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Transient induction of actin cytoskeletal remodeling associated with dedifferentiation,proliferation,and redifferentiation stimulates cardiac regeneration

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2537-2553页

作者： Wenbin Fu qiao Liao Yu shi Wujian Liu Hongmei Ren Chunmei Xu Chunyu zeng Department of Cardiology Daping Hospitalthe Third Military Medical University(Army Medical University)Chongqing 400042China Key Laboratory of Geriatric Cardiovascular and Cerebrovascular Disease Research Ministry of Education of ChinaChongqing 400042China Chongqing Key Laboratory for Hypertension Research Chongqing Cardiovascular Clinical Research CenterChongqing Institute of CardiologyChongqing 400042China State Key Laboratory of Trauma Burns and Combined InjuryDaping Hospitalthe Third Military Medical UniversityChongqing 400042China Cardiovascular Research Center Chongqing CollegeUniversity of Chinese Academy of SciencesChongqing 400042China State Key Laboratory of Trauma and Chemical Poisoning Chongqing 400042China

The formation of new and functional cardiomyocytes requires a 3-step process:dedifferentiation,proliferation,and redifferentiation,but the critical genes required for efficient dedifferentiation,proliferation,and redifferentiation remain *** our study,a circular trajectory using single-nucleus RNA sequencing of the pericentriolar material 1 positive(PCM1^(+))cardiomyocyte nuclei from hearts 1 and 3 days after surgery-induced myocardial infarction(MI)on postnatal Day 1 was reconstructed and demonstrated that actin remodeling contributed to the dedifferentiation,proliferation,and redifferentiation of cardiomyocytes after *** identified four top actin-remodeling regulators,namely Tmsb4x,Tmsb10,Dmd,and Ctnna3,which we collectively referred to as *** expressed changes of 2D2P,using a polycistronic non-integrating lentivirus driven by Tnnt2(cardiac-specific troponin T)promoters(Tnnt2-2D2P-NIL),efficiently induced transiently proliferative activation and actin remodeling in postnatal Day 7 cardiomyocytes and adult ***,the intramyocardial delivery of Tnnt2-2D2P-NIL resulted in a sustained improvement in cardiac function without ventricular dilatation,thickened septum,or fatal arrhythmia for at least 4 *** conclusion,this study highlights the importance of actin remodeling in cardiac regeneration and provides a foundation for new gene-cocktail-therapy approaches to improve cardiac repair and treat heart failure using a novel transient and cardiomyocyte-specific viral construct.

关键词： Single cell analysis Actin remodeling Tmsb4x Tmsb10 Dmd Ctnna3 Myocardial infarction Cardiomyocytes proliferation Cardiac regeneration Genetic therapy

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UCHL1 promotes the proliferation of porcine granulosa cells by stabilizing CCNB1

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1894-1907页

作者： Shengjie shi Huan Yuan Lutong Zhang Lei Gao Lili Zhao Xiangfang zeng shiyan qiao Guiyan Chu Chuanjiang Cai College of Animal Science and Technology Northwest A&F UniversityYangling 712100ShaanxiChina State Key Laboratory of Animal Nutrition Ministry of Agriculture Feed Industry CenterChina Agricultural UniversityBeijing 100193China

Background The proliferation of porcine ovarian granulosa cells(GCs)is essential to follicular development and the ubiquitin–proteasome system is necessary for maintaining cell cycle *** studies found that the deubiquitinase ubiquitin carboxyl-terminal hydrolase 1(UCHL1)regulates female reproduction,especially in ovarian ***,the mechanism by which UCHL1 regulates porcine GC proliferation remains *** UCHL1 overexpression promoted GC proliferation,and knockdown had the opposite ***1 is directly bound to cyclin B1(CCNB1),prolonging the half-life of CCNB1 and inhibiting its degradation,thereby promoting GC ***'s more,a flavonoid compound-isovitexin improved the enzyme activity of UCHL1 and promoted the proliferation of porcine *** UCHL1 promoted the proliferation of porcine GCs by stabilizing CCNB1,and isovitexin enhanced the enzyme activity of *** findings reveal the role of UCHL1 and the potential of isovitexin in regulating proliferation and provide insights into identifying molecular markers and nutrients that affect follicle development.

关键词： CCNB1 Granulosa cells Isovitexin Proliferation UCHL1

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Control of highly pathogenic avian influenza through vaccination

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Journal of Integrative Agriculture 2024年第5期23卷 1447-1453页

作者： Xianying zeng Jianzhong shi Hualan Chen State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin150069China

The stamping-out strategy has been used to control highly pathogenic avian influenza viruses in many countries,driven by the belief that vaccination would not be successful against such viruses and fears that avian influenza virus in vaccinated birds would evolve more rapidly and pose a greater risk to *** this review,we summarize the successes in controlling highly pathogenic avian influenza in China and make suggestions regarding the requirements for vaccine selection and *** addition,we present evidence that vaccination of poultry not only eliminates human infection with avian influenza virus,but also significantly reduces and abolishes some harmful characteristics of avian influenza virus.

关键词： avian influenza control highly pathogenic vaccination

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Towards kernelizing the classifier for hyperbolic data

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Frontiers of Computer Science 2024年第1期18卷 17-31页

作者： Meimei YANG qiao LIU Xinkai SUN Na shi Hui XUE School of Computer Science and Engineering Southeast UniversityNanjing 210096China MOE Key Laboratory of Computer Science and Information Integration(Southeast University) Nanjing 210096China

Data hierarchy,as a hidden property of data structure,exists in a wide range of machine learning applications.A common practice to classify such hierarchical data is first to encode the data in the Euclidean space,and then train a Euclidean ***,such a paradigm leads to a performance drop due to distortion of data embedding in the Euclidean *** relieve this issue,hyperbolic geometry is investigated as an alternative space to encode the hierarchical data for its higher ability to capture the hierarchical *** methods cannot explore the full potential of the hyperbolic geometry,in the sense that such methods define the hyperbolic operations in the tangent plane,causing the distortion of data *** this paper,we develop two novel kernel formulations in the hyperbolic space,with one being positive definite(PD)and another one being indefinite,to solve the classification tasks in hyperbolic *** PD one is defined via mapping the hyperbolic data to the Drury-Arveson(DA)space,which is a special reproducing kernel Hilbert space(RKHS).To further increase the discrimination of the classifier,an indefinite kernel is further defined in the Krein ***,we design a 2-layer nested indefinite kernel which first maps hyperbolic data into the DA spaces,followed by a mapping from the DA spaces to the Krein *** experiments on real-world datasets demonstrate the superiority ofthe proposed kernels.

关键词： data hierarchy hyperbolic cgeometry drury-arveson space krein space

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Modeling of multiphase flow in low permeability porous media:Effect of wettability and pore structure properties

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1127-1139页

作者： Xiangjie Qin Yuxuan Xia Juncheng qiao Jiaheng Chen Jianhui zeng Jianchao Cai National Key Laboratory of Petroleum Resources and Engineering China University of PetroleumBeijing102249China Research Institute of Petroleum Exploration and Development Beijing10083China

Multiphase flow in low permeability porous media is involved in numerous energy and environmental ***,a complete description of this process is challenging due to the limited modeling scale and the effects of complex pore structures and *** address this issue,based on the digital rock of low permeability sandstone,a direct numerical simulation is performed considering the interphase drag and boundary slip to clarify the microscopic water-oil displacement *** addition,a dual-porosity pore network model(PNM)is constructed to obtain the water-oil relative permeability of the *** displacement efficiency as a recovery process is assessed under different wetting and pore structure *** show that microscopic displacement mechanisms explain the corresponding macroscopic relative *** injected water breaks through the outlet earlier with a large mass flow,while thick oil films exist in rough hydrophobic surfaces and poorly connected *** variation of water-oil relative permeability is significant,and residual oil saturation is high in the oil-wet *** flooding is extensive,and the residual oil is trapped in complex pore networks for hydrophilic pore surfaces;thus,water relative permeability is lower in the water-wet *** the displacement efficiency is the worst in mixed-wetting systems for poor water *** negatively correlates with invading oil volume fraction due to strong capillary resistance,and a large microporosity corresponds to low residual oil *** work provides insights into the water-oil flow from different modeling perspectives and helps to optimize the development plan for enhanced recovery.

关键词： Low permeability porous media Water-oil flow Wettability Pore structures Dual porosity pore network model(PNM) Free surface model

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Dietary crude protein time-dependently modulates the bacterial community and metabolites and changes dietary nutrient efficiency in growing pigs

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Animal Nutrition 2024年第2期17卷 1-10页

作者： Yuming Wang Junyan Zhou Ning Cao Lu Wang Jiayu Tu Xiangfang zeng shiyan qiao State Key Laboratory of Animal Nutrition and Feeding Institute of Animal Sciences of Chinese Academy of Agricultural Sciences Animal Science and Technology College Beijing University of Agriculture State Key Laboratory of Animal Nutrition and Feeding Ministry of Agriculture Feed Industry CentreChina Agricultural University

The reduced nutrient digestibility of low-protein(LP) diets has been shown to be caused by the weakened fermentative capacity of the post-gut flora. The dynamic regulation of dietary protein contents on post-gut microbial population and fermentative metabolism is unclear. Twelve growing barrows(19.9 ± 0.8 kg) fitted with a T-cannula at the blind end of the cecum were randomly administered a highprotein(HP, 21.5% crude protein [CP]) diet or an LP(15.5% CP) diet for 28 d. The cecal content and feces were collected at d 1, 14, and 28 of the experiment for microflora structures and metabolite concentrations analysis. The nutrient digestibility coefficient and plasma biochemical parameters were also determined. Compared with the HP treatment, the LP treatment showed decreased plasma urea nitrogen concentration and apparent total tract digestibility of dry matter, gross energy, and CP(P < 0.01). In addition, urinary nitrogen losses, total nitrogen losses, and daily nitrogen retention in the LP treatment were lower than those in the HP treatment(P < 0.01), and the nitrogen retention-to-nitrogen intake ratio in the LP treatment was increased(P < 0.01). The HP group showed increased cecal total short-chain fatty acids(SCFA) concentration and fecal propionate, butyrate, and total SCFA concentrations(P < 0.05) on d 14 and 28, which may be mainly related to the elevated abundance of SCFA-producing bacteria, such as Ruminococcus, Lactobacillus, and Prevotella(P < 0.05). Probiotics, such as Bifidobacterium, Bacteroidales S24-7, and Rikenella, enriched in the LP treatment possibly contributed to reduced plasma endotoxin content. The differences in the abundances of almost all the above-mentioned flora appeared on d 28 but not d 14. Likewise, differences in the Simpson and Shannon indices and clustering patterns of the microbiota between treatments were also only observed on d 28. To sum up, in a time-dependent manner, the LP diet increased probiotics with gut-improving functions a

关键词： Low-protein diet Microorganism Nutrient digestibility Pig Short-chain fatty acid

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Achieving full mutualism with massive passive devices for multiuser MIMO symbiotic radio

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Science China(Information Sciences) 2024年第9期67卷 196-212页

作者： Jingran XU Zhuoyin DAI Yong zeng shi JIN Tao JIANG National Mobile Communications Research Laboratory Southeast University Purple Mountain Laboratories Research Center of 6G Mobile Communications School of Cyber Science and Engineering and Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology

Symbiotic radio(SR) is one of the attractive communication technologies to facilitate largescale Internet of Things(IoT) connections with enhanced energy and spectrum efficiency, where passive backscatter devices(BDs) modulate their information over the radio frequency(RF) signals emitted by the active primary transmitters(PTs). Meanwhile, the primary transmission can be strengthened with the additional multipaths created by BDs. To capitalize to a greater extent on the mutualism relationship between the two types of communication, this paper studies multiple-input multiple-output(MIMO) SR communication systems including multiple PTs and massive BDs. We derive the achievable rate expressions of each PT and BD, as well as the sum rate expressions of primary and secondary communication, *** asymptotic analysis is given to derive the active and passive communication rates with a large number of BDs. Furthermore, for the general case with a finite number of BDs, we study the precoding optimization problem to maximize the sum rate of primary communication, while ensuring that the sum rate of secondary communication and the individual rate for each PT and BD in the prescribed active and passive user sets satisfy the specified thresholds. Simulation results are presented to verify the analytical studies.

关键词： multiuser MIMO SR backscattering massive backscatter devices asymptotic analysis active and passive communication

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LncRNA HOTTIP facilitated tumor growth via stimulating the hnRNPA2B1/DKK1/Wnt/β-catenin regulatory axis in hepatocellular carcinoma

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Genes & Diseases 2024年第4期11卷 53-56页

作者： Weiqiang zeng Chuanjian shi Liqiang Deng Weiming Fu Jinfang Zhang Cancer Center Shenzhen Hospital(Futian)of Guangzhou University of Chinese MedicineShenzhenGuangdong 518000China Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhouGuangdong 510515China

Hepatocellular carcinoma(HcC)has become the fifth leading cause of cancer mortality worldwide in the past decade.1 Dysregulated long noncoding RNAs(lncRNAs)are closely associated with its occurrence and *** identified IncRNA named"HOXA transcript at the distal tip"(HOTTIP)has been considered as an oncogene in multiple ***,the mechanism underlying HOTTiP-mediated hepatocarcinogenesis remains mostly unknown.

关键词： DKK1 mortality stimulating

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Immune checkpoint inhibitor-associated gastritis:Patterns and management

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World Journal of Gastroenterology 2024年第14期30卷 1941-1948页

作者： Jing Lin Zhong-qiao Lin shi-Cheng Zheng Yu Chen Department of Medical Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350000Fujian ProvinceChina Phase I Clinical Trial Ward Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350000Fujian ProvinceChina School of Basic Medical Sciences Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina

Immune checkpoint inhibitors(ICIs)are widely used due to their effectiveness in treating various ***-related adverse events(irAEs)are defined as adverse effects resulting from ICI *** irAEs are a common type of irAEs characterized by intestinal side effects,such as diarrhea and colitis,which may lead to the cessation of *** irAE gastritis is rarely reported,it may lead to serious complications such as ***,irAE gastritis is often difficult to identify early due to its diverse *** steroid hormones and immunosuppressants are commonly used to reverse irAEs,the best regimen and dosage for irAE gastritis remains *** addition,the risk of recurrence of irAE gastritis after the reuse of ICIs should be *** this editorial,strategies such as early identification,pathological diagnosis,mana-gement interventions,and immunotherapy rechallenge are discussed to enable clinicians to better manage irAE gastritis and improve the prognosis of these patients.

关键词： Immunotherapy Immune checkpoint inhibitor Immune-related adverse events Immune checkpoint inhibitor-related gastritis

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Aboveground biomass stocks of species-rich natural forests in southern China are influenced by stand structural attributes,species richness and precipitation

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Plant Diversity 2024年第4期46卷 530-536页

作者： Wen-Hao zeng shi-Dan Zhu Ying-Hua Luo Wei shi Yong-Qiang Wang Kun-Fang Cao State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources College of ForestryGuangxi UniversityNanning 530004China Guangxi Key Laboratory of Forest Ecology and Conservation College of ForestryGuangxi UniversityNanning 530004China Key Laboratory of National Forestry and Grassland Administration on Biodiversity Conservation in Karst Mountainous Areas of Southwestern China School of Life SciencesGuizhou Normal UniversityHuaxi College TownGui'an DistrictGuiyang 550025China

Forests,the largest terrestrial carbon sinks,play an important role in carbon sequestration and climate change *** forest attributes and environmental factors have been shown to impact aboveground biomass,their influence on biomass stocks in species-rich forests in southern China,a biodiversity hotspot,has rarely been *** this study,we characterized the effects of environmental factors,forest structure,and species diversity on aboveground biomass stocks of 30 plots(1 ha each) in natural forests located within seven nature reserves distributed across subtropical and marginal tropical zones in Guangxi,*** results indicate that forest aboveground biomass stocks in this region are lower than those in mature tropical and subtropical forests in other ***,we found that aboveground biomass was positively correlated with stand age,mean annual precipitation,elevation,structural attributes and species richness,although not with species *** we compared stands with the same basal area,we found that aboveground biomass stock was higher in communities with a higher coefficient of variation of diameter at breast *** findings highlight the importance of maintaining forest structural diversity and species richness to promote aboveground biomass accumulation and reveal the potential impacts of precipitation changes resulting from climate warming on the ecosystem services of subtropical and northern tropical forests in ***,many natural forests in southern China are not fully ***,their continued growth will increase their carbon storage over time.

关键词： Subtropical forest Marginal tropical forest Aboveground biomass Species diversity Forest structural attribute Environment factor

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