西北地区>东北地区。(4)三类粮食作物化肥减量潜力较大的省份分别为:水稻集中在海南、广东、广西、河北、山东和江苏,可减少化肥使用总量为137.48万t;小麦集中在山西、安徽、山东、宁夏、陕西、内蒙古、河北和江苏,可减少化肥使用总量为208.78万t;玉米集中在吉林、广西、湖北和云南,可减少化肥使用总量为102.75万t。

关键词：绿色生产粮食作物过量施肥程度化肥减量农业补贴空间差异

2002—2015年中国主要粮食作物过量施肥程度的空间关联格局分析

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中国农业大学学报 2019年第4期24卷 187-201页

作者：潘丹郭巧苓孔凡斌江西财经大学经济学院南昌330013 江西财经大学生态经济研究院南昌330032

为使全国范围内化肥减量工作的开展更具有针对性,本研究采用C-D生产函数测算2002—2015年水稻、小麦、玉米3种粮食作物主产区的过量施肥程度,并运用空间自相关理论和冷热点分析方法,对中国主要粮食作物过量施肥程度的空间关联格局进行... 详细信息

为使全国范围内化肥减量工作的开展更具有针对性,本研究采用C-D生产函数测算2002—2015年水稻、小麦、玉米3种粮食作物主产区的过量施肥程度,并运用空间自相关理论和冷热点分析方法,对中国主要粮食作物过量施肥程度的空间关联格局进行分析。结果显示:1)水稻主产区过量施肥程度的高值区域在黄淮海地区、华南地区呈团块状分布,小麦主产区过量施肥程度的高值区域在北部高原地区、黄淮海地区和长江中下游地区连片分布,玉米主产区过量施肥程度的高值区域在华南地区、长江中下游地区和东北地区呈团块状分布,集聚特征显著。2)水稻、小麦和玉米过量施肥程度均呈现出较强的空间自相关性,小麦集聚程度最强,水稻居中,玉米最弱。3)水稻过量施肥程度的热点区域主要分布在黄淮海地区、长江中下游地区和华南地区,冷点区域主要分布在北部高原地区和东北地区;小麦过量施肥程度的冷热点空间分布特征表现为"中间热周围冷",热点区域集中在黄淮海地区和长江中下游地区,冷点区域集中在西北地区;玉米过量施肥程度的冷热点格局由"南热北冷"转变为"东热西冷",热点区域集中在西南地区、华南地区和长江中下游地区,冷点区域集中在西北地区。

关键词：粮食作物过量施肥程度空间自相关冷热点

地方政府股权会影响城市商业银行信贷投放的周期性特征吗?

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经济评论 2016年第4期 118-128页

作者：潘敏康巧灵朱迪星武汉大学经济与管理学院中国人民银行武汉分行

与全国性金融机构相比,我国城市商业银行与地方经济发展之间存在着更密切的内在联系。一方面,地方政府通过股权控制、高管派遣等机制促使城市商业银行服务于地方经济;另一方面,城市商业银行的发展也离不开地方经济发展。本文利用我国69... 详细信息

与全国性金融机构相比,我国城市商业银行与地方经济发展之间存在着更密切的内在联系。一方面,地方政府通过股权控制、高管派遣等机制促使城市商业银行服务于地方经济;另一方面,城市商业银行的发展也离不开地方经济发展。本文利用我国69家城市商业银行2005-2013年的年度非平衡面板数据,从地方经济周期波动的角度,实证分析了我国城市商业银行信贷投放的周期性特征和区域差异,以及不同区域政府持股变化对城市商业银行信贷周期特征的影响。结论表明,城市商业银行信贷投放行为表现出显著的逆周期特征,且在中西部地区更为明显。总体上,政府持股比例增加会强化城市商业银行信贷投放的逆周期性。但从分地区来看,东部地区地方政府持股比例的增加会显著增强其逆周期特征,而在中西部地区,政府持股比例的变化与城市商业银行信贷投放逆周期之间关系不显著。

关键词：银行治理经济周期信贷投放股权结构