Characterization of phloroglucinol derivatives and diterpenes in Euphorbia ebracteolata Hayata by utilizing ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry

作     者：Can-Jian Wang Ying-Qiao Jiang Dong-Hui Liu Xiao-Hong Yan Shuang-Cheng MA 

作者机构：Guangzhou Institute for Drug Control Guangzhou University of Chinese Medicine National Institute for Control of Pharmaceutical and Biological Products 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2013年第3卷第4期

页      面：292-297页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by National Science and Technology Support Program and Drug Safety Critical Technology (2006BAI14B00) funding subject-Common and Important Drug Safety Standards(2006BAI14B01) 

主　　题：Phloroglucinolderivatives Diterpenes Euphorbia ebracteolataHayata UPLC-Q-TOF/MS 

摘      要：Euphorbia ebracteolata Hayata （E. ebracteolata） is a Chinese herbal medicine used for the treatment of tumor diseases. An ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry （UPLC-Q-TOF/MS） based chemical profiling approach was established for the rapid separation and characterization on phloroglucinol derivatives and diterpenes in E. ebracteolata. Three phloroglucinol derivatives and nine diterpenes were identified by exact mass measurement and were further confirmed by Ms2 data. In addition, the chemical profiles of six compounds were acquired by reference standards. Furthermore, the fragmentation rules of phloroglucinol derivatives and diterpenes of E. ebracteolata were analyzed, and each chromatographic peak was classified.