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Longitudinal non-vascular transport pathways originating from acupuncture points in extremities visualised in human body

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Chinese Science Bulletin 2014年第35期59卷 5090-5095页

作者： Hongyi li Jiabin Tong Weiguo Cao Min Chen Hua li Hong Dai liang Xu Xiaoliang Chen Beijing Hospital of the Ministry of Health Institute of Computing Technology Chinese Academy of Sciences

A subcutaneous transport pathway in humans has been previously visualised by injection of a paramagnetic tracer into the specific region of *** the current study,we further investigated the behaviours of imaging tracers in the transport pathways using imaging *** types of imaging tracers,including Gd-DTPA,iodised oil,and fluorescein sodium,were hypodermically injected into different acupuncture points of healthy volunteers to visualise the transport pathways by magnetic resonance imaging(MRI),X-ray,CT,and a digital fluorescein *** longitudinal transport pathways in the arms and feet,which represent venous vessels and subcutaneous transport pathways(STPs) without well-defined boundaries,were visualised by *** the visualised veins,the partial walls of a few veins were enhanced by *** fluorescent images further indicated that STPs likely represent boundless *** findings in this study suggested that specific anatomical structures within the subcutaneous tissues or the partial walls of certain veins werenot vascular conduits but rather represented unique transport pathways in humans that warrant extensive future studies.

关键词：运输途径可视化血管穴位污水处理厂四肢成像技术荧光素钠

Assessment of causal effects of physical activity on neurodegenerative diseases:A Mendelian randomization study

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Journal of Sport and Health Science 2021年第4期10卷 454-461页

作者： Peng-Fei Wu Hui Lu Xiaoting Zhou Xuchen liang Ruizhuo li Wan Zhang Danyang li Kun Xia Center for Medical Genetics&Hunan Provincial Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangsha 410008China Department of Neurology Beth Israel Deaconess Medical Center&Harvard Medical SchoolBostonMA 02115USA Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Neurology Xiangya HospitalCentral South UniversityChangsha 410008China School of Physical Education Henan UniversityKaifeng 475001China School of Medicine South China University of TechnologyGuangzhou 510006China Department of Biology College of Arts&SciencesBoston UniversityBostonMA 02215USA CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China

Background:Physical activity has been hypothesized to play a protective role in neurodegenerative ***,effect estimates previously derived from observational studies were prone to confounding or reverse ***:We performed a two-sample Mendelian randomization(MR)analysis to explore the causal association of accelerometer-measured physical activity with 3 common neurodegenerative diseases:Alzheimer’s disease(AD),Parkinson’s disease(PD),and amyotrophic lateral sclerosis(ALS).We selected genetic instrumental variants reaching genome-wide significance(plier(MR-PRESSO),weighted median,and MR-Egger were implemented as sensitivity *** statistical analyses were performed using the R programming language(Version 3.6.1;R Foundation for Statistical Computing,Vienna,Austria).Results:Primary MR analysis and replication analysis utilized 5 and 8 instrumental variables,which explained 0.2%and 0.4%variance in physical activity,*** each set,one variant at 17q21 was significantly associated with PD,and MR sensitivity analyses indicated them it as an outlier and source of heterogeneity and *** results with the removal of outlier variants suggested odds ratios(ORs)of neurodegenerative diseases per unit increase in objectively measured physical activity were 1.52 for AD(95%confidence interval(95%CI):0.88-2.63,p=0.13)and 3.35 for PD(95%CI:1.32-8.48,p=0.01),while inconsistent results were shown in the replication set for AD(OR=1.06,95%CI:1.01-1.12,p=0.02)and PD(OR=0.99,95%CI:0.88-0.12,p=0.97).Similarly,the beneficial effect of physical activity on ALS(OR=0.51,95%CI:0.29-0.91,p=0.02)was not confirmed in

关键词： Alzheimer’s disease Amyotrophic lateral sclerosis Genetic epidemiology Mendelian randomization Parkinson’s disease Physical activity

Facile and Low-Cost Fabrication of a Thread/Paper-Based Wearable System for Simultaneous Detection of Lactate and pH in Human Sweat

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Advanced Fiber Materials 2020年第5期2卷 265-278页

作者： Gang Xiao Jing He Yan qiao Feng Wang Qingyou Xia Xin Wang ling Yu Zhisong Lu Chang-Ming li Institute for Clean Energy and Advanced Materials School of Materials and EnergySouthwest University1 Tiansheng RoadChongqing 400715People’s Republic of China State Key Laboratory of Silkworm Genome Biology Southwest University1 Tiansheng RoadChongqing 400715People’s Republic of China Chongqing Engineering and Technology Research Center for Novel Silk Materials Southwest University1 Tiansheng RoadChongqing 400715People’s Republic of China College of Food Science Southwest UniversityNo.2 Tiansheng RoadBeibei DistrictChongqing 400715People’s Republic of China Institute of Advanced Cross-Field Science Qingdao UniversityQingdao 266071People’s Republic of China

Wearable devices have received tremendous interests in human sweat analysis in the past few ***,the widely used polymeric substrates and the layer-by-layer stacking structures greatly influence the cost-efficiency,conformability and breathability of the devices,further hindering their practical ***,we report a facile and low-cost strategy for the fabrication of a skin-friendly thread/paper-based wearable system consisting of a sweat reservoir and a multi-sensing component for simultaneous in situ analysis of sweat pH and *** the system,hydrophilic silk thread serves as the micro-channel to guide the liquid *** papers were functionalized to prepare colorimetric sensors for lactate and *** smartphone-based quantitative analysis shows that the sensors are sensitive and *** pH may interfere the lactate detection,the pH detected simultaneously could be employed to correct the measured data for the achievement of a precise lactate *** being integrated with a hydrophobic arm guard,the system was successfully used for the on-body measurement of pH and lactate in the sweats secreted from the *** low-cost,easy-to-fabricate,light-weight and flexible thread/paper-based microfluidic sensing device may hold great potentials as a wearable system in human sweat analysis and point-of-care diagnostics.

关键词： Wearable sensors Thread/paper-based microfluidics Sweat analysis Point-of-care diagnostics Multi-sensing system

PCC0208017,a novel small-molecule inhibitor of MARK3/MARK4,suppresses glioma progression in vitro and in vivo

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Acta Pharmaceutica Sinica B 2020年第2期10卷 289-300页

作者： Fangfang li Zongliang liu Heyuan Sun Chunmei li Wenyan Wang liang Ye Chunhong Yan Jingwei Tian Hongbo Wang School of Pharmacy Key Laboratory of Molecular Pharmacology and Drug Evaluation(Yantai University)Ministry of EducationCollaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs inUniversities of ShandongYantai UniversityYantai 264005China Department of Clinical Medicine Binzhou Medical CollegeYantai 256603China GRU Cancer Center Augusta UniversityAugustaGA 30912USA

Gliomas are the most common primary intracranial neoplasms among all brain malignancies,and the microtubule affinity regulating kinases(MARKs)have become potential drug targets for ***,we report a novel dual small-molecule inhibitor of MARK3 and MARK4,designated as *** vitro,PCC0208017 strongly inhibited kinase activity against MARK3 and MARK4,and strongly reduced proliferation in three glioma cell *** compound attenuated glioma cell migration,glioma cell invasion,and *** mechanism studies revealed that PCC0208017 decreased the phosphorylation of Tau,disrupted microtubule dynamics,and induced a G2/M phase cell cycle *** an in vivo glioma model,PCC0208017 showed robust anti-tumor activity,blood-brain barrier permeability,and a good oral pharmacokinetic *** docking studies showed that PCC0208017 exhibited high binding affinity to MARK3 and *** together,our study describes for the first time that PCC0208017,a novel MARK3/MARK4 inhibitor,might be a promising lead compound for treatment of glioma.

关键词： Glioma PCC0208017 MARK3 MARK4 Molecular docking

Soil Organic Matter Fractions under Different Vegetation Types in Permafrost Regions along the Qinghai-Tibet Highway, North of Kunlun Mountains, China

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Journal of Mountain Science 2015年第4期12卷 1010-1024页

作者： SHANG Wen ZHAO lin WU Xiao-dong li Yu-qiang YUE Guang-yang ZHAO Yong-hua qiao Yong-ping Cryosphere Research Station on Qinghai-Tibet Plateau State Key laboratory of Cryospheric Sciences Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences University of Chinese Academy of Sciences Naiman Desertification Research Station Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of Sciences

As a key attribute of soil quality, soil organic matter(SOM) and its different fractions play an important role in regulating soil nutrient cycling and soil *** study evaluated the soil carbon(C) and nitrogen(N) concentrations in different SOM fractions(light– and heavy fractions,microbial biomass) under different vegetation types and analyzed their influencing factors in continuous permafrost regions along the Qinghai-Tibet Highway in the North of Kunlun Mountains, *** samples were collected in pits under four vegetation types — Alpine swamp meadow(ASM), Alpine meadow(AM), Alpine steppe(AS) and Alpine desert(AD) — at the depth of 0-50 *** vegetation coverage was the highest at ASM and AM, followed byAS and *** results indicated that the concentrations of light fraction carbon(LFC) and nitrogen(LFN), and microbial biomass carbon(MBC)and nitrogen(MBN) decreased as follows: ASM > AM >AS > AD, with the relatively stronger decrease of LFC,whereas the heavy fraction carbon(HFC) and nitrogen(HFN) concentrations were lower in AS soils than in the AD *** relatively higher proportions of LFC/SOC and MBC/SOC in the 0-10 cm depth under the ASM soils are mainly resulted from its higher substrate input and soil moisture *** analysis demonstrated that aboveground biomass, soil moisture content, soil organic carbon(SOC) and total nitrogen(TN) positively correlated to LFC, LFN, HFC, HFN, MBC and MBN, while p H negatively correlated to LFC, LFN, HFC, HFN, MBC and *** was no relationship between active layer thickness and SOM fractions, except for the *** suggested that vegetation cover, soil moisture content, and SOC and TN concentrations were significantly correlated with the amount and availability of SOM fractions, while permafrost had less impact on SOM fractions in permafrost regions of the central Qinghai–Tibet Plateau.

关键词： Soil organic matter light fraction Heavy fraction Microbial biomass Vegetation types Tibetan permafrost soil

De Novo Dissecting the Three‑Dimensional Facial Morphology of 2379 Han Chinese Individuals

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Phenomics 2024年第1期4卷 1-12页

作者： Hui qiao Jingze Tan Shaoqing Wen Menghan Zhang Shuhua Xu li Jin State Key Laboratory of Genetic Engineering Center for Evolutionary BiologyCollaborative Innovation Center for Genetics and DevelopmentSchool of Life SciencesFudan UniversityShanghai 200438China Ministry of Education Key Laboratory of Contemporary Anthropology Human Phenome InstituteZhangjiang Fudan International Innovation CenterFudan UniversityShanghai 201203China Institute of Archaeological Science Fudan UniversityShanghai 200433China Institute of Modern Languages and linguistics Fudan UniversityShanghai 200433China Department of liver Surgery and Transplantation liver Cancer Institute Zhongshan HospitalFudan UniversityShanghai 200032China

Phenotypic diversity,especially that of facial morphology,has not been fully investigated in the Han Chinese,which is the largest ethnic group in the *** this study,we systematically analyzed a total of 14,838 facial traits representing 15 categories with both a large-scale three-dimensional(3D)manual landmarking database and computer-aided facial segmented phenotyping in 2379 Han Chinese *** results illustrate that homogeneous and heterogeneous facial morphological traits exist among Han Chinese populations across the three geographical regions:Zhengzhou,Taizhou,and *** identifed 1560 shared features from extracted phenotypes,which characterized well the basic facial morphology of the Han *** particular,heterogeneous phenotypes showing population structures corresponded to geographical *** greatest facial variation among these geographical populations was the angle of glabella,left subalare,and right cheilion(p=3.4×10^(−161)).Interestingly,we found that Han Chinese populations could be classifed into northern Han,central Han,and southern Han at the phenotypic level,and the facial morphological variation pattern of central Han Chinese was between the typical diferentiation of northern and southern Han *** result was highly consistent with the results revealed by the genetic *** fndings provide new insights into the analysis of multidimensional phenotypes as well as a valuable resource for further facial phenotype-genotype association studies in Han Chinese and East Asian populations.

关键词： Phenotypes Three-dimensional facial imaging Facial morphology Han Chinese

Oxidation behavior of multi-component Ta-W-Al-Ti alloy at 1173 K

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Rare Metals 2021年第7期40卷 1940-1948页

作者： Jia-Xin li Yu-Hong Chen Zhang-Jun Bai Bao-Jun Zhao liang Jiang Lan-Er Wu School of Materials Science and Engineering North Minzu UniversityYinchuan 750021China CNMC Ningxia Orient Group Co.Ltd Shizuishan 753000China School of Chemical Engineering The University of QueenslandBrisbaneQLD 4072Australia

Ta-W alloys have unique properties but their applications at high temperatures are restricted due to their poor oxidation *** addition of Al and Ti decreases the oxidation rate of the alloy,as Al-contained protective oxide layer could be *** this study,ternary and quaternary Ta-W alloys containing Al and Ti were prepared by hot press *** microstructures and oxidation behaviors of the alloys were studied at1173 *** results show that the oxidation kinetics of all alloys follows a parabolic law at short oxidation *** cyclic oxidation,the kinetics of quaternary alloys still obeys the parabolic law but that of ternary alloy has been changed into linear law kinetics after 8-h *** ternary alloy,an outer layer with dense and continuous alumina was formed during the initial stage,and phase transformation caused the oxides to peel *** comparison,the quaternary alloys depicted continuously solid solution of the oxides ***,Al and Ti played key roles in oxidation degree and affected the oxidation kinetics of ternary and quaternary alloys.

关键词： Oxidation behavior Ta-W-based alloy Aluminum Titanium

Characteristics of rare-earth elements (REE),strontium and neodymium isotopes in hydrothermal fluorites from the Bailashui tin deposit in the Furong ore field,southern Hunan Province,China

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Chinese Journal Of Geochemistry 2008年第4期27卷 342-350页

作者： YUAN Shunda PENG Jiantang HU Ruizhong BI Xianwu QI liang li Zhaoli li Xiaomin SHUANG Yan State Key Laboratory of Ore Deposit Geochemistry Institute of Geochemistry Chinese Academy of Sciences Cruiyang 550002 China Graduate School Chinese Academy of Sciences Beijing 100049 China Institute of Mineral Resources Chinese Academy of Geological Sciences Beijing 100037 China

In this paper the authors present the REE concentrations and Sr and Nd isotopic compositions of fluorites from the Bailashui tin deposit of the Furong ore field,southern Hunan Province. The results showed that the total amount of REE in fluorites is usually low,ranging from 0.705 to 8.785 μg/g with the chondrite-normalized REE dis-tribution patterns similar to those of the Qitianling granites in the study area,characterized by LREE-enrichment patterns with pronounced negative Eu anomalies. The fluorites vary in Sr isotopic composition within the range of 0.7083-0.7091,the values are lower than those of the granites and higher than those of the host carbonate rocks in this area. The εNd(t) values of fluorites vary between -9.4 and +10.3,revealing that both the crust-and mantle-source materials were involved in the ore-forming hydrothermal fluids. Combined with previous studies on this ore deposit,the Bailashui tin deposit is temporally and spatially closely related with granitic magmatism in this area. The hydro-thermal fluorites are the product of fluid/rock interactions between granitic magmatic hydrothermal fluid and marine carbonate rocks. The REE and F in the ore-forming fluid were derived from the granites,whereas Sr in the ore-forming fluid came mainly from the granitic magmatic hydrothermal fluid and marine carbonate rocks,although variations in Sr isotopic composition cannot be explained by a simple mixture of these two end-members. Evidence demonstrated that the ore-forming fluids are of crustal-mantle mixing origin,but that the fluids were probably in-completely homogenized and this may be caused by inhomogeneous mixing of the fluids of different sources.

关键词：萤石同位素锡沉淀稀有地球元素

New insights into the flotation responses of brucite and serpentine for different conditioning times: Surface dissolution behavior

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International Journal of Minerals,Metallurgy and Materials 2021年第12期28卷 1898-1907页

作者： Ya-feng Fu Wan-zhong Yin Xian-shu Dong Chuan-yao Sun Bin Yang Jin Yao Hong-liang li Chuang li Hyunjung Kim College of Mining Engineering Taiyuan University of TechnologyTaiyuan 030024China School of Resources&Civil Engineering Northeastern UniversityShenyang 110819China State Key Laboratory of Mineral Processing Beijing 102628China Department of Chemical and Materials Engineering University of AlbertaEdmontonAlberta T6G 2V4Canada Department of Mineral Resources and Energy Engineering Jeonbuk National UniversityBaekje-daeroDeokjin-guJeonju-siJeollabuk-do561-756Republic of Korea

The inadvertent dissolution of gangue minerals is frequently detrimental to the flotation of valuable *** investigated the effect of conditioning time on the separation of brucite and serpentine by *** analyzing the Mg2+concentration,relative element content,and pulp viscosity,we studied the effect of mineral dissolution on brucite *** results of artificially mixed mineral flotation tests(with-10μm serpentine)showed that by extending the conditioning time from 60 to 360 s,a large amount of Mg2+on the mineral surface gradually dissolved into the pulp,resulting in a decreased brucite recovery(from 83.83%to 76.79%)and an increased recovery of serpentine from 52.12%to 64.03%.To analyze the agglomeration behavior of brucite and serpentine,we used scanning electron microscopy,which clearly showed the different adhesion behaviors of different conditioning ***,the total interaction energy,as determined based on the extended DLVO(Derjaguin-Landau-Verwey-Overbeek)theory,also supports the conclusion that the gravitational force between brucite and serpentine increases significantly with increased conditioning time.

关键词： behavior insight viscosity