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Intestinal monocarboxylate transporter 1 mediates lactate transport in the gut and regulates metabolic homeostasis of mouse in a sex-dimorphic pattern

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Life Metabolism 2024年第1期3卷 21-36页

作者： Shuo Wang Lingling Zhang Jingyu Zhao Meijuan Bai Yijun Lin qianqian chu Jue Gong Ju Qiu Yan Chen CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China

The monocarboxylate transporter 1(MCT1),encoded by gene Slc16a1,is a proton-coupled transporter for lactate and other monocar***1-mediated lactate transport was recently found to regulate various biological ***,how MCT1 and lactate in the intestine modulate the physiology and pathophysiology of the body is *** this study,we generated a mouse model with specific deletion of Slc16a1 in the intestinal epithelium(Slc16a1IKO mice)and investigated the functions of MCT1 in the *** fed a high-fat diet,Slc16a1IKO male mice had improvement in glucose tolerance and insulin sensitivity,while Slc16a1IKO female mice only had increased *** of intestinal MCT1 in male mice was associated with downregulation of pro-inflammatory pathways,together with decreased circulating levels of inflammatory cytokines including tumor necrosis factor alpha(TNFα)and C-C motif chemokine ligand 2(CCL2).Lactate had a stimulatory effect on pro-inflammatory macrophages in *** number of intestinal macrophages was reduced in Slc16a1IKO male mice in *** deletion of Slc16a1 in male mice reduced interstitial lactate level in the *** addition,treatment of male mice with estrogen lowered interstitial lactate level in the intestine and abolished the difference in glucose homeostasis between Slc16a1IKO and wild-type *** of intestinal MCT1 also blocked the transport of lactate and short-chain fatty acids from the intestine to the portal *** effect of Slc16a1 deletion on glucose homeostasis in male mice was partly mediated by alterations in gut *** conclusion,our work reveals that intestinal MCT1 regulates glucose homeostasis in a sex-dependent manner.

关键词： MCT1 intestine lactate short-chain fatty acids insulin resistance obesity

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公共图书馆助力乡村振兴价值实现路径思考

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河南图书馆学刊 2024年第1期44卷 15-17页

作者：褚倩倩枣庄市图书馆山东枣庄277100

推进乡村全面振兴,文化是灵魂,贯穿始终,深刻影响乡村振兴工程的实施与成效。公共图书馆作为社会教育的重要阵地,必须肩负起为乡村居民提供按需服务的重任,助力乡村产业、人才、文化、生态和组织全面振兴,彰显新时代自身核心价值。文章... 详细信息

推进乡村全面振兴,文化是灵魂,贯穿始终,深刻影响乡村振兴工程的实施与成效。公共图书馆作为社会教育的重要阵地,必须肩负起为乡村居民提供按需服务的重任,助力乡村产业、人才、文化、生态和组织全面振兴,彰显新时代自身核心价值。文章基于乡村文化发展的时代背景,剖析了乡村文化建设的困境,提出了公共图书馆助力乡村振兴的具体路径。

关键词：公共图书馆乡村振兴长效机制价值实现

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Omnidirectional annealing process for scalable perovskite films

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International Journal of Minerals,Metallurgy and Materials 2022年第8期29卷 1491-1492页

作者： Bo Cheng Dong Wang qianqian chu Liang chu State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals School of Materials Science and EngineeringLanzhou University of Tech-nologyLanzhou 730050China Institute of Carbon Neutrality and New Energy&School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China

Halide perovskites are promising photovoltaic materials due to the outstanding photoelectric properties and low-cost solution pro-cess;however,the low scalability and reproducibility of perovskite films hinder the *** medium annealing(LMA)method has provided a robust liquid environment and an omnidirectional heating field to modulate the growth of perovskite films for high quality with low defect density,desirable stoichiometry,high homogeneity,and less environmental *** fabricated perovskite solar cells exhibited excellent reproducibility and power conversion efficiencies exceeding 24.04%with 0.08 cm^(2) area and 23.15%with 1 cm^(2) area.

关键词： halide perovskite scalable and reproducible fabrication liquid medium annealing

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NUMERICAL ANALYSIS OF CRANK-NICOLSON SCHEME FOR THE ALLEN-CAHN EQUATION

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Journal of Computational Mathematics 2021年第5期39卷 655-665页

作者： qianqian chu Guanghui Jin Jihong Shen Yuanfeng Jin Department of Mathematics Yanbian UniversityYanji 133002China Department of Mathematics Science Harbin Engineering UniversityHarbin 150001China

We consider numerical methods to solve the Allen-Cahn equation using the second-order Crank-Nicolson scheme in time and the second-order central difference approach in *** existence of the finite difference solution is proved with the help of Browder fixed point *** difference scheme is showed to be unconditionally convergent in Loo norm by constructing an auxiliary Lipschitz continuous *** on this result,it is demonstrated that the difference scheme preserves the maximum principle without any restrictions on spatial step size and temporal step *** numerical experiments also verify the reliability of the method.

关键词： Allen-Cahn Equation Crank-Nicolson scheme Maximum principle Convergence

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The Some Properties of Skew Polynomial Rings

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Advances in Pure Mathematics 2016年第7期6卷 507-511页

作者： qianqian chu Hailan Jin Department of Mathematics College of Sciences Yanbian University Yanji China

This paper mainly studies some properties of skew polynomial ring related to Morita invariance, Armendariz and (quasi)-Baer. First, we show that skew polynomial ring has no Morita invariance by the counterexample. Then we prove a necessary condition that skew polynomial ring constitutes Armendariz ring. We lastly investigate that condition of skew polynomial ring is a (quasi)-Baer ring, and verify that the conditions is necessary, but not sufficient by example and counterexample.

关键词： Skew Polynomial Ring (Quasi)-Baer Ring Armendariz Ring Morita Context Ring Morita Invariance Nozero Divisor Ring

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High-performance liquid metal electromagnetic actuator fabricated by femtosecond laser

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International Journal of Extreme Manufacturing 2024年第2期6卷 511-521页

作者： Yiyu Chen Hao Wu Rui Li Shaojun Jiang Shuneng Zhou Zehang Cui Yuan Tao Xinyuan Zheng qianqian Zhang Jiawen Li Guoqiang Li Dong Wu Jiaru chu Yanlei Hu CAS Key Laboratory of Mechanical Behavior and Design of Materials Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education InstitutesDepartment of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefei 230027People’s Republic of China Key Laboratory of Testing Technology for Manufacturing Process of Ministry of Education Southwest University of Science and TechnologyMianyang 621010People’s Republic of China Department of Mechanical Engineering The University of Hong KongHong Kong Special Administrative Region of ChinaPeople’s Republic of China

Small-scale electromagnetic soft actuators are characterized by a fast response and simplecontrol,holding prospects in the field of soft and miniaturized *** use of liquid metal(LM)to replace a rigid conductor inside soft actuators can reduce the rigidity and enhance the actuation performance and *** research efforts,challenges persist in the flexible fabrication of LM soft actuators and in the improvement of actuation *** address these challenges,we developed a fast and robust electromagnetic soft microplate actuator based on a laser-induced selective adhesion transfer *** with unprecedentedly thin LM circuit and customized low Young’s modulus silicone rubber(1.03 kPa),our actuator exhibits an excellent deformation angle(265.25?)and actuation bending angular velocity(284.66 rad·s^(-1)).Furthermore,multiple actuators have been combined to build an artificial gripper with a wide range of *** actuator presents new possibilities for designing small-scaleartificial machines and supports advancements in ultrafast soft and miniaturized robotics.

关键词： soft actuators femtosecond laser liquid metal

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关于推进军民融合深度发展的思考

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北京理工大学学报（社会科学版） 2016年第4期18卷 109-112页

作者：褚倩倩北京理工大学管理与经济学院北京100081

优化资源配置是军民融合的本质,也是理解军民融合内涵的重要思路。军民融合的逻辑起点在于国防建设与经济建设的关系。优化资源配置的关键在于社会总需求的牵引,并兼顾多种主体的权利和利益。军民融合体现的是国家整体利益,需要把它转... 详细信息

优化资源配置是军民融合的本质,也是理解军民融合内涵的重要思路。军民融合的逻辑起点在于国防建设与经济建设的关系。优化资源配置的关键在于社会总需求的牵引,并兼顾多种主体的权利和利益。军民融合体现的是国家整体利益,需要把它转化为各利益主体都可以接受并能积极推进的工作格局。推进军民融合深度发展,关键要抓住优化资源配置,国家、政府、军队、产业、企业不同层级各有所侧重展开工作。国家注重顶层设计,政府部门按职能分工贯彻军民融合战略,军队部门重在破除封闭体系,产业层面注重产业融合,企业要坚持市场导向,加快企业改革。

关键词：军民融合资源配置利益主体利益共赢

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Continuous high-efficient water-electricity cogeneration over a hybrid solar-driven water evaporation system and the working mechanism

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Science China Materials 2024年第7期67卷 2371-2372页

作者： Dewei chu School of Materials Science and Engineering University of New South WalesSydneyNSW 2052Australia

With the escalation of industrialization and population growth,energy and clean water shortages pose an unprecedented threat to sustainable ***,it is imperative to develop green and effective strategies to address these *** this context,solar-driven interfacial water evaporation(SIWE)has emerged as a highly promising low-carbon solution to the water-energy nexus[1].By locating the evaporator at airwater interfaces,heat localization can be achieved,leading to high-efficient water evaporation and freshwater *** significantly,taking advantage of the special conditions during SIWE has opened numerous opportunities for generation of extra electrical power[2,3].Throughout the processes of SIWE,various elements such as photons,waves,capillary flow,evaporation,vapor motions,condensation,and droplet sliding can all be harnessed to produce electricity through photovoltaic,thermoelectric,thermogalvanic,pyroelectric,piezoelectric,triboelectricity and hydrovoltaic effects[3].Extensive research efforts have provided valuable insights for the development of water-electricity cogeneration(WEG)hybrid systems.

关键词： mechanism evaporation piezoelectric

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Paving the way toward soil safety and health:current status,challenges,and potential solutions

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 63-73页

作者： Chiheng chu Lizhong Zhu College of Environmental and Resource Sciences Zhejiang UniversityHangzhou 310058China

Soil is a non-renewable resource,providing a majority of the world’s food and fiber while serving as a vital carbon ***,the health of soil faces global threats from human activities,particularly widespread contamination by industrial *** physical,chemical,and biological remediation approaches encounter challenges in preserving soil structure and function throughout the remediation process,as well as addressing the complexities of soil contamination on a regional *** solutions encompass monitoring and simulating soil processes,with a focus on utilizing big data to bridge micro-scale and macro-scale ***,reducing pollutant emissions to soil is paramount due to the significant challenges associated with removing contaminants once they have entered the soil,coupled with the high economic costs of ***,it is imperative to implement advanced remediation technologies,such as monitored natural attenuation,and embrace holistic soil management approaches that involve regulatory frameworks,soil health indicators,and soil safety monitoring *** the enduring health and resilience of soils necessitates a blend of interdisciplinary research,technological innovation,and collaborative initiatives.

关键词： Soil safety and health Source emission reduction Process monitoring and simulation Green remediation technology Soil health management

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TDP-43 is a key molecule accelerating development of Alzheimer’s disease following traumatic brain injury

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Neural Regeneration Research 2024年第5期19卷 955-956页

作者： chu Chen Department of Cellular and Integrative Physiology Long School of MedicineUniversity of Texas Health Science Center at San AntonioSan AntonioTXUSA

Currently,more than 55 million people have dementia worldwide and Alzheimer’s disease(AD)is one of the most common causes of dementia in ***,no effective therapies are currently available for the prevention and treatment of *** is largely due to our limited understanding of the mechanisms underlying the neuropathogenesis of *** has widely been recognized that AD is heterogeneous and that multi-factors are contributing to the pathogenesis of *** evidence suggests that traumatic brain injury(TBI)is an important risk factor for the development of AD and dementia later in life(Guo et al.,2000;Johnson et al.,2010).However,the precise mechanism by which TBI contributes to developing AD has yet to be elucidated.

关键词： Alzheimer traumatic

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