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Sympathetic Nerve Mediated Spinal Glia Activation Underlies Itch in a Cutaneous T-Cell Lymphoma Model

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Neuroscience Bulletin 2022年第4期38卷 435-439页

作者： Fang Tong Qianru He Wan-Jie Du Huan Yang Dongping Du Shaofeng Pu Qingjian Han State Key Laboratory of Medical Neurobiology and MOE Frontier Center for Brain Science Institutes of Brain ScienceFudan UniversityShanghai 200433China Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-Innovation Center of NeuroregenerationJiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairNantong UniversityNantong 226001China Pain Management Center Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China

Dear Editor,Cancer-associated itch can be described as pruritus associated with malignancy.Although intractable itch associated with specific types of cancer afflicts patients badly,few effective treatments are available due to limited knowledge about the mechanisms of such itch.Globally,cancer-associated itch is an uncommon symptomin malignancy.

关键词： malignancy cancer Cancer

Cancer profiles in China and comparisons with the USA:a comprehensive analysis in the incidence,mortality,survival,staging,and attribution to risk factors

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Science China(Life Sciences) 2024年第1期67卷 122-131页

作者： Siyi he Changfa Xia he Li Maomao Cao Fan Yang Xinxin Yan Shaoli Zhang Yi Teng qianru Li Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

China faces a disproportionate cancer burden to the population size and is undergoing a transition in the cancer spectrum.We extracted data in five aspects of cancer incidence,mortality,survival,staging distributions,and attribution to risk factors in China,the USA and worldwide from open-source databases.We conducted a comprehensive secondary analysis of cancer profiles in China in the above aspects,and compared cancer statistics between China and the USA.A total of 4,546,400 new cancer cases and 2,992,600 deaths occurred in China in 2020,accounting for 25.1%and 30.2%of global cases,respectively.Lifestyle-related cancers including lung cancer,colorectal cancer,and breast cancer showed an upward trend and have been the leading cancer types in China.41.6%of new cancer cases and 49.3%of cancer deaths occurred in digestive-system cancers in China,and the cancers of esophagus,nasopharynx,liver,and stomach in China accounted for over 40%of global cases.Infection-related cancers showed the highest population-attributable fractions among Chinese adults,and most cancers could be attributed to behavioral and metabolic factors.The proportions of stage I for most cancer types were much higher in the USA than in China,except for esophageal cancer(78.2%vs.41.1%).The 5-year relative survival rates in China have improved substantially during 2000–2014,whereas survival for most cancer types in the USA was significantly higher than in China,except for upper gastrointestinal cancers.Our findings suggest that although substantial progress has been made in cancer control,especially in digestive system cancers in China,there was still a considerable disparity in cancer burden between China and the USA.More robust policies on risk factors and standardized screening practices are urgently warranted to curb the cancer growth and improve the prognosis for cancer patients.

关键词： cancer burden survival rate neoplasm staging risk factors China

Stomach cancer burden in China: Epidemiology and prevention

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Chinese Journal of Cancer Research 2023年第2期35卷 81-91页

作者： Xinxin Yan Lin Lei he Li Maomao Cao Fan Yang Siyi he Shaoli Zhang Yi Teng qianru Li Changfa Xia Wanqing Chen Offce of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Cancer Prevention and Control Shenzhen Center for Chronic Disease ControlShenzhen 518020China

In 2020, stomach cancer was the fifth most commonly diagnosed cancer and the fourth leading cause of cancer-related death worldwide. Due to the relatively huge population base and the poor survival rate, stomach cancer is still a threat in China, and accounts for nearly half of the cases worldwide. Fortunately, in China, the incidence and mortality rates of stomach cancer presented a declining trend owing to the change of individual life styles and the persistent efforts to prevent stomach cancer from the governments at all levels. helicobacter pylori(H. pylori)infection, poor eating habits, smoking, history of gastrointestinal disorders, and family history of stomach cancer are the main risk factors for stomach cancer in China. As a result, by taking risk factors for stomach cancer into account, specific preventive measures, such as eradicating H. pylori and implementing stomach cancer screening projects, should be taken to better prevent and decrease the burden of stomach cancer.

关键词： Stomach cancer burden China risk factors prevention

Burden of liver cancer:From epidemiology to prevention

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Chinese Journal of Cancer Research 2022年第6期34卷 554-566页

作者： qianru Li Maomao Cao Lin Lei Fan Yang he Li Xinxin Yan Siyi he Shaoli Zhang Yi Teng Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Cancer Prevention and Control Shenzhen Center for Chronic Disease ControlShenzhen 518020China

In this review,we offer a concise overview of liver cancer epidemiology in China and worldwide from the official databases of GLOBOCAN 2020 and the National Cancer Registry in China.We also summarized the evidence for the main risk factors associated with liver cancer risk and discuss strategies implemented in China to control the liver cancer burden.Overall,liver cancer was the sixth most commonly diagnosed cancer and the third leading cause of cancer-related death worldwide in 2020.Although China contributed to nearly half of cases across the world alone,the incidence and mortality rates of liver cancer presented a declining trend owing to the persistent efforts from the governments at all levels.The current liver cancer burden in China still faces an arduous challenge due to the relatively large population base as well as the substantially low survival rate(12.1%).To better control the liver cancer burden with the lowest cost,specific measures should be conducted by reducing exposure to established risk factors such as hepatitis B infection and aflatoxin.The promotion of surveillance is also an important method to prolong the survival of liver cancer.This review will provide basic information for future direction on the control of liver cancer burden.

关键词： Liver cancer China epidemiology risk factors prevention

Differential gene expression in primary cultured sensory and motor fibroblasts

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Differential gene expression in primary cultured sensory and...

Colorectal cancer burden,trends and risk factors in China:A review and comparison with the United States

中国神经科学学会第十二届全国学术会议

作者： Meng Cong Qianru He Shu Yu Fei Ding Key laboratory of neuroregeneration of Jiangsu and Ministry of Education CoInnovation Center of Neuroregeneration Nantong University

Objective The peripheral nerve is composed by sensory and motor nerves. The proteomics technique has been used to determine the protein profile of them, and 100 proteins showed differential expressions between sensory and motor nerves. The differential expression protein has difference expression of neuron, also of SCs and fibroblasts. This study aimed to compare the gene expression of sensory and motor fibroblasts by using Whole rat genome microarray analysis, thus contributing to our understanding of different functions of both fibroblasts in sensory and motor nerves. Methods Cell culture and immunocytochemistry. All animal experiments were performed in accordance with institutional guidelines. Sprague-Dawley（SD） rats（7-8 day old）. The purity of motor and sensory fibroblasts was further evaluated by flow cytometric analysis（FCA）. The motor and sensory fibroblasts were harvested after purification and the samples were subjected to whole rat genome microarray analysis.Total RNA was extracted from sensory and motor fibroblasts using Trizol method, and c DNA was synthesized in accordance with the instructions of Omniscript? RT kit. Quantitative real time RT-PCR（q RT-PCR） was conducted in CFX96? Real-Time PCR System using Fast Start? SYBR Green q PCR Master Mix according to the manufactur’s specification. The real time cell analyzer and E-plate 16 system allows for label-free, noninvasive monitoring, real time of the viability of cultured cells using impedance. The proliferation capacity of motor and sensory fibroblasts was further evaluated by 5-ethynyl-2’-deoxyuridine（Ed U） labeling kit. The cell migration of sensory and motor fibroblasts was examined in 6.5 mm transwell chambers with 8 μm pores as described previously. For fibroblasts transfection, si RNAs（1, 2 and 3） for Cxcl 3, si RNAs（1, 2 and 3） for Cxcl 10, and nontargeting negative control. Results（1） Immunohistochemistry and FCA with the antibody against Thy-1, a specific marker for fibroblasts, provided further evidence for the purity of primary sensory a

关键词： sensory fibroblasts motor fibroblasts cell proliferation cell migration peripheral nervous

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Chinese Journal of Cancer Research 2022年第5期34卷 483-495页

作者： qianru Li Hongliang Wu Maomao Cao he Li Siyi he Fan Yang Xinxin Yan Shaoli Zhang Yi Teng Changfa Xia Ji Peng Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College/Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and ImplementBeijing 100021China Department of Anesthesiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Cancer Prevention and Control Shenzhen Center for Chronic Disease ControlShenzhen 518020China

Objective:China and the United States(the U.S.)have the heaviest colorectal cancer(CRC)burden with considerable variations in temporal trends.This study aims to analyze the temporal patterns of CRC burden and its risk factors in China and the U.S.across the past three decades.Methods:Data were extracted from the Global Burden of Disease(GBD)Study in 2019,including cases,deaths,disability-adjusted life-years(DALYs),age-standardized rate(ASR),and summary exposure value(SEV)of CRC in China and the U.S.between 1990 and 2019.Annual average percentage changes(AAPCs)of CRC burden were calculated using the Joinpoint regression model.The mortality in CRC attributable to potential risk factors was characterized by countries,gender,and age groups.Results:In 2019,there were 607,900 and 227,241 CRC cases,and 261,777 and 84,026 CRC deaths in China and the U.S.,respectively.The age-standardized incidence rate(ASIR)was 30.55 per 100,000 in China and 41.86 per100,000 in the U.S.,and the age-standardized mortality rate(ASMR)was 13.86 per 100,000 in China and 14.77 per100,000 in the U.S.CRC incidence,mortality,and DALY rate in the U.S.showed downward trends in the past three decades(AAPC=-0.47,-1.06,and-0.88,respectively),while upward trends were observed in China(AAPC=3.11,1.05,and 0.91,respectively).Among the cause of CRC,the leading risk factor contributing to CRC death was low milk in China and smoking in the U.S.,respectively.Conclusions:From 1990 to 2019,the burden of CRC in China increased dramatically,particularly for males and middle-aged and elderly people.The management of the major risk factors associated with the high burden of CRC should be enhanced.

关键词： Colorectal cancer burden trends China the U.S

BDNF secreted from nerve fibroblasts promotes neurite outgrowth of motoneurons by activating ERK and AKT pathway

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BDNF secreted from nerve fibroblasts promotes neurite outgro...

中国解剖学会2021年年会

作者： he qianru Shi Haiyan Cong Meng Ding Fei Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Nantong University

Peripheral nerve fibroblasts play an important role in the process of nerve development and regeneration.The present study revealed that fibroblasts with different tissue sources,such as peripheral nerve fibroblasts (N-Fbs) and cardiac Fbs (C-Fbs),exerted distinct effects on motoneurons.Compared to C-Fbs,N-Fbs significantly promoted neurite outgrowth of motoneurons in vitro.

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模型平均辅助抽样估计方法研究

统计与决策 2023年第9期39卷 35-41页

作者：陈茜儒贺建风广东金融学院金融数学与统计学院广州510630 华南理工大学经济与金融学院广州510006

大数据背景下,数据维度高是辅助变量的重要特征,会在超总体模型建模过程中带来模型的不确定性问题,导致单一模型辅助抽样估计精度降低。为此,文章将模型平均方法引入模型辅助抽样估计的框架中。首先,在线性超总体模型下,结合模型平均方... 详细信息

大数据背景下,数据维度高是辅助变量的重要特征,会在超总体模型建模过程中带来模型的不确定性问题,导致单一模型辅助抽样估计精度降低。为此,文章将模型平均方法引入模型辅助抽样估计的框架中。首先,在线性超总体模型下,结合模型平均方法和广义回归估计思想,提出了模型平均辅助抽样估计量;其次,通过数值模拟验证了模型平均辅助抽样估计优于单一模型辅助抽样估计,尤其是在存在干扰信息时,其估计优势更加明显;最后,用实际数据验证了模型平均辅助抽样估计的优势。

关键词：抽样估计模型平均模型辅助辅助信息

Cancer statistics for young adults aged 20 to 49 years in China from 2000 to 2017: a population-based registry study

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Science China Life Sciences 2023年

作者： Yi Teng Changfa Xia he Li Maomao Cao Fan Yang Xinxin Yan Siyi he Mengdi Cao Shaoli Zhang qianru Li Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

An increasing cancer incidence among adults younger than 50 years has been reported for several types of cancer in multiple countries. We aimed to report cancer profiles and trends among young adults in China. Data from the China Cancer Registry Annual Report were used to estimate incidence and mortality among young adults(ages 20–49 years) in China in 2017, and an age-period-cohort model was employed to estimate the average annual percent change(AAPC) in incidence and mortality from 2000 to 2017. All 25 cancer types were grouped into obesity-or overweight-associated cancers(12 cancer types) and additional cancers(13 cancer types). In 2017, there were 681,178new cases and 214,591 cancer deaths among young adults in China. Among young adults, the most common cancers were thyroid, breast,cervical, liver, lung, and colorectal cancer, and the leading causes of cancer deaths were liver, lung, cervical, stomach, breast, and colorectal cancer. From 2000 to 2017, the cancer incidence increased for all cancers combined among young adults, with the highest AAPC(1.46%) for adults aged 20–24 years, while cancer mortality decreased, with the highest AAPC(-1.63%) for those aged 35–39 years.In conclusion, the cancer incidence in China has increased among young adults, while cancer mortality has decreased for nearly all ages.Cancer control measures, such as obesity control and appropriate screening, may contribute to reducing the increasing cancer burden among young adults.

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