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Danshen: a phytochemical and pharmacological overview

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Chinese Journal of Natural Medicines 2019年第1期17卷 59-80页

作者： MEI Xiao-Dan CAO Yan-Feng CHE Yan-Yun LI Jing SHANG Zhan-Peng ZHAO Wen-Jing qiao Yan-jiang ZHANG Jia-Yu School of Chinese Pharmacy Beijing University of Chinese Medicine College of Pharmaceutical Science Yunnan University of Traditional Chinese Medicine College of Basic Medicine Jinzhou Medical University Beijing Research Institute of Chinese Medicine Beijing University of Chinese Medicine

Danshen, the dried root or rhizome of Salvia miltiorrhiza Bge., is a traditional and folk medicine in Asian countries, especially in China and Japan. In this review, we summarized the recent researches of Danshen in traditional uses and preparations, chemical constituents, pharmacological activities and side effects. A total of 201 compounds from Danshen have been reported, including lipophilic diterpenoids, water-soluble phenolic acids, and other constituents, which have showed various pharmacological activities, such as anti-inflammation, anti-oxidation, anti-tumor, anti-atherogenesis, and anti-diabetes. This article intends to provide novel insight information for further development of Danshen, which could be of great value to its improvement of utilization.

关键词： Danshen Traditional uses Chemical constituents Quality control Pharmacological activities

Copper-Catalyzed Enantioselective Synthesis of α-Hydroxyamine Using Monodentate Phosphoramidites

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有机化学 2004年第Z1期24卷 43-44页

作者： DONG,Lin CUN,Lin-Feng GONG,Liu-Zhu MI,Ai-qiao jiang,Yao-Zhong Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041

　　Development of new methods for the introduction of a nitrogen atom to a carbonyl group is still the most important synthetic target. Cu-catalyzed addition of organozinc reagents to α,β-unsaturated carbonyl compounds has been the subject of intensive investigation.[1] Moreover, trapping of the intermediate Zn-enolates has been achieved using nitrosobenzene. To demonstrate the feasibility of developing enantioselective variants of these tandem C-C bond formations,α,β-unsaturated substrates a～d was subjected to standard reaction conditions using Feringa's (L1*, L2*) and our own phosphoramidite ligands (L3*, L4*). In this reaction, medium to high levels of enantioselectivities were observed.……

关键词： carbonyl compounds methods for

Why the abnormal phenomena of D-band center theory exist?A new BASED theory for surface catalysis and chemistry

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Chinese Journal of Catalysis 2024年第9期64卷 44-53页

作者： Zelong qiao Run jiang Jimmy Yun Dapeng Cao State Key Laboratory of Organic‐Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Qingdao International Academician Park Research Institute Qingdao 266000ShandongChina School of Chemical Engineering The University of New South WalesSydneyNSW 2052Australia

Since the D-band center theory was proposed,it has been widely used in the fields of surface chemistry by almost all researchers,due to its easy understanding,convenient operation and relative ***,with the continuous development of material systems and modification strategies,researchers have gradually found that D-band center theory is usually effective for large metal particle systems,but for small metal particle systems or semiconductors,such as single atom systems,the opposite conclusion to the D-band center theory is often *** solve the issue above,here we propose a bonding and anti-bonding orbitals stable electron intensity difference(BASED)theory for surface *** newly-proposed BASED theory can not only successfully explain the abnormal phenomena of D-band center theory,but also exhibits a higher accuracy for prediction of adsorption energy and bond length of intermediates on active ***,a new phenomenon of the spin transition state in the adsorption process is observed based on the BASED theory,where the active center atom usually yields an unstable high spin transition state to enhance its adsorption capability in the adsorption process of intermediates when their distance is about 2.5Å.In short,the BASED theory can be considered as a general principle to understand catalytic mechanism of intermediates on surfaces.

关键词： Surface chemistry Surface catalysis D-band center theory Bonding orbital Anti-bonding orbital

Photo-induced 1,2-aryl migration of 2-chloro-1-arylpropanone under batch and flow conditions:Rapid,scalable and sustainable approach to 2-arylpropionic acids

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Chinese Chemical Letters 2024年第2期35卷 366-369页

作者： qiao Li Minjie Liu Meifen jiang Li Wan Yingtang Ning Fen-Er Chen College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China Engineering Center of Catalysis and Synthesis for Chiral Molecules Fudan UniversityShanghai 200433China Shanghai Engineering Center of Industrial Catalysis for Chiral Drugs Shanghai 200433China Institute of Pharmaceutical Science and Technology Zhejiang University of TechnologyHangzhou 310014China

We report the photo-mediated 1,2-aryl migration of 2‑chloro-1-arylpropanones to 2-arylpropionic acids using HCOONa as an acid *** pragmatically focused study obviates the multiple-step sequence in the industrially employed,ZnO-promoted rearrangement strategy,and offers rapid access to various 2-arylpropionic acids under environmentally friendly ***,the successful transfer of this batch photochemistry to a continuous flow platform led to improved scalability and enabled the gram-scale synthesis of loxoprofen.

关键词： Green chemistry Flow chemistry 2-Arylpropionic acids Photo-Favorskii reaction

Direct synthesis of a disinfectant with fresh scent of green plants by semi-hydrogenation of alkynol on Pd single-atom catalysts

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Nano Research 2024年第5期17卷 3872-3878页

作者： Yan jiang Xuetong Yu Yuxia Ji Xunzhu jiang Yalin Guo Tianbo Li Liang Gao Rui Lang Yanxiong Fang Botao qiao Jinxiang Dong School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116024China Guangdong Provincial Key Laboratory of Plant Resources Biorefinery Guangzhou 510006China School of Chemical Engineering and Technology China University of Mining and TechnologyXuzhou 221116China

Alcohol-based disinfectants have protected people in the coronavirus disease 2019(COVID-19)pandemic,but olfactory stimuli of ethanol may evoke unpleasant memories associated with stressful situations in the devastating infectious *** smell of ethanol in household cleaning and disinfectant products can be covered up by the fragrance additives,and 3-hexenol is especially appreciated for the characteristic,strong odor of green *** production of 3-hexenol relies on the selective hydrogenation of 3-hexyn-1-ol,where Lindlar catalyst is normally used for the superior *** achieving such catalytic transformation in ethanol solution seems as a direct way to produce a disinfectant with green aroma,a popular consumer product in the post-COVID era,severe leaching of toxic Pb hinders Lindlar catalyst as a promising *** find that the Fe_(2)O_(3) supported Pd single-atom catalyst is highly selective to fulfill semi-hydrogenation of 3-hexyn-1-ol in 75%ethanol,and the aforementioned household product is readily generated after filtrating the stable,solid catalyst out of reaction ***-atom catalysts have been frequently utilized for fine-chemical synthesis,while in this work they make stunning debut in practical manufacture of daily used products.

关键词： single-atom catalysis hydrogenation fragrance household product coronavirus disease 2019(COVID-19)

Characterization of phloroglucinol derivatives and diterpenes in Euphorbia ebracteolata Hayata by utilizing ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry

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Journal of Pharmaceutical Analysis 2013年第4期3卷 292-297页

作者： Can-Jian Wang Ying-qiao jiang Dong-Hui Liu Xiao-Hong Yan Shuang-Cheng MA Guangzhou Institute for Drug Control Guangzhou University of Chinese Medicine National Institute for Control of Pharmaceutical and Biological Products

Euphorbia ebracteolata Hayata （E. ebracteolata） is a Chinese herbal medicine used for the treatment of tumor diseases. An ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry （UPLC-Q-TOF/MS） based chemical profiling approach was established for the rapid separation and characterization on phloroglucinol derivatives and diterpenes in E. ebracteolata. Three phloroglucinol derivatives and nine diterpenes were identified by exact mass measurement and were further confirmed by Ms2 data. In addition, the chemical profiles of six compounds were acquired by reference standards. Furthermore, the fragmentation rules of phloroglucinol derivatives and diterpenes of E. ebracteolata were analyzed, and each chromatographic peak was classified.

关键词： Phloroglucinolderivatives Diterpenes Euphorbia ebracteolataHayata UPLC-Q-TOF/MS

Staged and hybrid approach in the treatment of complex aortic dissection

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Chinese Medical Journal 2008年第15期121卷 1492-1496页

作者： WANG Li-xin FU Wei-guo GUO Da-qiao CHEN Bin jiang Jun-hao YANG Jue SHI Zhen-yu WANG Yu-qi Department of Vascular Surgery Zhongshan Hospital Fudan University Shanghai 200032 China

Multilevel aortic disease presents a formidable challenge for vascular surgeons. In the past,multilevel aortic surgery was performed simultaneously or subsequently. Single-stage intervention is thought to be associated with a high incidence of complications, and sequential repair requires several major surgical interventions. The rupture of residual lesion, however, may take place while waiting the second operation. Endovascular treatment is recognized as a viable alternative to the treatment of the diseased aortic areas especially in the high-risk patient, as it could markedly lower the incidence of complications compared with other procedures. However, thoracic aortic anatomy must be favorable to the placement of a stent-grafi （SG）. Sufficient proximal and distal landing zone is mandatory to deploy the SG and ensure a satisfactory exclusion result. Therefore, complex dissection with multiple-tear located extremely near the orifice of the visceral arteries is excluded from orthodox endovascular therapy. Here we present a case of multi-teared dissecting aneurysm treated by a four-staged hybrid surgery with placement of 5 SGs.

关键词： aortic dissection hybrid surgery endovascular repair renal auto transplantation

威廉环毛蚓中8种核苷提取工艺优化及含量测定

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中成药 2024年第8期46卷 2526-2530页

作者：宇泉霖吴雪纯邱旖宋嘉佳蒋巧萍孙常胜吴婧楠蔡程科王洪飞北京中医药大学中药学院北京102400 北京量子高科制药有限公司北京102200

目的优化威廉环毛蚓中尿嘧啶、次黄嘌呤、黄嘌呤、尿苷、胸腺嘧啶、肌苷、鸟苷、2′-脱氧鸟苷提取工艺,并测定其含量。方法以料液比、超声时间、超声温度为影响因素,次黄嘌呤、总核苷含量为评价指标,正交试验优化提取工艺。HPLC法测定... 详细信息

目的优化威廉环毛蚓中尿嘧啶、次黄嘌呤、黄嘌呤、尿苷、胸腺嘧啶、肌苷、鸟苷、2′-脱氧鸟苷提取工艺,并测定其含量。方法以料液比、超声时间、超声温度为影响因素,次黄嘌呤、总核苷含量为评价指标,正交试验优化提取工艺。HPLC法测定各核苷含量,分析采用Agilent C_(18)色谱柱(4.6 mm×250 mm,5μm);流动相甲醇-水,梯度洗脱;体积流量1 mL/min;柱温30℃;检测波长260 nm。结果最佳条件为料液比1∶250,超声时间30 min,超声温度60℃。8种核苷在各自范围内线性关系良好(R^(2)>0.9990),平均加样回收率99.11%~103.27%,RSD 0.85%~2.89%。结论该方法稳定可靠,可用于威廉环毛蚓中核苷的提取与含量测定。

关键词：威廉环毛蚓核苷提取工艺含量测定正交试验 HPLC

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超大直径泥水盾构防滞排关键技术研究

隧道建设（中英文） 2021年第S2期41卷 620-625页

作者：姜桥中铁高新工业股份有限公司北京100071

在隧道施工中超大直径泥水盾构常面临气垫舱受排渣通道限制堵塞、排浆口受渣土粒径影响堵塞及泥浆循环系统配置不合理导致堵塞等滞排问题,以深圳春风隧道工程为例,对超大直径泥水盾构的泥浆循环系统展开研究。基于流体力学原理,进行超... 详细信息

在隧道施工中超大直径泥水盾构常面临气垫舱受排渣通道限制堵塞、排浆口受渣土粒径影响堵塞及泥浆循环系统配置不合理导致堵塞等滞排问题,以深圳春风隧道工程为例,对超大直径泥水盾构的泥浆循环系统展开研究。基于流体力学原理,进行超大直径泥水盾构泥浆循环系统关键参数计算,实现泥浆循环系统进排浆流量、管径、泵站的合理配置,提高泥浆循环系统对大粒径渣石、高流速泥浆的适应性。在理论研究的基础上,设计前舱直排掘进模式,降低开挖舱渣土滞排风险;设计主机段小循环模式,提高主机段携渣能力;应用主机段排渣分级破碎技术,避免大粒径渣石堵塞排渣口及排浆泵。经深圳春风隧道施工结果可知,本方法能够有效降低泥水舱、气垫舱、排渣口等关键部位渣土滞排风险。

关键词：超大直径泥水盾构泥浆循环系统参数配置渣土滞排