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Comparative Analysis of Epidemiological Features of HIV/AIDS Cases Aged Over and Under 50 Years Old—China,2010-2022

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China CDC weekly 2023年第48期5卷 1079-1083页

作者： Yushan Hou Yichen Jin Chang Cai qianqian qin Houlin Tang Fan Lyu National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Introduction:Recent data indicate a year-on-year increase in the proportion of human immunodeficiency virus/acquired immunodeficiency syndrome(HIV/AIDS)cases reported among individuals aged≥50 in *** study compares the epidemiological characteristics of HIV/AIDS cases in populations above and below 50 years of *** doing so,it seeks to scrutinize the current epidemiological landscape of HIV within these distinct age cohorts and suggest tailored interventions for each ***:We utilized data from the Chinese HIV/AIDS Comprehensive Response Information Management System for our comparative *** regression analysis was employed to assess the trends in standardized detection ***:In China,the number of newly reported HIV/AIDS cases in the 15-49 age group increased from 51,436 in 2010 to 55,397 in 2022,while it increased from 11,751 in 2010 to 51,856 in 2022 in the group aged≥50 *** years have seen a greater proportion and detection rate of HIV/AIDS cases among the≥50 age demographic compared to the 15-49 age *** 2022,significant statistical differences were observed between males and females in both age cohorts with respect to education,marital status,occupation,mode of transmission,location of diagnosis,and ***:The observed trend of a rising proportion of HIV/AIDS cases in individuals aged 50 years and older necessitates heightened *** is imperative that we develop and implement interventions specifically designed to prevent and control the transmission of HIV within this demographic.

关键词： HIV/AIDS diagnosis analysis

Type one protein phosphatases(TOPPs)contribute to the plant defense response in Arabidopsis

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Journal of Integrative Plant Biology 2020年第3期62卷 360-377页

作者： Yaqiong Liu Jia Yan qianqian qin Jing Zhang Yan Chen Lulu Zhao Kai He Suiwen Hou MOE Key Laboratoryof Cell Activities and Stress Adaptations School of Life SciencesLanzhou UniversityLanzhou 730000China

Plant immunity must be tightly controlled to avoid activation of defense mechanisms in the absence of pathogen attack. Protein phosphorylation is a common mechanism regulating immune signaling. In Arabidopsis thaliana, nine members of the type one protein phosphatase(TOPP) family(also known as protein phosphatase 1, PP1) have been identified. Here, we characterized the autoimmune phenotype of topp4-1, a previously identified dominant-negative mutant of TOPP4. Epistasis analysis showed that defense activation in topp4-1 depended on NON-RACE-SPECIFIC DISEASE RESISTANCE1,PHYTOALEXIN DEFICIENT4, and the salicylic acid *** generated topp1/4/5/6/7/8/9 septuple mutants to investigate the function of TOPPs in plant immunity. Elevated defense gene expression and enhanced resistance to Pseudomonas syringae pv. tomato(Pst) DC3000 in the septuple mutant indicate that TOPPs function in plant defense responses. Furthermore, TOPPs physically interacted with mitogen-activated protein kinases(MAPKs)and affected the MAPK-mediated downstream defense pathway. Thus, our study reveals that TOPPs are important regulators of plant immunity.

关键词： plant Arabidopsis TOP

Spatial Analysis of People Living with HIV/AIDS Transmitted Through Commercial Heterosexual Contact or Non-Marital Non-Commercial Heterosexual Contact—China,2018

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China CDC weekly 2021年第15期3卷 316-319页

作者： Zhilong Dong Xiaohong Pan Chang Cai qianqian qin George F.Gao Fan Lyu National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Zhejiang Provincial Center for Disease Control and Prevention HangzhouZhejiangChina National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina.

Summary What is already known about this topic?Significant changes in human immunodeficiency virus(HIV)transmission modes have occurred in China,and the proportion of heterosexual transmission increased in recent *** is added by this report?The proportions of diverse transmission routes and subgroups of heterosexual transmission were analyzed by provincial-level administrative divisions(PLADs).

关键词： HIV/AIDS Spatial immunodeficiency

Estimation and Projection of the HIV Epidemic Trend among the Migrant Population in China

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Biomedical and Environmental Sciences 2011年第4期24卷 343-348页

作者： MENGXiaoJun WANG Lu Susan CHAN Kathleen Heather REILLY PENG ZhiHang GUO Wei DING GuoWei DING ZhengWei qin qianqian National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206 China Department of Public Health Nanjing Medical University Nanjing 210029 Jiangsu China

Objective The migrant population is a vulnerable group for HIV infection in *** potential epidemic trends among migrants is critical for developing HIV preventative measures in this *** The Estimation and Projection Package （EPP） model was used to process prefecture and county-level surveillance data to generate HIV prevalence and epidemic trends for migrant populations in *** The prevalence of HIV among migrants in 2009 was estimated at 0.075% （95% CI：0.042%,0.108%） in *** HIV epidemic among migrants is likely to increase over the next 5 years,with the prevalence expected to reach 0.110% （95% CI：0.070%,0.150%） by *** Although the 2009 estimates for the HIV/AIDS epidemic in China indicate a slower rate of increase compared with the national HIV/AIDS epidemic,it is estimated to persistently increase among migrants over the next 5 *** will have a strong impact on the overall future of the HIV epidemic trend in China and evidence-based prevention and monitoring efforts should be expanded for this vulnerable population.

关键词： China Transients and migrants Estimation and projection package HIV/AIDS

Evolution of HIV Epidemic and Emerging Challenges—China,1989–2023

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China CDC weekly 2024年第48期6卷 1251-1256页

作者： Chang Cai Houlin Tang Dongmin Li qianqian qin Fangfang Chen Yichen Jin Fan Lyu National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Introduction:This study aimed to provide a comprehensive analysis of the human immunodeficiency virus(HIV)epidemiological landscape in China through a historical review and current ***:Data were extracted from China’s HIV/AIDS Comprehensive Response Information Management System(CRIMS).Transmission patterns across different phases were visualized using stacked area *** correlations between transmission routes were analyzed using scatter plots and Pearson correlation *** extent and trends of HIV spread among the general population were evaluated using Venn diagrams and Cochran-Armitage ***:The HIV epidemic in China evolved through four distinct phases:injecting drug user(IDU)dominated(1989–1994),former plasma donor(FPD)outbreak(1995–2005),sexual transmission dominance(2006–2014),and general population spread(2015–present).A strong correlation was observed between provinces reporting high numbers of IDU cases and those with elevated heterosexual transmission(r=0.88,P<0.001).Between 2015 and 2023,393,926 cases were identified among the general population through non-marital and non-commercial heterosexual contact(NMNCHC).The proportion of general population cases among heterosexual transmissions increased significantly from 46.2%to 55.7%(Z=42.7,P<0.001).Conclusion:The significant spread of HIV into the general population necessitates the development of targeted prevention strategies for both high-risk and general populations to address emerging epidemiological challenges.

关键词： prevention elevated IDU

IL-13/IL-13RA2 signaling promotes colorectal cancer stem cell tumorigenesis by inducing ubiquitinated degradation of p53

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Genes & Diseases 2024年第1期11卷 495-508页

作者： Baoyu He Jing Liang qianqian qin Yuqin Zhang Shuo Shi Jinghe Cao Zhixin Zhang qingli Bie Rou Zhao Li Wei Baogui Zhang Bin Zhang Department of Laboratory Medicine Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJiningShandong 272000China Postdoctoral Mobile Station of Shandong University of Traditional Chinese Medicine JinanShandong 250355China Department of Reproductive Medicine Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJiningShandong 272000China Department of Gastrointestinal Surgery Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJiningShandong 272000China Institute of Forensic Medicine and Laboratory Medicine Jining Medical UniversityJiningShandong 272067China

Cancer stem cells(CSCs)are considered tumor-initiating cells and the main drivers of disease *** these rare cancer cells,however,remains challenging with respect to therapeutic ***,we report the up-regulation of IL-13RA2 expression in colorectal cancer(CRC)tissues and spheroid *** expression of IL-13RA2 was positively correlated with canonical stemness markers in *** further demonstrated that the level of IL-13 was up-regulated in the serum of CRC ***,recombinant IL-13(rIL13)stimulation promoted the sphere formation,proliferation,and migration of CRC cells in vitro and enhanced tumorigenesis in *** phenotype could be reversed by knocking down ***,IL-13 activated autophagy by inducing LC3I/LC3II transformation in CRC-CSCs,which was crucial for the biological functions of *** further demonstrated that IL-13RA2 acted as a modular link of the E3 ligase UBE3C and the substrate p53 protein,enhancing the interaction of UBE3C and p53,thereby inducing the K48-linked ubiquitination of *** conclusion,the IL-13/IL-13RA2 signaling cascade promotes CRC-CSC self-renewal and tumorigenesis by inducing p53 ubiquitination,adding an important layer to the connection between IL-13 and p53,which can be translated into novel targeted therapies.

关键词： Autophagy Colorectal cancer stem cells IL-13/IL-13RA2 signaling p53

Survival of People Living with HIV/AIDS from Pre-ART Era to Treat-all Era—China,1985–2022

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China CDC weekly 2024年第48期6卷 1264-1270页

作者： Shi Wang Houlin Tang Decai Zhao Chang Cai Yichen Jin qianqian qin Fangfang Chen Liping Fei Hehe Zhao Zhongnian Yang Fan Lyu National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Introduction:A comprehensive analysis of nationwide survival trends for people living with human immunodeficiency virus/acquired immunodeficiency syndrome(HIV/AIDS,PLWHA)from the initial reported case to present has not been *** study evaluated the survival outcomes of PLWHA reported in China from 1985 to ***:We analyzed data from PLWHA recorded in the National HIV/AIDS Comprehensive Response Information Management System from 1985 to *** rates were calculated using Kaplan-Meier curves,and factors associated with survival time were analyzed using Cox proportional hazard ***:Progressive relaxation of antiretroviral therapy initiation criteria led to significant improvements in survival rates across different diagnostic periods in *** 1-year and 5-year cumulative survival rates increased from 85.2%and 66.1%in the 1985–2003 cohort to 91.1%and 81.4%in the 2016–2022 *** proportional hazard analysis revealed elevated mortality risks among males,individuals aged≥65 years,those with injection drug use or other transmission routes,hospital-tested patients,and those with lower CD4 counts at diagnosis or without ***:Antiretroviral therapy has effectively reduced mortality risk among PLWHA in *** efforts should focus on expanding HIV testing to reduce the proportion of late diagnoses with lower CD4 counts and providing targeted,differentiated services for older populations to further decrease mortality risk among PLWHA.

关键词： Survival HIV/AIDS mortality

Investigation on the Extraction of Chloroplast Proteome

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Agricultural Biotechnology 2014年第2期3卷 35-36页

作者： Chengcheng SHAO qianqian qin Xu ZHANG Yun WANG Xiaodan YAN Fugui CHEN College of Life Sciences Anhui Normal University

As an important subcellular organelle for plant photosynthesis, chloroplast proteome research has become an important branch and hot issue of plant pro- teonfics. However, no efficient method has been established for extracting chloroplast proteome from plant leaves. In this paper, recent advances in extraction meth- ods of plant chloroplast proteome were summarized, which laid solid foundation for establishing efficient and practicable extraction methods of chloroplast proteome.

关键词： Chloroplast Proteome Extraction

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重度火烧干扰下的森林土壤功能

应用与环境生物学报 2021年第2期27卷 503-512页

作者：秦倩倩刘艳红北京林业大学生态与自然保护学院北京100083 北京林业大学森林资源生态系统过程北京市重点实验室北京100083

随着全球气候变暖,森林火灾发生频率显著增加,火烧作为森林结构和功能变化的主要驱动因子之一,其燃烧过程在短期或长期尺度上影响森林土壤功能和生物地球化学循环.本文从重度火烧引起的温度效应与森林土壤功能的关系着手,就重度火烧干... 详细信息

随着全球气候变暖,森林火灾发生频率显著增加,火烧作为森林结构和功能变化的主要驱动因子之一,其燃烧过程在短期或长期尺度上影响森林土壤功能和生物地球化学循环.本文从重度火烧引起的温度效应与森林土壤功能的关系着手,就重度火烧干扰对森林土壤功能(水源涵养、缓冲过滤、养分循环、碳存储和生物栖息)的影响和自然恢复森林土壤功能的演变规律及恢复时限进行了综述和讨论.重度火烧造成大量的森林植被和凋落物损失,直接导致土壤温度升高、有机质减少和酸碱性增强,致使土壤酶变性和土壤微生物死亡,并通过氧化、挥发、灰分颗粒对流和淋溶等途径改变了森林土壤的养分浓度,而林地微环境的变化间接影响了土壤功能的演变规律和生态恢复.鉴于不同火烧类型和恢复年限对不同地区、不同类型以及不同层次森林土壤影响的复杂性,未来需要对重度火烧干扰后自然恢复的森林土壤功能进行长期定位且系统地研究,明确土壤各功能间相互作用及土壤功能恢复的机制;此外,土壤斥水性、微量元素和活性有机碳等对重度火烧干扰的响应以及重度火烧与微生物多样性对土壤多功能性的级联效应亦亟待进一步研究.(图3参142)

关键词：森林重度火烧土壤功能自然恢复演变规律