检索结果-南通市图书馆

“Exploring petroleum inside source kitchen”: Shale oil and gas in Sichuan Basin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2020年第7期63卷 934-953页

作者： Caineng zou Zhi YANG Shasha SUN qun ZHAO Wenhua BAI Honglin LIU Songqi PAN Songtao WU Yilin YUAN PetroChina Research Institute of Petroleum Exploration and Development Beijing 100083China

The Sichuan Basin is rich in shale oil and gas resources,with favorable geological conditions that the other shale reservoirs in China cannot ***,the basin is an ideal option for fully"exploring petroleum inside source kitchen"with respect to onshore shale oil and gas in *** paper analyzes the characteristics of shale oil and gas resources in the United States and China,and points out that maturity plays an important role in controlling shale oil and gas *** shale oil and gas exhibit high proportions of light hydrocarbon and wet gas,whereas Chinese marine and transitional shale gas is mainly dry gas and continental shale oil is generally heavy.A comprehensive geological study of shale oil and gas in the Sichuan Basin reveals findings with respect to the following three ***,there are multiple sets of organic-rich shale reservoirs of three types in the basin,such as the Cambrian Qiongzhusi Formation and Ordovician Wufeng Formation-Silurian Longmaxi Formation marine shale,Permian Longtan Formation transitional shale,Triassic Xujiahe Formation lake-swamp shale,and Jurassic lacustrine *** shale gas enrichment is mainly controlled by four elements:Deep-water shelf facies,moderate thermal evolution,calcium-rich and silicon-rich rock association,and closed roof/***,the"sweet section"is generally characterized by high total organic carbon,high gas content,large porosity,high brittle minerals content,high formation pressure,and the presence of lamellation/bedding and natural ***,the"sweet area"is generally characterized by very thick organic-rich shale,moderate thermal evolution,good preservation conditions,and shallow burial depth,which are exemplified by the shale oil and gas in the Wufeng-Longmaxi Formation,Longtan Formation,and Daanzhai Member of the Ziliujing ***,the marine,transitional,and continental shale oil and gas resources in the Sichuan Basin account for 50%,25%,and 30%of the res

关键词： Shale oil Shale gas Marine facies Continental facies Transitional facies Resource potential Sweet area Sweet section Source rock oil and gas Shale oil and gas revolution "Sichuan-Chongqing Daqing-Gas"

A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy

在线全文

学校读者我要写书评

暂无评论

Nano Research 2020年第8期13卷 2216-2225页

作者： Hongwei Lu Yongjing Xu Ruirui qiao Ziwei Lu Pin Wang Xindan Zhang An Chen Liming zou Zhongling Wang Department of Radiology Shanghai General HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai200080China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China ARC Centre of Excellence in Convergent Bio-Nano Science and Technology Monash Institute of Pharmaceutical SciencesMonash University381 Royal ParadeParkvilleVIC3052Australia Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhou215006China Department of Gastroenterology Nanjing Drum Tower HospitalAffiliated Hospital of Nanjing University Medical SchoolNanjing210029China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen518055China

Construction of micro tumor sensitive theranostic nanoagents that can increase the accuracy of imaging diagnosis and boost the therapeutic efficacy has been demonstrated for a promising approach for diagnosis and treatment of ***,we reported a novel super-paramagnetic iron oxide(SPIO)based nanoplatform that possess significantly enhanced magnetic resonance property and photothermal effect for tumor theranostic *** polyethylene glycol with four phenylboronic acid(PEG-B4)/CNTs@porphyrin(ph)/SPIO(BCPS)nanoplatform was simply prepared via integrated SPIO,ph,and a novel dendrimer with PEG liner and four PBA groups(PEG-B4)on the surface of carbon nanotubes(CNTs).Subsequently,a significant T2 relaxation rate enhanced can be achieved by the reduced accessibility of water to SPIO ***,the synergetic enhanced photothermal from BCPS nanoplatform contributed to better photothermal effect for cancer ***,the targeting ability to sialic acid overexpressed tumor was further introduced from phenylboronic acid from *** showed that BCPS nanoplatform could not only selectively identify solid tumors and detect micro-sized metastatic tumor(1 mm)in the liver,but also effectively ablate tumors in a xenograft model,thereby achieving a complete cure rate of 100%at low laser *** results highlight the potential of BCPS nanoplatform for accurate micro-tumor diagnosis and effective tumor therapy.

关键词： theranostic agent clustered SPIO nanoplatform T2 MRI micro-tumor detection photothermal therapy synergetic effect

Skeletal phenotypes and molecular mechanisms in aging mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zoological Research 2024年第4期45卷 724-746页

作者： qiao Guan Yuan Zhang Zhi-Kun Wang Xiao-Hua Liu Jun zou Ling-Li Zhang School of Exercise and Health Shanghai University of SportShanghai 200438China College of Athletic Performance Shanghai University of SportShanghai 200438China

Aging is an inevitable physiological process,often accompanied by age-related bone loss and subsequent bone-related diseases that pose serious health *** on skeletal diseases caused by aging in humans is challenging due to lengthy study durations,difficulties in sampling,regional variability,and substantial ***,mice are preferred for such studies due to their similar motor system structure and function to humans,ease of handling and care,low cost,and short generation *** this review,we present a comprehensive overview of the characteristics,limitations,applicability,bone phenotypes,and treatment methods in naturally aging mice and prematurely aging mouse models(including SAMP6,POLG mutant,LMNA,SIRT6,ZMPSTE24,TFAM,ERCC1,WERNER,and KL/KL-deficient mice).We also summarize the molecular mechanisms of these aging mouse models,including cellular DNA damage response,senescence-related secretory phenotype,telomere shortening,oxidative stress,bone marrow mesenchymal stem cell(BMSC)abnormalities,and mitochondrial ***,this review aims to enhance our understanding of the pathogenesis of aging-related bone diseases.

关键词： Aging Premature aging Mice Bone Gene knockout

Jug-PLGA-NPs, a New Form of Juglone with Enhanced Efficiency and Reduced Toxicity on Melanoma

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2022年第10期28卷 909-917页

作者： YUE Wu-heng QIN Lan-qun CAI Juan MEI Rui QIAN Han-qing zou Zheng-yun The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing(210008)China Department of Oncology Taicang TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhouJiangsu Province(215499)China The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjing(210008)China The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital Medical School of Nanjing University&Clinical Cancer Institute of Nanjing UniversityNanjing(210008)China

Objective: To verrify the anti-tumor efficacy and toxicity between juglone(Jug) and Jug-loaded poly lactic-co-glycolic acid(PLGA) nanoparticles(Jug-PLGA-NPs). Methods: Jug-PLGA-NPs were prepared by ultrasonic emulsification. The anti-tumor activity of Jug(2, 3, 4 μg/mL) and Jug-PLGA-NPs(Jug: 2, 3, 4 μg/mL) in vitro was measured by MTT assay and cell apoptosis analysis. The distribution, anti-tumor effect and biological safety in vivo was evaluated on A375 nude mice. Results: With the advantage of good penetration and targeting properties, Jug-PLGA-NPs significantly inhibited proliferation and migration of melanoma cells both in vitro and in vivo(P<0.05 or P<0.01) with acceptable biocompatibility. Conclusions: Jug can inhibit the growth of melanoma but is highly toxic. With the advantage of sustained release, tumor targeting, anti-tumor activity and acceptable biological safety, Jug-PLGA-NPs provide a new pharmaceutical form for future application of Jug.

关键词： juglone PLGA nanoparticles malignant melanoma Jug-PLGA-NPs

Synthesis and Evaluation of the Analogues of Penicillide against Cholesterol Ester Transfer Protein

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2013年第3期31卷 355-370页

作者： qiao Zhang Chunlin Deng Lisong Fang Wenwei Xu qun Zhao Jiange Zhang Yiping Wang Xinsheng Lei School of Pharmacy Fudan University Shanghai 201203 China Department of Medicinal Chemistry School of Pharmaceutical Science Zhengzhou University Zhenezhou Henan 450001 China Shanghai Institute of Materia Medica Chinese Aeademy of Sciences Shanghai 201203 China

A series ofpenicillide analogues, with modifications at C-3 and C-9 positions, are synthesized as potential cho-lesteryl ester transfer protein （CETP） inhibitors. The preliminary in vitro inhibition assay provided s... 详细信息

关键词： cross-coupling lactone inhibitors cholesterol ester transfer protein penicillide

The Effect of Transportation and Housing Subsidies on Urban Sprawl

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Science and Information 2018年第3期9卷 237-248页

作者： qiao CAI zou WANG Lingling XIAO School of Economics and Management Beijing Jiaotong University

This paper analyses theoretically the effect of transportation and housing subsidies on urban sprawl,modal choice decisions and urban spatial structure using a spatial general equilibrium model in a monocentric city with two transport modes. Our analysis shows that public transit subsidy leads to urban shrink,whilst subsidizing automobile and housing make the city sprawl. We also find the effects of the other factors on urban sprawl,such as households income and demand,rural land rent,the income tax rate,the total fixed cost of public transit and automobile and the travelling marginal cost of public transit and automobile. Furthermore,this paper also studies how to maximize the urban-area-wide spatial equilibrium utility level.

关键词： monocentric city subsidies urban sprawl spatial equilibrium

Teleportation of N-Particle Entangled GHZ State via Entanglement Swapping

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2006年第4X期46卷 595-598页

作者： SHA Jin-qiao FANG Jian-Xing ZHU Shi-qun JIANG Wei-Xing QIAN Xue-Min School of Physical Science and Technology Suzhou University Suzhou 215006 China

In this scheme, N non-maximally entangled particle pairs are used as quantum channel to teleport an unknown N-particle entangled GHZ state via entanglement swapping. In order to realize this teleportation, the sender Alice operates Bell-state measurement on particles belonging to herself. Then she informs the results to the receiver Bob through classical communication. According to the results, Bob operates corresponding transformation to reconstruct the initial state. The advantage of this scheme is that it needs only one common unitary matrix for Alice＇s different results, which has a more general meaning. As a special case, teleporting an unknown three-particle entangled GHZ state is proposed.

关键词： quantum teleportation N-particle entangled GHZ state entanglement swapping

A genetic diversity assessment of starch quality traits in rice landraces from the Taihu basin,China

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2016年第3期15卷 493-501页

作者： AO Yan XU Yong CUI Xiao-fen WANG An TENG Fei SHEN Li-qun LIU qiao-quan Key Laboratory of Crop Genetics and Physiology of Jiangsu Province/Co-Innovation Center for Modern Production Technology of Grain Crops/College of Agriculture Yangzhou UniversityYangzhou 225009P.R.China Suzhou Chien-Shiung Institute of Technology Suzhou 215411P.R.China

There are nearly 1 000 rice landrace varieties in the Taihu basin, China. To assess the genetic diversity of the rice, 24 intragenic molecular markers（representing 17 starch synthesis-related genes） were investigated in 115 Taihu basin rice landraces and 87 improved cultivars simultaneously. The results show that the average genetic diversity and polymorphism information content values of the landraces were higher than those of improved cultivars. In total, 41 and 39 allele combinations（of the 17 genes） were derived from the landraces and improved cultivars, respectively; only two identical allele combinations were found bet ween the two rice variety sources. Cluster analysis, based on the molecular markers, revealed that the rice varieties could be subdivided into five groups and, within these, the japonica improved rice and japonica landrace rice varieties were in two separate groups. According to the quality reference criteria to classify the rice into grades, some of the landraces were found to perform we ll, in terms of starch quality. For example, according to NY /T595-2002 criteria from the Ministry of Agriculture of China, 25 and 33 landraces reached grade 1, in terms of their apparent amylose content and gel consistency. Th e varieties that had outstanding quality could be used as breeding materials for rice quality breeding programs in the future. Our study is useful for future applications, such as genetic diversity studies, the protection of rice variety and improvment of rice quality in breeding programs.

关键词： intragenic molecular marker starch synthesis improved cultivars cluster analysis polymorphism information content

Role of lncRNA MALAT1 in UVA-induced corneal endothelial senescence

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2023年第5期10卷 1795-1798页

作者： Yujie qiao Bin Zhang Yani Wang Tian Sang Shengqian Dou Chunxiao Dong qun Wang Qingjun Zhou State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of OphthalmologyShandong Eye InstituteShandong First Medical University&Shandong Academy of Medical SciencesQingdaoShandong 266071China Qingdao Eye Hospital of Shandong First Medical University QingdaoShandong 266071China Qingdao University QingdaoShandong 266071China Eye Hospital of Shandong First Medical University(Shandong Eye Hospital) JinanShandong 250021China

The corneal endothelial monolayer is responsible for maintaining corneal transparency through its barrier and pump *** cells do not proliferate in vivo,and aging-related reductions in cell density make the endothelium fragile.1 However,the molecular mechanism associated with the aging corneal endothelium remains *** this study,we used ultraviolet A(UVA)-light-induced senescence to mimic the degenerative endothelial changes during ***1,the most abundant long non-coding RNA(lncRNA)gene in the cornea,was markedly down-regulated after UVA *** inhibition or activation of Malat1 expression genetically led to the aggravation or remission of the cellular aging phenotype after UVA ***,an in vitro model established by the human corneal endothelial cell line(HCEC)recapitulated the morphological and molecular changes during aging,encouraging the investigation of the underlying *** observed changes in the mitochondrial bioenergetic profiles of HCECs accompanied by extensive cell aging and reduced reproductive capacity after MALAT1 was silenced by gene-targeting ***,Malat1 knockout(KO)aggravated mouse corneal endothelial senescence and dysfunction,which reinforced our *** findings indicate that MALAT1 may contribute to the delay of aging processes involving endothelial cells and provide a new therapeutic target for treating aging-related corneal endothelium disorders.

关键词： MALAT1 corneal markedly