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Chondrogenic medium in combination with a c-Jun N-terminal kinase inhibitor mediates engineered cartilage regeneration by regulating matrix metabolism and cell proliferation

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Regenerative Biomaterials 2023年第1期10卷 1468-1480页

作者： Peiling Zhang qianyi wang Jie Chen Zheng Ci Wei Zhang Yu Liu Xiaoyun wang Guangdong Zhou Department of Plastic and Reconstructive Surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200023China National Tissue Engineering Center of China Shanghai200241China Department of Research Institute of Plastic Surgery Wei Fang Medical CollegeWei FangShandong261041China Department of Anesthesiology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200023China Department of Plastic Surgery Tong Ren HospitalShanghai Jiao Tong University School of MedicineShanghai200050China

Cartilage tissue engineering is a promising strategy for repairing cartilage ***,achieving satisfactory cartilage regeneration in vitro and maintaining its stability in vivo remains a *** key to achieving this goal is establishing an efficient cartilage regeneration culture system to retain sufficient active cells with physiological functions,generate abundant cartilage extracellular matrix(ECM)and maintain a low level of cartilage ECM *** current chondrogenic medium(CM)can effectively promote cartilage ECM production;however,it has a negative effect on cell ***,the specific c-Jun N-terminal kinase pathway inhibitor SP600125 promotes chondrocyte proliferation but inhibits ECM ***,we aimed to construct a three-dimensional cartilage regeneration model using a polyglycolic acid/polylactic acid scaffold in combination with chondrocytes to investigate the effect of different culture modes with CM and SP600125 on in vitro cartilage regeneration and their long-term outcomes in vivo *** results demonstrate that the long-term combination of CM and SP600125 made up for each other and maximized their respective advantages to obtain optimal cartilage regeneration in ***,the long-term combination achieved stable cartilage regeneration after implantation in vivo with a relatively low initial cell-seeding ***,the long-term combination of CM and SP600125 enhanced in vitro and in vivo cartilage regeneration stability with fewer initial seeding cells and thus optimized the cartilage regeneration culture system.

关键词： JNK inhibitor chondrogenic medium in vitro in vivo cartilage regeneration

Elastic Fiber‑Reinforced Silk Fibroin Scaffold with A Double‑Crosslinking Network for Human Ear‑Shaped Cartilage Regeneration

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Advanced Fiber Materials 2023年第3期5卷 1008-1024页

作者： qianyi wang Xinyue Ran Jian wang Sinan wang Peiling Zhang Erji Gao Baoshuai Bai Junfeng Zhang Guangdong Zhou Dong Lei Department of Plastic and Reconstructive Surgery Shanghai 9th People’s HospitalShanghai Jiao Tong University School of MedicineShanghai Key Lab of Tissue EngineeringShanghai 200011People’s Republic of China Research Institute of Plastic Surgery Weifang Medical UniversityWeifang 261053People’s Republic of China Department of Cardiology Shanghai 9th People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011People’s Republic of China

Tissue engineering provides a promising approach for regenerative *** ideal engineered tissue should have the desired structure and functional properties suitable for uniform cell distribution and stable shape fidelity in the full period of in vitro culture and in vivo ***,due to insufficient cell infiltration and inadequate mechanical properties,engineered tissue made from porous scaffolds may have an inconsistent cellular composition and a poor shape retainability,which seriously hinders their further clinical *** this study,silk fibroin was integrated with silk short fibers with a physical and chemical double-crosslinking network to fabricate fiber-reinforced silk fibroin super elastic absorbent sponges(Fr-SF-SEAs).The Fr-SF-SEAs exhibited the desirable synergistic properties of a honeycomb structure,hygroscopicity and elasticity,which allowed them to undergo an unconventional cyclic compression inoculation method to significantly promote cell diffusion and achieve a uniform cell distribution at a ***,the regenerated cartilage of the Fr-SF-SEAs scaffold withstood a dynamic pressure environment after subcutaneous implantation and maintained its precise original structure,ultimately achieving human-scale ear-shaped cartilage ***,the SF-SEAs prepara-tion showed valuable universality in combining chemicals with other bioactive materials or drugs with reactive groups to construct microenvironment bionic *** established novel cell inoculation method is highly versatile and can be readily applied to various *** on the design concept of dual-network Fr-SF-SEAs scaffolds,homogenous and mature cartilage was successfully regenerated with precise and complicated shapes,which hopefully provides a platform strategy for tissue engineering for various cartilage defect repairs.

关键词： Silk fibroin Fiber-reinforced Elastic scaffold Cellular distribution Cartilage regeneration

One-year direct and indirect costs of ischaemic stroke in China

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Stroke & Vascular Neurology 2024年第4期9卷 380-389,I0032-I0043页

作者： Wei Lv Anxin wang qianyi wang Ruimin wang Qin Xu Shuqing Wu Yi Han Yong Jiang Jinxi Lin Jing Jing Hao Li Yongjun wang Xia Meng Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina School of Basic Medical Science Capital Medical UniversityBeijingChina Department of Cardiology Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityGuangzhouChina Health Economic Research Institute Sun Yat-Sen UniversityGuangzhouChina

Background This is the first real-world study to estimate the direct costs and indirect costs of first-ever ischaemic stroke with 1-year follow-up in China,based on a nationally representative *** Patients were chosen from 20 geographically diverse sites from the nationally representative database China National Stroke Registry-III(CNSR-III).The inclusion criteria were surviving patients who were hospitalised with first-ever ischaemic stroke from February 2017 to February 2018(the index event);aged 18–80 during the index event;no history of other stroke *** primary endpoints were direct medical costs,direct non-medical costs,indirect costs and total cost(ie,the sum of all cost components).Patient characteristics and clinical data were extracted from ***-related in-hospital direct medical costs were collected from hospital electronic medical *** patient survey collected data related to out-of-hospital direct medical costs,direct non-medical costs and indirect *** secondary objective was to explore clinical factors associated with cost outcomes through univariate analysis and multiple *** The study enrolled 520 *** total cost was 57567.48 CNY,with 26612.67 CNY direct medical costs,2787.56 CNY direct non-medical costs and 28167.25 CNY indirect *** analysis showed that longer lengths of stay during the index event,higher National Institutes of Health Stroke Scale(NIHSS)and modified Rankin Scale scores were associated with higher costs in all ***,EuroQol 5 Dimension utility scores were associated with decreased costs except direct non-medical *** regressions showed that higher admission NIHSS scores were independently associated with higher direct medical costs,indirect costs and total *** 3-month utilities were associated with lower total *** This real-world study showed substantial 1-year economic burden following first-ever ischaemic stroke

关键词： indirect costs Dimension

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单层亚波长金属光栅偏振器透射机理研究

光学学报 2015年第7期35卷 57-63页

作者：王志文褚金奎王倩怡大连理工大学机械工程学院辽宁大连116024

为从物理层面理解亚波长金属光栅偏振透射现象以及光栅参数对偏振透射的影响,基于等效介质理论定性解释了单层亚波长金属光栅的偏振透射现象,给出了各个光栅参数对偏振性能的影响规律。对于不同条件下透射峰值产生的机理,基于法布里-珀... 详细信息

为从物理层面理解亚波长金属光栅偏振透射现象以及光栅参数对偏振透射的影响,基于等效介质理论定性解释了单层亚波长金属光栅的偏振透射现象,给出了各个光栅参数对偏振性能的影响规律。对于不同条件下透射峰值产生的机理,基于法布里-珀罗共振理论给出了定量解释。对于等效介质理论和法布里-珀罗共振理论的准确性给出了验证及分析。通过两理论定性或定量的对单层亚波长金属光栅偏振器透射机理的系统分析,将有助于更清晰地理解金属光栅偏振器的偏振透射影响规律。

关键词：光栅透射机理等效介质理论亚波长金属光栅法布里-珀罗共振

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数据服务中心的隐私保护框架设计与应用研究

华中科技大学学报（自然科学版） 2016年第S1期44卷 152-157页

作者：王倩宜欧阳荣彬北京大学计算中心北京100871

针对北京大学数据服务中心在为全校提供数据共享和数据再利用服务的同时,也存在很多信息和隐私安全方面的问题,分析了数据服务中心的隐私安全问题,设计了数据服务中心的隐私保护框架(DSP-PPF),并且基于这个框架在隐私数据的分类方法、... 详细信息

针对北京大学数据服务中心在为全校提供数据共享和数据再利用服务的同时,也存在很多信息和隐私安全方面的问题,分析了数据服务中心的隐私安全问题,设计了数据服务中心的隐私保护框架(DSP-PPF),并且基于这个框架在隐私数据的分类方法、隐私数据的访问控制和面向数据发布的隐私保护三个方面展开应用研究.通过应用所提技术进行隐私数据组织和管理,结果表明数据既能得到合理的保护,又能最大程度地发挥效用.

关键词：隐私保护隐私策略隐私保护框架隐私数据分类隐私访问控制数据发布

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基于互联网大数据的脱敏分析技术研究

数据分析与知识发现 2018年第2期2卷 58-63页

作者：周倩伊王亚民王闯西安电子科技大学经济与管理学院西安710126

【目的】基于现有的脱敏技术,改进匿名组的划分效果,得到较优的脱敏模型及算法。【方法】基于k-匿名技术,改进维度划分标准,以KD树作为存储结构,构造新算法。利用Python实现程序,比较所产生的匿名组数量、NCP百分比,验证算法的可行性与... 详细信息

【目的】基于现有的脱敏技术,改进匿名组的划分效果,得到较优的脱敏模型及算法。【方法】基于k-匿名技术,改进维度划分标准,以KD树作为存储结构,构造新算法。利用Python实现程序,比较所产生的匿名组数量、NCP百分比,验证算法的可行性与有效性。【结果】新算法能够使得脱敏后整个数据集所生成的匿名组个数达到最大。且NCP百分比低于同类算法。【局限】对于有某一属性离散程度显著的数据集,循环计算划分维度较为繁琐。【结论】新算法相比于传统算法增加了匿名组个数,相比于同类算法,信息损失较低。

关键词：数据脱敏 k-匿名模型取整划分

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基于双目视觉的非凸复杂形貌物体干涉分析

仪器仪表学报 2021年第3期42卷 262-269页

作者：张湛舸王乾一屈玉福北京航空航天大学仪器科学与光电工程学院北京100191 杭州海康威视数字技术股份有限公司杭州310051

传统基于点云分析的物体与场景干涉检测算法使用层次包围盒或空间分解的方法判断是否发生干涉,不能获取物体与场景各点的准确安全距离数值。提出一种基于双目视觉点云的非凸复杂形貌物体干涉分析方法,该方法首先使用双目立体视觉算法对... 详细信息

传统基于点云分析的物体与场景干涉检测算法使用层次包围盒或空间分解的方法判断是否发生干涉,不能获取物体与场景各点的准确安全距离数值。提出一种基于双目视觉点云的非凸复杂形貌物体干涉分析方法,该方法首先使用双目立体视觉算法对已标定的双目相机拍摄的场景快速重建点云,然后用待分析的物体三维点云和重建的场景点云数据求解干涉问题,使用K-D树搜索的方法快速确定指定点的干涉距离,使用相机光轴方向的点云坐标关系确定是否干涉。方法在某探测器内场实验中的干涉检测正确率为100%。且相较于现有干涉检测算法,本方法可准确获取物体表面是否干涉及具体距离信息,并借助双目点云沿参考相机光轴方向有效简化相交测试计算复杂度,在降采样下单点检测的时间不超过0.15 s,能够满足非凸复杂形貌物体和各类地形的干涉快速分析的需求。所提方法圆满完成了嫦娥五号在轨月面采样封装中采样点选择的采样器-地形干涉分析任务。

关键词：双目重建干涉分析 K-D树

高质量推进审计实践创新、理论创新和制度创新

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审计研究 2024年第3期 10-13,36页

作者：高占江王倩逸浙江工商大学会计学院 310018

习近平总书记围绕加强审计工作、完善审计制度和更好发挥审计监督在推进国家治理体系和治理能力现代化中的重要作用作出一系列重要论述,科学、系统、深刻地回答了新时代审计事业发展的根本性、方向性、全局性和战略性问题,提出一系列新... 详细信息

习近平总书记围绕加强审计工作、完善审计制度和更好发挥审计监督在推进国家治理体系和治理能力现代化中的重要作用作出一系列重要论述,科学、系统、深刻地回答了新时代审计事业发展的根本性、方向性、全局性和战略性问题,提出一系列新理念和新论断,形成了新时代党在审计领域的重大理论和实践成果,为做好新时代审计工作指明了前进方向、提供了根本遵循。深入学习贯彻习近平总书记关于审计工作重要论述,必须以更高的审计站位、创新的审计理念、正确的审计逻辑和科学的审计思维加快推进审计实践创新、高度重视审计理论创新和积极探索审计制度创新,把审计制度优势更好地转化为国家治理效能。

关键词：国家治理审计监督审计创新

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内分泌系统疾病的肝脏表现

中华肝脏病杂志 2022年第4期30卷 352-356页

作者：王倩怡欧晓娟贾继东首都医科大学附属北京友谊医院肝病中心北京市肝硬化转化医学重点实验室国家消化系统疾病临床医学研究中心北京100050

肝脏作为次级内分泌器官,与整个内分泌系统之间存在密切联系。多种内分泌系统疾病可影响到肝脏,如甲状腺功能亢进/减退症、糖尿病、肾上腺、性腺相关疾病等,并可表现为肝细胞损伤(转氨酶升高)、胆管损伤(胆汁淤积)、肝细胞脂肪变性、血... 详细信息

肝脏作为次级内分泌器官,与整个内分泌系统之间存在密切联系。多种内分泌系统疾病可影响到肝脏,如甲状腺功能亢进/减退症、糖尿病、肾上腺、性腺相关疾病等,并可表现为肝细胞损伤(转氨酶升高)、胆管损伤(胆汁淤积)、肝细胞脂肪变性、血管损伤及肝占位等多种形式。激素水平异常引起的直接、间接肝损伤、治疗内分泌疾病药物的不良反应是其常见的机制。此外,内分泌疾病可同时合并肝脏疾病如自身免疫性甲状腺炎易合并自身免疫性肝炎;全身系统性疾病也可同时累及内分泌系统和肝脏,如系统性红斑狼疮、IgG4相关疾病等。临床上遇到不明原因肝损伤的患者,需注意内分泌系统疾病的甄别。

关键词：内分泌系统内分泌病胆汁淤积肝细胞损伤肝细胞脂肪变性